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백서의 척수허혈시 허혈시간에 따른 신경손상과 유전자발현의 변화에 관한 연구
권재영,박상인,류지흠 대한마취과학회 2000 Korean Journal of Anesthesiology Vol.38 No.5
Background: Spinal cord ischemia initiates a deleterious cascade of biochemical events that ultimately result in an increased intracellular calcium concentration. Many papers have been published on this topic but without a clear consensus on the best way of minimizing the problem. For the further study of preventing neurological injury after spinal ischemia, the proper animal model is necessary. In this study we compared spinal ischemia time on neurologic and histopathologic outcome, and inflammatory gene expression in transient spinal ischemia. Methods : Rats were anesthetized with halothane, and divided into 4 groups: 12.5 minutes of spinal ischemia (Group 1), 15 minutes of spinal ischemia (Group 2), 17.5 minutes of spinal ischemia (Group 3), and 20 minutes of spinal ischemia (Group 4). Spinal ischemia was produced by both induced hypotension and thoracic aortic cross clamping. After spinal ischemia neurologic scores were assessed after 1, 3, 6, and 24 hours. After 24 hours, rats were euthanized and spinal cords were removed for histopathologic assessment and an assay of TNF- a and IL-1 mRNA. Results : The neurologic scores worsened according to the ischemia time. The histopathologic scores correlated well with the neurologic scores. The TNF- a and IL-1 mRNA expression results of group 2 were larger than those of group 1. There were no significant differences between group 2, group 3, and group 4. Conclusions: Inflammatory gene expressions are increased during transient spinal ischemia. After 15 minutes of ischemia, no further increase of mRNA expression was shown. The 15 minutes of spinal ischemia was sufficient for the spinal ischemic study in rats. (Korean J Anesthesiol 2000; 38: 904~ 909)
Beneficial Effects of Hesperetin in a Mouse Model of Temporal Lobe Epilepsy
권재영,정운주,김동운,김세환,문경준,홍정완,전민태,신민상,장정호,김상룡 한국식품영양과학회 2018 Journal of medicinal food Vol.21 No.12
Abnormal reorganization of the dentate gyrus and neuroinflammation in the hippocampus represent characteristic phenotypes of patients suffering from temporal lobe epilepsy. Hesperetin, a flavanone abundant in citrus fruit, is known to have protective effects by preventing inflammation and oxidative stress in neuronal cultures and in the adult murine brain. However, the protective effects of hesperetin against epileptic seizures in vivo remain unclear, despite one study reporting anticonvulsant effects in vitro. In this study, we report that oral administration of hesperetin not only delays the onset of seizures triggered by kainic acid (KA) but also contributes to the attenuation of granule cell dispersion in the KA-treated hippocampus. Moreover, we observed that hesperetin administration inhibited the expression of pro-inflammatory molecules produced by activated microglia in the hippocampus. Thus, administration of hesperetin might be beneficial for preventing epileptic seizures.
Effect of processing method on platycodin D content in Platycodon grandiflorum roots
권재영,이혜민,김나현,이제현,우미희,김진웅,김영식,이동호 대한약학회 2017 Archives of Pharmacal Research Vol.40 No.9
Platycodon grandiflorum root is a traditionalmedicine and food material rich in triterpenoid saponins. Its major constituent, platycodin D (PD), is known to havevarious pharmacological properties, but processing methodsmay influence the PD content. In this study, a fullyvalidated HPLC–ELSD method was developed for thequantification of PD in various states of 73 P. grandiflorumroot samples from East Asia, and it exhibited a markedvariation of the content. Furthermore, the effects of processingprocedures such as peeling and drying temperatureon the PD content were investigated using UPLC–ELSDanalysis, and as a result, a significant influence ofprocessing methods such as peeling and heating of sampleson the content was confirmed. Specifically, unpeeledsamples that were dried at 40 C showed the greatest PDcontent. The obtained results could facilitate the reliablestandardization of P. grandiflorum for precise authenticationand efficacious applications.
말기암 환자의 통증 치료에 있어 서방형 모르핀과 경피형 펜타닐의 비교 연구
권재영,백승완,신상욱,김해규,김인세,박두진 대한통증학회 2000 The Korean Journal of Pain Vol.13 No.1
Background: For terminal cancer pain management, controlled-release oral morphine (morphine sulfate tablet, MST) is a simple and convenient regimen. Recently, fentanyl transdermal therapeutic system (F-TIS, transdermal fentanyl) has been developed and became one of the alternative ways of providing adequate pain relief. This open prospective study was designed to compare the analgesic efficacy and safety of MST and transdermal fentanyl in the management of terminal cancer pain. Methods: In this open comparative and randomized study, 64 terminal cancer patients received one treatment for 15 days, controlled-release oral morphine (MST group) or fentanyl transdermal therapeutic system (F-TTS group). Daily diaries about the vital sign, visual analogue scale (VAS) for pain, opioids requirement, co-anagesics, adjuvant drugs and adverse effects were completed with 24 patients in MST group, 18 patients in F-TTS group. Results: The majority of patients in both treatment groups were late-stage cancer and their distribution was not different in both groups. Daily opioids requirement was 126.4 mg in MST uced in F-TTS group (P$lt;0.05). The incidence of nausea, vomiting and constipation was lower in F-TTS group (P$lt;0.05). Patients satisfaction was similar, but F-TTS patient group favored continous use of same treatment compared with MST group after the study was finished. Conclusions: Transdermal fentanyl seems to be safe and similar analgesic effect to controlled-release oral morphine for the control of the terminal cancer patients. However, transdermal fentanyl provides a simpler and more convenient especially in respect to constipation, nausea & vomiting. To determine the exact analgesic effect, cost-effectiveness and complications, controlled trials should be followed.