만성육아종질환 환자에서 합병된 식도 폐쇄 사례 -만성육아종질환의 육아종성 식도 폐쇄

김지수,황진솔,최영훈,김우선,김중곤,Kim, Ji Soo,Hwang, Jinsol,Choi, Young Hun,Kim, Woo Sun,Kim, Joong Gon 대한소아감염학회 2014 Pediatric Infection and Vaccine Vol.21 No.1

CGD 환자에서는 면역 체계의 결함으로 인한 반복적인 감염과 육아종 형성이 특징적이다. CGD 환자에서 육아종의 형성에 의한 식도 폐쇄는 매우 드문 합병증 중 하나로 CGD 환자의 육아종 형성에 의한 식도 폐쇄의 치료에 대해서는 불현성 감염이 동반될 가능성이 있어 스테로이드 치료와 항생제 치료에 대한 논란이 있어왔다. 저자들은 항생제 치료에 반응하지 않는 육아종 형성에 의한 식도 폐쇄 증상을 보인 8세 만성육아종질환 환자를 보고하는 바이다. 환자는 스테로이드 치료 이후에 임상적 증상과 영상 검사 상의 급격한 호전을 보였으나 스테로이드 치료를 중단한 지 한 달 뒤 환자의 식도 폐쇄 증상은 재발하였고, 이는 스테로이드를 재 투약 후 호전되었다. 스테로이드 중단 이후 한 차례 다시 재발하였으나, 항생제 치료 후 호전되었고 이후 추가적 재발 없이 경과 관찰 중이다. Chronic granulomatous disease (CGD) is an inherited immunodeficient disease characterized by recurrent infections and granuloma formation. Granulomatous obstruction of esophagus is one of the rare complications of CGD. The use of steroids and antimicrobials for esophageal obstruction by granuloma in CGD patients has been controversial due to the possibility of concomitant inapparent infection. We report a case of esophageal obstruction in an 8-year-old CGD patient showing the poor response to antibiotics therapy. However, dramatic improvement of symptoms and radiologic findings of esophageal obstruction were achieved after steroid therapy. One month after discontinuation of steroid, esophageal obstruction recurred and the patient was re-treated with steroid. After that time, he experienced one more recurrence of esophageal obstruction. This symptom subsided after antibiotics therapy without steroid and he has been followed up to the present without further relapse.

자사주 매입 기업의 성과 분석

김지수,김진노 嶺南大學校社會科學硏究所 2002 社會科學硏究 Vol.22 No.1

본 논문은 1994에서 1997년 사이 공개시장 자사주 매입 기업의 성과를 분석함으로써 자사주 매입 기업의 동기를 파악하고자 하였다. 흔히 자사주 매입의 동기는 크게 두 가지 가설에 의하고 있다. 하나가 정보신호 가설이고 나머지 하나는 여유현금 흐름 가설이다. 본 연구에 사용된 총 표본은 166개 기업으로 짝짓기 방법에 의한 분석을 하였다. 분석은 자사주 매입전 3년부터 매입후 3년까지 총 7년간에 걸친 기업의 장기 성과를 연도별로 분석하는 방법을 사용하였다. 비모수 방법론인 윌콕슨의 부호검정과 회귀분석을 행하였다. 표본을 q비율에 의하여 나누어서 결과를 분석하였다. 이러한 방법에 의한 결과를 요약하면 아래와 같다. 1) 자산에 대한 현금흐름으로 나타나는 성과는 자사주 매입후 증가하는 것으로 나타났다. 2) 높은 성장기회를 가진 그룹(q>1)에서는 자사주 매입후 성과의 증가가 자산 매각등에 의한 자산 효율성의 개선에 의한 것으로 나타났다. 3) 낮은 성장기회를 가진 그룹(q<1)에서는 자사주 매입후 성과의 증가라 주로 매출액 증가에 의한 것으로 나타났다. 이러한 결과를 바탕으로 서로 다른 투자기회를 가진 기업들에 있어서 자사주 매입의 동기는 다른 것으로 나타났고, 그 중에서 신호가설이 본 표본에서는 지지되는 가설로 나타났다.

