심한 호중구 감소증을 보인 X-관련성 범저감마글로불린혈중 1례

이경연 ( Kyoung Yeon Lee ),이동규 ( Dong Kyu Lee ),박준은 ( Jun Eun Park ),이재호 ( Jae Ho Lee ),이명익 ( Myung Ik Lee ) 대한소아알레르기호흡기학회 2002 소아알레르기 및 호흡기학회지 Vol.12 No.4

저자들은 폐렴치료 중 1개월 이상 심한 호중구 감소증이 지속되었던, 유전자 분석으로 확진된 XLA 환아를 경험하였기에 문헌고찰과 함께 보고하며, 만성 혹은 반복되는 감염의 증상과 함께 호중구 감소증이 나타날 때 XLA를 포함한 면역결핍질환을 의심하는 것이 필요하다고 사료된다. X-linked agammaglobulinemia(XLA) is characterized by markedly reduced number of B lymphocytes, panhypogammaglobulinemia, recurrent bacterial infections in the first few years of life because of genetic defect for Bruton`s tyrosine kinase at Xq22 region. A

예비유아교사의 공감능력이 적응적 정서조절전략에 미치는 영향

이경연(Kyoung Yeon Lee) 학습자중심교과교육학회 2024 학습자중심교과교육연구 Vol.24 No.10

목적 본 연구는 예비유아교사의 공감능력, 대인관계능력, 적응적 정서조절전략의 관계를 분석하고 예비유아교사의 공감능력, 대인관계능력이 적응적 정서조절전략에 미치는 영향을 알아보고자 하였다. 또한, 공감능력이 적응적 정서조절전략에 미치는 영향에 있어 대인관계능력의 매개효과를 밝히는 것에 그 목적이 있다. 방법 서울시에 소재한 2년제 전문대학의 유아교육과에 재학 중인 예비유아교사 175명을 대상으로 공감능력, 대인관계능력, 적응적 정서조절전략에 대한 설문을 실시하여 자료를 수집하였고, 수집된 자료는 SPSS 18.0 프로그램을 사용하여 Pearson의 r을 구하 , 고회귀분석을 실시하였다. 결과 첫째, 예비유아교사의 공감능력, 대인관계능력, 적응적 정서조절전략은 유의미한 상관이 있는 것으로 나타났다. 둘째, 공감능력, 대인관계능력은 적응적 정서조절전략을 예측할 수 있는 변인으로 나타났다. 셋째, 공감능력이 적응적 정서조절전략에 미치는 영향에 있어 대인관계능력은 부분매개 효과가 있는 것으로 나타났다. 결론 공감능력과 대인관계능력의 증진을 통해 예비유아교사의 적응적 정서조절전략의 활용을 높일 수 있음을 시사한다. 이를 통해 교사양성과정에서 예비유아교사의 공감능력과 대인관계능력을 높이고 나아가 적응적 정서조절전략을 활용할 수 있는 프로그램 개발에 시사점을 제공할 수 있을 것으로 본다. Objectives This study aimed to analyze the relationship between pre-service early childhood teachers' empathic ability, interpersonal relationship skills, and adaptive emotional regulation strategies. Additionally, it sought to in-vestigate the impact of pre-service early childhood teachers' empathic ability and interpersonal relationship skills on adaptive emotional regulation strategies. Furthermore, the purpose was to illuminate the mediating effect of interpersonal relationship skills in the relationship between empathic ability and adaptive emotional regulation strategies. Methods A total of 175 pre-service early childhood teachers enrolled in the Early Childhood Education Department of a 2-year college located in Seoul were surveyed regarding their empathic ability, interpersonal relationship skills, and adaptive emotional regulation strategies. The data collected were analyzed using SPSS 18.0 software to compute Pearson's r and conduct regression analysis. Results First, it was found that there were significant correlations among pre-service early childhood teachers' empathic ability, interpersonal relationship skills, and adaptive emotional regulation strategies. Second, empathic ability and interpersonal relationship skills emerged as predictors of adaptive emotional regulation strategies. Third, in terms of the impact of empathic ability on adaptive emotional regulation strategies, interpersonal rela-tionship skills were found to have a partial mediating effect. Conclusions The enhancement of empathic ability and interpersonal relationship skills suggests the potential to increase the utilization of adaptive emotional regulation strategies among pre-service early childhood teachers. This implies providing insights for the development of programs aimed at enhancing pre-service early childhood teachers' empathic ability and interpersonal relationship skills, ultimately enabling them to utilize adaptive emo-tional regulation strategies.

