Effect of Statin Use on Liver Cancer Mortality Considering Hypercholesterolemia and Obesity in Patients with Non-Cirrhotic Chronic Hepatitis B

김기애,심재준,이지성,김병호,김정욱,오치혁,오창모,오인환,박소연 연세대학교의과대학 2019 Yonsei medical journal Vol.60 No.12

Little is known about the benefits of statin use on liver cancer mortality among patients with chronic hepatitis B (CHB) consideringhypercholesterolemia and obesity. A nationwide retrospective cohort study was conducted using data from a Health ExaminationCohort of the National Health Insurance Service of Korea. Data on CHB patients with no other concurrent liver diseasewere acquired, and statin use was defined as a cumulative daily dose ≥28. A 3-year landmark analysis was performed to avoid immortaltime bias. Patients who started statin therapy within the landmark date were considered statin users. A Cox regressionanalysis was applied to assess associations between statin use and liver cancer mortality considering hypercholesterolemia andobesity. Among 13063 patients, 193 (1.5%) died of liver cancer during the mean follow-up period of 10.6 years. After adjusting fordemographic and metabolic factors, statin use [hazard ratio (HR), 0.17; 95% confidence interval (CI), 0.04–0.70] and hypercholesterolemia(HR, 0.46; 95% CI, 0.24–0.88 for total cholesterol ≥240 mg/dL) were associated with a decreased risk of liver cancer mortality,whereas body mass index (BMI) ≥30 kg/m2 was associated with an increased risk of liver cancer mortality (HR, 2.46; 95% CI,1.20–5.06). This study showed that statin use was associated with decreased liver cancer mortality when adjusting for cholesterollevels and BMI. This study found that hypercholesterolemia was independently associated with decreased liver cancer mortalityregardless of statin use.

남극 대기에서의 PM<SUB>2.5</SUB> 내 Sugar 특성 분석

김기애,장은호,김연태,박지연,박기태,윤영준,정창훈,김용표,이지이 한국대기환경학회 2019 한국대기환경학회 학술대회논문집 Vol.2019 No.11

남극 대기 중 유기 에어로졸의 주요 발생원 규명

김기애,유하영,김연태,박지연,박기태,윤영준,정창훈,김용표,이지이 한국대기환경학회 2021 한국대기환경학회 학술대회논문집 Vol.2021 No.10

남극은 지구상에서 인위적인 오염의 영향이 가장 적은 곳임에도 불구하고 기후변화의 영향으로 인해 남극 환경은 많은 변화가 일어나고 있다. 현재 남극에서는 기후변화 영향 및 원인 규명을 위한 다양한 연구가 진행되고 있다. 특히 대기 중 에어로졸은 기후변화에 직간접적인 영향을 미치기 때문에 에어로졸의 물리화학적 특성을 이해하려는 연구가 진행되고 있지만 이에 대한 이해가 부족한 실정이다. 대기 에어로졸은 인위적, 자연적으로 비롯되며 이들이 구성되는 성분은 그 배출특성에 따라 각기 다른 구성을 가진다. 따라서 대기에어로졸의 발생 특성을 파악하기 위해 다양한 개별유기성분들의 분석이 필요하다. 본 연구에서는 fatty acids (13종), dicarboxylic acids (16종), benzencarboxylic acids (4종), sugars (12종), sugar-alcohols (9종), resin acids (2종), sterols (7종) phenolic acids (2종) 그리고 cis-pinonic acid를 포함한 총 66종의 유기성분들을 분석하였다. 이들은 주로 바이오매스 연소나 광화학반응 또는 자연적인 생물기원에 의해 생성/배출되는 것으로 알려져 있다. 따라서 이들 구성성분의 농도 분포 특성을 파악한다면 남극 대기 에어로졸 내 유기성분의 기원을 파악할 수 있고, 이를 통해 인위적 오염원과 자연적 영향이 남극에어로졸에 미치는 영향을 파악할 수 있다. 이를 위해 본 연구에서는 남극반도의 킹조지섬에 위치한 남극세종기지(62.2°S, 58.8°W)에서 PM2.5를 채취하였고 GC-MS/MS를 이용하여 유기성분들의 정성 및 정량분석을 수행하였다. 또한 남극 PM2.5 내 유기성분들의 농도 수준을 파악하고, 각 개별성분들의 분포비율을 통해 남극 대기 에어로졸 내 유기성분들의 생성기원의 특성을 이해하고자 하였다.

가정과 실습의 효율화를 위한 학습자료 개발에 관한 연구 - 고등학교 의생활 영역의 스커트 만들기를 중심으로 -

김기애,김여숙 한국가정과교육학회 2001 한국가정과교육학회지 Vol.13 No.3

The Purpose of this study is to enhance the efficiency of clothing-making units in the textbook of Home Economics for the high school students. I handed out a research paper with several questions to 75 teachers and 87 students to find out the realities of the education. There are several problems of making clothes at class: lack of time, appropriate equipment and efficient learning material. To solve these problems. I made a half-sized skirt kit utilizing OPTI Tex. a type of CAD in fashion design and copied it by silkscreen. and let the students use it. Both of the teachers and students showed positive response to the newly made kit of my own. saying that \"it is very handy to prepare and it\`s very helpful to figure out how to make skirt. \" Using the kit. we could reduce the time to make clothes by about 60 % and do well in the classroom without any sewing machines.

