The Heterochromatin Protein 1 (HP1) Family: Put Away a Bias toward HP1

권소희,Jerry L. Workman 한국분자세포생물학회 2008 Molecules and cells Vol.26 No.3

Heterochromatin protein 1 (HP1) was first described in Drosophila melanogaster as a heterochromatin associated protein with dose-dependent effect on gene silencing. The HP1 family is evolutionarily highly conserved and there are multiple members within the same species. The multi-functionality of HP1 reflects its ability to interact with diverse nuclear proteins, ranging from histones and transcriptional co-repressors to cohesion and DNA replication factors. As its name suggests, HP1 is well-known as a silencing protein found at pericentromeres and telomeres. In contrast to previous views that heterochromatin is transcriptionally inactive; noncoding RNAs transcribed from heterochromatic DNA repeats regulates the assembly and function of heterochromatin ranging from fission yeast to animals. Moreover, more recent progress has shed light on the paradoxical properties of HP1 in the nucleus and has revealed, unexpectedly, its existence in the euchromatin. Therefore, HP1 proteins might participate in both transcription repression in heterochromatin and euchromatin.

방문간호 관리형 스마트 약박스 시스템 개발

권소희,한영민,김영주,박서혜 한국융합과학회 2024 한국융합과학회지 Vol.13 No.11

연구목적 본 연구의 목적은 가정에서 다제약물을 복용하는 환자의 복약 순응도와 투약 관리를 개선하기 위해 스마트 약박스 시스템을 개발하는 것이다. 연구방법 간호 연구자, 가정 호스피스 간호사와 의사, 소프트웨어 개발자, 공학자로 구성된 다학제 팀이 필요한 기능을 식별하고 기능을 설계하고, 스마트 약박스와 연동되는 애플리케이션을 개발했다. 스마트 약박스 시스템의 주요 기능은 다음과 같다. 1) 다양한 제형 수납을 위한 서랍형 디자인, 2)LED 조명 및 모바일 애플리케이션 알림, 3) 복약 확인을 위한 RFID 카드 시스템, 4) 필요시 약물 관리, 5)의료진과의 실시간 데이터 공유. 개발된 시제품의 기능검증을 위해 가정 호스피스 서비스 받는 환자 2명에게 7일간 사용하도록 하였다. 결과 스마트 약박스와 애플리케이션은 의도한 모든 기능을 성공적으로 수행하는 것으로 확인되었다. 기능검증 기간 중 한 가지 시스템 오류가 발생했지만 즉시 해결되었고, 방문 간호사는 스마트 약박스가 가정에 있는 환자의 투약 관리에 유용함을 보고하였다. 결론 스마트 약박스 시스템은 가정에서 다제복용 환자의 복용 준수와 약물 관리를 개선하는 데 효용이 있는 것으로 확인되었다. 향후 다양한 방문간호 현장에서 임상시험을 통해 사용자 경험을 확인하고, 사용자 피드백을 통한 기능 개선과 안정성 확인이 필요하다. Purpose This study aimed to develop a Smart Medication Box (SMB) to enhance medication adherence and management for patients on polypharmacy at home. Methods A multidisciplinary team of nursing researchers, home care providers, software developers, and engineers identified required functions, designed features, and developed the SMB. Key features include: 1) Drawers for different medication types (pills, patches, sprays); 2) LED lights and mobile app notifications; 3) An RFID card system for intake tracking; 4) Pain assessment for Pro-Renata(PRN) medications; 5) Real-time data sharing with healthcare providers. The device was tested on two home care patients over seven days. Results The SMB and application were successfully developed with the intended functions. One technical issue arose during testing but was resolved. Visiting nurses found the SMB useful and feasible for monitoring medication adherence. Conclusion The SMB was found to be effective in improving medication adherence and medication management in patients taking multiple medications at home. In the future, clinical trials in various visiting nursing sites are needed to confirm user experience and improve functionality and stability through user feedback.