자연놀이 경험을 통한 동요개사하기 활동이 유아의 창의성, 자연친화적 태도, 음악적 표현능력에 미치는 영향

이경연(Lee, Kyoung-Yeon),조형숙(Cho, Hyung-Sook) 한국어린이미디어학회 2016 어린이미디어연구 Vol.15 No.1

본 연구는 자연놀이 경험을 통한 동요개사하기 활동이 유아의 창의성, 자연친화적 태도, 음악적 표현능력에 미치는 영향을 알아보는데 그 목적이 있다. 연구의 대상은 서울시 금천구에 소재한 S유치원에 다니는 만5세반 유아 30명이었으며, 실험집단에는 자연놀이 경험을 통한 동요개사하기 활동을 실시하였고, 비교집단에는 같은 기간 동안 자연놀이 경험을 통한 연관 활동을 실시하였다. 연구결과 첫째, 자연놀이 경험을 통한 동요개사하기 활동은 유아의 창의성의 하위요인인 유창성, 융통성, 독창성, 상상력에서 긍정적인 효과가 있었다. 둘째, 자연친화적 태도의 하위 요인인 동물과 식물에 대한 관심과 애호, 생명에 대한 존중 의식, 인공적인 환경보다 자연 환경 선호에 긍정적인 효과가 있는 것으로 나타났다. 셋째, 음악적 표현능력의 하위 요인인 노래 부르기, 악기연주하기, 신체 표현하기, 음악 만들기 증진에 긍정적인 효과가 있는 것으로 나타났다. The aim of this study is to investigate the effects of the activity of rewriting children’s song through nature play experience on children’s creativity, nature friendly attitude, and musical expressive capability. The research participants were 30 children, aged five and a half years, attending S Kindergarten located in Geumcheon District, Seoul. The experimental group engaged in an activity of rewriting a children’s song through nature play experience. The comparison group participated in a related activity through nature play experience during the same period. The results revealed that, first, the activity of rewriting a children’s song through nature play experience had positive effects on the participants’ fluency, flexibility, originality, and imagination, the sub-factors of children’s creativity. Second, it had positive effects on having an interest in or liking animals and plants, respect for life, and preference for the natural environment over artificial environments, the sub-factors of nature friendly attitude. Third, it had positive effects on singing, playing instruments, expression with the body, and improvement in music making, the sub-factors of musical expressive capability.

도시 공공공간의 공공성 인식에 관한 기초연구 - 세대 간 인식 조사를 바탕으로 -

이경연(Lee, Gyeong-Yeon),오지은(Oh, Ji-Eun),하미경(Ha, Mi-Kyoung),변기동(Byun, Gi-Dong) 대한건축학회 2022 대한건축학회 학술발표대회 논문집 Vol.42 No.1

Publicness is a social value that requires empathy and consensus from members of society. Therefore, this study investigated the public awareness of urban public space targeting young people and the elderly with different socio-cultural backgrounds in growth. First, both groups consider strengthening publicness important in improving the quality of life of individuals, the elderly consider more. Second, both groups recognized most effectively the improvement of publicness by improving the physical environment. Third, youth emphasized publicness in space for various activities, and the elderly are important in the residential environment. Fourth, as "health" and "sustainability" have emerged as social values, both groups have recognized "sustainability" as an important factor in publicness.

