곤충 단백질 기반 반려동물 사료와 장내 미생물–면역 축: 분자 기전과 연구 동향(총설)

이호성,이상원,이영섭,이성진 강원대학교 동물생명과학연구소 2026 동물자원연구 Vol.37 No.2

반려동물의 장내 미생물은 소화와 영양 대사뿐만 아니라 면역 조절과 질병 감수성에 관여하는 핵심 요소로 인식되고 있으며, 식이 구성은 이러한 장내 미생물 환경을 조절하는 중요한 요인으로 작용한다. 최근 지속 가능한 단백질원으로 주목받고 있는 곤충 단백질은 반려견과 반려묘의 영양 요구를 충족할 수 있는 대안적 사료 원료로서 활용 가능성이 제시되고 있다. 곤충 단백질 기반 식이는 장내 미생물의 전반적인 다양성을 급격히 변화시키기보다는 특정 미생물 군집과 미생물 유래 대사산물 수준에서 점진적인 변화를 유도하는 경향을 보이며, 이러한 변화는 숙주 면역 반응과의 상호작용 가능성을 시사한다. 특히 장내 미생물 유래 대사산물은 TLR, NF-κB 및 MAPK 신호 전달 경로와 연관되어 면역 항상성 조절에 영향을 미칠 수 있는 것으로 알려져 있다. 그러나 반려동물 모델에서 곤충 단백질 기반 식이가 장내 미생물–면역 축에 미치는 분자적 기전을 직접적으로 규명한 연구는 아직 단편적인 수준에 그치고 있다. 향후에는 곤충 단백질을 활용한 식이가 장내 미생물 조절을 통해 반려동물의 면역 항상성과 건강 증진에 기여할 수 있는지를 명확히 하기 위한 기전 중심의 체계적인 연구가 필요하다. The gut microbiota of companion animals is recognized as a key factor involved not only in digestion and nutrient metabolism, but also in immune regulation and disease susceptibility. Dietary composition plays a crucial role in regulating this gut microbial environment. Insect protein, recently attracting attention as a sustainable protein source, is being proposed as an alternative feed ingredient that can meet the nutritional needs of companion dogs and cats. Rather than drastically altering the overall diversity of the gut microbiota, insect protein-based diets tend to induce gradual changes in specific microbial communities and microbial-derived metabolites. These changes suggest the possibility of interactions with the host immune response. In particular, gut microbial metabolites are known to influence immune homeostasis through association with TLR, NF-κB, and MAPK signaling pathways. However, studies directly elucidating the molecular mechanisms by which insect protein-based diets affect the gut microbiota-immune axis in companion animal models are limited. In the future, systematic, mechanism-focused research will be needed to clarify whether a diet utilizing insect proteins can contribute to the improvement of immune homeostasis and health in companion animals through regulation of intestinal microflora.

프리캐스트 콘크리트 세그먼트의 합성섬유 보강재 적용에 따른 구조적 성능 평가

이호성,김창용,이승원,김승준,이경진,Lee, Hoseong,Kim, Changyong,Lee, Sean S.,Kim, Seungjun,Lee, Kyeongjin 한국터널지하공간학회 2018 한국터널지하공간학회논문집 Vol.20 No.2

쉴드TBM 터널의 프리캐스트 콘크리트 세그먼트 라이닝의 보강재로 철근이 주로 사용되어 왔으나, 철근 보강량을 줄이기 위하여 섬유보강재를 적용하는 연구가 진행되어 오고 있다. 세계적으로 터널 시공성을 향상시키기 위하여 강섬유보강재를 적용한 연구와 시공이 진행되어 왔으나, 터널 라이닝 방수막에 대한 펀칭, 자체 부식에 의한 내구성 및 미관상의 문제로 인하여 이에 대한 적용이 국내에서는 미뤄지고 있는 실정이며, 이에 대한 대책으로 합성섬유가 강섬유의 대체제로 주목 받고 있다. 이 연구에서는 섬유(강섬유, 합성섬유) 보강재를 사용한 프리캐스트 콘크리트 세그먼트의 파괴시험을 통하여 성능을 분석하여 현장에서의 적용 가능성을 평가하였다. 그 결과 강섬유와 합성섬유의 조합이나 합성섬유의 혼입량에 따라 보조철근의 대체가 가능한 것으로 분석되었다.

