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Botulinum toxin A 단독및 Verapamil 또는 Lidocaine 병용투여후 가토상직근의 신경재생에 관한 연구
문남주,김재찬,신경환,구본술,송계용 중앙대학교 의과대학 의과학연구소 1991 中央醫大誌 Vol.16 No.2
The purpose of the present study was to observe the morphological changes of nerve following intramuscular injection of Botulinum toxin A (B.toxin A) alone or combined with verapamil or lidocaine at the neuromuscular junction. Thirty five rabbits were divided into five experimental groups : A ; saline, B; B.toxin A (2.5U), C; B, toxin A (2.5U) with lidocaine, D; B.toxin A (2.5U) with verapamil and E; B.toxin A (1.25U). Degree of ptosis was measured daily, and morphological change of superior rectus muscle was examined on 3 days, 1 week, 2 weeks, 3 weeks, 4 weeks, 6 weeks and 8 weeks after injection. Light and electron microscopic observation was performed following H & E, Bodian silver stain. was performed following H & E and Bodian silver stain. 1. Degree of ptosis was most severe in B.toxin A (2.5U) group followed by combined verapamil or lidocaine injected group (p<0.01). The degree of ptosis was more market in the 2.5U group of B,toxin A than the 1.25U group. 2. Structural changes of the nerve included hydropic degeneration of axoplasm in both myelinated and unmyelinated nerve fibers as well as Schwann cells after 3days. Hydropic degeneration of axoplasm, death of Schwann cells and splitting of myelin sheath were marked after 3weeks. 3. The degree of the degenerative changes were most extensive in B. toxin A (2.5U) group followed by combined verapamil or lidocaine injected group. The reparative process and early sprouting of tne nerve was noted after 6weeks in B. toxin A group and almost complete regeneration was noted after 8weeks in all groups. 4. The degree of morphologic changes was more marked in the 2.5U group of B. toxin A than 1, 25U group. 5. Muscular changes exhibited diffuse intracellular edema, atrophy, seperating myofilaments associated with focal lysis vacuolization. It was suggested that the effeots of Botulinum toxin A couid be modified by combined application of other drugs and different dosages of the B. toxin A in the clinical use.
김지택,문남주,Jee Taek Kim,Nam Ju Moon 대한안과학회 2007 대한안과학회지 Vol.48 No.9
Purpose: To Carry out a low vision quality of life questionnaire and to evaluate subjective quality of life of low-vision patients. Methods: The subject were 250 patients whose visual acuity was between hand motion and 0.3 among the patients at our clinic. The normal control group included 60 patients. After a review of the literature, we selected a useful questionnaire to assess quality of life in low vision patients and translated the questionnaire into Korean. The questionnaire used had 25 items concerning low vision and each question was multiple-choice, and the sum of the total points was used to assess of the quality of life. Results: The range of scores was from 0 to 125 points (the higher the score, the higher the quality of life). Fifty-one patients among 250 patients in the low vision group replied to our questionnaire. Fifty patients among 60 patients in the control group replied. The average low vision quality of life (LVQOL) score for patients with low vision (67.3±26.7) was significantly lower than the average score of those with normal vision (114±9.72). There was no statistically significant difference between the average score of patients questioned by mail versus telephone Conclusions: The score of low vision patients was significantly lower than that of the control group, so this questionnaire can be applied to low vision patients specifically to evaluate quality of life. Optimally, the the questionnaire shoud be administered before and after the low vision consultation. The comparision of prerehabilitation score with postrehabilitation score might be helpful to evaluate the quality of life in a post rehabilitation state.