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- 저자 : 이경아 (검색결과 10,002 건)
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Development and Comparison of Warfarin Dosing Algorithms in Stroke Patients
이경아,조선미,이경열,최종락 연세대학교의과대학 2016 Yonsei medical journal Vol.57 No.3
Purpose: The genes for cytochrome P450 2C9 (CYP2C9) and vitamin K epoxide reductase complex subunit 1 (VKORC1) have been identified as important genetic determinants of warfarin dosing and have been studied. We developed warfarin algorithm for Korean patients with stroke and compared the accuracy of warfarin dose prediction algorithms based on the pharmacogenetics. Materials and Methods: A total of 101 patients on stable maintenance dose of warfarin were enrolled. Warfarin dosing algorithm was developed using multiple linear regression analysis. The performance of all the algorithms was characterized with coefficient of determination, determined by linear regression, and the mean of percent deviation was used to predict doses from the actual dose. In addition, we compared the performance of the algorithms using percentage of predicted dose falling within ±20% of clinicallyobserved doses and dividing the patients into a low-dose group (≤3 mg/day), an intermediate-dose group (3–7 mg/day), and high-dose group (≥7 mg/day). Results: A new developed algorithms including the variables of age, body weight, and CYP2C9 and VKORC1 genotype. Our algorithmaccounted for 51% of variation in the warfarin stable dose, and performed best in predicting dose within 20% of actual dose and intermediate-dose group. Conclusion: Our warfarin dosing algorithm may be useful for Korean patients with stroke. Further studies to elucidate clinical utilityof genotype-guided dosing and find the additional genetic association are necessary.
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