한의진단명과 진단요건의 표준화 연구 II (표준화 실례) : 2차년도 연구결과 중간 보고

양기상,최선미,최승훈,안규석,박경모,박종현,김성우,신승호,정우열,전병훈,고현,김정범,신상우,김성훈,김동희,권영규,엄현섭,장혜옥 한국한의학연구원 1996 한국한의학연구원논문집 Vol.2 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the second year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows; - differential diagnosis according to condition of body fluid, differentiation of syndromes according to the state of qi and blood, differential diagnosis according to relative excessiveness or deficiency of yin and yang(氣血陰陽津液辨證) - differentiation of diseases according to pathological changes of the viscera and their interrelation - analyzing and differentiating of febrile diseases in accordance with the theory of the six channels(傷寒辨證) The individual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name(異名), notion of diagnosis pattern, index of differentiation of symptoms and signs(辨證指標), the main point of diagnosis, analysis of diagnosis pattern(證候分析), discrimination of diagnosis pattern(證候鑑別), a way of curing a diseases(治法), prescription(處方), herb in common use(常用藥物), diseases appearing the diagnosis pattern(常見疾病), documents(文獻調査). This study was carried out on the basis of the Chinese documents and references.

수종 수산화칼슘 Sealer의 근관폐쇄효과에 관한 전기화학적연구

신동훈,최국렬,홍찬의 大韓齒科保存學會 1995 Restorative Dentistry & Endodontics Vol.20 No.1

AbstractThe purpose of this electrochemical study was to determine and compare the sealing effect of three commonly used calcium hydroxide-based sealers (Sealapex, Apexit, and CRCS) with that of Roth 801 which is a ZOE-based sealer.64 single rooted teeth were used in this experiment. After removing the crown, the teeth were devided into 4 groups of 15 in each and obturated with gutta-percha and experi- mental sealers. 4 teeth were as controls(2 positive and 2 negative).The results were as follows : 1. During the observation period, all sealers showed varying degree of microleakage. 2. The mean leakage currents according to the electrochemical study of each group showed 0.418??0.006mV for Roth 801, 2.03??0.035mV for Sealapex, 3.33??0.069mV for Apxit and 6.48??0.097mV for CRCS group. The positive control group showed 600mV. 3. There were statistically significant difference in mean leakage among experimental groups. ZOE-typed Roth 801 sealer was the lowest, and Sealapex, Apexit, CRCS group in that order showed increased leakage (P<0.05). 4. Roth 801, Sealapex and Apexit group showed increasing leakage with time, but CRCS group showed stable or decreasing leakage tendency.

수종 코어용 복합레진 수복재의 물성에 관한 연구

신수일,신동훈 大韓齒科保存學會 2004 Restorative Dentistry & Endodontics Vol.29 No.2

The purposes of this study were to estimate the material properties of the recently developed domestic composite resins for core filling material (Chemical, Dual A, Dual B; Vericom, Korea) and to compare them with other marketed foreign products (CorePaste, Den-Mat, USA; Ti-Core, Essential Dental Systems, USA: Support, SCI-Pharm, USA). Six assessments were made; working time, setting time, depth of polymerization, flexural strength, bonding strength, and marginal leakage. All items were compared to ISO standards. All domestic products satisfied the minimum requirements from ISO standards (working time: above 90 seconds, setting time: within 5 minutes), and showed significantly higher flexural strength than Core Paste. Dual A and B could, especially, reduce the setting time to 60 seconds when cured with 600 mW/㎠ light intensity. All experimental materials showed 6 mm depth of polymerization. Bond strengths of Ti-Core and Dual B materials were significantly higher than the other materials. Furthermore, three domestic products and Ti-Core could reduce the microleakage effectively.