한국형 사별돌봄자신감 척도 개발

권소희,김영주 한국간호교육학회 2021 한국간호교육학회지 Vol.27 No.2

Purpose: The purpose of this study is to evaluate the validity and reliability of the Korean Bereavement Care Confidence Scale (K-BCCS). Methods: The Perinatal Bereavement Care Confidence Scale (PBCCS) was translated into Korean according to an algorithm of cultural adaptation process and excluded six items which were specific to perinatal bereavement. A total of 229 clinical nurses participated in the study. Construct validity, convergent validity, discriminant validity, and group comparison validity were evaluated, and Cronbach’s α was calculated to estimate the reliability of the K-BCCS. Results: The K-BCCS consisted of 31 items in 7 factors, including knowledge and skills for bereavement care (12 items), organizational support (6 items), awareness of the needs (3 items), interpersonal skills (3 items), workload influence (2 items), continuous education (2 items), and understanding the grief process (3 items). The factor loading of 31 items within the 7 factors ranged from .60 to .86. For the convergent validity, the construct reliability (CR) ranged from .74 to .94, and the average variance extracted (AVE) ranged from .49 to .73, which is considered acceptable. The discriminant validity showed that the AVEs of the subscales were greater than the square of the correlation coefficient r. The nurses who had experience providing bereavement care (t=4.94, p<.001) or had received bereavement education (t=6.64, p<.001) showed higher K-BCCS values those without experience. The Cronbach’s α of 31 items was .93 and ranged from .60 to .94 per subscale. Conclusion: The K-BCCS is a valid and reliable tool for evaluating nurses' confidence in bereavement care. 본 연구는 임상간호사의 사별돌봄자신감을 측정하기 위해 최근 국외에서 개발된 주산기 사별돌봄자신감 척도(PBCCS)를 한국어로 번역하고 도구를 수정한 후 타당도와 신뢰도를 검증하였다. 한국형 사별돌봄자신감 척도(K-BCCS)는 PBCCS의 주산기에 국한되는 항목을 제외하거나 수정하였고, 타당도 검증에서 요인적재량이 낮은 문항, 개념신뢰도와 평균분산추출값을 낮추는 문항을 제외하여 최종 31문항, 7개 하위척도로 구성되었다. K-BCCS는 구성타당도와 수렴타당도, 판별타당도, 신뢰도가 검증되어 국내 임상에서 사별돌봄자신감을 측정하는 도구로써 적용 가능함이 확인되었다. 본 도구를 이용하여 임상간호사의 사별가족 돌봄에 대한 자신감 정도를 파악하고 그 결과를 사별돌봄 교육 및 연구에 반영함으로써, 사별 가족들에게 질 높은 돌봄을 제공할 수 있을 것으로 기대된다.

전처리 방식에 따른 AI 이미지와 실사 이미지의 분류 성능 비교

권소희,최현성,김웅기,엄소은,손명균,이충권 한국경영정보학회 2023 한국경영정보학회 학술대회논문집 Vol.2023 No.11

본 연구는 생성이미지와 실사이미지의 분류를 위한 최적의 이미지 전처리 기법을 탐색한다. Stable diffusion과 크롤링을 통해 구축한 데이터셋에 sharpening, grayscale, canny, diffusion, ELA(Error Level Analysis) 총 5가지 전처리 기법을 적용하여 모델별 성능을 비교하고자 한다.

Wheel of Wellness Counseling in Community Dwelling, Korean Elders: A Randomized, Controlled Trial

