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증례 : 혈액종양 ; 급성 백혈병 환자에서 Vincristine에 의해 유발된 다발성 신경병증
백수영 ( Su Young Back ),박병배 ( Byeong Bae Park ),박동원 ( Dong Won Park ),김주형 ( Joo Hyoung Kim ),정경희 ( Kyong Hee Jung ),김혜영 ( Hye Young Kim ),박소연 ( So Yeon Park ) 대한내과학회 2009 대한내과학회지 Vol.76 No.5
본 증례의 경우처럼 급성 림프구성 백혈병 환자에서 항암화학요법 후 발생하는 다발성 뇌신경 및 말초성 신경병증은 유사한 임상증상으로 나타나는 질환들과의 감별진단이 필요하겠고, 중추신경계 증상이 같이 동반되어 있더라도 vincristine에 의한 신경독성의 가능성을 고려해야 하겠다. When neurological symptoms occur during the treatment of acute lymphoblastic leukemia, the differential diagnosis includes a leukemic infiltration of the nervous system, drug toxicity, infection, and other neurological disorders. We describe a 16-year-old girl with acute lymphoblastic leukemia that appeared to be complicated by vincristine-induced peripheral and cranial poly-neuropathy after induction chemotherapy. She presented with right ptosis six weeks after the first dose of vincristine, and her neurological symptoms progressed to peripheral polyneuropathy. She recovered from these neurological symptoms over the next three months. Leukemic involvement of the nervous system and other neurological disorders could be excluded as potential causes of the neurological symptoms. This report shows that vincristine-induced neurotoxicity should be considered as a cause of cranial neuropathy that develops during the treatment of acute lymphoblastic leukemia. (Korean J Med 76:611-616, 2009)
초기 부적응 도식과 경계선 성격장애 성향 간의 관계: 정서조절곤란의 매개효과
백수영 ( Suyoung Baik ),김은정 ( Eunjung Kim ) 사단법인 아시아문화학술원 2021 인문사회 21 Vol.12 No.1
본 연구는 초기 부적응 도식과 경계선 성격장애 성향 간의 관계에서 정서조절곤란이 매개하는 지 검증하고자 하였다. 이를 위해 경기도 소재 대학생 338명을 대상으로 그들의 초기 부적응적인 심리 도식, 정서조절곤란, 경계선 성격장애 성향을 평가하는 설문지를 실시하였다. 연구 결과, 정서조절 곤란은 초기 부적응 도식과 경계선 성격장애 성향 간의 관계를 부분 매개하였다. 본 연구는 정서조절 곤란이 초기 부적응 도식과 경계선 성격장애 성향을 매개한다는 것을 검증함으로써 경계선 성격장애 성향에 미치는 기제를 확인하였다. 또한, 본 연구에서는 경계선 성격장애 성향의 하위차원들에 대해 살펴보고, 경계선 성격장애 성향을 지닌 사람들을 예방하고 치료하는 데 인지행동에 초점을 둔 변증법적 행동치료, 수용전념치료 등 정서 조절에 초점을 둔 개입이 필요하다는 것을 제안하며 본 연구의 제한점과 향후 연구의 방향을 제시하였다. This study investigated whether emotional dysregulation mediated the relationship between early maladaptive schema and borderline personality disorder features. A total of three hundreds thirty eight people completed questionnaires to assess young schema questionnaire, difficulties in emotion regulation scale and personality assessment inventory - borderline feature scale. Results indicated that difficulties in emotion regulation partially mediated the relationship between early maladaptive schema and borderline personality disorder features. This study confirmed mechanism of borderline personality disorder features. In addition, this study examines the lower dimensions of borderline personality disorder features, and focuses on emotional regulation such as dialectic behavioral therapy, which focuses on cognitive behavior, and acceptance and commitment therapy to prevent and treat people with borderline personality disorder features. The clinical implications, limitations and future directions of the present study were discussed.
류마티스 관절염 환자에서 leflunomide 복용 중 발생한 용혈성 빈혈 1예
박소연,백수영,박세우,김주형,손창남,조수경,김일,배상철 대한임상약리학회 2008 Translational and Clinical Pharmacology Vol.16 No.2
Leflunomide is a new isoxazole based disease-modifying antirheumatic drug for the treatment of rheumatoid arthritis. Leflunomide alone or combination with methotrexate has been reported to be safe as well as effective in patients with rheumatoid arthritis. Although a few cases of leflunomide-induced pancytopenia were identified, leflunomide-induced hemolytic anemia in rheumatoid arthritis has not been reported yet. We present a case of leflunomide-induced hemolytic anemia in a patient with rheumatoid arthritis. Leflunomide is a new isoxazole based disease-modifying antirheumatic drug for the treatment of rheumatoid arthritis. Leflunomide alone or combination with methotrexate has been reported to be safe as well as effective in patients with rheumatoid arthritis. Although a few cases of leflunomide-induced pancytopenia were identified, leflunomide-induced hemolytic anemia in rheumatoid arthritis has not been reported yet. We present a case of leflunomide-induced hemolytic anemia in a patient with rheumatoid arthritis.