초두구로부터 분리한 비환식 트리테르페노이드계 화합물의 세포 접착인자 저해활성

김지수,노문철,김강성,김관희,임병용,Kim, Ji-Soo,Rho, Mun-Chual,Kim, Gang-Seong,Kim, Koanhoi,Rhim, Byung-Yong 한국해양바이오학회 2007 한국해양바이오학회지 Vol.2 No.4

The present study purified two noncyclic triterpenoids, compound 1 and compound 2, that intervene interaction of ICAM-1 and LFA-1 from ethanol extracts of Alpinia katsumadai. The compound 1 and 2 inhibited adherence of sICAM-1 to THP-1 cells with an $IC_{50}$ of $7.59{\mu}g/m{\ell}$ 및 $6.98{\mu}g/m{\ell}$, respectively, without affecting viability of the cells. The compound 1 and 2 also inhibited interaction of CHO-ICAM-1 cells with THP-1 cells with an $IC_{50}$ $6.7{\mu}g/m{\ell}$ 및 $5.5{\mu}g/m{\ell}$, respectively. These findings suggest that the noncyclic triterpenoids from Alpinia katsumadai have inhibitory activities against cell adherent molecules. The present study proposes that noncyclic triterpenoids from Alpinia katsumadai can applied to therapeutic approaches to the diseases that are associated with adhesion of inflammatory cells. 1. 천연자원으로부터 ICAM-1과 LFA-1 매개성 세포접착 저해제를 탐색한 결과, 초두구 에탄올 추출물은 이에 대한 저해 활성을 나타내었다. 2. 초두구로부터 세포 접착 인자 활성에 관한 물질을 분리 정제하기 위하여, 각종 용매추출과 컬럼 크로마토그래피를 이용하여 얻은 화합물 1과 2로 세포접착인자 저해활성을 확인하였다. 3. 분리된 화합물 1과 2의 sICAM-1과 THP-1 세포와의 결합저해활성 측정 결과, $IC_{50}$ 값은 각각 $7.59{\mu}g/m{\ell}$ 및 $6.98{\mu}g/m{\ell}$로 측정되었다. 실험에 사용된 농도에서는 세포독성을 보이지 않았다. 4. 분리된 화합물 1과 2의 CHO-ICAM-1과 THP-1 세포간의 결합저해활성을 측정한 결과, $IC_{50}$ 값이 각각 $6.7{\mu}g/m{\ell}$ 및 $5.5{\mu}g/m{\ell}$로 측정되었다. 5. 이상의 실험 결과로 미루어 보아, 초두구로부터 분리한 비환식 트리테르페노이드계 화합물들은 세포 접착인자에 대한 저해활성을 가지고 있다고 볼 수 있으며 이 기전을 통하여 생길 수 있는 질환에 대한 치료제 개발에 유효할 것이다. 특히 동맥경화에 대해서는 새로운 기전으로 접근하고 있으므로 기존의 치료제들의 작용기작과는 다른 약품의 개발이 기대된다. 또한 ICAM-1은 염증반응 및 암의 전이에도 관련되어 있으므로, 동맥경화 관련 질환이외에도 다양한 질환에 대한 의약품으로의 응용도 기대된다.

체내에서 성숙이 재개된 생쥐난자의 투명대 경화

김지수,김해권,박종민,이승재,이준영,김문규,Kim, Ji-Soo,Kim, Hae-Kwon,Park, Jong-Min,Lee, Seung-Jae,Lee, Joon-Young,Kim, Moon-Kyoo 대한생식의학회 1997 Clinical and Experimental Reproductive Medicine Vol.24 No.1

It is well known that the zona pellucidae of mouse oocytes become "hardened" when they are allowed to mature in vitro in the absence of serum components. To see if oocytes already undergone meiotic resumption in vivo exhibit similar zona hardening, hardening of ZP of cumulus-enclosed oocytes(CEOs) was examined after culture in vitro since their release from follicles various hours after hCG injection. When CEOs matured in vivo for 3h or longer were subjected to culture in vitro for 14h with BSA alone, zona hardening was significantly reduced compared to those cultured in vitro from the begining of maturation. However, when CEOs matured in vivo for 5h were freed from cumulus cells and then cultured in vitro with BSA alone, little reduction of zona hardening was observed. Preincubation of CEOs for 5h with fetuin, one of the well known inhibitor of in vitro zone hardening, did not prevent zona hardening during its subsequent culture of CEOs for 14h without fetuin. However, when CEOs precultured with both fetuin and PMSG for 5h and then further cultured with BSA alone for 14h, zona hardening was dramatically reduced. Under these conditions, the expansion of cumulus cell was observed. In addition, CEOs cultured with both BSA and dbcAMP to prevent their meiotic resumption showed a significant increase of zona hardening. Whether the observed zona hardening was correlated with the conversion of ZP2 to $ZP2_{f}$ was examined. Zona pellucida, isolated from CEOs matured for 5h in vivo and then further cultured with BSA alone was subjected to SDS-PAGE. Most of ZP2 molecules from these CEOs did not undergo conversion from ZP2 to $ZP2_{f}$. From these results, it is concluded that CEOs undergone meiotic resumption in vivo do not exhibit zona hardening when they were subsequently cultured in vitro without serum components. It appears that cumulus cells play an important role in this phenomenon.