권소희 한국간호과학회 2015 Journal of Korean Academy of Nursing Vol.45 No.3

Purpose: The purpose of this study was to investigate the effects of Wheel of Wellness counseling on wellness lifestyle, depression,and health-related quality of life in community dwelling elderly people. Methods: A parallel, randomized controlled, open label, trialwas conducted. Ninety-three elderly people in a senior welfare center were randomly assigned to two groups: 1) A Wheel of Wellnesscounseling intervention group (n=49) and 2) a no-treatment control group (n=44). Wheel of Wellness counseling consisted ofstructured, individual counseling based on the Wheel of Wellness model and provided once a week for four weeks. Wellness lifestyle,depression, and health-related quality of life were assessed pre-and post-test in both groups. Results: Data from 89 participantswere analyzed. For participants in the experimental group, there was a significant improvement on all of the wellness-lifestylesubtasks except realistic beliefs. Perceived wellness and depression significantly improved after the in the experimental group (n =43)compared to the control group (n=46) from pre- to post-test in the areas of sense of control (p=.033), nutrition (p=.017), exercise(p=.039), self-care (p<.001), stress management (p=.017), work (p=.011), perceived wellness (p=.019), and depression (p=.031). One participant in the intervention group discontinued the intervention due to hospitalization and three in the control group discontinuedthe sessions. Conclusions: Wheel of Wellness counseling was beneficial in enhancing wellness for the community-dwelling elderlypeople. Research into long-term effects of the intervention and health outcomes is recommended.

호스피스완화의료서비스 성과평가 도구개발

권소희 한국간호과학회 2011 Journal of Korean Academy of Nursing Vol.41 No.3

Purpose: The purpose of this study was to develop and validate a hospice·palliative care performance measure which would cover more than just physical symptoms or quality of life. Methods: Through an intensive literature review, the author chose questions that measured aspects of physical, emotional, spiritual, social, or practical domains pertinent to hospice·palliative care for inclusion in the scale. Content validation of the questions was established by 15 hospice·palliative care professionals. A preliminary Hospice Palliative Care Performance Scale (HPCPS) of 20 questions was administered to 134 pairs of terminal cancer patients from 5 hospice palliative care units and their main family caregiver. A validation study was conducted to evaluate construct validity and internal consistency. Results: Factor analysis showed 14 significant questions in five subscales; Physical, Emotional, Spiritual, Social, and Patient’ rights. There were no significant differences between the ratings by patients and family members except for three out of the 14 questions. The measure demonstrated construct validity, and Cronbach’s α of the subscales ranged from .73 to .79. Conclusion: The HPCOS demonstrated acceptable validity and reliability. It can be used to assess effectiveness of hospice·palliative care for terminal cancer patients in practice and research.

산업장내(産業場內) 건강검진(建康檢診) 자료(資料)를 활용(活用)한 사상체질(四象體質)의 평가(評價)

권소희,이기남,Kwon So-Hui,Lee Ki-Nam 대한예방한의학회 2002 대한예방한의학회지 Vol.6 No.2

The subjects were 420 workers who received oriental and western health examination both in the workplaces for 1 month. This study was planned for the reflection of western health examination results through evaluation of Sasang constitution with use of data from western health examination, and for the presentation of basic data applicable to constitutional medicine with preventive medicine. Data that were collected in field research were analyzed into frequencies, One-Way ANOVA, Chi-square testing by the study purposes, and the research results were as follows: 1. The distribution of Sasang constitution in 420 subjects was Taeumin > Soumin > Soyangin, and the general characteristics of subject by Sasang constitution were no significant difference. 2. For the measured values for body by the subject of Sasang constitution, Taeumin had higher value for height, body weight, systolic and diastolic blood pressure than other 2 constitutions. Soumin had the lowest values in average for all items, and on the other hand, Soyangin had high pulse pressure compared to other constitutions. It was significant difference between constitutions. 3. For the hematological average, Taeumin had high average for FBS, Total-C, GPT, and Taeumin ,and Soyangin had high in Hb compared to Soumin. Soyangin had the highest average for ${\gamma}-GPT$, and there were significant differences between FBS, Total-C, Hb, GPT, ${\gamma}-GTP$, excepting for GOT. 4. For the result of health examination by the Sasang constitution of subject, Taeumin showed the highest percentage in the items of obesity, primary care, secondary suspicion, and showed significant difference by the constitution. For the distribution of the past disease history by the health examination result of Sasang constitution, Taeumin and Soumin had high prevalence rate for hypertension, liver disease, and Soyangin had high prevalence rate for liver disease, hypertension. For the requirement of lifestyle improvement to the subject, the highest requirements by the Sasang constitution were physical exercise for Soumin, regulation of body weight for Taeumin, and it showed significant difference. For the requirement of primary care by the constitution, the highest requiremetns were obesity control for Taeumin, blood pressure control for Soumin, Soyangin, and liver suspicion was the highest distribution for each constitution in the case of having decision for secondary suspicion.

