제 2회 런던 한.영 여성과학자 포럼

이연희,Lee, Yeon-Hui 한국과학기술단체총연합회 2006 과학과 기술 Vol.39 No.11

제 1형 신경섬유종증 환자에서 발생한 절반-망막중심정맥폐쇄

이연희,김경남,신경섭,김정열,Yeon Hee Lee,MD,Kyoung Nam Kim,MD,Kyoung Sup Shin,MD,Jung Yeul Kim,MD 대한안과학회 2010 대한안과학회지 Vol.51 No.1

Purpose: We report on a case of hemi-central retinal vein occlusion (Hemi-CRVO) which occurred in a patient with Type 1 neurofibromatosis. Case summary: A 31-year-old woman presented with a chief complaint of a one-month history of decreased visual acuity in the left eye. The patient had Type 1 neurofibromatosis but had no other systemic diseases. The best corrected visual acuity (BCVA) was 0.8 in the right eye and 0.05 in the left eye. Multiple Lisch nodules were present in the irises of both eyes on slit lamp examination. Fundus examination revealed a hemi-central retinal artery occlusion in the left eye. Optical coherence tomograms showed that the central macular thickness was 192 microns in the right eye and 732 microns in the left eye. There was cystoid macular edema in the left eye. A fluorescein angiogram showed delayed filling in the superior branch retinal vein of the left eye. There was an extensive area of non-perfusion of the retinal capillary in the corresponding area, including the perifoveal area. Blood tests for hyper-coagulability, autoimmune disorders, connective tissue disorders and other tests for the brain and carotid artery and coronary artery disease showed no abnormal findings. The clinical course was monitored following an intravitreal injection of bevacizumab (AvastinⓇ). Eight months later, the BCVA had improved to 0.2. Conclusions: Although it is rare, hemi-CRVO occurring in younger patients who have no underlying diseases could be related to neurofibromatosis. J Korean Ophthalmol Soc 2010;51(1):150-154

연구소재은행 (KNRRCs)

이연희,Lee, Yeon-Hui 한국미생물학회 2010 微生物과 産業 Vol.36 No.2

순무와 ${\beta}-sitosterol$의 고지혈증 억제에 대한 연구

이연희,이은옥,박수영,이효정,윤병수,김정효,김성훈,Rhee Yun-Hee,Lee Eun-Ok,Park Soo-Young,Lee Hyo-Jung,Yoon Byong-Su,Kim Jung-Hyo,Kim Sung-Hoon 대한동의생리학회 2005 동의생리병리학회지 Vol.19 No.6

To evaluate the anti-hyperlipidemic effect of Brassica rapa L. and its major compound, $\beta$-sitosterol, the present study was undertaken, hypercholesterolemia was induced in rats with poloxamer-407, Triton WR-1339, 30% corn oil high cholesterol diet. The ethanol extract of Brassica rapa L. significantly decreased total cholesterol (TC), phospholipid, triglyceride at doses of 200 mg/kg, and $\beta$-sitosterol significantly exerted anti-hyperlipidemic activity at a dose of 15 mg/kg in rats with hyperlipidemia. Taken together, Brassica rapa L. and $\beta$-sitosterol can be useful agents for the prevention or treatment of hyperlipidemia.

인공지능의 현장적용을 위한 KSB 인공지능 플랫폼 기술

이연희,강현중,김영민,김태환,안후영,유태완,이호성,임완선,김현재,표철식,Lee, Y.H.,Kang, H.J.,Kim, Y.M.,Kim, T.H.,Ahn, H.Y.,You, T.W.,Lee, H.S.,Lim, W.S.,Kim, H.J.,Pyo, C.S. 한국전자통신연구원 2020 전자통신동향분석 Vol.35 No.2

Recently, the focus of research interest in artificial intelligence technology has shifted from algorithm development to application domains. Industrial sectors such as smart manufacturing, transportation, and logistics venture beyond automation to pursue digitalization of sites for intelligence. For example, smart manufacturing is realized by connecting manufacturing sites, autonomous reconfiguration, and optimization of manufacturing systems according to customer requirements to respond promptly to market needs. Currently, KSB Convergence Research Department is developing BeeAI-an on-site end-to-end intelligence platform. BeeAI offers end-to-end service pipeline configuration and DevOps technologies that can produce and provide intelligence services needed on-site. We are hopeful that in future, the BeeAI technology will become the base technology at various sites that require automation and intelligence.

특발성 비대경수막염에 동반된 급성 양안 시력 소실

이연희,김정열,남기엽,Yeon-Hee Lee,MD,Jung Yeul Kim,MD,Ki Yup Nam,MD 대한안과학회 2011 대한안과학회지 Vol.52 No.7

Purpose: To report a case of bilateral optic neuropathy related with idiopathic hypertropic pachymeningitis. Case summary: A 66-year old woman presented with acute visual loss that developed 6 days previously in the right eye and 3 days prior in the left eye. During the initial evaluation, her visual acuity was light perception in the right eye and counting fingers at 30 cm in the left eye. A relative afferent papillary defect (RAPD) was noted in the patient’s right eye. On brain MRI, the duramater was thickened and enhanced by contrast. The erythrocyte Sedimentation Rate (ESR) and C-reactive protein (CRP) level were increased and myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA) as positive. Other neurological and medical abnormalities were not found. Under the suspicion of bilateral optic neuropathy due to idiopathic hypertrophic pachymeningitis, the patient was treated with methylprednisolone pulse therapy. Two days after the treatment, the visual acuity was hand movements at 20 cm in the right eye and 0.6 in the left eye. Three months after the treatment, the visual acuity was counting fingers at 20 cm in the right eye, and 0.7 in the left eye. The right eye showed optic disc pallor and diffuse retinal nerve fiber layer (RNFL) defect. The left eye showed a suspicious RNFL defect, and was otherwise normal. Conclusions: The authors report a rare case of optic neuropathy related with idiopathic hypertrophic pachymeningitis. Idiopathic hypertrophic pachymeningitis should be considered as one of the various causes of optic neuropathy. J Korean Ophthalmol Soc 2011;52(7):893-896