구안와사에 대한 훈증요법 복합치료 효과

김지수,박수연,최창원,김경수,김경옥,위통순,양승정,Kim, Ji-Soo,Park, Soo-Yeon,Choi, Chang-Won,Kim, Kyeong-Soo,Kim, Kyeong-Ok,Wei, Tung-Shuen,Yang, Seung-Joung 대한한의학방제학회 2015 大韓韓醫學方劑學會誌 Vol.23 No.1

Objectives : This study was performed to investigate the effect of herbal steam therapy on peripheral facial paralysis. Methods : 55 patients with peripheral facial paralysis were treated with Korean Medicine therapy including herbal steam therapy. We evaluated the effect of Korean Medicine therapy including herbal steam therapy by Yanagihara grading system. Results : 1. 55 patients were treated with Korean Medicine therapy and 23.27±14.11 times of herbal steam therapy. 2. After treatment, Y-system score was significantly increased(p-value＜0.001) from 18.00±6.5514 to 35.00±6.3404. Conclusions : Herbal stream therapy seem to be effective to improve symptoms of peripheral facial paralysis. Further studies will be needed to identify the beneficial of herbal steam therapy on peripheral facial paralysis.

말초성 안면신경마비에 대한 매선요법 복합치료 효과

김지수,박수연,김경수,김경옥,위통순,최창원,양승정,Kim, Ji-Soo,Park, Soo-Yeon,Kim, Kyeong-Soo,Kim, Kyeong-Ok,Wei, Tung- Shuen,Choi, Chang-Won,Yang, Seung-Joung 대한한방안이비인후피부과학회 2015 한방안이비인후피부과학회지 Vol.28 No.2

Objective : This study was performed to investigate the effect of Needle-Embedding Therapy on peripheral facial paralysis. Method : We investigated 60 cases of patients with peripheral facial paralysis, and devided patients into two groups : We treated one group by complex korean medical treatment with Needle-Embedding therapy, and did the other group by complex korean medical treatment without Needle-Embedding therapy. Yanagihara grading system at baseline and final were used for evaluating the effect of the treatment. Results : 1. In Needle-Embedding therapy group and non Needle-Embedding therapy group, compared with baseline, at final, Y score was significantly increased.2. At final, there was significant difference in improvement between Needle-Embedding therapy group and non Needle-Embedding therapy group. Conclusions : Needle-Embedding therapy seem to be effective to improve symptoms of peripheral facial paralysis. Further studies will be needed to identify the beneficial of Needle-Embedding therapy on peripheral facial paralysis.

한복과 한푸의 차이점 분석에 관한 연구

김지수,나영주,Kim, Jisu,Na, Youngjoo 대한가정학회 2022 Human Ecology Research(HER) Vol.60 No.2

(K)Hanbok, which is Korea's traditional clothing, differs from the Chinese Hanfu or Japanese Kimono. This study aims to understand the fundamental differences between (K)Hanbok and Hanfu. The Goryeo Dynasty (K)Hanbok, which was particularly popular in China, was established because the Ming Dynasty Hanfu and Chinese fashion were considerably influenced by the 'Koryo Yang'. Firstly, while (K)Hanbok is bulky, Hanfu of the Han Dynasty is characterized by forming a slim silhouette. Due to the climate of the Northern Hemisphere, (K)Hanbok shows a rich silhouette comprising multiple layers of inner pants and a pleated skirt over a voluminous underskirt. On the other hand, the Han's Hanfu creates a straight silhouette in the form of a wrap, revealing the contours of the body. The pleated skirt of the (K)Hanbok can use six to twelve width fabrics, depending on the social position; however, the Hanfu of the Han is a skirt without any pleats. Secondly, the clothing patterns, which have various shapes, are totally different in how they are made and sewn. The Korean (K)Hanbok is a two-piece separate, whereas the Chinese Hanfu style is a one-piece with a skirt. The short length of the (K)Hanbok jacket has a Sup which is cut and pasted allowing the front closure to overlap. Nevertheless, the Hanfu of the Han does not have this Sup because it is of a wrap-around, one-piece style and has an exceptionally large front, and wraps around at the waist which extends to the sides. Thirdly, the (K)Hanbok jacket has separate string Gorums for fastening, and an additional belt around the waist; however, in the case of Gorum, it is unnecessary for a wrapping style of Hanfu. Fourthly, Koreans as an agricultural horse-riding people, basically wore the trousers attached a comfortable gusset, while the Chinese Hanfu had no pants, but the Chinese wore Gaedanggo pants which exposed the hips, inevitably during the Warring States period.

