새로운 한의학 병인분류체계의 연구

박해모,이기남,황귀서,신용철,고성규,이해웅,이영준,임병묵,이상재,정명수,장보형,박선주,이선동,Park, Hae Mo,Lee, Kinam,Hwang, Guiseo,Shin, Yongchul,Go, Sunggyu,Lee, Haewoong,Lee, Youngjun,Lim, Byungmook,Lee, Sangjae,Jung, Myungsu,Jang, Bohyung 대한예방한의학회 2013 대한예방한의학회지 Vol.17 No.2

Objectives : This research aimed to develop a new etiologic classification for traditional Korean Medicine in order to respond to the social and environmental change. Methods : We reviewed the existing theories on etiological classification for East Asian Medicine thoroughly and discussed the problems and limitations. Based on the experts' consensus, we abstracted disease factors and etiologic items. Results : The disease factors are classified into three parts: the human body, the environment, and the interaction between the human body and the environment. We defined them as the inner factor, the external factor, and the interaction between the inner and the external factors. The inner factor is free from the influence of the environment, and it causes diseases solely from the components of the human body. It is divided into genetic factors. The external factor is defined as a case when a disease occurs due to a factor outside the human body and includes external injuries, environmental pollution, and natural disasters. The interaction between the inner and the external factors is a disease factor that causes diseases by the interaction of the human body and the environment and includes emotions, habits, and social environment. As a result of the analysis, it was possible to see the meanings at a single glance as the scattered and fractional meanings were integrated with focus on medicinal herbs, but the increasing number of analyzed medicinal herbs tended to more and more complicate their relationships, thus, requiring additional work like filtering. Conclusions : The new etiologic classification of Korean Medicine fully reflects the perspectives on life in Korean Medicine while embracing the changes in modem society. Also, by avoiding the usage of ambivalent terms and wrong classification methods, the new classification system constructs intuitive and concise etiology and improves usability in clinical medicine.

대한예방한의학회지 게재논문의 경향성에 대한 연구 - 창간호(1997년)로부터 2010년까지 -

박해모,Park, Hae-Mo 대한예방한의학회 2011 대한예방한의학회지 Vol.15 No.1

Objective : The purpose of this study was to identify the trend of research in the Korean Journal of Oriental Preventive Medicine and to suggest future perspective for oriental preventive medicine research. Method : The contents of 344 articles published in this journal was reviewed from its beginning year 1997 to year 2010. Result : The number of articles was increased as times go on. An analysis of the research design showed, experimental research (in vivo or in vitro) was 36.9%, survey research was 26.5%, review was 20.1%. In the major classifications of topics published, health management 28.5%, oriental medicine effectiveness 25.3%, herbal safety and toxicity 13.1%, and environmental and occupational medicine 9.0% respectively. Conclusion : There has been a lack of health preservation(Yang-saeng) topic, epidemiology and health statistics topic. Further research need qualitative study and each subjects of oriental preventive medicine.

간기능검사이상의 위험요인으로써 한약복용영향에 관한 단면연구

박해모,신헌태,박철수,이선동,Park, Hae-Mo,Shin, Heon-Tae,Park, Cheol-Soo,Lee, Sun-Dong 대한예방한의학회 2008 대한예방한의학회지 Vol.12 No.2

Objectives : The aim of this study was to evaluate effects of herbal medicine and other associated factors for abnormal liver function tests(especially total bilirubin, AST, ALT, and ${\gamma}$GT) levels in outpatients at an oriental medical clinic. Methods : A cross-sectional study based on clinical records was conducted on 504 patients at one Oriental medical clinic in Seoul, Korea. They were tested a liver function tests for screening and 497 patients ranging from the age of 4 to 74 were chosen for the study. Patients with basal liver disease or DM were excluded during the screening process. Patients were classified into case(abnormal) and control(normal) groups by normal liver function test references. Results and Conclusions : In this study, Significant correlations for abnormal total bilirubin levels was age, for abnormal AST was gender, for abnormal ALT were gender, smoking, marriage status, and job, for abnormal ${\gamma}$GT were age, gender, obesity, alcohol, smoking, marriage status, and job using the Chi-square test(p<0.05). There was no significant correlations for abnormal LFTs by using herbal medication history, and intake duration. After controlling other covariates, logistic regression analysis showed that the significant associated factors for abnormal total bilirubin levels were age(odds ratio[OR]=0.87, 95% confidence intervals [CI]=0.87-0.99). For abnormal AST levels was obesity(OR=2.45, CI=1.2-4.9), for abnormal ALT levels were age(OR=1.01, CI=0.99-1.03), male gender(OR=3.31, CI=1.62-6.76), and obesity(OR=3.71 CI=2.28-6.08). For abnormal ${\gamma}$GT levels were male gender(OR=4.83 CI=1.34-17.43), obesity(OR=3.29, CI=1.74-6.22), alcohol (OR=2.51, CI=1.19-5.28), and smoking(OR=2.29, CI=1.16-4.50). Herbal medication history was not as a risk factor for all abnormal liver function tests. Therefore, people who are male, obese, alcohol drinker and smoker will have higher liver function test levels. But intake of herbal medication or the duration of intake may not be the risk factor for abnormal liver function test results.

