“MB의 대선자금, 판도라 상자 열릴까?”

권민석 (사)방송기자연합회 2012 방송기자 Vol.8 No.-

상악 정중 과잉치 증례 중 선천 결손치 발생에 관한 임상적 고찰

권민석,정태성,김신,Kwon, Min-Seok,Jung, Tae-Sung,Kim, Shin 대한소아치과학회 2002 大韓小兒齒科學會誌 Vol.29 No.4

소아치과 임상에서 정중 과잉치는 비교적 흔히 볼 수 있는 치아의 발육이상이다. 그런데, 이와 더불어 인접 치아가 선천 결손된 경우에는 배열상에 국소적으로 여러 문제점을 유발하기도 한다. 이처럼 동일 개체에서 과잉치와 선천 결손이 동시에 나타난 경우를 'hypo-hyperodontia' 또는 'oligo-pleiodontia'라고 부른다. 발생학적으로는 반대 현상인 이 두 가지 치아이상이 병발된 증례에 관해서는 지금까지 소수의 증례보고가 발표된 바 있다. 본 고에서는 정중 과잉치를 가지고 있는 환아 중에서 치아의 선천 결손이 나타난 발생양상을 조사하고, 치아의 선천 결손에 관한 기존의 역학 자료와 비교해 보았다. 지난 3년간 부산대학교병원 소아치과에 과잉치 발거를 주소로 내원한 $5{\sim}12$세 아동 310명 (남아 247명, 여아 63명)을 대상으로, 이들의 파노라마사진을 통하여 제 3대구치를 제외한 선천 결손치의 분포를 조사하여 다음과 같은 결과를 얻었다. 1. 정중 과잉치를 가진 증례 중 치아의 선천 결손 발생빈도는, 남자 247명중 39명(15.8%), 여자 63명중 14명(22.2%)으로, 전체적으로는 310명중 53명(17.1%)이었다. 2. 치아별 선천 결손의 분포는 상악 측절치와 하악 제 2소구치에서 각각 22.7%, 상악 제 2소구치 17.3%, 하악 측절치 16.0%로 나타났다. 상하악의 분포는 상악에서 49.3%, 하악에서 50.7%로 나타났고, 통계학적으로 약간의 차이는 없었다. 3. 결손치의 갯수는 1개인 경우가 67.9%, 2개인 경우가 22.7%, 3개인 경우가 9.4%로 나타났다. Mesiodens is developmental tooth anomaly which is commonly found in clinical pediatric dentistry. however, it may cause many partial problem in tooth alignment when congenitally missing teeth was accompanied by mesiodens. The terms, concomitant hypodontia and hyperdontia' and oligo-pleiodontia' have been used to describe the condition in witch developmental absence of teeth and supernumerary teeth are present in the same individual. Only a few case reports of this rare condition which is opposite developmental phenomena exist in the literature. The purpose of this study is survey of congenitally missing teeth in mesiodens case and to compare previous literature of congenitally missing teeth in normal. The subjects were 310 children(247 male and 63 female) at the age from 5 to 12 years visiting the Department of Pediatric Dentistry, Pusan National University Hospital with mesiodens for last 3 years. With their pantomograms we studied congenitally missing teeth except permanent 3rd molar. 1. The preference of congenitally missing teeth in mesiodens cases was revealed to be 17.1%(53 out of 310 in total), and there was a higher prevalence in females(22.2%) than in males(15.8%). 2. The most frequently missing teeth were maxillary lateral incisors(22.7%) and mandibular second premolars(22.7%), followed by maxillary second premolar(17.3%), and mandibular lateral incisors(16.0%). There was no significant differences between maxilla(49.3%) and mandible(50.7%). 3. In number of congenitally missing teeth per person, 69.9% had one missing tooth, 22.7% had two missing teeth and 9.4% had three missing teeth.