Amoxicillin의 근육투여에 따른 수온별 넙치 체내 약동학적 특성

김지수,이지훈,이수진,박관하,Kim, Ji-Soo,Lee, Ji-Hoon,Lee, Soo-Jin,Park, Kwan-Ha 한국어병학회 2015 한국어병학회지 Vol.28 No.1

아목시실린(AMOX)의 수온에 따른 약동학적 특성과 잔류량을 알아보기 위해 넙치(평균 100 g)를 $(17{\pm}2)^{\circ}C$ 및 $(22{\pm}2)^{\circ}C$에 수용하여 1회 근육투여한 후 시간에 따른 혈장, 간, 신장의 잔류농도를 HPLC-UVD로 분석하였다. 이 측정결과를 바탕으로 2-compartmental model로 PKSolver program을 이용하여 AMOX의 반감기, AUC 등의 pharmacokinetic parameter를 조사하였다. 혈장, 간, 신장의 최고농도 및 도달시간의 범위가 각각 $27.23-257.36{\mu}g/m{\ell}$ (0.05-0.91 h), $5.49-41.65{\mu}g/g$ (1.36-3.28 h), $16.75-129.31{\mu}g/g$ (1.95-4.49 h)으로 나타났다. 수온에 따른 잔류기간을 시험하기 위해 어체중 kg 당 40 및 400 mg을 투여한 후 LC-MS/MS로 분석하였다. 40 mg/kg은 5일 후, 400 mg/kg은 7일 후에 각각 최대잔류허용량인 0.05 mg/kg 이하로 검출되었다. The pharmacokinetic properties and residue levels of amoxicillin (AMOX) were studied after intramuscular injection to cultured olive flounders ($100{\pm}50g$), Paralichthys olivaceus. For pharmacokinetic studies, AMOX of 20 to 80 mg/kg body weight was administered at $17{\pm}2^{\circ}C$ or $22{\pm}2^{\circ}C$ and AMOX concentrations were determined in plasma, the liver, and the kidney by HPLC-UVD. Plasma samples were assessed at 0.25, 0.5, 1, 3, 6, 12, 24, 48, 72, 96, 168 hours post-dose, whereas liver and kidney concentrations were measured at 0.25 to 48 hours post-dose. The kinetic profiles of AMOX were analyzed by fitting to a 2-compartmental model with PKSolver program. The following parameters were obtained for a single dosage of 20, 40 and 80 mg/kg of body weight at $22^{\circ}C$ and 20 and 40 mg/kg of body weight at $17^{\circ}C$ in plasma, liver and kidney, respectively: $C_{max}$ (the peak concentration)= $27.23-257.36{\mu}g/m{\ell}$, $5.49-41.65{\mu}g/g$, $16.75-129.31{\mu}g/g$; $t_{max}$ (the time for peak concentration)= 0.05-0.91, 1.36-3.28, 1.95-4.49 h. For residue studies, AMOX of 40 and 400mg/kg was administered, and muscle samples were taken at 2, 5, 7, 14 and 21 days post-dose. The residueof AMOX in the muscle were found under the MRLs (maximum residue levels) within 7 days for the two doses.

공공도서관의 VR 기반 교육문화프로그램 개발에 관한 연구

김지수,김성주,박신이,신지원,권선영,Kim, Ji Soo,Kim, Seong Ju,Park, Si Ni,Shin, Ji Won,Kwon, Sun Young 한국정보관리학회 2021 정보관리학회지 Vol.38 No.2

최근 들어 다양한 분야에서 VR 기술을 활용한 콘텐츠가 점차 증가하고 있으며 기술 또한 급속도로 보급되는 추세이다. 이러한 배경에서 공공도서관 또한 시대의 흐름에 따라 VR 기술을 활용한 서비스를 제공할 필요가 있다. 이에 본 연구는 공공도서관의 교육적, 문화적 기능을 고려한 VR 기반 교육문화프로그램을 제안하는 것을 목적으로 한다. 이를 위해 VR 프로그램이 진행되고 있는 국내·외 공공도서관 및 산업군 사례 조사 그리고 선행연구, 이론분석을 통해 적용점 및 시사점을 도출하였으며 이를 종합, 검토하여 공공도서관에서의 VR 기반 교육문화프로그램을 제안하였다. 본 연구에서 제시한 VR 기반 교육문화프로그램은 향후 공공도서관에서 VR 기반 교육문화프로그램 기획을 위한 기초 자료로 활용될 수 있을 것이다. Recently, content using VR technology in various fields is gradually increasing, and the technology is also rapidly spreading. Against this background, public libraries also need to provide services using VR technology according to the flow of the times. Therefore, this study drew application points through the investigation and analysis of domestic and foreign public libraries where VR programs are underway. And based on this, a final proposal is prepared after planning and reviewing VR-based educational and cultural programs in public libraries. VR-based educational and cultural programs introduced can be used as basic data for planning VR-based cultural programs in public library.

SAW 필터 소개 및 개발 동향

김지수,박성일 ( Ji Soo Kim,Sung Il Park ) 한국전기전자재료학회 1997 전기전자재료학회논문지 Vol.10 No.2