미생물 포괄고정화를 위한 고정화재의 비교검토

신동범,윤창훈,강경수 제주대학교 환경연구소 1997 환경연구논문집 : 제주대 Vol.5 No.-

We conducted the experiments to find out the appropriate gelling materials for the treatment of waste water by immobilizing microorganisms inside the gels. The gelling materials known to immobilize microorganisms or cells in them are polyacrylamide, polyvinylalcohol, sodium alginate, κ-carrageenan and chitosan. The gel strengths were determined by the breaking points of the pellet using a rheometer with reaction time. The polyacrylamide gels were retained their solidities and activities excellently compared with the other pellets of polyvinylalcohol, sodium alginate and chitosan with reaction time. It is considered that, in the other hand, the polyacrylamide gels are toxic to the single microorganisms and cells by free radicals during the formation of gels. We used activated sludge for the mmobilization, so it didn't matter the toxicity caused by free radicals. The profiles of waste water treatment by all the immobilized pellets using in this study were showed nearly similar patterns, but gel strength of all the gels except polyacrylamide pellets were getting weak and weak as reaction time goes by. It was concluded that the polyacrylamide gels are excellent for immobilization of activated sludge for waste water treatment, but in the case of immobilization of single microorganisms or cells, natural polysaccharides of sodium alginate, κ -carrageenan or chitosan are thought to be suitable, and it must be developed the techniques for elevating gel strength of nautral polysaccharides.

마케팅 실행의 문화적 측면에 관한 고찰 : 마케팅파워의 문화적 존중과 특수성을 중심으로

신왕우,김동훈,우기남 제주대학교 경상대학 경영경제연구소 2000 경영경제연구 Vol.2 No.-

고주파수대역에 적용되는 Fe-( BN, Si₃N₄)박막의 미세구조와 자기적특성에 관한 연구

申東勳,張勝彦,李宰源,南勝義 弘益大學校 科學技術硏究所 1997 科學技術硏究論文集 Vol.8 No.-

We have investigated the magnetic properties of FeBN thin films deposited by using RF magnetron sputtering and Fe-BN composite target. It was investigated that the area fraction of BN chips on the Fe target and partial pressure of nitrogen was the main factors influencing the soft magnetic properties and resistivity of FeBN thin film. The low addition of N₂increases significantly the soft magnetic properties and electrical resistivity. The good soft magnetic properties are obtained at N₂partial pressure of 5%, but futher increase in N₂ partial pressure degrade the soft magnetic properties due to formation of nitrides such as Fe₄N, Fe₂∼₃N. In a sputtering process, as the area fraction of BN increases, FeBN thin films fabricated at the area fraction of 0.25 exhibt soft magnetic properties (Bs∼17kG, Hc∼10e, μ∼1000).

담도에 생긴 이소성 췌장에 의한 폐쇄성 황달

신동훈 고신대학교 의과대학 2010 고신대학교 의과대학 학술지 Vol.25 No.2

Ectopic pancreas is an uncommon developmental anomaly, Futhermore obstructive jaundice by ectopic pancreas in common bile duct is very rare. We reported a case of ectopic pancreas in common bile duct mimicking distal cholangiocarcinoma. MRCP and percutaneous cholangiogram demonstrated a distal common bile duct obstruction suspicious of cholangiocarcinoma. A 79-year old male patient presented abdominal pain and obstructive jaundice. He underwent a pylorus-preserving pancreaticoduodectomy. Histology showed a nodule of ectopic pancreatic tissue in distal common bile duct. We report this very rare case of ectopic pancreas in common bile duct mimicking distal cholangiocarcinoma.

간췌담도계의 복강경 수술의 최신 지견

신동훈 고신대학교 의과대학 2009 고신대학교 의과대학 학술지 Vol.24 No.2

Many studies have recently reported on laparoscopic hepatobiliary-pancreas surgery, although its development has been slow compared to laparoscopy in others field. Laparoscopic hepatobiliary-pancreas surgery resection is one of the last areas of resistence to the offensive of the laparoscopic surgery. Diffusion of laparoscopic hepatobiliary-pancreas surgery is still limited to few center, and its result are not yet clarified. The reasons for the limited development of laparoscopic Hepatobiliary-pancreas surgery; First, technical problems are anticipated Second, hemorrhage may be more difficult to control laparoscopically, and the risk of gas embolism may be increased by the use of pneumoperitoneum. The third problem is a fear of oncological inadequacy and tumor spread. The author described here the technical considerations for performing laparoscopic Hepatobiliary-pancreas surgery including indication, operation tips and results of surgery. The conclusion, carefully selected patients, author find laparoscopic hepatobiliary-pancreas surgery to be a usefull surgical procedure.

