적극적 스트레스 대처매개 중재가 임상실습 스트레스와 만족도에 미치는 영향

이정윤,황혜경,Lee, Jeong-Yun,Hwang, Hye-Kyung 한국임상보건과학회 2019 한국임상보건과학회지 Vol.7 No.2

Purpose: This study aimed to determine the mediating effects of aggressive stress response on the association between clinical practice stress and clinical practice satisfaction in ophthalmic optics majors and provide basic data that could help form opticians' professionalism and make clinical practice more effective. Methods: This study was conducted in 236 sophomores and juniors in Daegu and North Gyeongsang Province who had finished clinical practice. Hierarchical regression analysis and mediating effect testing were performed to determine the associations among clinical practice stress, clinical practice satisfaction, and aggressive stress response and determine the mediating effects of aggressive stress response on the association between clinical practice stress and clinical practice satisfaction. Results: Clinical practice stress was significantly negatively correlated with clinical practice satisfaction and aggressive stress response (p<0.01), and aggressive stress response was significantly positively correlated with clinical practice satisfaction (p<0.01). The association between clinical practice stress and clinical practice satisfaction was more likely to be explained by the addition of clinical practice stress than by being aggressive stress response controlled, which statistically significantly met the criteria for mediating effects (p<0.001). Conclusions: It is necessary to pay more attention to program development and teaching methods within the department of ophthalmic optics so that ophthalmic optics majors can utilize aggressive stress response to overcome clinical practice stress effectively and improve clinical practice satisfaction.

풍향계 - 탈핵 에너지 전환 시대의 대한민국 원자력 - 핵심은 안전

이정윤,Lee, Jeong-Yun 한국원자력산업회의 2017 원자력산업 Vol.37 No.7

"적게 먹지 않아도 된다"에 속지 말라

이정윤,Lee, Jeong-Yun 한국과학기술단체총연합회 2003 과학과 기술 Vol.36 No.7

실시간 신호제어를 위한 신경망 적용 지체최소화 주기길이 설계모형 개발

이정윤,김진태,장명순,Lee, Jeong-Yun,Kim, Jin-Tae,Jang, Myeong-Sun 한국도로교통협회 2005 도로교통 Vol.99 No.-

도로표지 설계에 사용성 평가기법 도입방안 검토 연구

이정윤,김주영,Lee, Jeong-Yun,Kim, Ju-Yeong 한국도로교통협회 2004 도로교통 Vol.96 No.-

측두하악관절의 골관절염

이정윤,Lee, Jeong-Yun 대한안면통증구강내과학회 2013 Journal of Oral Medicine and Pain Vol.38 No.1

측두하악관절 골관절염은 측두하악장애의 한 형태로 관절조직의 생리적 내성을 초과하는 기능적 부하가 지속적으로 관절에 가해졌을 때 관절연골 및 연골하 골조직의 점진적 파괴와 이차적 염증을 특징으로 하는 질환이다. 관절면에 가해지는 물리적 하중은 관절내에서 기질파괴 단백효소나 염증성 cytokine, 유리기의 활성을 증가시키고, 그에 따라 골조직의 퇴행과 재형성 사이의 균형을 깨뜨려 골조직의 흡수를 야기한다. 최근에는 물리적 하중 이 외에 비만세포에서 유래하는 adipokine이 골흡수를 증가시킨다는 보고들이 있으나 측두하악관절에 적용하기에는 아직 추가적인 연구가 필요하므로 현재로서 골관절염의 치료는 관절의 기능적 부하를 줄이고 환자의 생리적 내성을 증가시키는 방향으로 이루어져야 한다. 임상증상은 충분한 기간 정확한 술식대로 시행한 물리치료, 약물치료, 교합안정 장치치료 등의 보존적 처치와 관절강내 주사요법이나 관절세척술 및 관절경 수술과 같은 추가적인 외과적 처치에 의해 성공적으로 조절될 수 있으나, 임상증상의 개선이 골파괴의 중지와 재형성을 담보하는 것은 아니므로 임상증상의 개선 이 후에도 지속적인 골변화의 추적관찰이 필요하다. 또한, 골변화 활성 자체를 직접적으로 조절할 수 있는 활용 가능한 치료법이 없는 한, 지속적인 동기유발과 행동조절을 통해 관절에 가해지는 기능적 부하를 환자 스스로 조절할 수 있도록 끊임없이 교육하는 것이 골변화를 겪는 측두하악관절로 하여금 보다 이른 시기에 보다 유리한 정형적 안정에 도달하게 함으로써 골관절염을 보다 성공적으로 조절할 수 있는 길이라고 할 수 있다. Osteoarthritis (OA) of the temporomandibular joint (TMJ) is a severe form of temporomandibular disorders (TMDs), presenting gradual breakdown of articular cartilage and subchondral bone by the functional load sustained to exceed the physiologic tolerance of the joint. In such a joint loaded, offensive bioactive materials such as matrix degrading proteins, cytokines, and free radicals increase in concentration to shift the tissue response in the joint to degeneration from regeneration or remodeling. Recently, it has been issued that obesity can play an offensive role in pathogenesis of OA in a metabolic way. Adipokines released by adipose cells are present at higher concentration in the arthritic joint and joints of obese individuals. However, because of conflicting data reported, further scientific study should be performed to elucidate the practical role of adipokines in pathogenesis of TMJ OA. As far as the clinical signs and symptoms of TMJ OA are not much different from those of other forms of TMD and any definitive treatment modality to control directly the bone resorptive activity is not available yet, the treatment of TMJ OA should be directed to reduce the physical load and enhance the physiologic tolerance of the joint by means of conservative treatment such as physical therapy, medication, and occlusal splint therapy for sufficient period and, if needed after that, supplementary surgical procedure such as intra-articular injection, arthrocenthesis, and arthroscopic surgery that have turned out to be effective to control OA signs and symtpoms. Enthusiastic reassurance and motivation for patients to control behaviors for themselves to reduce unnecessary functional load in daily life is very important for the joint to reach to more favorable orthopedic stability of the TMJ more quickly, guaranteeing more successful management TMJ OA.

