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근타박상시 치료용 초음파가 Substance-P 발현에 미치는 효과에 대한 면역조직화학적 연구
김용수,김석범,김진상,박래준,Kim Yong Su,Kim Seok Beom,Kim Jin Sang,Park Rae Jun 대한물리치료학회 2003 대한물리치료학회지 Vol.15 No.1
The purpose of this study was to evaluate the effect of therapeutic ultrasound after muscle contusion injury by observed immunoreactivity of substance-P that plays an important role in pain transmission. Ultrasound irradiation(1MHz, 1W/$cm^{2}$ continuous mode, treatment time 5 min) was applied through water submersion technique to 1 limb daily by kept off 5cm from muscle belly of gastrocnemius. The result of this study were as follows. 1. The substance-P was expressed in lamina I and II of dorsal horn of spinal cord, also in lamina IV and around of central cannel of spinal cord. Experimental group was lower expressed than control group with the exception of 1 days. 2. The substance-P immunoreactivity was decreased for 5 days together in lumbar and sacral region of all groups, expecially experimental group was rapidly. These data suggest therapeutic ultrasound may stimulate pain relief by diminish of substance-P in dorsal horn of spinal cord.
김용수,정신,윤상원,이정길,김태선,김재휴,김수한,강삼석,이제혁,Kim, Yong-Su,Jung, Shin,Yoon, Sang-Won,Lee, Jung-Kil,Kim, Tae-Sun,Kim, Jae-Hyoo,Kim, Soo-Han,Kang, Sam-Suk,Lee, Je-Hyuk 대한신경외과학회 2000 Journal of Korean neurosurgical society Vol.29 No.7
Objective : Object : A 7-year retrospective clinical and MRI study was reviewed to evaluate the characteristics of pineal cyst. We evaluated results of clinical and radiologic change of pineal cyst during follow up period. Patients and Methods : From 1992 to 1999, 50 patients with pineal cyst were visited for evaluation. Follow up clinical information was obtained from patients or clinical record through phone conversation. also radiologic findi-ngs of pineal cyst in mid-sagittal MRI were reviewed in detail. Results : Pineal cysts were usually asymptomatic and detected incidentally during evaluation of other diseases. Sagittal MRI is the most useful diagnostic test. The radiologic findings of pineal cyst were isointensity on T1WI comared to CSF and slightly high signal intensity on T2WI. Cyst wall was variably enhanced on Gad-enhanced T1WI. The average size of cyst was $13.9{\times}13.0mm$. The pineal cyst was classified into five groups according to previous report. Long term behavior of these lesions are not apparent, but in our study they showed no specific changes in clinical and radiological aspects during 25 months. Conclusion : Although long-term follow up results are needed, the pineal cyst are considered as normal variants. In our 25 months follow up results, there was no rapid change of cyst both clinically and radiologically. Therefore, frequent radiologic evaluation seems unnecessary except type III pineal cyst.
복강내 전이된 혈관 중심성 T-세포 림프종의 한방치료 : 증례보고
김용수,윤성우,Kim, Yong-Su,Yoon, Seong-Woo 대한암한의학회 2005 大韓癌韓醫學會誌 Vol.10 No.1
Angiocentric T-cell lymphoma is a rare form of peripheral T-cell lymphoma. The disease typically manifests clinically as an aggressive, progressively destructive disorder often with a fatal outcome. It is the aim of the present paper to derive further studies evaluating the effectiveness of Korean traditional medicine on angiocentric T-cell lymphoma with intra-abdominal metastasis. A patient with high fever, weight loss, night sweat and general weakness(B symptoms) was diagnosed as angiocentric T-cell lymphoma and chemotherapy was done more than 10 times. But the response to chemotherapy was poor, finally the lymphoma involved liver and spleen. The abdominal CT showed the hepatosplenomegaly, diffuse lymphoma of liver and spleen, massive ascites, minimal pleural effusion. Then the patient gave up the chemotherapy and only herb medications (Bohyunsoamtang-A,B) were administered. The ascites, high fever and hepatosplenomegaly gradually reduced to normal. He survived for 7 years after first diagnosis, which is much longer than average survival time in angiocentric T-cell lymphoma with B symptoms. This case may give us a possibility of that Korean traditional herb medications offer potential benefits for patients with angiocentric T-cell lymphoma, and more researches are needed.