상아질 지각과민 처치제의 임상적 효과에 대한 연구

신동훈,조경모 大韓齒科保存學會 2000 Restorative Dentistry & Endodontics Vol.25 No.2

대뇌 기저핵 신경세포 일차배양에서 망간에 의해 유도된 Appoptosis : 형태학적인 소견

신동훈,김상표,정용욱,배재훈,송대규,백원기 大韓産業醫學會 2000 대한직업환경의학회지 Vol.12 No.1

목적 : 본 실험은 대뇌기저핵의 신경세포를 배양하여 망간(MnCl₂)을 투여한 후 망간독성에 의한 신경세포의 apoptosis를 형태학적인 소견으로 관찰하였다. 방법 : 배양된 신경세포에 0.01에서 10μM Mnc12를 48시간동안 처리한 후 TUNEL (TdT-mediated dUTP Nick End Labelling)법 및 투과전자현미경학적으로 관찰하였다. 결과 : TUNEL방법을 이용하여 관찰한 결과 TUNEL반응에 갈색으로 양성반응을 나타내는apoptotic 세포의 수가 대조군에 비해 MnCl₂를 투여한 군에서 유의하게 높게 나타났으며(P〈0.05), 투과전자현미경학적 소견상 대조군의 신경세포들은 핵인(nucleolus)이 두드러지게 특징적으로 보이면서 핵막과 세포질내 소기관들이 잘 보존되어 있으며, 세포질내망(ER)과 사립체(mitochondria)를 특히 많이 가지고 있었다. Mnc12를 48시간 동안 처리한 군에서 이질염색질(heterochromatin)이 핵막으로 이동하면서 응집되어 있었으며, 핵내 불규칙한 형태의 염색질이 나타나 분절이 진행되는 소견을 보였고, Apoptosis의 가장 특징적인 초기 소견인 막으로 둘러싸인 반달모양의 핵내염색질의 분절편(fragment-ed chromatin)과 주위의 상대적으로 정상적인 소기관으로 구성된 apoptotic body를 관찰할 수 있었다. 결론 : 신경세포에서 망간에 의해 apoptosis가 유도됨을 형태학적인 방법으로 확인할 수 있었으며 망간에 의한 세포사망양상에 apoptosis가 하나의 기전이 될 수 있을 것이다. Objectives : Manganese is cytotoxic to the central nervous system including basal gan-glia. Its toxic mechanism is related to oxidative stress, mediated by toxic free radicals but is specultives. In the present study , we have investigated to manifest apoptosis in man-ganese-induced cytotoxicity in primary neuronal cell culture of rat basal ganglia. Methods : To detect apoptotic neuronal cells were stained by the terminal deoxynu-cleotide (TdT) -mediated dUTP nick end-labelling (TUNEL) method and apoptotic changesin nuclei of neurons were observed by electron microscopy. Results : We showed that TUNEL immunostain showed brownish signal in the nuclei of apoptotic cells and the proportions of apoptotic cells in Manganese treatment groups were more higher than controls. On transmission electron microscopy, there were chromatine condensation with margination toward nuclear membrane and condensation of cyto-plasm in the treated with luM MnCl²for 48 hours in a basal ganglia neurons. Apoptotic bodies were found and consisted of semilunar-like condensed nuclei with relatively intact cytoplasmic organelles. Conclusions : Apoptosis appears to be one mechanism in the manganese-induced net-ronal cell death. Manganese intoxication is a convenient model for apoptosis study.