인삼(Panax ginseng Meyer)의 친유성 영양소에 대해 토양의 종류와 유기질 비료 의 효과에 관한 비교 연구

권창,김소연,안연주,양유진,김승현,정일민 한국약용작물학회 2018 한국약용작물학술대회 발표집 Vol.2018 No.05

Background : The interest in paddy-converted fields to be used as an alternative new farming area for the stable ginseng production is increasing, and made up -32% of the total ginseng cultivation area in Korea in 2014. Therefore, this study examined how soil types and fertilizer regimes influence fatty acid (FA) and vitamin E (Vit-E) variation in 6-years-old ginseng root. Methods and Results : Ginseng variety “Jagyeongjong” was cultivated upland and paddy-converted field, and three organic fertilizers were applied to both fields, at 0, 1, 2, and 4 tons per 1,000 ㎡, prior to the ginseng seedling transplantation. The 37 FAs and 8 Vit-E were analyzed with GC-FID. We observed significant variation in both FA and Vit-E contents owing to the type and quantity of organic fertilizer used in each soil type during cultivation. Unsaturated FAs were approximately 2.7-fold higher in ginseng than in saturated FAs. Linoleic, palmitic, and oleic acids were the most abundant FAs detected in ginseng roots. Additionally, α-tocopherol was the major Vit-E detected. In particular, the increased application of rice straw compost or food waste fertilizer elevated the quantity of nutritionally desirable FAs and bioactive Vit-E in ginseng root. Partial least square-discriminant analysis (PLS-DA) score plots showed that soil type might be the main cause of differences in FA and Vit-E levels in ginseng. Specifically, the PLS-DA model indicated that palmitic acid is a suitable FA marker in determining whether ginseng plants were grown in a paddy-converted field or an upland field. Moreover, linoleic acid levels were highly correlated with α-linolenic acid (r = 0.8374) according to Pearson's correlations and hierarchical clustering analysis. Conclusion : This study investigated how soil type, as well as organic fertilizer type and amount, altered the FA and Vit-E profiles in ginseng roots. Therefore, these preliminary data should be beneficial to ginseng farmers and any industries involved in the production of high quality and nutritional ginseng products.

원자층 증착법을 이용한 Y₂O₃, Al₂O₃ 박막의 물리적 특성 연구

권창,지영연,박인래 한국표면공학회 2023 한국표면공학회 학술발표회 초록집 Vol.2023 No.5

Guide-Wire Assisted Endobiliary Forceps Biopsy Sampling

권창일,김태헌,김경아 대한소화기내시경학회 2017 Clinical Endoscopy Vol.50 No.4

Brief report

아리스토텔리스의 定義觀

權昌殷(KWON, CHANG-UN) 한국서양고전학회 1996 西洋古典學硏究 Vol.10 No.-

Performance of disposable endoscopic forceps according to the manufacturing techniques

권창일,김광일,문종필,윤호,고원진,조주영,홍성표 대한내과학회 2019 The Korean Journal of Internal Medicine Vol.34 No.3

Background/Aims: Recently, to lower the production costs and risk of infection, new disposable biopsy forceps made using simple manufacturing techniques have been introduced. However, the effects of the manufacturing techniques are unclear. The aim of this study was to evaluate which types of biopsy forceps could obtain good-quality specimens according to the manufacturing techniques. Methods: By using an in vitro nitrile glove popping model, we compared the popping ability among eight different disposable biopsy forceps (one pair of biopsy forceps with cups made by a cutting method [cutting forceps], four pairs of biopsy forceps with cups made by a pressing method [pressing forceps], and three pairs of biopsy forceps with cups made using a injection molding method [molding forceps]). Using an in vivo swine model, we compared the penetration depth and quality of specimen among the biopsy forceps. Results: In the in vitro model, the molding forceps provided a significantly higher popping rate than the other forceps (cutting forceps, 25.0%; pressing forceps, 17.5%; and molding forceps, 41.7%; p = 0.006). In the in vivo model, the cutting and pressing forceps did not provide larger specimens, deeper biopsy specimen, and higher specimen adequacy than those obtained using the molding forceps (p = 0.2631, p = 0.5875, and p = 0.2147, respectively). However, the molding forceps showed significantly more common crush artifact than the others (cutting forceps, 0%; pressing forceps, 5.0%; and molding forceps, 43.3%; p = 0.0007). Conclusions: The molding forceps provided lower performance than the cutting and pressing forceps in terms of crush artifact.

