원발부위불명암의 진단과 치료

김영생 ( Young Saing Kim ),이순일 ( Soon Il Lee ) 대한내과학회 2021 대한내과학회지 Vol.96 No.5

Cancer of unknown primary (CUP) is a heterogenous group of cancers for which the anatomical site of origin is unidentifiable on the basis of standard evaluation and imaging. CUPs account for 2-5% of all malignancies and are characterized by early metastatic dissemination, aggressive clinical course, and poor response to palliative chemotherapy. It is important to identify favorable-risk CUP patients (10-20%), as they harbor chemo-sensitive and potentially curable tumors, and may require long-term disease control. Empirical combination chemotherapy has traditionally been the standard first-line therapy for most patients (80-90%), who do not belong to favorable-risk subsets; however, this approach has only modest benefits, with a median overall survival of < 1 year. Evidence supporting the clinical use of molecular tissue of origin (TOO) tests is still lacking. Two recent randomized clinical trials failed to show the benefit of TOO-based site-specific therapy over empirical chemotherapy. In an era of precision medicine, the use of comprehensive molecular profiling will provide opportunities to identify patient subsets who are susceptible to targeted therapies and immunotherapies. (Korean J Med 2021;96:408-414)

The Effects of Ellis & Short-Term Memory-based Reading Program for Down's Syndrome Children

김영생,왕경수,이영철 대한사고개발학회 2010 사고개발 Vol.6 No.2

Children with D.S./I.D. are not proficient in reading. The purpose of this research is to investigate the effects of Ellis & short term memory-based reading program for children with D.S./I.D.. According to Ellis(1970), children with D.S./I.D. are disrupted when they read Korean words, sentences, or tale books, if reading task is beyond their short term memory (1,2,3). So in this research we adapted Kim's program (2004) considering their short term memory to four children with D.S./I.D.. Research were done at home and at school. by their mothers. Researchers took videotapes and photos to get reading changes of subjects and each mother reported the results of her teaching on the web site. After 23-41 months subjects succeeded in mastering 1,450 syllables and came to read through 30-180 of tale books. And subjects who mastered reading before entering school or during the 1st semester of the 1st grade began to think that they could do anything at school and that they were the same as other classmates because they also could read tale books and textbooks fluently. Conclusively, When teaching to read to the children with D.S./I.D. , the start level of the ability to read 19 Korean syllables '가 나 다...하 까...빠' or 'ㄱ ㄴ ㄷ...ㅎ ㄲ...ㅃ‘ is important, and first of all considering the short term memory of each of them is very important. And mastered early before entering school, children with D.S./I.D also began to think that they were the same as normal children.

Digital Volume Control IC 설계와 제작 ( Design and Fabrication of a Digital Volume Control IC )

김영생,장영욱,고진수,신명철 대한전자공학회 1985 대한전자공학회 학술대회 Vol.1985 No.1

전정 유모세포에서 Minocycline 전 처리를 통한 Neomycin 이독성예방효과;Reactive Oxygen Species와 Caspase-3 활성억제

김영생,안진철,백인영,이정구,정재윤 대한이비인후과학회 2006 대한이비인후과학회지 두경부외과학 Vol.49 No.12

Background and Objectives:Aminoglycosides, a commonly used antibiotic agent, destroys the sensory hair cells in the cochlearand vestibular system leading to irreversible hearing loss and balance problem. Minocycline, a second-generation tetracyclineantibiotic, has been known to possess anti-apoptotic properties in addition to its antimicrobial action. We hypothesized thatminocycline would attenuate aminoglycosides induced vestibulotoxicity in rat utricles. Subjects and Method:Utricular maculaeprepared from postnatal day 3-4 rats were treated with neomycin alone or in combination with minocycline. For hair cell count,utricles were stained with phalloidin- FITC. Reactive oxygen species (ROS) was assessed using the fluorescent probe, hydrofluorescentdiacetate acetyl ester (H2DCFDA). Caspase-3 activity was also examined using the fluorescent caspase-3 substrate.Results:Neomycin induced dose-dependent loss of utricular hair cells. Minocycline reduced ROS production and caspase-3activation in neomycin treated utricular hair cells. Conclusion:Minocycline has protective effect in neomycin induced ototoxicityin rat utricle by inhibiting ROS production and caspase-3 activity. (Korean J Otolaryngol 2006;49:1159-64)

취학 1년 전, 조기학습만으로 예방 효과 탁월

김영생 한국교육과정평가원 2009 교육광장 Vol.31 No.-

Randomized Phase II Study of Pemetrexed Versus Gefitinib in Previously Treated Patients with Advanced Non-small Cell Lung Cancer