공공공간의 건축적 공공성에 대한 연구 경향 분석

이경연(Lee, Gyeong-Yeon),오지은(Oh, Ji-Eun),하미경(Ha, Mi-Kyoung),변기동(Byun, Gi-Dong) 대한건축학회 2021 대한건축학회 학술발표대회 논문집 Vol.41 No.2

Recently, with the emphasis on the role of publicness, various studies on publicness have been conducted in various areas of society. Therefore, the purpose of this study is to identify trends in ’publicness of public space’ related studies conducted over the last two decades. To understand the contents of the study, we analyzed the frequency of the study by year, keywords in the paper, and subjects of the study. The analysis contents are as follows. First, public-related research has increased rapidly in the mid-2000s and continues steadily. Second, the publicness research perspective is expanding from an urban perspective to a user-centered perspective. Third, the subjects and subjects of the study are being materialized and diversified.

PDLs22 재조합 단백질의 합성과 평가

이경연,최용석,이유진,배현숙,김흥중,조광희,장현선,박주철,Lee, Kyoung Yeon,Choi, Yong-Seok,Lee, You-Jin,Bae, Hyun-Sook,Kim, Heung-Jeong,Cho, Kwang-Hee,Jang, Hyun-Seon,Park, Joo-Cheol 대한치주과학회 2007 Journal of Periodontal & Implant Science Vol.37 No.1

Periodontal ligament (PDL) is the connective tissue located between the tooth root and alveolar bone. In a previous study, PDLs22 was isolated as a PDL-specific gene by using subtractive hybrid-ization between cultured PDL fibroblasts and gingival fibroblasts. It was also suggested that PDLs22 plays important roles in the development, differentiation and maintenance of periodontal tissues. However, little is known about functional study of PDLs22 using recombinant protein in PDL fibroblast differentiation and periodontium formation. In this study, in order to produce the PDLs22 recombinat protein, PDLs22 expression vector were constructed and expressed its protein in various host cell and temperature conditions. The results were as follows: 1. PDLs22 protein was not strongly expressed In the induction system using pRSET-PDLs22 construct. 2. When the BL21(DE3) pLysS was used as a expression host, PDLS22 protein was strongly ex-pressed in the induction system using pHCEIIBNd-PDLs22 construct. 3. The PDLs22 protein was recognized at a molecular weight of 28 kDa in western blots. 4. Almost of the expressed PDLs22 protein was not soluble and observed like as inclusion body. 5. The protein solubility was not improved after modification of induction time and temperature during PDLs22 protein production. In this study, the system for the PDLs22 protein production was connstructed. However, the re-results suggest that further studies will be needed to produce the considerable amount of PDLs22 re-combinat protein, which can use for the periodontal regeneration.

독성 쇼크 증후군 증상을 나타낸 비전형적 가와사끼병 1례

이경연,박준은,박우성,Lee, Kyoung Yeon,Park, Jun Eun,Park, Woo Sung 대한소아청소년과학회 2002 Clinical and Experimental Pediatrics (CEP) Vol.45 No.8

Toxic shock syndrome(TSS) is clinically similar to Kawasaki disease(KD) in that both of them are characterized by fever, desquamating rash and mucous membrane erythema. In contrast the main feature of TSS is hypotension, whereas the complication of KD is coronary vasculitis. We report an 8-year-old boy who fulfilled the crireria for TSS and KD. Initially he showed clinical features of TSS, so he was treated with intravenous antibiotics and supportive management. But the fever sustained, and the coronary aneurysm that is the main complication of Kawasaki disease was shown by echocardiogram on Day 14. He was treated with intravenous immunoglobulin twice and the fever subsided and general condition was improved. 저자들은 8세 남아에서 고열, 저혈압, 부정형 피부 발진, 의식저하, 결막염, 구토, 설사, 핍뇨, 혈소판 저하, 혈액배양 음성과 같은 독성 쇼크 증후군의 증상과 함께 관상동맥류를 포함한 가와사끼병의 임상증상을 보인, 독성 쇼크 증후군 증상으로 나타난 비전형적 가와 사끼병 1례를 경험하였기에 문헌고찰과 함께 보고하며, 독성 쇼크 증후군의 치료 중 발열이 지속될 때 가와사끼병의 비전형적인 증상 발현일 수 있음을 염두해야 할 것으로 사료된다.