무장애 주택설계에 관한 국내외 국가표준의 비교 연구 -현관, 침실, 거실을 중심으로

이호성,최찬환,이특구,Lee, Ho Sung,Choi, Chan-Hwan,Lee, Teuk-Koo 한국의료복지시설학회 2010 의료·복지 건축 Vol.16 No.1

This is a comparative study mainly on foreign countries' domestic standards and laws on barrier free housing construction that can be applied to the dwelling of elderly friendly apartment housing. Eight countries - the United States, Germany, Canada, Switzerland, the United Kingdom, Australia, Japan, and China - were reviewed as foreign cases. The analyzed subjects were design standards only for the disabled and the aged. To compare barrier-free guides of the eight countries, each barrier-free guide on three space units (entrance, bedroom, living room) was divided into 11 design items and 36 design factors. The comparative analysis on foreign cases was based on the design guide according to Korea's KS P 1509 (principle and recommendation for designing dimension of dwelling in consideration of the elderly). Some factors -if with dimensions- were compared by means of the skewness of distribution. In the analysis result, there were not only common standards for the nine countries such as a dimension of the space for wheelchair movement but also different standards such as heights of outlets and horizontal lengths of bathtub grab bars. The detailed analysis shows that it is urgently necessary to prepare new domestic national design standards for 8 factors that foreign countries already have. It is also needed to immediately prepare dimension standards for the design factors, which have no detailed dimensions but only national guides, in consideration for anthropometric dimension.

하드 디스크 드라이브 서보 제어기의 설계

이호성 제어로봇시스템학회 1998 제어로봇시스템학회지 Vol.4 No.3

하드디스크 드라이브 Dual Actuator 기술의 동향

이호성,Lin Guo 제어로봇시스템학회 2000 제어로봇시스템학회지 Vol.6 No.2

기본상수를 이용한 SI 기본단위의 재정의

이호성 한국광학회 2019 한국광학회지 Vol.30 No.4

Revision of the International System of Units (SI) in terms of fundamental constants was achieved by the 26th General Conference on Weights and Measures (CGPM) in November 2018. Four base units (kilogram, ampere, kelvin, and mole) of SI were redefined by fixing the values of the Planck constant h, elementary charge e, Boltzmann constant k, and Avogadro constant N A respectively. In this paper the scientific principle for redefining the kilogram from the Planck constant with the Kibble balance is explained as an example. The revised SI takes effect on May 20, 2019.

Takotsubo Cardiomyopathy Associated with Severe Hypocalcemia Secondary to Idiopathic Hypoparathyroidism

이호성,Se-Whan Lee,Young Kyu Jung,Ung Jeon,박상호,Seung Jin Lee,Won-Yong Sin,Dong-Kyu Jin 대한심장학회 2013 Korean Circulation Journal Vol.43 No.8

The etiology and pathophysiology of takotsubo cardiomyopathy have not yet been fully clarified. We report a case of takotsubo cardio -myopathy associated with severe hypocalcemia secondary to hypoparathyroidism. A 69-year-old woman presented with acute pulmonary edema caused by severe left ventricular dysfunction with apical ballooning compatible with takotsubo cardiomyopathy. Laboratory tests revealed severe hypocalcemia secondary to idiopathic hypoparathyroidism. Coronary angiography showed normal coronary artery func-tion. Her symptoms and signs of heart failure improved dramatically with the correction of hypocalcemia through calcium and calcitriol replacement.

