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김석호,한영택 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.11
This paper describes an investigation of novelRAGE inhibitors with improved drug-like properties. Toidentify the improved drug-likeRAGE inhibitor, we designedand synthesized pyrimidine-2-carboxamide analogs based onour previous work. Several potent analogs with improvedhydrophilicity were identified by evaluation of RAGE inhibitoryactivity. In particular, one of the potent (diethylamino)ethoxymethoxy analogs did not exhibit undesiredcytotoxicity in contrast with the parent RAGE inhibitors.
김석호,김성훈,Marzia Rahman,김정민 한국미생물학회 2018 The journal of microbiology Vol.56 No.12
In this study, we sought to isolate Salmonella Enteritidis-specific lytic bacteriophages (phages), and we found a lytic phage that could lyse not only S. Enteritidis but also other Gramnegative foodborne pathogens. This lytic phage, SS3e, could lyse almost all tested Salmonella enterica serovars as well as other enteric pathogenic bacteria including Escherichia coli, Shigella sonnei, Enterobacter cloacae, and Serratia marcescens. This SS3e phage has an icosahedral head and a long tail, indicating belong to the Siphoviridae. The genome was 40,793 base pairs, containing 58 theoretically determined open reading frames (ORFs). Among the 58 ORFs, ORF49, and ORF25 showed high sequence similarity with tail spike protein and lysozyme-like protein of Salmonella phage SE2, respectively, which are critical proteins recognizing and lysing host bacteria. Unlike SE2 phage whose host restricted to Salmonella enterica serovars Enteritidis and Gallinarum, SS3e showed broader host specificity against Gram-negative enteric bacteria; thus, it could be a promising candidate for the phage utilization against various Gram-negative bacterial infection including foodborne pathogens.
SKull법에 의한 Colored Cubic Zirconia(CCZ)단결정 성장
김석호,최종건,정대식,오근호 한국세라믹학회 1988 한국세라믹학회지 Vol.25 No.5
Colored Cubic Zircona(CCZ) single crystals were grown by the skull melting method. The grown crystals were doped with up to 0.1wt% transition (Cu, Ni, Co, Ti, Fe, Mo, Cr, V, Mn) metal ions on ZrO2-Y2O3(9.5~10mol%) and their Optical transmission spectra(λ=300~800nm)data were obtained. Various colors were pronounced due to dopant effects in the grown Crystals.
Lack of Dream-Capital among Korean Youths: Rationally Chosen or Culturally Forbidden?
김석호,김홍중,이상규,김은지,권오재 서울대학교 사회발전연구소 2018 Journal of Asian Sociology Vol.47 No.3
This paper attempts to provide empirical evidence in understanding the ways that contemporary youth pursue their dreams in Korea. This paper examines the rational aspect of "dreaming" or "non-dreaming” by employing two concepts: dream-capital and penetration. In this paper, dream-capital is conceptualized as a seed that facilitates the accumulation of other capitals. It is the total capacity to dream and is composed of four dimensions: imagination, hope, optimism and resilience. Penetration is defined as the “cognitive judgment about the (un)realizability of dream.” It refers to the discrepancy that exists between judgment about the capacity, condition and qualification required to fulfill one’s dream and judgment about the extent to which one thinks she is equipped with that capacity, condition and qualification. Penetration consists of four factors: individual traits, ascribed status, individual qualifications, and national/social conditions. By analyzing the “Korean Youth Values Survey” data, this paper first examines how the general level of dream-capital is influenced by the total penetration score. And then, it also investigates the effects of four types of penetration on four dimensions of dream-capital. The results confirm that dream-capital is strongly affected by penetration. The ability to penetrate insufficient resources in pursuing dreams leads to lowering of dream-capital. Second, penetration on ascribed status and societal factors are found to be important predictors of dream-capital. These results reveal that for youth, the judgment made on their ascribed status rather than judgements made on individual trait or qualification plays a more important role in promoting dream-capital. The results imply that dreams are pursued and formed in close relation to rational cognitions among Korean youth. Korean youth are more likely to have dreams for long-term future when they believe that those dreams can be realized. Dreams are then rationalized fantasies.
Skull법에 의한 Cubic Zirconia 단결정 성장
김석호,최종건,오근호,조영환,김영준,오봉인,강원호 한국세라믹학회 1988 한국세라믹학회지 Vol.25 No.2
Yttria-Stabilized Cubic Zirconia Crystals with Various Y2O3 amounts (6-15mol%) were grown by the Skull melting technique. The modeling of the nucleation at the Skull bottom and the best growth condition were studied. The abrupt changes in generator heating Power and lowering rate of crucible caused the dendritic growth in the grown crystal. The optimum condition of cubic Zirconia single crystals was obtained when the lowering rate was gradually increased. The effect of Y2O3 amounts on the perfection adn the color of the grown crystal were determined. The darkish color generated in the crystals added Y2O3 amounts over 12mol% was eliminated by the annealing in air at 1200$^{\circ}C$ for 24hrs.
고주파수용 필터 설계를 위한 자이레이터 회로에 관한 연구
金石鎬,趙成翊,金東龍 全北大學校 1991 論文集 Vol.33 No.-
Switched-capacitor(SC) circuits have already been established in audio frequency range. However, SC circuits are not suitable for high frequency filters, because of the necessity of anti-aliasing filters and the limitation of high-frequency characteristics due to GBW(Gain-Band-Width) products of operational amplifiers. To overcome those disadvantages, a gyrator filtering techniques have been proposed. LC simulation method using gyrators is readily available to abtain low-sensitivity active RC filters. In this paper, highly linear MOS transconductor with the gain factor controllable by offering offset voltage is presented, and to validate transconductor characteristics, computer simulation using PSPICE was performed. Gyrator circuit is designed using MOS transconductor circuits, and for filter design, floating inductor, floating resistor and grounded resistor which are simulated by gyrator circuits are presented.