인가저장품목 선정방법이 사용자대기기간에 미치는 영향

권민석,이상진 한국로지스틱스학회 2022 로지스틱스연구 Vol.30 No.6

The military is taking various efforts to reduce the CWT(Customer Waiting Time). In order to promote the effective supply and guarantee the operational availability of equipment, studies are undertaken to reduce CWT and its variances. The greatest factor on CWT is whether military has an inventory or not. This study focuses on changing effects for selecting ASL(Authorized Stockage Item) related to whether the military has an inventory. Currently, the ASL selection method does not consider cost, demand, and item characteristics, and lacks objectivity due to individual works of the item manager. To overcome these, we propose a new selection method that combines the COSDIF(Cost Differential) model of U.S. military with a Linear Programming model. This study consists of four steps. The first step selects candidate items to be reviewed for COSDIF cost analysis. The second step is to conduct a cost analysis. The third stage is to select an optimal ASL on a Linear Programming model under various constraints such as budget, weight, and volume. In the final step, we compare the existing ASL with the newly selected ASL to verify the effect of CWT using simulations. In addition, we consider top-down and bottom-up method to apply on each scenario. As a result of applying the newly selected ASL, the average and variance of CWT decreased by 14.5∼19.7% compared to the existing method. In addition, the cost can be reduced by 7% to 12%.

Two-Round Mixed Lymphocyte Reaction for Evaluation of the Functional Activities of Anti-PD-1 and Immunomodulators

권민석,최영준,사모아,박수형,신의철 대한면역학회 2018 Immune Network Vol.18 No.6

Immune checkpoint inhibitors (ICIs), such as anti-PD-1 and anti-PD-L1 Abs, have shown efficacy for the treatment of various cancers. Although research has actively sought to develop new ICIs and immunomodulators, no efficient in vitro assay system is available to evaluate their functional activities. In the present study, we established a two-round MLR with human PBMCs for evaluation of the T cell-activating capacity of anti-PD-1 and other immunomodulators. We initially performed conventional MLR for this purpose. However, anti-PD-1 blocking Abs could not increase the proliferation of allo-reactive T cells in conventional MLR because PD-L1+ and PD-L2+ cells disappeared gradually during MLR. Therefore, we re-applied the same stimulator PBMCs to the allo-stimulated responder cells as a second-round MLR on day 6 when anti-PD-1 or immunomodulators were also added. In this two-round MLR, the proliferation of allo-reactive T cells was enhanced by anti-PD-1 in a dose-dependent manner or by immunomodulators, such as lenalidomide and galunisertib, a TGF-β receptor-1 inhibitor. Proliferation was further increased by the combination of immunomodulators with anti-PD-1. Here, we established a modified two-round MLR method with human PBMCs for evaluation of the functional activities of anti-PD-1 and immunomodulators.

조종사 임무 효율과 피로도를 고려한 비행 스케줄 최적화

권민석,윤찬일 한국산업경영시스템학회 2019 한국산업경영시스템학회 학술대회 Vol.2019 No.추계

광원의 유형에 따른 광중합 수복재의 중합양상

권민석,정태성,김신,Kwon, Min-Seok,Jung, Tae-Sung,Kim, Shin 대한소아치과학회 2003 大韓小兒齒科學會誌 Vol.30 No.2