Bile Flow Phantom Model and Animal Bile Duct Dilation Model for Evaluating Biliary Plastic Stents with Advanced Hydrophilic Coating

권창일,김광일,Seok Jeong,Won Seop Lee,Don Haeng Lee,Kwang Hyun Ko,Sung Pyo Hong,Ki Baik Hahm 거트앤리버 소화기연관학회협의회 2016 Gut and Liver Vol.10 No.4

Background/Aims: The efforts to improve biliary plastic stents (PSs) for decreasing biofilm formation and overcome short patency time have been continued. The aim of this study is to evaluate the effect of advanced hydrophilic coating for patency and biodurability of PS. Methods: Using an in vitro bile flow phantom model, we compared patency between prototype PS with hydrophilic coating (PS+HC) and prototype PS without hydrophilic coating (PS-HC). We performed an analysis of the degree of luminal narrowing by microscopic examination. Using an in vivo swine bile duct dilation model made by endoscopic papillary closure and stent insertion, we evaluated biodurability of hydrophilic coating. Results: In the phantom model, PS+HC showed less biofilm formation and luminal narrowing than PS-HC at 8 weeks (p<0.05). A total of 31 stents were inserted into the dilated bile duct of seven swine models, and 24 stents were successfully retrieved 8 weeks later. There was no statistical difference of stent patency between the polyethylene PS+HC and the polyurethane PS+HC. The biodurability of hydrophilic coating was sustained up to 8 weeks, when assessing the coating layer by scanning electron microscopy examination. Conclusions: Advanced hydrophilic coating technology may extend the patency of PS compared to uncoated PS.

항암치료 환자의 B형 및 C형 간염바이러스 감염과 간기능 이상

권창일 ( Chang Il Kwon ),이지현 ( Ji Hyun Lee ),최기현 ( Ki Hyun Choi ),고광현 ( Kwang Hyun Ko ),홍성표 ( Sung Pyo Hong ),황성규 ( Seong Gyu Hwang ),박필원 ( Pil Won Park ),오도연 ( Do Yeun Oh ),임규성 ( Kyu Sung Rim ),김세현 ( Se 대한소화기학회 2006 대한소화기학회지 Vol.48 No.6

목적: 항암화학치료 중 또는 후에 간 기능 이상이 흔히 동반되며, 특히 바이러스에 감염되어 있는 경우 바이러스 재활성화나 증식에 의해 중증 간 기능 이상이나 전격간염이 발생하기도 한다. 그러나 우리나라 바이러스 보유자의 항암 화학치료 후 간 기능 악화에 대한 연구가 미흡하다. 이에 저자들은 단일기관에서 항암화학치료를 받는 악성종양 환자에서 B형 또 C형 간염바이러스 감염의 유병률과 간 기능 이상 발생률, B형 간염바이러스 재활성화율과 만성 B형 간염 환자에서 예방적인 라미부딘 투여 효과 등을 알아보고자 하였다 대상 및 방법 : 2000년 1월부터 2005년 6월까지 포천중문의대 분당차병원에 내원하여 악성종양을 진단받고 항암화학요법을 시행 받은 환자 1,477명을 대상으로 의무기록을 통한 후향 분석을 시행하였다. 바이러스 검사나 간기능 검사가 제대로 시행되지 않았거나 만성 간염에 의해 유발된 간암 환자 등 668명을 제외한 총 809명을 대상으로 분석하였다. 결과: 간염바이러스 유병률은 6.6%였으며, 바이러스 보유자에서 aminotransferase 수치가 유의하게 증가하였다. 그러나 다른 간 기능 수치나 두 군 간에 간 기능 이상 발생률은 유의한 차이가 없었다. B형 간염 환자 40명 중, 항암치료로 인해 바이러스 재활성화가 된 환자는 6명(15%)이었으며, 모두 라미부딘 투여로 HBV DNA 음전과 간기능의 정상화가 유지되었다. 결론: 항암치료를 받는 환자에서 바이러스 보유 상태가 중증의 간기능 이상 발생에 큰 영향을 미치지 않았으며, 이의 원인으로 간 기능 악화에 대한 라미부딘 투여의 예방 및 치료 효과가 영향을 주었을 것이라 추측한다. 향후 바이러스 보유의 영향과 라미부딘 예방 투여의 필요성과 효과에 대해 전향 코호트 연구가 필요하다. Background/Aims: Liver dysfunction and reactivation of hepatitis virus are well-described complications in cancer patients who receive cytotoxic chemotherapy and may result in varying degrees of liver damage. However, there has been just few reports on such complications and on the preemptive use of lamivudine in Korea. The aims of this study were to determine the prevalence of hepatitis B and C virus infection and the incidence of liver dysfunction in patients with malignancies who receive chemotherapy, to determine the reactivation rate of hepatitis B virus (HBV) in those patients, to evaluate the effect of preemptive use of lamivudine in patients with HBV infection. Methods: Among 1,477 patients who received chemotherapy due to various malignancies from January 2000 to June 2005, 668 patients with incomplete viral studies or hepatitis related malignancy were excluded. A retrospective study was conducted by reviewing the medical records of remaining 809 patients. Results: The overall prevalence rate of hepatitis B or C virus in patients receiving chemotherapy was 6.55% (53/809). The incidences of liver dysfunction was not significantly different between hepatitis virus positive group and negative group. Reactivation rate of hepatiris B or C virus after chemotherapy was 15% (6/40). In all patients who received lamivudine therapy, aspartate aminotransferase and alanine aminotransferase level were normalized and HBV DNA negativity achieved. Conclusions: The existence of hepatitis virus in patients receiving chemotherapy did not significantly influence the development of severe liver dysfunction, owing probably to the lamivudine therapy. Further prospective studies are required to ascertain the reactivation of hepatitis virus in patients receiving chemotherapy and the need for prophylactic lamivudine therapy in HBV positive patients. (Korean J Gas­troenterol 2006:48:408-414)

