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유방암 치료에 대한 한의 임상 가이드라인 개발을 위한 기초연구
이강욱,유화승,이진선,이남헌,Lee, Kang-Wook,Yoo, Hwa-Seung,Lee, Jin-Sun,Lee, Nam-Hun 대한한방부인과학회 2016 大韓韓方婦人科學會誌 Vol.29 No.2
Objectives : The purpose of this study was to present the clinical practice guidelines for breast cancer through the analysis of existing clinical practice guidelines in Western and Chinese medicine. Methods : The literature search was performed regarding conventional and integrative medical treatment of breast cancer using Google Scholar, KIOM OASIS, PUBMED and Jisan library of Daejeon university. Results : Breast cancer is the fifth most common cancer in Korea. Recent studies revealed that combining conventional and integrative medical treatment can reduce the sequela of surgical operation and improve survival rate. However there isn’t still a systemic clinical guideline for breast cancer in korean medicine. This study will be a preliminary study to establish clinical practice guidelines of Korean Medicine for breast cancer.Conclusions : Further objective and systemic clinical studies related to Korean Medicine are needed to develope more advanced clinical practice guidelines of breast cancer.
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한인진(韓茵蔯), 울금(鬱金), 산사(山査), 단삼(丹蔘) 발효복합추출물이 RAW264.7 및 HUVEC 세포에서 나타나는 이상지질혈증 관련 염증인자 발현 및 항산화에 미치는 영향
이강욱,조현경,유호룡,설인찬,김윤식,Lee, Kang-wook,Cho, Hyun-kyoung,Yoo, Ho-ryong,Seol, In-chan,Kim, Yoon-sik 대한한방내과학회 2018 大韓韓方內科學會誌 Vol.39 No.4
Objectives: To investigate the effect of fermented extract of Artemisiae Iwayomogii Herba, Curcumae Longae, Crataegi Fructus and Salviae Miltiorrhizae Radix (FMH) on anti-inflammation associated with dyslipidemia and anti-oxidation in RAW264.7 and HUVEC cells. Methods: The total polyphenols, total flavonoids, DPPH radical scavenging activity, ABTS radical scavenging activity, and cytotoxicity of FMH were measured. RAW264.7 cells treated with FMH were tested for production of NO, and for cytokine and LTB4 levels and HUVEC cells treated with FMH were examined for production of cDNA of genes related to inflammation. Results: 1. FMH contained polyphenols and flavonoids. The DPPH and ABTS radical scavenging activity of FMH increased in a concentration-dependent manner. 2. FMH treatment inhibited the production of nitric oxide (NO), cytokines, and LTB4 in RAW264.7 cell when compared to the untreated control group. 3. FMH decreased the transcription of pro-inflammatory genes, whereas it increased transcription of anti-inflammatory genes, in HUVEC cells. Conclusion: FMH is effective as an antioxidant and for treatment and prevention of dyslipidemia, atherosclerosis, ischemic heart disease, stroke, and other cardiocerebrovascular diseases.
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이강욱 서울대학교 규장각한국학연구원 2020 한국문화 Vol.0 No.89
Siljik was a regular post given based on Munsan-gye rank system and Musan-gye rank system with actual tasks receiving regular stipend. It embraced the characteristics of bonjik, nokjik, functional post, and regular post while their opposite gyeomjik, murokgwan, nominal post as gunjik, and temporary post gagwan was not included in siljik. Sanjik operated only in military posts, which was mostly gyeomjik with actual duties. Sanjik differed from siljik in that most of them were gyeomjik, and differed from gunjik in that they had actual tasks. However, in a sense that sanjik was also given according to Musan-gye rank system, it also belonged to jeongjik. Therefore, sanjik was one of the military post’s jeongjik, distinct from japjik․siljik․gunjik․heojik. In a broad sense, jeongjik was an opposite concept to japjik, referring to every civil and military post given by Munsan-gye and Musan-gye rank system. This definition of jeongjik encompassed gyeomjik, gunjik, murokgwan, and gagwan as well as siljik. In a narrow sense, jeongjik shared the same notion with siljik where gyeomjik, gunjik, murokgwan, and gagwan were not included. Cheajik was a post where several officials held one vacant position in turn and received their stipend only when they were at work. This was implemented in order to distribute limited amount of posts to the increasing number of public official candidates as much as possible. Cheajik was not separate from jeongjik or siljik but any posts regardless of siljik, gunjik, jeongjik or japjik, as far as it possessed official stipend, could be operated as cheajik. Gaseoljik was an additionally established post besides the limited number of civil and military posts. It took up the same official title stated by law. Gaseoljik operated in several ways: it was established when necessary and thereafter abolished; it was additionally established besides the limited number of posts and became a regular one; it was assigned to a temporary post. Depending on where it would be additionally established, it was possible for any posts including silgwan, gyeomgwan, and gagwan. Gwonseoljik was a temporary post established to perform certain tasks for the time being. Unlike gaseoljik, therefore, it did not take up the existing title stated by law but made their own title, which would naturally disappear after the task was done. Gwonseoljik could either be established with the gwonseol public office or without it only as a post. Every gwonseoljik operated as a gyeomjik. In sum, civil and military yangban posts in late Joseon largely consisted of jeongjik given by Munsan-gye and Musan-gye rank system, japjik given by Japjik-gye rank system, and togwanjik given by Togwanjik-gye rank system. Among them, jeongjik included siljik, a regular post with stipend; stipendless posts as gyeomjik and murokgwan; additionally established posts as gaseoljik and gwonseoljik. Gunjik and sanjik was also included in the military post’s jeongjik. Cheajik was established to pay stipend to those unsalaried officials and thus any posts with enough finances, regardless of siljik, gunjik, or japjik, were able to be operated as cheajik. Since cheajik was an idea for the operation of posts, it could not be used as a comparative concept to jeongjik.