Duchenne/Becker 근이영양증에서의 Dystrophin 유전자 분석

박수연(Su Yeon Park) 고경남(Kyung Nam Koh) 임병찬(Byung Chan Lim) 강호석(Ho Seok Kang) 이경연(Kyoung Yeon Lee) 황희(Hee Hwang) 채종희(Jong Hee Chae) 최지은(Ji Eun Choi) 김기중(Ki Joong Kim) 황용승(Yong Seun Hwang) 대한소아신경학회 2004 대한소아신경학회지 Vol.12 No.1

목적 : 국내 Duchenne/Becker 근이영증에서의 dystrophin 유전자 결실은 빈도 및 그 분포를 알아보고 유전형과 임상형의 관계를 분석하여, 국내 유전 역학 자료를 마련하고 좀 더 효과적인 유전 상담 및 예방 방법을 모색해보고자 하였다. 방법 : 1999년 1월부터 2003년 7월까지 서을대학교병원에서 상기 질환으로 진단 후 추적 관찰중인 89명의 환자를 대상으로 하였다. 임상 진단 후 근생검을 시행, dystrophin 면역조직화학 염색을 하였으며 dystrophin 유전자 결실은 혈액에서 추출한 DNA를 이용, multiplex PCR 방법을 이용하여 진단하였다. 결과 : 국내 DMD/BMD 환자의 dystrophin 유전자 결실률은 54%였고, 결실 부위의 hot spot은 exon 44-54 부위로 전체 결실 환자의 80%를 차지하였다. 결실이 확인되지 않았던 22명의 환자에서 23개의 exon을 대상으로 직접염기서열 분석을 시행한 결과 6명의 환자에서 6종류의 점돌연변이를 발견하였다. 유전형과 임상형의 관계에 대한 분석 결과 중심형 결실이 근위형에 비해, 다중 결실이 단일 결실에 비해 증상 발생 연령이 어리고 진행이 다소 빠른 경향을 보였으나 통계적으로 유의한 관련성은 찾을 수 없었다. 결론 : 국내 DMD/BMD 환자의 결실률은 54%였으며 hot spot은 exon 44-54였다. 따라서 혈액 유전자 검사로 진단할 수 없는 약 50%의 환자의 진단을 위해서는 근생검 및 dystrophin 항체 면역 조직화학 검사를 통한 진단이 시행되어야 할 것이다. 또한 세밀한 가족력 조사를 포함하여 적절한 보인자 검사를 통해 합리적인 유전 강담을 진행하고 이에 기초한 질병 발생 예방 및 교육 등이 필요할 것으로 생각된다. Purpose : Duchenne/Becker muscular dystrophy(DMD/BMD) is an X-linked recessive disorder caused by mutations of dystrophin genes. The purpose of the present study is to determine the frequency and the patterns of dystrophin gene deletions and to investigate the correlation of genotypes and phenotypes. Methods : There were included a total of 89 children(88 boys and I girl) diagnosed as DMD/BMD by immunohistochemistry and/or genetic analysis from 1999 to 2003 at Seoul National University Children´s Hospital. We analyzed the genomic DNA by multiplex PCR using a 26 dystrophin exon primer set. Direct sequencing was performed on 23 exons(in which point mutations were detected in other previous reports) in 22 patients without deletions. Phenotype and genotype relationship analysis was performed on the basis of retrospective clinical reviews. Results : The frequency of dysmorphin gene deletions was 54%(32/59), which is lower than that of European and American data. Exon deletions were detected in 59 cases and the deletion "hot spots" were exon 44-54 constituting 80% of all deletions. In 6 cases without detectable deletions, 6 point mutations(3 nonsense mutations and 3 nucleotide variants) were detected The patients whose deletions were in the central parts or the patients with multiple exon deletions tended to show earlier symptom onsets and more rapid progressions of weakness but there were no statistical significances. Conclusion : Since deletions in dystrophin genes were detected in about 50% of the patients, studies on dystrophin protein expressions using muscle biopsy samples must be done for correct diagnosis.