김영생,조은경,우현선,홍준식,안희경,박인근,심선진,경선영,강신명,박정웅,정성환,박진희,이재훈,신동복 대한암학회 2016 Cancer Research and Treatment Vol.48 No.1

Purpose This study aimed to evaluate the efficacy and safety of pemetrexed versus gefitinib in patients with advanced non-small cell lung cancer (NSCLC) previously treated with chemotherapy. Materials and Methods Patients with advanced (stage IIIB or IV) or recurrent NSCLC were randomly assigned to receive either 500 mg/m! of pemetrexed intravenously every 3 weeks or gefitinib 250 mg/day orally. The primary end point was progression-free survival (PFS) at 6 months. Results A total of 95 patients were enrolled (47 for pemetrexed and 48 for gefitinib). Most patients were male (72%) and current/ex-smokers (69%), and 80% had non-squamous cell carci- noma. The epidermal growth factor receptor (EGFR) mutation status was determined in 38 patients (40%); one patient per each arm was positive for EGFR mutation. The 6-month PFS rates were 22% and 15% for pemetrexed and gefitinib, respectively (p=0.35). Both arms showed an identical median PFS of 2.0 months and a median overall survival (OS) of 8.5 months. In EGFR wild-type patients, higher response rate (RR) and longer PFS as well as OS were achieved via pemetrexed compared with gefitinib, although there were no signifi- cant differences (RR: 39% vs. 9%, p=0.07; median PFS: 6.6 months vs. 3.1 months, p=0.45; median OS: 29.6 months vs. 12.9 months, p=0.62). Toxicities were mild in both treatment arms. Frequently reported toxicities were anemia and fatigue for pemetrexed, and skin rash and anorexia for gefitinib. Conclusion Both pemetrexed and gefitinib had similar efficacy with good tolerability as second-line treat- ment in unselected patients with advanced NSCLC. However, pemetrexed is considered more effective than gefitinib for EGFR wild-type patients.

국제투자규범의 방향과 우리나라의 대응책

김영생 수원대학교 1997 企業經營硏究 Vol.6 No.-

국제투자규범으로 WTO에는 貿易關聯措置(TRIMs), 서비스교역에 관한 一般協定(GATS), 知的財務産權에 관한 協定(TRIPs) 등이 있으며 OECD에는 자본이동 자유화규약이 있다. 1998년에 성립될 OECD의 多者間 投資協定(MAI)은 包括性, 多者性, 透明性, 投資保護, 紛爭解決면에서 보다 높은 수준의 협정을 목표로 논의가 진행되고 있다. 그동안 우리나라는 외국인 투자업종을 제한하는 등 국제투자자유화 제규범에서 유보사항을 인정받아 왔으나 앞으로는 어렵게 될 것이다. 국제투자에 대한 자유화규범의 진전에 대응하여 우리나라는 외국인 투자에 대한 自由化계획을 앞당길 뿐만 아니라, 內需市場과 海外市場의 통합에 대응하여 국내기업의 국제경쟁력을 높여야 한다. MAI에서는 신금융상품의 인정, 설립권의 보장, 외국은행지점의 본점자본금 인정 등이 허용되어야 한다. 또한 현재와 같은 내국민대우의무의 광범위한 유보는 과감하게 철폐하여야 한다. 앞으로 우리나라는 國境間 M&A에 있어서 友好的 M&A뿐만 아니라 敵對的 M&A까지 허용하지 않을 수 없으므로 이에 대한 준비를 하여야 한다.

알루미늄 호일의 친수코팅 성능 개선에 관한 실험적 연구

김영생,길용현,박환영,윤백,김자수소,김병열 대한설비공학회 1999 설비공학 논문집 Vol.11 No.6

It is usual to use hydrophilic-coated aluminum foil for evaporator fin of air-conditioners to reduce air flow resistance caused by the water droplets condensed on the fin surface. The major effect of a hydrophilic coating is to reduce the contact angle of the condensate and prevent bridging of the condensate between the adjacent fins. The performance of hydrophilic coating generally tends to be degraded as it is used since the coating material is washed down by the condensate. In the present work, several types of hydrophilic coatings were evaluated in terms of durability of hydrophilicity, corrosion resistance and heat resistance. Results showed that an improved hydrophilic coating of resin type presented superb qualify in terms of durability and corrosion resistance while having almost the same level of qualify in heat resistance compared with the others.

[외국정책사례] 중국에서 창업과 일자리 창출의 길을 묻다

김영생 한국자치학회 2018 월간 공공정책 Vol.148 No.-

環境技術 開發 및 國際的 移轉 政策 : 淸淨技術을 중심으로

金永生 水原大學校 社會科學硏究所 1999 社會科學論集 Vol.11 No.-