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이강욱,노철규 의과학연구소 1991 全北醫大論文集 Vol.15 No.4
There has been only some guidelines for treatnents of concomitant ipsilateral fractures of the humerus and forearm both bone, so-called floating elbow. The authors reviewed 11 patients of floating elbow who were treated at Chonbuk National University Hospital between January 1984 and June 1991. The results were as follows: 1. Average age was 28 years old and the most common cause of injury was belt injury 2. The most common combined injury was nerve paralysis and we treated it with relatively good result by conservative treatment. 3. The method of internal fixation using plate & screws showed better result than other method of treatments. 4. In younger patients, the better results were obtained than older patients.
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이강욱,최영환,신영태,노흥규,서광선 충남대학교 의과대학 지역사회의학연구소 1986 충남의대잡지 Vol.13 No.1
Twenty eight cases of primary IgA nephropathy were diagnosed and studied in the Department of Internal Medicine, Chungnam National University Hospital over a period of 49 months from June 1981 to July 1985. The results were summerized as follows: 1. These cases represented 45.2% of patients with primary glomerular diseases undergoing renal biopsy and immunofluorescent studies during the same period. 2. There were 20 males and 8 females. They were 15 to 54 years old and the average age was 29.1. 3. The main symptoms were loin pain, gross hematuria, myalgia, fatigability and generalized edema in 18, 15, 12, 12, and 4 cases, respectively. Upper respiratory tract infection symptoms were presented in 50% of the cases of all patient just before and during the course of disease. 4. Proteinuria was observed in 27 cases and hematuria was seen in 23 cases, Among hematuria, the gross hematuria was observed in 15 cases. Hypoalbuminemia and hypercholesterolemia was presented in 4 cases with generalized edema. Serum BUN and creatinine were elevated in 3 cases with marked decreased Creatinine Clearence in 3 cases (Ccr<50ml/min). 5. The light microscopic findings showed mainly mesangial proliferative glomerulonephritis and focal and segmental glomerular sclerosis in 11 and 7 cases, respectively. Immunofluorescent microscopic findings disclosed diffuse mesangial deposit of IgA in all cases. IgG, igM, C3 and fibrinogen deposits were observed in mesangium in 5, 4, 20, and 7 cases, respectively.
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이강욱,카이호 요시유키,후쿠시마 타카후미,타나까 테츠,고야나기 미쯔마사,Lee, Kang-Wook,Kaiho, Yoshiyuki,Fukushima, Takafumi,Tanaka, Tetsu,Koyanagi, Mitsumasa 대한의용생체공학회 2010 의공학회지 Vol.31 No.4
To restore visual sensation of blind patients, we have proposed a fully implantable retinal prosthesis comprising an three dimensionally (3D) stacked retinal chip for transforming optical signal to electrical signal, a flexible cable with stimulus electrode array for stimulating retina cells, and coupling coils for power transmission. The 3D stacked retinal chip is consisted of several LSI chips such as photodetector, signal processing circuit, and stimulus current generator. They are vertically stacked and electrically connected using 3D integration technology. Our retinal prosthesis has a small size and lightweight with high resolution, therefore it could increase the patients` quality of life (QOL). For realizing the fully implantable retinal prosthesis, we developed a retinal prosthesis module comprising a retinal prosthesis chip and a flexible cable with stimulus electrode array for generating optimal stimulus current. In this study, we used a 2D retinal chip as a prototype retinal prosthesis chip. We fabricated the polymide-based flexible cable of $20{\mu}m$ thickness where 16 channels Pt stimulus electrode array was formed in the cable. Pt electrode has an impedance of $9.9k{\Omega}$ at 400Hz frequency. The retinal prosthesis chip was mounted on the flexible cable by an epoxy and electrically connected by Au wire. The retinal prosthesis chip was cappted by a silicone to pretect from corrosive environments in an eyeball. Then, the fabricated retinal prosthesis module was implanted into an eyeball of a rabbit. We successfully recorded electrically evoked potential (EEP) elicited from the rabbit brain by the current stimulation supplied from the implanted retinal prosthesis module. EEP amplitude was increased linearly with illumination intensity and irradiation time of incident light. The retinal prosthesis chip was well functioned after implanting into the eyeball of the rabbit.
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