한약재내의 미량원소의 의의와 치료효과에 대한 고찰

박해모,이선동,Park Hae-Mo,Lee Sun-Dong 대한예방한의학회 2000 대한예방한의학회지 Vol.4 No.2

Trace element are involved in enzymatic activities, immunological reactions. physiological mechanisms. Deficiency in some trace elements, such as iron and iodine. is still an important health problem, The role of trace elements deficiency is suspected in various clinical situations and is now confirmed by well designed supplementation studies. However, the importance of trace elements as chinese herbal constituents is not sufficiently appreciated by the oriental medical profession, although in recent years a significant increase of new finding on their essential character in chinese herbal medicine occurred. It is well known that herbal medicine contains a variety of trace elements which would show therapeutic effects with active components in herbal medicine . In china, recent work showed some positive correlation between trace element and traditional chinese medicine (TCM) in terms of therapeutic effects even if their role in therapeutic effects is still obscure. In korea, not much attention has been on the therapeutic importance of trace element contained in herbal medicine Here, the therapeutic effects of trace element in TCM were reviewed and summarized. 1. Iron, copper, zinc and manganese are mainly contained in TCM. In addtion, chromium, magnesium, molybdenum, nickel, alminium, cobalt, arsenic and selenium has been studied for their therapeutic effects 2. Zinc, is decreased in patients who have deficiency of kindney(腎虛) and chronic disease. Fe is decreased in patients who have deficiency of blood(血虛). However copper is increased in patients who have chronic disease and hepatic disease.3 Iron concentration is high in herbs used for tonifying and nourishing yin or blood(補陰補血藥) Zinc concentration is high also in herb used for tonifying kidiney and vital essence(補腎補精藥). In addition. copper concentration Is high in herb used for replenishing qi(補氣藥) 4 In herbal drugs, the therapeutic substances in TCM are not only organic but also inorganic. It seems that trace elements would be one of components in herb for its therapeutic effects. This indicates that therapeutic effects of TCM should be extended not only to herb itself, bur also to trace elements contained in herb.

달생탕이 랫드의 모체와 태자에 미치는 영향에 대한 연구

박해모,김창석,이선동,이장우,유재홍,김판기,Park, Hae-Mo,Kim, Chang-Seok,Lee, Sun-Dong,Lee, Jang-Woo,Ryu, Jae-Hong,Kim, Pan-Gyi 한국환경보건학회 2006 한국환경보건학회지 Vol.32 No.4

The experiments was undertaken to evaluate the effects of herbal medicine, Dalsaengtang, in pregnant rats and fetuses. Female Sprague-Dawley rats were orally administered with the Dalsaengtang at dose of 5 mg/kg/day for 20 days. Pregnant rats were sacrificed at 20th day of gestation, and observed internal and reproductive organs. Approximately live fetuses in the 20th day of gestation were randomly selected and fixed in 95% ethanol. To observe skeletal malformations, fetuses were stained with alcian blue and alizarin red S. Maternal body weight of dalsaengtang treated group has a tendency to increase compared to that of control group. The relative liver and kidney weights of dalsaengtang treated group were also increased to that of control group. There were no significant changes between two groups in blood chemistry and hematological values. There were no significant changes in number of corpus luteum, implantation, live fetuses and implantation rate, delivery rate, late resorption rate and sex ratio. But Dalsaengtang administered group showed lower early resorption rate than the control group. From the sex ratio, number of females, bigger than number of males in the control group, and more males than females in Dalsaengtang administered group. Neonatal body weight and number of fetus of Dalsaengtang group were increased to that of control group. The fetuses of dams treated with Dalsaengtang didn't showed external malformation. Vertebral and sternal variations were observed in Dalsaengtang group but, compared to the control, those variations were insignificant. The number of ribs, cervical, thoracic, and lumber were normal. The number of sacral and caudal vertebrae were increased. Fetuses showed significant difference in the number of caudal vertebra (P<0.01). From these results, it can be concluded that Dalsaengtang showed no toxicity effects on maternal body weight, early resorption rate, and number of live fetuses. There were no significant changes in organ weight, hematological data, reproductive organs. Although skeletal variations were showed in vertebrate and sternum, Dalsaengtang did not shown significant changes in bone malformation.