Epidemiology of Juvenile Idiopathic Arthritis in 2016-2017 : incidence, prevalence and age of onset

권소희,박성훈,김지원,김성규,최정윤 대한내과학회 2019 대한내과학회 추계학술발표논문집 Vol.2019 No.1

인간-반려견 산책 분석을 통한 인간-너머 도시의 가능성 모색

권소희 한국환경사회학회 2024 한국환경사회학회 학술대회 자료집 Vol.2024 No.11

자동차 중심, 주택 공급 중심의 기존의 도시계획에 대한 대안적 접근으로 지속가능한 도시, 포용도시와 같이 기존에 주목받지 못한 존재들을 포함한 도시계획에 대한 관심이 증가하고 있다. 본 연구에서는 반려견의 본능을 충족시키기 위한 인간의 활동이면서 동시에 도시의 새로운 마주침을 만들어내는 활동인 반려견 산책을 통해서 인간중심적 도시에서 가려져 있던 도시의 모순을 드러내고자 한다. 반려견 산책을 가능하게 한 제도적 맥락으로 동물보호법, 동물 등록제, 반려견 목줄 2m법, 반려견 놀이터를 살펴보았으며, 배설물, 쓰레기, 사체와 같이 인간 바로 옆에 있었지만 비가시화되었던 존재들과, 공생공략을 위한 전략으로서 반려견 순찰대를 탐색함으로써 반려견 산책이 드러내는 다종 공동체의 얽힘을 파악하였다. 반려견이라는 비인간과의 산책을 통해 비인간뿐만 아니라 정상 인간으로 대우받지 못한 인간에게 필요한 도시의 권리를 탐색하여 인간-너머의 도시를 위해서 다리가 두 개가 아닌 모든 것들이 방랑할 수 있는 도시가 요구됨을 밝히는 바이다.

간호사를 위한 호스피스 연수교육 요구도 조사

권소희,양성경,박명희,최상옥,Kwon, So-Hi,Yang, Seong-Kyeong,Park, Myung-Hee,Choe, Sang-Ok 한국호스피스완화의료학회 2008 한국호스피스.완화의료학회지 Vol.11 No.3

Purpose: This study aimed to assess the educational needs for nurses who care for terminal cancer patients and their families. To identify top needs along with key issues in consideration to develope hospice training program and provide specific recommendations. Methods: A cross-sectional design with nurses from nine universities' hospice specialist courses and seven cancer centers was used. Data were collected via e-mail or mail service from March to April in 2008. One hundred seventy three questionnaires were returned (return rate: 73.6%), and 156 questionnaires were eventually analyzed. The questionnaire consisted of Mason and Ellershaw's The Self-efficacy in Palliative Care (SEPC) and self-reporting confidence and educational needs in hospice care. Results: The mean age of the participants was 37.94 years, 82.1% were staff nurses, and 44.9% completed over six months hospice education. Mean$\pm$standard deviation score for total SEPC was $2.67{\pm}.62$, which was lower than average (score 3), with communication score being the lowest ($2.49{\pm}.69$). The lowest self-reporting confidence score was $2.03{\pm}.77$ in hospice administration and management, followed by providing complement therapy ($2.34{\pm}.77$), bereavement care ($2.34{\pm}.71$), lymph edema management ($2.35{\pm}.79$), and care planning ($2.36{\pm}.81$). The participants reported that additional education is needed in all topics, with pain management score being the highest ($3.71{\pm}.50$), followed by pain and symptom evaluation ($3.67{\pm}.52$), care for dying ($3.67{\pm}.52$), and communication and counseling ($3.63{\pm}.53$). There were significant subgroup differences in SEPC and self-reporting confidence between groups who completed 6 months hospice education or not, however, no significant difference in educational need between the groups. Conclusion: This study showed the need for developing hospice training program to improve compentency of nurses in hospice palliative care.