분진색상에 따른 광전식연기감지기 챔버의 응답특성에 관한 연구

이호성,김시국 한국화재소방학회 2017 한국화재소방학회논문지 Vol.31 No.5

This paper is based on a study of the response characteristics of photoelectric type smoke detector chambers according todust color. Due to an amendment to the Fire Safety Codes to automatic fire alarm systems and visual alarm device, theinstallation of indoor smoke detectors has become mandatory, but in Korea there is still insufficient research on thenon-operation or false alarms that could arise in indoor environments by indoor dust and other environmental conditions etc. In light of this, for this study, research was conducted on the indoor adaptability of smoke detector under various colors offiber dust that were judged to occur most frequently in among the common indoor dust, photoelectric smoke detector withthe lattice-type smoke detection chamber that the smoke detector which is most popular in the country was used, and fourcolors of fiber dust (brown, white, gray and black) were used the test dusts for carrying out dust and sensitivity testing. Also,the voltage of the photocell part of the smoke chamber was measured, and the scattering phenomenon in the chamber wasobserved. The result of the testing showed that all four dust types were suitable for dust and sensitivity testing underconditions of pollution A. Yet, there were occasions, at pollution B or C, where the brown, white and gray dust would causefail alarm during operation testing. And black dust was confirmed to cause non-operation during operation testing. In the caseof brown and white dust, the voltage measurement result of the photocell part of the smoke chamber confirmed that thevoltage increases as the pollution level increases, and in the case of gray and black dust, the voltage decreases. 본 논문은 분진 색상에 따른 광전식연기감지기 챔버의 응답특성에 관한 연구이다. 국내 자동화재탐지설비 및 경보설비의 화재안전기준의 개정으로 연기감지기의 실내 적용이 의무화되었으나, 아직까지 국내에서는 실내 환경에서발생되는 실내먼지 및 환경조건 등에 의해 발생될 수 있는 부작동 및 비화재보에 대한 연구가 미비한 편이다. 이에본 연구에서는 실내먼지 중 가장 많이 발생될 것으로 판단되는 다양한 색상의 섬유분진에 따른 연기감지기의 실내적응성을 연구하기 위해 국내에 가장 많이 보급화 되어 있는 격자형의 연기챔버를 가진 광전식 연기감지기를 실험대상으로 하고, 갈색, 백색, 회색, 흑색 4종류의 섬유분진을 실험분진으로 하여 분진시험 및 감도시험을 진행하였다. 또한, 연기챔버의 수광부 전압을 측정하여 챔버 내부의 산란현상을 관찰하였다. 실험결과 4종류의 분진 모두 오염도A에서는 분진시험 및 감도시험에서 모두 적합한 것으로 나타났다. 반면, 오염도 B와 C에서는 갈색, 백색, 회색분진의 경우 작동시험 및 부작동시험에서 분진오염에 의한 오작동이 나타났고, 흑색분진의 경우 작동시험에서 부작동이발생되는 것으로 확인되었다. 연기챔버의 수광부 전압측정 결과는 갈색 및 백색분진의 경우 오염도가 증가할수록전압이 증가하였고, 회색 및 흑색분진의 경우 전압이 감소하는 것을 확인하였다.

전분질 원료를 달리한 입국 막걸리의 품질 특성

이호성,배동훈,박영서 한국산업식품공학회 2014 산업 식품공학 Vol.18 No.3

Two fungal strains named 1508 and 1601, and one yeast strain named 51286 were selected from nuruk. Eighteendifferent kojis with various starch sources were prepared using these strains and their saccharogenic powers (SP)were measured. Their quality characteristics were also analyzed. Koji, which was prepared with wheat and glutinousrice, showed the highest saccharogenic power (SP) with a value of 90 among kojis inoculated with strain 1508. Theethanol content of makgeolli prepared with each koji was in the range of 9 to 13%. Makgeolli made with brownrice showed the highest value Ethanol content. When the total Brix of makgeolli was measured, makgeolli madewith glutinous rice using the 1508 koji showed the highest value with 11.3 Bx. Reducing sugar content was thehighest with a value of 4.8% in the glutinous rice group using 1508 koji. The total acidity of makgeolli was in therange of 6.0 to 9.1 w/v%. As the total acidity (w/v%) of makgeolli increased, the pH value decreased. There wasno significant difference in the shelf lives of makgeolli prepared with the various starch sources.

보조생식술을 시행한 난임환자에서의 뜸 치료에 대한 체계적 문헌고찰 및 메타분석

이호성,박용덕,이혜정,황덕상,장준복,이창훈,이진무,김동일 대한한방부인과학회 2022 대한한방부인과학회지 Vol.35 No.2

Objectives: The purpose of this study is to investigate the effectiveness of moxibustion in infertility with In Vitro Fertilization and Embryo Transfer (IVF-ET). Methods: We searched 8 databases (Embase, PubMed, CiNii, CNKI, OASIS, ScienceOn, KMBASE, KISS)to identify eligible studies published before 2021 Oct. We included randomized controlled clinical trials (RCTs) using moxibustion in infertility with IVF-ET. The methodological quality of each RCT was assessed by the Cochrane risk of bias tool. Results: Two RCT studies were eligible in our review. The overall risk of bias was evaluated as unclear. The meta-analysis of 2 trials indicated that favorable results for the use of moxibustion with IVF-ET. Conclusions: This systematic review and meta-analysis of clinical trials suggests that moxibustion with IVF-ET can effect on Infertility patients. However, because of studies included analysis was biased due to unclear risk of bias and unreliable study design, future RCT studies and additional Meta-Analysis are needed to judge the supplementary treatment role of moxibustion in infertility with IVF-ET.