한약이 실험동물의 태자에 미치는 생식독성학적 영향 -오적산을 중심으로-

박해모,신헌태,이선동,Park, Hae-Mo,Shin, Heon-Tae,Lee, Sun-Dong 대한예방한의학회 2008 대한예방한의학회지 Vol.12 No.2

Purpose : The experiments was undertaken to evaluate the effects of Ojeoksan-herbal medicine, in rats' fetus Methods : Female Sprague-Dawley rats were orally administered with the Ojeoksan at dose of 5mg/kg/day for 20 days. Pregnant rats were sacrificed at 20th day of gestation, and observed internal and reproductive organs. Approximately live fetuses in the 20th day of gestation were randomly selected and fixed in 95% ethanol. Results : Neonatal body weight and number of fetus of Ojeoksan group were increased to that of control group. The fetuses of dams treated with Ojeoksan didn't showed external malformation. Vertebral and sternal skeletal variations were observed in Ojeoksan administered group, but compared to the control, those skeletal variations were insignificant. There were no significant changes in number of ribs, cervical, thoracic, lumber, sacral and caudal Conclusion : From these results, it can be concluded that Ojeoksan showed no toxicity effects on number of live fetuses. There were no significant changes in skeletal variations were showed in vertebrate and sternum, Ojeoksan weren't shown significant changes in bone malformation. We need more precise study to investigate the mechanism of early or late resorption by the herbal medicines such as Ojeoksan.

오적산이 실험동물의 모체에 미치는 생식독성학적 연구

박해모,신헌태,이선동,Park, Hae-Mo,Shin, Heon-Tae,Lee, Sun-Dong 대한예방한의학회 2008 대한예방한의학회지 Vol.12 No.1

Purpose : The experiments was undertaken to evaluate the effects of herbal medicine, Ojeoksan, in pregnant rats Methods : Female Sprague-Dawley rats were orally administered with the Ojeoksan at dose of 5mg/kg/day for 20 days. Pregnant rats were sacrificed at 20th day of gestation, and observed internal and reproductive organs. Approximately live fetuses in the 20th day of gestation were randomly selected and fixed in 95% ethanol. Results : Maternal body weight of Ojeoksan treated group has a tendency to increase compared to that of control group. There were no significant difference in internal and reproductive organs. There were no significant changes between two groups in blood chemistry and hematological values. There were no significant changes in number of corpus luteum, implantation, live fetuses and sex ratio. But Ojeoksan administered group showed higher delivery rate, early resorption rate than the control group. Also Ojeoksan administered group showed higher implantation rate, late resorption rate than the control group. Conclusion : From these results, it can be concluded that Ojeoksan showed no toxicity effects on maternal body weight and number of live fetuses. There were no significant changes in organ weight, hematological data, reproductive organs. We need more precise study to investigate the mechanism of early or late resoption by the herbal medicines such as Ojeoksan.

한.양약 복용이 간기능이상에 미치는 영향에 대한 연구

박해모,신헌태,이선동,Park, Hae-Mo,Shin, Heon-Tae,Lee, Sun-Dong 대한예방한의학회 2007 대한예방한의학회지 Vol.11 No.2

Objectives : The aim of this study was to evaluate effects of herbal medicine and other associated factors for abnormal liver function tests(especially total bilirubin, AST, ALT, and ${\gamma}GT$) levels in outpatients at an oriental medical clinic. Methods : A cross-sectional study based on clinical records was conducted on 1,871 patients at one Oriental medical clinic in Seoul, Korea. 504 patients received a liver function tests for screening and 497 patients ranging from the age of 4 to 74 were chosen for the study. Patients with basal liver disease or DM were excluded during the screening process. Patients were classified into case(abnormal) and control(normal) groups by normal liver function test references. Results and Conclusions : In this study, 33.0% of the patients were females, and 67.0% were males. The mean age was $34.7{\pm}11.9$ years old. The mean total protein value was $6.78{\pm}0.66g/dL$(male $6.79{\pm}0.61$, female $6.76{\pm}0.76$), albumin $3.89{\pm}0.50g/dL$(male $3.94{\pm}0.47$, female $3.81{\pm}0.54$), total bilirubin $0.51{\pm}0.35mg/dL$(male $0.54{\pm}0.39$, female $0.45{\pm}0.23$), AST $23.31{\pm}18.22U/L$(male $26.37{\pm}20.73$, female $17.09{\pm}8.72$), ALT $33.49{\pm}36.36U/L$(male $40.56{\pm}41.77$, female $19.13{\pm}12.64$), LDH $258.07{\pm}74.84mg/dL$(male $263.68{\pm}73.77$, female $246.70{\pm}75.92$), and ${\gamma}GT$ $39.64{\pm}59.16U/L$(male $50.15{\pm}69.43$, female $17.83{\pm}8.36$). The percentage of abnormal total bilirubin levels(>1.0) in these patients was 2.6%, abnormal AST levels(>39m, >29f) 8.5%, ALT levels(>47m, >32f) 18.8%, and ${\gamma}GT$ (>50m, >40f) 19.9%.