절연유중 부분방전 검출을 위한 안테나의 최적 설계

이정윤,조향은,박대원,길경석,오재근,Lee, Jung-Yoon,Jo, Hyang-Eun,Park, Dae-Won,Kil, Gyung-Suk,Oh, Jae-Geun 한국전기전자재료학회 2013 전기전자재료학회논문지 Vol.26 No.4

This paper dealt with the radiated electromagnetic wave detection of partial discharge (PD) in oil for insulation diagnostics of oil-immersed transformers. Three types of electrode system were fabricated to simulate the insulation defects that could occur in oil-immersed transformers. Frequency components of radiated electromagnetic wave in oil was measured by broadband bi-conical antennas of 300 MHz~2 GHz and a spectrum analyzer of 9 kHz~3 GHz. Frequency component of electromagnetic waves from PD in oil were highly distributed at 500 MHz. From the result, a narrow-band monopole antenna with the center frequency of 500 MHz was fabricated. We could detect PD signal in insulation oil without an influence of external noise by a measurement system which consists of the prototype monopole antenna, a LNA (Low Noise Amplifier), an oscilloscope and a spectrum analyzer.

Effects of red ginseng oil(KGC11 o) on testosterone-propionate-induced benign prostatic hyperplasia

이정윤,김소혁,김석호,김종한,배봉석,구기방,Seung Ho So,Jeongmin Lee,Yoo-Hyun Lee 고려인삼학회 2022 Journal of Ginseng Research Vol.46 No.3

Benign prostatic hyperplasia (BPH) is a disease characterized by abnormal proliferation ofthe prostate, which occurs frequently in middle-aged men. In this study, we report the effect of redginseng oil (KGC11o) on BPH. Methods: The BPH-induced Sprague-Dawley rats were divided into seven groups: control, BPH, KGC11o25, 50, 100, 200, and finasteride groups. KGC11o and finasteride were administered for 8 weeks. The BPHbiomarkers, DHT, 5AR1, and 5AR2, androgen receptor, prostate-specific antigen (PSA), Bax, Bcl-2, andTGF-b were determined in the serum and prostate tissue. The cell viability after KGC11o treatment wasdetermined using BPH-1 cells, and, androgen receptor, Bax, Bcl-2, and TGF-b were confirmed by westernblotting. Results: In the in vivo study, administration of KGC11o reduced prostate weight by 18%, suppressed DHT(up to 22%) and 5AR2 (up to 12%) levels from administration of 100 mg/kg KGC11o (P < 0.05). PSA wassignificantly downregulated dose-dependently from at the concentration of 50 mg/kg KGC11o (P < 0.05). BPH-1 cell viability significantly reduced through the treatment with KGC11o. In vitro and vivo, AR, Bcl-2TGF-b levels reduced significantly but Bax was increased (P < 0.05). Conclusion: These results suggest that KGC11o may inhibit the development of BPH by significantlyreducing the levels of BPH biomarkers via 5ARI, anti-androgenic effect, and anti-proliferation effect,serving as a potential functional food for treating BPH.