Bowel Obstruction Caused by an Intramural Duodenal Hematoma: A Case Report of Endoscopic Incision and Drainage

권창일,고광현,홍성표,황성규,박필원,임규성,김효영 대한의학회 2009 Journal of Korean medical science Vol.24 No.1

Complications associated with an intramural hematoma of the bowel, is a relatively unusual condition. Most intramural hematomas resolve spontaneously with conservative treatment and the patient prognosis is good. However, if the symptoms are not resolved or the condition persists, surgical intervention may be necessary. Here we describe internal incision and drainage by endoscopy for the treatment of an intramural hematoma of the duodenum. A 63-yr-old woman was admitted to the hospital with hematemesis. The esophagogastroduodenoscopy (EGD) showed active ulcer bleeding at the distal portion of duodenal bulb. A total of 10 mL of 0.2% epinephrine and 2 mL of fibrin glue were injected locally. The patient developed diffuse abdominal pain and projectile vomiting three days after the endoscopic treatment. An abdominal computed tomography revealed a very large hematoma at the lateral duodenal wall, approximately 10×5 ㎝ in diameter. Follow-up EGD was performed showing complete luminal obstruction at the second portion of the duodenum caused by an intramural hematoma. The patient’s condition was not improved with conservative treatment. Therefore, 21 days after admission, endoscopic treatment of the hematoma was attempted. Puncture and incision were performed with an electrical needle knife. Two days after the procedure, the patient was tolerating a soft diet without complaints of abdominal pain or vomiting. The hematoma resolved completely on the follow-up studies.

경피배액술로 치료한 십이지장 벽내 혈종 1예

권창일 ( Chang Il Kwon ),최기현 ( Ki Hyun Choi ),고은향 ( Eun Hyang Ko ),이지현 ( Ji Hyun Lee ),송영준 ( Young Jun Song ),고광현 ( Kwang Hyun Ko ),홍성표 ( Sung Pyo Hong ),박필원 ( Pil Won Park ) 대한소화기학회 2007 대한소화기학회지 Vol.49 No.1

Complicating intramural hematoma is an interesting, relatively unusual condition. Various etiologic factors have been described, with the most common being blunt trauma, anticoagulant therapy, Henoch-Schonlein purpura and blood dyscrasias. Most intramural hematomas resolve spontaneously with conservative treatment, and the prognosis is good. However, if the abdominal pain or obstruction does not resolve with medical management over seven to ten days, complications such as infarction or peritonitis may occur, and surgical intervention might be required. We report a case of intramural hematoma of duodenum treated with percutaneous drainage and embolization of bleeding focus which was complicated with acute pancreatitis after anticoagulation treatment in a patient with recurrent history of deep vein thrombosis. In addition, we reviewed reports of intramural hematoma of the duodenum and treatment strategies. (Korean J Gastroenterol 2007;49:45-49)

40세 여성에서 발생한 극세포해리 극세포종 1예

권창일 ( Chang Il Kwon ),정서미곤 ( Seo Mi Gon Jeong ),김지연 ( Chi Yeon Kim ) 대한피부과학회 2021 大韓皮膚科學會誌 Vol.59 No.7

Acantholytic acanthoma is a rare benign neoplasm of epidermal keratinocytes that clinically presents as a solitary, asymptomatic keratotic papule or nodule on the trunk. A 40-year-old female visited our hospital with a 20-year history of a single papule on her right thigh. On physical examination, the lesion measured 0.5×0.4 cm in size and appeared brown in color with central hyperkeratosis. Histopathological evaluation showed hyperkeratosis, acanthosis, papillomatosis, dyskeratosis, and acantholysis. Only six cases of acantholytic acanthoma have been reported in Korea. We report a rare case of acantholytic acanthoma that occurred in a 40-year-old female who presented with a keratotic papule on her right thigh. (Korean J Dermatol 2021;59(7):564∼567)