화농성 근염과 감염성 대동맥류로 진행한 Klebsiella pneumoniae 간농양 1예
김주형,김지은,백수영,구태연,이경아,정경희,김현철,김혜영,배현주 대한감염학회 2008 감염과 화학요법 Vol.40 No.6
Klebsiella pneumonias causes pyogenic infections in various sites, with the risk of which increases in patients with diabetes mellitus. Recently, K. pneumoniae has emerged as a leading cause of pyogenie liver abscess, Primary liver abscess caused by K. pneumoniae in the absence of underlying hepatobiliary disease is commonly associated with metastatic infections such as endophthalmitis, meningitis, brain abscess and infection in other sites. We experienced a case of K. pneumonias liver abscess associated with septic metastatic lesions including pyomyositis and infected aneurysm of aorta. Despite the aggressive management with antibiotics, surgical pus drainage and aortic bypass graft, patient died of ventilator associated pneumonia and multiorgan failure. Our experience suggests that clinicians should be alert to septic metastatic infections when they treat a patient with K. pneumonias liver abscess.
정상면역 환자에서 외상 후 발생한 Mycobacterium fortuitum에 의한 무릎아래주머니염 1예
박동원,김지은,백수영,박혜선,손창남,안성은,박혜정,장시형,백승삼,최충혁,최태열,배현주 대한감염학회 2008 감염과 화학요법 Vol.40 No.5
Mycobacterium fortuitum is a rare pathogen, frequently found in water, soil, animals and plant materials, It can cause infections involving skin, soft tissue and skeletal system after direct inoculation of the pathogen through surgical traumas, Punctures and injections. We report a case of infrapatellar bursitis caused by M. fortuitum in an immunocompetent, 42-year-o1d female, which occurred after bicycle trauma. She experienced marked improvement after surgical excision and debridement of the wound site and antimicrobial therapy.
정상면역 환자에서 외상 후 발생한 Mycobacterium fortuitum에 의한 무릎아래주머니염 1예
박동원,김지은,백수영,박혜선,손창남,안성은,박혜정,장시형,백승삼,최충혁,최태열,배현주 대한감염학회 2008 Infection and Chemotherapy Vol.40 No.5
Mycobacterium fortuitum is a rare pathogen, frequently found in water, soil, animals and plant materials. It can cause infections involving skin, soft tissue and skeletal system after direct inoculation of the pathogen through surgical traumas, punctures and injections. We report a case of infrapatellar bursitis caused by M. fortuitum in an immunocompetent, 42-year-old female, which occurred after bicycle trauma. She experienced marked improvement after surgical excision and debridement of the wound site and antimicrobial therapy.
화농성 근염과 감염성 대동맥류로 진행한 Klebsiella pneumoniae 간농양 1예
김주형,김지은,백수영,구태연,이경아,정경희,김현철,김혜영,배현주 대한감염학회 2008 Infection and Chemotherapy Vol.40 No.6
Klebsiella pneumoniae causes pyogenic infections in various sites, with the risk of which increases in patients with diabetes mellitus. Recently, K. pneumoniae has emerged as a leading cause of pyogenic liver abscess. Primary liver abscess caused by K. pneumoniae in the absence of underlying hepatobiliary disease is commonly associated with metastatic infections such as endophthalmitis, meningitis, brain abscess and infection in other sites. We experienced a case of K. pneumoniae liver abscess associated with septic metastatic lesions including pyomyositis and infected aneurysm of aorta. Despite the aggressive management with antibiotics, surgical pus drainage and aortic bypass graft, patient died of ventilator associated pneumonia and multiorgan failure. Our experience suggests that clinicians should be alert to septic metastatic infections when they treat a patient with K. pneumoniae liver abscess.
소라페닙 치료 실패 후 세포독성화학요법으로 완전반응을 보인 폐전이를 동반한 간세포암 1예
박화선 ( Hwa-sun Park ),장재영 ( Jae Young Jang ),백민영 ( Min Young Baek ),김용권 ( Yong Kwon Kim ),윤현진 ( Hyun Jin Youn ),백수영 ( Su Young Back ),정승원 ( Soung Won Jeong ),이세환 ( Sae Hwan Lee ),김상균 ( Sang Gyune Kim ) 대한간암학회 2017 대한간암학회지 Vol.17 No.1
Hepatocellular carcinoma (HCC) is the 2nd most common cause of cancer related death in Korea and well-known malignancy with poor prognosis. Sorafenib is the first-line molecular targeted agent in patients with extra-hepatic spread of HCC. However, complete response is extremely rare in patients treated with sorafenib and the disease control rate is only 43%. We report a 53-year-old man with advanced HCC with pulmonary metastasis who showed complete response by cytotoxic chemotherapy with doxorubicin and cisplatin with relatively tolerable adverse effects after failure of treatment with sorafenib. (J Liver Cancer 2017;17:72-76)