예비유아교사의 동물 돌봄 체험을 통한 돌봄 관련 인식의 변화

윤선영(Yoon, Seon-Young),이경연(Lee, Kyoung-Yeon) 한국영유아교원교육학회 2018 유아교육학논집 Vol.22 No.5

본 연구는 예비교사의 동물 돌봄 체험을 통한 돌봄 관련 인식의 변화를 살펴보는 데 목적이 있다. 연구방법은 예비유아교사 28명을 대상으로 13주 동안 진행되었고, 물고기 ‘구피’ 돌보기, 주 1회 관찰일지 쓰기, 조별 돌봄토의, 최종보고서 발표로 진행되었다. 수집된 자료는 주제별로 분류하여 범주화하고 그 결과를 분석하였다. 연구결과는 첫째, 예비교사들은 돌봄의 개념에 대하여 ‘매우 귀찮은 일’에서 ‘더불어 성장하는 가치 있는 일’로 인식하였다. 둘째, 예비교사들은 돌봄의 주체로서 먼저, 돌봄 대상에 대해 ‘수동적으로 반응하는 생명체’에서 ‘적극적 학습자’로 인식하게 되었다. 다음으로, 돌봄 제공자인 자신들을 ‘밥 챙겨주는 책임자’에서 ‘건강한 성장을 돕는 엄마’로 인식하게 되었다. 또한 예비교사들은 돌봄 동물을 매개로 하는 돌봄 공동체인 동료들과의 토의를 통해 다른 예비교사들과의 관계에도 긍정적인 변화가 나타났다고 인식하였다. 셋째, 돌봄 관계에 대해 예비교사들은 ‘일방적 돌봄 관계’에서 ‘상호 호혜적 돌봄 관계’로의 변화를 인식하는 것으로 나타났다. 따라서 예비교사 교육과정에서 돌봄 체험의 필요성에 비해 기회가 별로 없는 현실을 감안할 때 동물 돌봄을 체험해보는 직접 체험이 하나의 대안이 될 수 있을 것이라 본다. The purpose of this study was to investigate pre-service teachers’ changes related to caring through their animal care experiences. During the 13 week guppy care experience, the methods included pre-service teachers caring for guppies, writing weekly observation notes, conducting group discussions about the care-taking, and delivering a final report presentation. The collected data were classified and categorized into subject matters and then the results were analyzed. The results were as follows. First, the pre-service teachers changed their perceptions of the concept of caring from ‘a very annoying work’ to ‘valuable work of growing together.’ Second, as the main agents of caring, the pre-service teachers changed their perceptions of the caring targets from ‘life forms that react passively’ to ‘active leaners.’ Next, as caring providers, they perceived themselves as ‘mothers who help healthy growth’ rather than ‘persons responsible for feeding.’ Furthermore, through discussions with colleagues, with whom the caring community was formed by having the cared animals as the intermediaries, the pre-service teachers perceived that positive changes occurred in the relationships with other pre-service teachers. Third, with respect to the caring relationship, the pre-service teachers detected the change from ‘one-way caring relationships’ to ‘mutually reciprocal caring relationships.’ Therefore, considering that in reality, there are not that many opportunities for the caring experience in the pre-service teacher curricula compared to the needs, a direct experience of providing animal care would be an alternative solution.

도시 공공공간의 공공성 평가지표 구축을 위한 기초연구

오지은(Oh, Ji-Eun),이경연(Lee, Gyeong-Yeon),하미경(Ha, Mi-Kyoung),변기동(Byun, Gi-Dong) 대한건축학회 2022 대한건축학회 학술발표대회 논문집 Vol.42 No.1

The purpose of this study is to establish an evaluation index that can evaluate "publicity", an important value that determines the level of publicness of public spaces. To this end, the main evaluation index was prepared through a series of processes of literature search, analysis of existing evaluation factors, selection and definition of evaluation factors, and analysis of evaluation factors for each factor. By deriving publicity evaluation factors of public spaces and preparing evaluation indicators, we intend to provide basic data for improving the publicness of architectural and urban spaces.