북극에서 남극 대기까지의 유기에어로졸의 공간분포 및 조성

김기애,박지연,박기태,윤영준,안윤경,정창훈,김용표,이지이 한국대기환경학회 2023 한국대기환경학회 학술대회논문집 Vol.2023 No.10

힘셀프의 동물 되기:『팔이 셋 달린 남자』에서

김기애 현대영미어문학회 2007 현대영미어문학 Vol.25 No.4

Edward Albee's The Man Who Had Three Arms is another act of criticism on the artificial values of the American middle class. Himself was once world-famous because of the third arm growing from his back and gives an address to the audience about the saga of his life. As the play's theme deals with Albee's usual concerns, the play's form is experimental. Albee tears down the invisible fourth wall and turns the theatre into a place of becoming which invites the audience to actively participate. I will examine the play using the Deleuze and Guattari's concepts of becoming-animal and the three major characteristics of minor literature. Himself experiences a becoming-animal, which leads him to become a nomadic subject. He deterritorializes the American society and culture, and finds his fame and success are acquired through being a talentless freak. Himself's becoming-animal, use of deterritorialized language, the play's political nature, and the collective assemblage of enunciation all serve to characterize the play as minor literature.

안면도 대기 중 PM<SUB>2.5</SUB> 내 n-alkanes의 월별 농도 분포 특성

김기애,이종식,김은실,정창훈,김용표,이지이 한국대기환경학회 2017 한국대기환경학회 학술대회논문집 Vol.2017 No.11

Many faces of the GPCR‑arrestin interaction

김기애,Ka Young Chung 대한약학회 2020 Archives of Pharmacal Research Vol.43 No.9

G protein-coupled receptors (GPCRs) belongto a major receptor family and regulate important physiologicaland pathological functions. Upon agonist activation,GPCRs couple to G proteins and induce the activation of Gprotein-dependent signaling pathways. The agonist-activatedGPCRs are also phosphorylated by G protein-coupled receptorkinases (GRKs), which promote their interaction witharrestins. Arrestin binding induces desensitization (i.e.,inability to couple to G proteins) and/or internalization ofGPCRs. Arrestins not only desensitize and/or internalizeGPCRs but also mediate other downstream signals such asmitogen-activated protein kinases. G protein-mediated signalingand arrestin-mediated signaling often result in differentfunctional outcomes, and therefore, it has been suggestedthat signaling-selective regulation of GPCRs could lead tothe development of more effective treatments with fewer sideeffects. Thus, studies have attempted to develop functionallybiased (i.e., signaling-selective) GPCR-targeting drugs. Tothis end, it is important to elucidate the structural mechanismunderlying functionally biased GPCR signaling, whichincludes understanding the structural mechanism underlyingthe GPCR-arrestin interaction. This review aims discuss thestructural aspects of the GPCR-arrestin interaction, focusingon the differences between reported GPCR-arrestin complexstructures.

A Case of Ruptured Mycotic Hepatic Artery Aneurysm Successfully Treated Using Arterial Embolization

김기애,이한주,진영주,양지은,이민정,박지현,이보영 영남대학교 의과대학 2012 Yeungnam University Journal of Medicine Vol.29 No.1

Mycotic hepatic artery aneurysms (HAAs) have become very rare due to antibiotics. Untreated, they have a high possibility of rupture and mortality. In this paper, on the case of a 67-year-old male who had severe right-upperquadrant abdominal pain and a history of infective endocarditis is reported. The computed tomography (CT) and arterial angiography findings led to a diagnosis of a ruptured mycotic HAA. The CT showed an HAA and the formation of an intrahepatic hematoma caused by aneurysmal rupture. The arterial angiography showed a mycotic HAA that arose from the right posterior hepatic artery. Percutaneous transcatheter arterial embolization was used to successfully treat the HAA. Since then, the patient has been doing well, without symptoms.

『세 명의 키 큰 여인』: 한 여성의 독백

김기애 현대영미어문학회 1998 현대영미어문학 Vol.16 No.1

In his Pulitzer prize-winning play, Three Tall Women (1994), Edward Albee examines his relationship with his adoptive mother, Frances Albee. As her type is not an unfamiliar character in Albee's plays, the way her type is presented differs from the way in other plays. Albee uses new and unique dramatic and theatrical techniques in presenting the character. This paper examines these techniques and their effects. Three Tall Women is composed of two acts. Act I is realistic in characterization and mood, whereas Act Ⅱ is expressionistic and Brechtian. Three women of Act I reappear as three ages of the same woman in Act Ⅱ. In Act Ⅱ they talk with each other about their lives and occasionally they come out to the front of the stage to talk directly to the audience. Thus, they tear down the invisible wall between the stage and the audience. Besides, there is Mannequin "A" in bed and a young man on stage. They do not talk with three women, but they stay on stage till the end of the play They create a dream-like and expressionistic mood and play the role of the audience on stage as well. The dramatic and theatrical techniques aim to encourage the audience to actively participate in the dramatic experience. In addition, they are used to raise the consciousness of the audience to improve the society.