본 연구는 기존의 할로겐광(XL 3000, 3M, U.S.A.)과 비교하여 새로운 중합광원인 플라즈마광(Flipo, LOKKI, France)과 Light Emitting Diode(이하 LED, Elipar Free light, 3M, U.S.A.)광의 효율성을 평가할 목적으로 시도되었다. 이에 본 연구에서는 첫째, 일정 광도 하에서 플라즈마광과 LED광의 중합시간에 따른 중합도의 변화를 검토하여 할로겐광의 미세경도와 유사한 광조사 시간을 알아보고, 둘째, 중합반경에 따라 균일한 중합이 이루어지는지를 보기 위해 광조사 부위의 중심부와 외측 변연부에서의 중합도의 차이를 비교하였다. 2mm 두께의 복합레진 시편의 상면과 하면의 미세경도의 측정을 통해 중합도를 평가, 비교해 본 결과 다음과 같은 결론을 얻었다. 1. Z-100의 미세경도 측정치 비교에서, 대조군인 할로겐광을 40초 적용한 경우는, 플라즈마광 6-9초, LED광 40-60초를 적용한 경우와 유사하였다(P>0.05). 2. Tetric Flow의 미세경도에서는 대조군인 할로겐광을 40초 적용한 경우, 플라즈마광 9초, LED광 40-60초를 적용한 경우와 유사하였다(P>0.05). 3. Dyract AP의 경우, 할로겐광 40초를 조사한 것은, 플라즈마광 6-9초, LED광 20-40초를 적용한 경우와 유사하게 나타났다(P>0.05). 4. Fuji II LC에서는 할로겐광을 40초 적용한 경우가, 플라즈마광 9초, LED광 20-60초를 적용한 경우와 유사하게 나타났다(P>0.05). 5. Fuji II LC를 제외한 모든 시료에서 할로겐, 플라즈마, LED광 모두 시편의 중앙에서 외측으로 갈수록 미세경도는 유의하게 감소되었다(p<0.05). The purpose of this study was to compare the effect of exposure time on the polymerization of surface and 2 mm below the surface of light-cured restorative materials cured with three different light sources; conventional halogen light curing unit(XL 3000, 3M, U.S.A.), plasma arc light curing unit(Flipo, LOKKI, France) and light emitting diode(LED) light curing unit(Elipar Free light, 3M, U.S.A.) and compare the uniformity of polymerization from the center to the periphery of resin surfaces according to polymerization diameter cure with three different light sources. From the experiment, the following results were obtained. 1. In Z-100, Plasma arc light exposure time of 6 to 9 seconds and LED light exposure time of 40 to 60 seconds produced microhardness values similar to those produced with 40 second exposure to a conventional halogen light(p>0.05). 2. In Tetric Flow, Plasma arc light exposure time of 9 seconds and LED light exposure time of 40 to 60 seconds produced microhardness values similar to those produced with 40 second exposure to a conventional halogen light(p>0.05). 3. In Dyract AP, Plasma arc light exposure time of 6 to 9 seconds and LED light exposure time of 20 to 40 seconds produced microhardness values similar to those produced with 40second exposure to a conventional halogen light(p>0.05). 4. In Fuji II LC, Plasma arc light exposure time of 9 seconds and LED light exposure time of 20 to 60 seconds produced microhardness values similar to those produced with 40second exposure to a conventional halogen light(p>0.05). 5. Except Fuji II LC, microhardness was decreased from the center to the periphery in all light sources(p<0.05).

춘천 소양로1가(93-8번지) 주유소 및 판매시설 신축공사부지 내 유적

권민석 중부고고학회 2018 중부고고학회 학술대회논문집 Vol.2018 No.5

대장암 환자에서 Capecitabine과 Bevacizumab 병합요법 후 발생한 6번 뇌신경 마비 1예

권민석,허정,박송이,최창원,홍정용,문남주,황인규 중앙대학교 의과대학 의과학연구소 2015 中央醫大誌 Vol.40 No.3

We report a transient sixth nerve palsy case after administration of capecitabine and bevacizumab. A 37-year-old woman with advanced colon cancer developed diplopia due to a sixth nerve palsy, 7 weeks after receiving capecitabine and bevacizumab. Brain imaging with MRI did not show a space occupying lesion or vascular lesion that could explain her sixth nerve palsy. After stopping all chemotherapeutic drugs for 4 weeks, the diplopia resolved without special therapy. Considering her previous history of long-term exposure to 5-fluorouracil as the metabolite of capecitabine, the bevacizumab was causative drug, associated with sixth nerve palsy. This is the first reported case of bevacizumab induced sixth nerve palsy in colon cancer.

구연발표1 : 구연3 ; 기존의 골수응고절편법을 보완한 골수표본제작방법

권민석,박종문,김한식,박훈희,차명수,한경자 대한임상병리사협회 2009 임상혈액검사학회 발표자료집 Vol.11 No.1

단일모드 광도파로와 다중모드 광도파로의 수직방향 결합을 이용한 필터

권민석,신상영 한국통신학회 2001 한국통신학회 기타 간행물 Vol.2001 No.10