갑상샘눈병증과 관련된 사시의 자연경과

이연희,황정민,오세열,Yeon Hee Lee,M,D,Jeong Min Hwang,M,D,Sei Yeul Oh,M,D 대한안과학회 2006 대한안과학회지 Vol.47 No.12

Purpose: This study investigated the natural course of strabismus associated with thyroid ophthalmopathy. Methods: A retrospective review was performed on the medical records of 31 patients with strabismus associated with thyroid ophthalmopathy who had been followed up for more than 6 months and had not received surgery. For the purpose of this study, a significant change of deviation angle was defined as more than 10 prism diopters in the primary position. Results: Forty-two percent of patients showed a significant change in deviation angle during the observation period of 23.8±17.7 months. The direction of the change was vertical in 32%, horizontal in 3%, and vertical and horizontal in 6% of patients. A significant change of deviation angle developed in 30% of patients within 6 months from the initial ophthalmologic examination, in 24% between 6 and 12 months, and in 13% of patients between 12 and 18 months from the initial examination. Conclusions: Although the deviation angle of strabismus associated with thyroid ophthalmopathy tended to stabilize with time, it nonetheless was susceptible to change even 12 months after the initial ophthalmologic examination. In addition, a vertical change in the deviation angle was more frequent than a horizontal change

개방성 안구손상 환자의 시력 예후 인자와 안외상점수의 예측도

이연희,곽주영,이성복,Yeon Hee Lee,MD,Joo Young Kwag,MD,Sung Bok Lee,MD,PhD 대한안과학회 2012 대한안과학회지 Vol.53 No.6

Purpose: To determine the prognostic factors of visual outcome in open globe injury and to assess the possibility of an ocular trauma score (OTS) model of predictive value in open globe injuries in Koreans. Methods: The medical records of 242 patients with open globe injury from 2000 to 2010 were retrospectively reviewed. Prognostic factors of visual outcome, positive predictive rate, and negative predictive rate were surveyed. Results: In the multivariate analysis, old age, relative afferent pupillary defect, impaired initial visual acuity and retinal detachment were the worst predictive factors of vision survival. In OTS categories 1 and 2, worse final visual acuity was acquired, and positive predictive rate and negative predictive rate for assessment of final visual acuity less than 0.02 were 70.1% and 89.8%, respectively. Conclusions: The prognostic factors of open globe injury associated with impaired final visual acuity were old age, relative afferent pupillary defect, worse initial visual acuity, retinal detachment and OTS categories 1 and 2. The OTS may have prognostic value in open globe injuries in Korean patients. However, identified prognostic factors of the present study did not entirely coincide with those of other Koreans or previous studies. Therefore, additional studies on the modified open globe injury as a prognostic model in Korean patients are needed. J Korean Ophthalmol Soc 2012;53(6):825-832

섬모체망막동맥폐쇄가 첫 임상 증후로 나타난 안매독 환자 1예

이연희,남기엽,김정열,Yeon Hee Lee,Kiyup Nam,Jung Yeul Kim 대한안과학회 2011 대한안과학회지 Vol.52 No.10

Purpose: To report a case of a neurosyphilis patient with cilioretinal artery occlusion as the first manifestation. Case summary: A 58-year old man presented with a visual impairment which developed 5 days earlier in his right eye. During initial evaluation, the visual acuity in the right eye was 0.02. On fundus examination, a whitening adjacent to the macula was observed and fluorescein angiography showed filling delay and late leakage of the cilioretinal arteries. The patient was diagnosed with cilioretinal artery occlusion. Two weeks after his initial visit, visual acuity in the patient’s right eye improved to 0.7 and retinal whitening was decreased on fundus examination. Three months later, a visual decrease in the right eye reoccurred and the visual acuity was 0.01. Anterior chamber cell reaction with hypopyon was observed on slit lamp examination and vitreal opacity was noted during fundus examination. Among the numerous tests performed in order to determine the cause of uveitis, RPR antibody and treponemal antibody were found positive. The patient was diagnosed with neurosyphylis and 2 weeks after intravenous administration of penicillin, visual acuity improved to 0.7 and anterior chamber cell reaction as well as vitreal opacity decreased. Conclusions: The authors reported a case of cilioretinal artery occlusion suspected secondary to neurosyphilis. J Korean Ophthalmol Soc 2011;52(10):1254-1258

Ciprofloxacin , HK - 3140 , Norfloxacin , Ofloxacin 에 대한 Escherichia coli 저항균주의 특성

이연희,김경순,편희은,박원봉,박명환,김완주 ( Yeon Hee Lee,Kyung Soon Kim,Hee En Pyun,Woon Boong Park,Myung Hwan Park,Wan Joo Kim ) 생화학분자생물학회 1992 BMB Reports Vol.25 No.2

Resistant strains of Escherichia coli were obtained against ciprofloxacin, ofloxacin, norfloxacin and HK-3140. Each resistant strain showed cross-resistance to other quinolones and peniciline-G. To find out the resistant mechanism, lipid and outer membrane proteins of the cells were separated and analyzed with gas chromatography and SDS denaturing gel electrophoresis. Lipid profiles from sensitive and resistant cells showed no big differences while outer membrane protein profiles showed a large variation. Sensitive cells showed better uptake of quinolone than resistant cells suggesting that the resistance against quinolone was resulted from the change in permeability through the outer membrane proteins.