대표공종의 선정을 통한 약식 기성 산정 방법에 관한 연구 - 자연형 하천공사를 중심으로

이정윤,우성권,Lee, Jeong-Yoon,Woo, Sung-Kwon 한국건설관리학회 2010 한국건설관리학회 논문집 Vol.11 No.1

내역서를 기반으로 하는 국내 공공공사의 기성 산정 방법은 작업진도의 산출과 무관한 기성고 산정과 많은 양의 서류작성과 복잡한 절차 등의 많은 문제점이 있다. 국가계약법에서 정식과 약식 기성 산정 방법으로 구분되며, 이중에서 약식 기성 산정 방법은 절차와 신청서류를 간소화하여 이와 같은 문제점을 상당 부분 해결 가능하지만 이의 활용이 미비한 실정이다. 본 연구에서는 작업분류체계의 수립과 이를 기반으로 선정된 대표공종의 진도율을 이용하여 기성을 산정하는 방법을 제안하였으며, 자연형 하천공사의 실적공사 데이터를 수집하여 이를 적용을 통한 국내 공공공사의 기성 산정 방법과의 비교를 통해, 기성 산정을 위한 관리항목의 감소로 인한 업무 부담의 감소와 빠르고 효과적인 기성 산정을 통한 업무효율의 증가 등 그 효율성을 검증하였다. 이러한 기성 산정 방법론의 도입은 기존 방법의 문제점 해결을 통한 업무효율의 증가뿐만 아니라 향후 공공공사의 사업관리에 있어서 그 효율성이 검증된 공정-공사비 통합관리의 기반을 다지는 데 있어 큰 의미가 있다. In domestic public works, there are several problems in the measurement of payments based on the bill of quantity, which doesn't match with the activity progress rate, heavy paper works and complicated procedures. It can be classified formal and simplified method. By using the simplified method, it can be solved many problems by summarizing the procedure, but is not generally used. This paper proposes a payment method by progress measurement for specified activity based on WBS(Work Breakdown Structure) verifying efficiency which reduced cost account and advanced work on payment compare to method of domestic public works using the data about construction of eco-river. This method will be an important contribution on being a base for cost-schedule integrated management which were verified and also improving efficiency on measuring payment.

Biomarker-guided targeted therapy in platinum-resistant ovarian cancer (AMBITION; KGOG 3045): a multicentre, open-label, five-arm, uncontrolled, umbrella trial

이정윤,김병기,Jae Weon Kim,Jung Bok Lee,Eunhyang Park,Je-Gun Joung,김성훈,Chel Hun Choi,Hee Seung Kim 대한부인종양학회 2022 Journal of Gynecologic Oncology Vol.33 No.4

Objective: Management of heavily pre-treated platinum-resistant ovarian cancer remains a therapeutic challenge. Outcomes are poor with non-platinum, single-agent chemotherapy (CT); however, molecularly targeted anticancer therapies provide new options. Methods: This open-label, investigator-initiated, phase 2 umbrella trial (NCT03699449) enrolled patients with platinum-resistant ovarian cancer (at least 2 prior lines of CTand Eastern Cooperative Oncology Group 0/1) to receive combination therapy based on homologous recombination deficiency (HRD) and programmed death ligand 1 (PD-L1) status determined by archival tumour sample assessment. HRD-positive patients were randomised to either olaparib 200mg bid tablet + cediranib 30mg qd (arm 1) or olaparib 300mg bid tablet + durvalumab 1,500mg q4w (arm 2). HRD-negative patients were allocated to either durvalumab 1,500 mg q4w + pegylated liposomal doxorubicin (PLD) or topotecan or weekly paclitaxel (6 cycles; arm 3, those with PD-L1 expression) or durvalumab 1,500 mg q4w + tremelimumab 75mg q4w (4 doses) + PLD or topotecan or weekly paclitaxel (4 cycles; arm 4, those without PD-L1 expression). Arm 5 (durvalumab 1,500 mg q4w + tremelimumab 300mg [1 dose] + weekly paclitaxel [60 mg/m2 D1,8,15 q4w for 4 cycles] was initiated after arm 4 completed. The primary endpoint was objective response rate (ORR; Response Evaluation Criteria in Solid Tumours 1.1). Results: Between Dec 2018 and Oct 2020, 70 patients (median 57 years; median 3 prior treatment lines [range 2–10]) were treated (n=16, 14, 5, 18, and 17, respectively). Overall ORR was 37.1% (26/70, 95% confidence interval=25.9, 49.5); 2 achieved complete response. ORR was 50%, 42.9%, 20%, 33.3%, and 29.4%, respectively. Grade 3/4 treatment-related adverse events (TRAEs) were reported in 37.5%, 35.7%, 20%, 66.7%, and 35.3% of patients, respectively. No TRAEs leading to treatment discontinuation and no grade 5 TRAEs were observed. Conclusion: This study, the first biomarker-driven umbrella trial in platinum-resistant recurrent ovarian cancer, suggests clinical utility with biomarker-driven targeted therapy. All treatment combinations were manageable, and without unexpected toxicities.