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장재영 ( Jae Young Jang ), 김연수 ( Yun Soo Kim ), 김상균 ( Sang Gyune Kim ), 김영석 ( Young Seok Kim ), 조영덕 ( Young Deok Cho ), 이준성 ( Joon Sung Lee ), 진소영 ( So Young Jin ), 이문성 ( Moon Sung Lee ), 김주현 ( Ju Hyun Kim ), 심찬섭) 대한간학회 2006 Clinical and Molecular Hepatology(대한간학회지) Vol.12 No.4
장재영 ( Jae Young Jang ), 이준성 ( June Sung Lee ), 김형준 ( Hyung-joon Kim ), 심재준 ( Jae-Jun Shim ), 김지훈 ( Ji Hoon Kim ), 김보현 ( Bo hyun Kim ), 권준혁 ( Choon Hyuck Kwon ), 이승덕 ( Seung Duk Lee ), 이해원 ( Hae Won Lee ), 김정훈 ) 대한간암학회 2017 대한간암학회지 Vol.17 No.1
The General Rules for the Study of Primary Liver Cancer was published in June 2001 as the first edition. Since then, the 5th edition of the General Rules for the Study of Primary Liver Cancer was published by the 17th Committee of the Korean Liver Cancer Association based on the most recent data. The 5th edition of the General Rules for the Study of Primary Liver Cancer ranged over numerous topics such as anatomy, medical assessment of the patients, staging of hepatocellular carcinoma, description of the image findings, summary of hepatic resection, description of the surgical specimens, liver transplantation, reporting the pathological findings, pathological examinations of liver specimen, non-surgical treatment, radiotherapy, and assessment of tumor response after non-surgical treatment of hepatocellular carcinoma. The 5th General Rules for the Study of Primary Liver Cancer will not only become the basis of academic development for liver cancer studies in Korea, but also serve as the primary form of national liver cancer data accumulation based on standardized rules. (J Liver Cancer 2017;17:19-44)
본 논문은 아두이노(Uno R3)와 가스센서(MQ2)를 기반으로 위험상황을 감지하고 가스센서와 스마트폰을 연결하여 위험상황을 보다 빠르게 대처하고자 한다. 위험상황 감지는 가스감지센서를 사용하였으며 이 센서들은 아두이노를 통해 상황을 판별하는 서버와 실시간으로 데이터를 주고받는다. 서버에서 위험상황이 있다고 판단되면 스마트폰에 진동, 알람, 탈출경로 및 긴급연락 화면을 사용자에게 알린다.
Esophageal variceal bleeding is a common complication of liver cirrhosis. Non-selective beta blockers (NSBB) have been established in numerous studies as one of the medical treatment for cirrhosis, especially in the primary and secondary prevention of variceal bleeding. The dose of NSBB is adjusted for a reduction in the resting heart rate by 25%, to 55 beat/min, or until the occurrence of adverse effect. The mean adjusted dose of propranolol in Korean study is 160 mg/day. Nevertheless, low dose propranolol is frequently used in real clinical field. A study by Kwon et al. showed that effect of propranolol in the prevention for esophageal rebleeding was superior in maximally-tolerable dose group of propranolol than low dose group. In this editorial, we have reviewed the studies of prevention for variceal rebleeding focusing on the dose of propranolol. (Korean J Med 2014;86:30-32)
장재영 ( Jae Young Jang ), 김효종 ( Hyo Jong Kim ), 지성길 ( Sung Gil Chi ), 이길연 ( Kil Yeon Lee ), 남기덕 ( Ki Deuk Nam ), 김남훈 ( Nam Hoon Kim ), 이상길 ( Sang Kil Lee ), 주광로 ( Kwang Ro Joo ), 동석호 ( Seok Ho Dong ), 김병호 ( Byun) 대한소화기학회 2005 대한소화기학회지 Vol.45 No.4
목적: XIAP 유전자는 세포자멸사를 억제하는 대표적인 IAP 유전자이다. 최근에 XIAP의 caspase 억제 기능을 차단함으로서 세포자멸사를 촉진하는 Smac/DIABLO, HtrA2, XAF1 단백질이 확인되었다. 이번 연구에서는 인간 대장암조직에서 XAF1, Smac/DIABLO, HtrA2 유전자의 발현양상을 분석하여 대장암 발생과의 연관성을 파악하고자 하였다. 대상 및 방법: 10종의 대장암 세포주와 40예의 대장암조직 및 인접 정상 대장조직 Background/Aims: X-linked inhibitor of apoptosis (XIAP) is the most potent member of the IAP family that exerts antiapoptotic effects. Recently, XIAP-associated factor 1 (XAF1) and two mitochondrial proteins, Smac/DIABLO and HtrA2, have been identified to
Alcoholic liver disease (ALD) is a leading cause of liver-related morbidity and mortality. ALD encompasses a spectrum of disorders ranging from asymptomatic steatosis, alcoholic steatohepatitis, fibrosis, cirrhosis and its related complications. Moreover, patients can develop an acute-on-chronic form of liver failure called alcoholic hepatitis (AH). Most patients are diagnosed at advanced stages of the disease with higher rates of complications and mortality. The mainstream of therapy of ALD patients, regardless of the disease stage, is prolonged alcohol abstinence. The current therapeutic regimens for AH (i.e. prednisolone) have limited efficacy and targeted therapies are urgently needed.