한약재 복용으로 인한 금속 섭취량 추정 및 위해성 평가 연구

박해모,최경호,정진용,이선동,Park Hae-Mo,Choi Kyung-Ho,Jung Jin-Yong,Lee Sun-Dong 한국환경보건학회 2006 한국환경보건학회지 Vol.32 No.2

Metal contamination of medicinal herbs is of growing concern because of their potential adverse health effects. In this study, metal exposures were estimated and their potential health risks were preliminarily evaluated using available data including metal contamination levels and consumption estimates of herbal medicine in Korea. Consumption and contamination data of 34 medicinal herbs abundantly used in Oriental medicine in Korea were used in this study. Lead, mercury, arsenic, cadmium, cobalt, and chrome were identified as contaminants of potential health concerns. Even based on a conservative exposure scenario, i.e., consuming 5 times more herbal medicine with 95th percentile contamination levels, health risks associated with herbal medicine consumption were estimated to be minuscule. Herbal consumption was 0.3% of the provisional tolerable daily intake levels recommended by Joint Expert Committee on Food Additives (JECFA) of WHO/FAO. However, it should be noted that there are several important assumptions and uncertainties associated with this evaluation: This study was conducted for only 34 types of medicinal herbs of which consumption and metal contamination data were available. In addition, there are no reliable herbal medicine consumption data among Korean population. The pattern and amount of herbal (medicine) consumption in Korea need to be investigated in order to conduct more refined risk assessment associated with metal contamination in medicinal herbs.

『승정원일기』를 통해 살펴본 영조의 송절차 복용에 관한 연구

박해모(Hae-Mo Park),정지훈(Ji-Hun Jung) 한국의사학회 2021 한국의사학회지 Vol.34 No.2

『승정원일기』에 실린 기사를 분석하여 조선 21대 왕인 영조의 송절차 복용에 대하여 고찰하였다. 송절차는 우슬, 오가피, 송절 등의 재료로 술을 빚어 복용하는 처방으로 『승정원일기』를 통틀어 영조 대에만 등장하는 처방이다. 영조는 송절차가 다리의 병의 치료에 효과가 뛰어난 처방이라고 인식하였고, 신하와 의관들이 ‘차’라고 명명한 것에 힘입어 다양한 방법으로 복용하였다. 금주령을 내린 후 이를 어긴 신하를 처벌한 상황에서 술의 형태를 띤 처방을 복용하는 영조로서는 내적 갈등이 많았으며, 스스로 송절차를 술이라고 인식하였다. 영조 대의 신하와 의관들은 왕의 몸은 국가의 안위와 관련된 것이기에 질병 치료를 위하여 송절차를 복용해야만 하는 명분을 만들어 줌으로써 영조의 행위를 합리화시켰다. An article published in the 『Seungjeongwon Ilgi』 was analyzed to examine the take a dose Songjeol-tea by King Yeongjo, the 21st king of the Joseon Dynasty. Songjeol-tea is a prescription that makes alcohol with some ingredients and Songjeol[松節], and appears only in King-Yeongjo era throughout 『Seungjeongwon Ilgi』. King Yeongjo recognized that the Songjeol-tea was an excellent prescription for the treatment of leg diseases, and took it in various ways thanks to the title of tea by his officials and doctors. There were many internal conflicts as King Yeongjo taking a prescription in the form of alcohol in a situation where a official who violated it was punished after issuing prohibition of drinking alcohol, and he himself recognized the Songjeol-tea as alcohol. The officials and doctors of King Yeongjo s reign rationalized King Yeongjo s actions by creating a justification for taking the Songjeol-tea to treat the disease because the king s body was related to the safety of the state.