김용수,김영훈,Kim, Yong-Su,Kim, Young-Hoon 한국건설관리학회 2010 한국건설관리학회 논문집 Vol.11 No.4
본 연구는 공동주택 시공VE 사례조사를 통한 설계VE의 문제점을 분석하여 이를 바탕으로 설계VE의 효율화방안을 제시하는 것을 목적으로 수행되었다. 이를 위해 국내 5개 건설사의 공동주택 시공VE 현황을 조사하였다. 또한 5개 건설사에서 수행한 공동주택 프로젝트를 대상으로 시공VE 적용 현황을 분석하였다. 이와 같은 목적과 방법에 따른 연구 결과를 요약하면 다음과 같다. 첫째, 설계VE의 효율성 제고를 위해 시공VE 데이터베이스 구축 및 활용에 필요한 정보판리 제계를 제시하였다. 둘째, 시공VE 업무체계 개선을 통한 설계VE 수행 프로세스 개선안을 제시하였다. 셋째, 공통주택의 효율적인 설계VE 대상 선정을 위한 고려사항과 설계단계별 중점 VE대상을 제시하였다. The purpose of this study is to efficiency scheme to design VE through the case studies of construction VE forapartments. The adapted research method includes five case studies of construction VE and analysis of constructionVE practice. The results of this study are as follows 1) For efficiency of design VE, data management system whichis necessary for construction VE database establishment and its application were proposed. 2) Through workingsystem improvement of construction VE, an improvement to design VE performance process was proposed. 3)Consideration factors and main VE items for efficient design VE item selection of apartment buildings wereproposed.
근타박상시 치료용 초음파가 혈관내피성장인자와 Substance-P 발현에 미치는 효과에 대한 면역조직화학적 연구
김용수,오태영,김석범,Kim Yong-Su,Oh Jae-Young,Kim Souk-Boum 대한물리치료학회 2003 대한물리치료학회지 Vol.15 No.4
Therapeutic angiogenesis is the controlled induction or stimulation of new blood vessel formation to reduce unfavourable tissue effects caused by local hypoxia and to enhance tissue repair. Therapeutic ultrasound can be considered as a physical agent to deliver therapeutic angiogenesis. The purpose of this study was to evaluate the effect of therapeutic ultrasound after muscle contusion injury by observed immunoreactivity of vascular endothelial growth factor(VEGF) that plays an important role in angiogenesis and substance-P in pain transmission. Ultrasound irradiation(1MHz, $1W/cm^2$, continuous mode, treatment time 5 min) was applied through water submersion technique to 1 limb daily by kept off 5cm from muscle belly of gastrocnemius. The result of this study were as follows. 1. In morphological observation, there were no significant changes excepts of 7 days. At 7 days, granular tissue viewed abundantly in control group. In other groups, general feature were increased interspace of muscle fiber; centronucleated muscle fiber; collapsed of muscle and nerve tissue; appeared inflammatory cell. 2. The VEGF was expressed in interspace of muscle fiber. Especially, at 7 days in experimental group, VEGF was showed in connective tissue surrounding gastrocnemius muscle. 3. The VEGF was higher expressed in experimental group at 2 and 3 days, but in control group at 7 days. These data suggest therapeutic ultrasound enhanced production of VEGF in the early day relatively, therefore stimulated angiogenesis in the skeletal muscle induced contusion injury. Also therapeutic ultrasound may stimulate pain relief by diminish of substance-P in dorsal horn of spinal cord.