Gastroesophageal varices are the most common lethal complication of cirrhosis that result most directly from portal hypertension. Patients with cirrhosis and gastroesophageal varices have an hepatic venous pressure gradient (HVPG) of at least 10~12 mmHg. An increased portal pressure gradient results from both an increase in resistance to portal flow and an increase in portal blood inflow. Patients whose HVPG decreased to < 12 mmHg or at least 20% from baseline levels have a lower probability of developing recurrent variceal hemorrhage. Therefore, a reduction in HVPG is most important. Nonselective β-blockers are the gold standard in the prevention of first variceal hemorrhage in pateints with medium/large varices. Endoscopic variceal ligation (EVL) has been established as an alternative to nonselective β-blockers for the prevention of initial variceal hemorrhage. The combination of vasoconstrictive pharmacological therapy and variceal ligation is the preferred approach to the management of acute variceal hemorrhage. Prophylactic antibiotic therapy is considered standard of care as adjunctive treatment of the acute bleeding episode. Both combination pharmacological therapy and EVL have been proven effective for the prevention of recurrent variceal hemorrhage. For failures of medical therapy, TIPS or surgically created shunts are excellent salvage procedures. (Korean J Med 75:6-14, 2008)
본 논문에서는 다면체의 특성요소가 보유하는 물리량의 계산을 위한 다항식을 자동정리 수법의 하나인 Wu의 방법으로 유도하고 유도식의 타당성 확인과 안정성 조사를 행한다. 다면체의 정점과 직선, 각각에 대응하는 투영 정점과 직선 사이에 성립하는 모든 관계식을 다항식으로 표현하여 계산 목표 물리량이 포함된 식을 결론식으로 나머지는 가정식으로 분류한다. 이 명제에 Wu의 방법을 적용시켜 계산식을 자동으로 유도한다. 이 식으로 변의 길이, 각도, 면적등이 계산될 수 있음을 simulation을 통해 확인하고 유도식의 안정성을 조사한다.
Occult HBV infection is defined as the presence of HBV DNA in the liver (with or without detectable or undetectable HBV DNA in the serum) of individuals testing negative for HBsAg. Studies on occult HBV infection in hepatitis C patients have reported highly variable prevalence, because the prevalence of occult HBV infection varies depending on the hepatitis B risk factors and methodological approaches. The most reliable diagnostic approach for detecting occult HBV detection is through examination of liver DNA extracts. HCV has been suspected to strongly suppress HBV replication up to the point where it may be directly responsible for occult HBV infection development. However, more data are needed to arrive at a definitive conclusion regarding the role of HCV in inducing occult HBV infection. Occult HBV infection in chronic hepatitis C patients is a complex biological entity with possible relevant clinical implications. Influence of occult HBV infection on the clinical outcomes of chronic hepatitis C may be considered negative. However, recent studies have shown that occult HBV infection could be associated with the development of hepatocellular carcinoma and contribute to the worsening of the course of chronic liver disease over time in chronic hepatitis C patients. Nevertheless, the possible role of occult HBV infection in chronic hepatitis C is still unresolved and no firm conclusion has been made up until now. It still remains unclear how occult HBV infection affects the treatment of chronic hepatitis C. Therefore, in order to resolve current controversies and understand the pathogenic role and clinical impacts of occult HBV infection in chronic hepatitis C patients, well-designed clinical studies are needed. (Korean J Gastroenterol 2013;62:154-159)