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Jae-Bin Seo,Woo-Hyun Lim,Hack-Lyoung Kim,Sang-Hyun Kim,Myung-A Kim,Joo-Hee Zo 대한임상노인의학회 2020 대한임상노인의학회지 Vol.21 No.2
Background: The ankle-brachial index is a useful tool to detect lower extremity peripheral artery disease, which is affected by exercise. The aging process causes degenerative vascular changes. The aim of this study was to elucidate the association between aging and changes in the ankle-brachial index after exercise. Methods: We analyzed data from ninety-nine patients who underwent ankle-brachial index tests and graded maximal aerobic exercise tests because of chest pain. The ankle-brachial index was measured before and after the exercise test. The correlation between age and changes in the ankle-brachial index after exercise was investigated using Pearson’s correlation coefficient. Results: The ankle-brachial index decreased after exercise, compared with that at rest (before vs. after: 1.11±0.06 vs. 1.05±0.08, P<0.001, 1.12±0.06, vs. 1.06±0.08, P<0.001; right and left, respectively). Upper-extremity systolic blood pressure did not change from baseline, and upper extremity diastolic blood pressure only increased slightly. However, the lower-extremity systolic and diastolic blood pressures decreased significantly. The correlation coefficients of the association between aging and changes in both the right and left ankle-brachial index indices were 0.319 and 0.255 (P=0.001 and P=0.011), respectively. Conclusion: A positive correlation was observed between aging and changes in the ankle-brachial index after exercise.
Jae Won Seo,Kyu Seong Park,Gwang Bin Lee,Sang-eun Park,Jae-Hoon Choi,Myeong Hee Moon 대한면역학회 2023 Immune Network Vol.23 No.4
Lipid accumulation in macrophages is a prominent phenomenon observed in atherosclerosis. Previously, intimal foamy macrophages (FM) showed decreased inflammatory gene expression compared to intimal non-foamy macrophages (NFM). Since reprogramming of lipid metabolism in macrophages affects immunological functions, lipid profiling of intimal macrophages appears to be important for understanding the phenotypic changes of macrophages in atherosclerotic lesions. While lipidomic analysis has been performed in atherosclerotic aortic tissues and cultured macrophages, direct lipid profiling has not been performed in primary aortic macrophages from atherosclerotic aortas. We utilized nanoflow ultrahigh-performance liquid chromatography-tandem mass spectrometry to provide comprehensive lipid profiles of intimal non-foamy and foamy macrophages and adventitial macrophages from Ldlr−/− mouse aortas. We also analyzed the gene expression of each macrophage type related to lipid metabolism. FM showed increased levels of fatty acids, cholesterol esters, phosphatidylcholine, lysophosphatidylcholine, phosphatidylinositol, and sphingomyelin. However, phosphatidylethanolamine, phosphatidic acid, and ceramide levels were decreased in FM compared to those in NFM. Interestingly, FM showed decreased triacylglycerol (TG) levels. Expressions of lipolysis-related genes including Pnpla2 and Lpl were markedly increased but expressions of Lpin2 and Dgat1 related to TG synthesis were decreased in FM. Analysis of transcriptome and lipidome data revealed differences in the regulation of each lipid metabolic pathway in aortic macrophages. These comprehensive lipidomic data could clarify the phenotypes of macrophages in the atherosclerotic aorta.
서동석(Dong-Seok Seo),김재영(Jae-Young Kim),정재황(Jae-Hwang Jeong),박학수(Hak-Soo Bark),유욱준(Wook-Joon Yu),고상범(Sang-Beom Go),김정헌(Jeong-Heon Kim),장동혁(Dong-Hyouk Jang),서무엽(Mu-Yeb Seo),조빈행(Bin-Haing Cho),성하정(Ha-Jung 한국농약과학회 2003 농약과학회지 Vol.7 No.4
To investigate the toxicological effects of technical of IAP-3006, we performed subchronic oral toxicity study in Sprague-Dawley (SD) rats. In the subchronic dietary study, rats of both sexes were fed diets containing technical of IAP-3006 at concentrations of 0, 1000, 10,000, or 15,000 ppm for 90 days. No clinical signs and mortality were observed in animals treated with technical of IAP-3006 throughout the experimental period. There were also no significant changes in body weights, feed consumption, and any gross or histopathological lesions. Although there were statistically significant differences between the control and treated groups in some relative and absolute organ weights, and hematological and biochemical analyses, the data were in biologically normal ranges and did not show a dose-dependent manner. From these results, it is suggested that subchronic oral toxicity NOEL of technical of IAP-3006 in rats may be over 15,000 ppm.
토양 수분함량 변화에 따른 용적전기전도도 변화와 포화침출액전기전도도의 상관관계
백누리(Nuri Baek),서보성(Bo-Seong Seo),정영재(Young-Jae Jeong),이승민(Seung-Min Lee),김한중(Han-Joong Kim),오효림(Hyo-Lim, Oh),최현수(Hyeon-Su Choi),박서우(Seo-Woo Park),허수빈(Su-Bin Seo),신은서(Eun-Seo Sin),최우정(Woo-Jung Choi) 한국토양비료학회 2021 한국토양비료학회 학술발표회 초록집 Vol.2021 No.11
간척농지 염농도 관리를 위해서 염농도 자동계측기 설치가 확대되고 있다. 자동계측기에서는 용적전기 전도도(Bulk electrical conductivity, EC<SUB>b</SUB>)가 측정되는데, EC<SUB>b</SUB>는 토양 수분에 크게 영향을 받는다. 따라서, EC<SUB>b</SUB>를 토양 수분함량에 독립적인 포화침출액 전기전도도(Saturated-paste extract EC, EC<SUB>e</SUB>)로 환산할 필요가 있다. 본 연구에서는, 실내 토조실험을 통해 사양토와 미사질 양토를 이용하여 EC<SUB>b</SUB>와 EC<SUB>e</SUB>의 상관관계를 구명하였다. 토조에 세 가지 수준의 염농도로 조정된 토양을 충진하고 염농도 센서(Teros12)를 설치한 후 수분을 과포화 상태로 조정하여 각각의 토양에 대해 약 2주간 실험을 수행하였다. 사양토의 EC<SUB>e</SUB>는 4.5, 7.0, 10.5 dS m<SUP>-1</SUP> 였고, 미사질양토의 EC<SUB>e</SUB>는 4.3, 7.8, 11.4 dS m<SUP>-1</SUP> 였다. 시간이 경과함에 따라 토양 수분 함량은 증발에 의해 약 0.2 cm³ cm<SUP>-3</SUP>로 감소하였다. 수분 함량이 과포화에서 약 0.3 cm³ cm<SUP>-3</SUP> 수준으로 감소하는 동안 EC<SUB>b</SUB>는 염 농축에 의해 증가하였지만, 그 이후부터는 수분 함량이 감소함에 따라 이온 활동도가 감소하여 EC<SUB>b</SUB>도 감소하였다. EC<SUB>b</SUB>가 EC<SUB>e</SUB>에 가장 근접하게 측정되는 수분함량은 토양 염농도 수분별로 상이하였는데, 사양토의 경우 ECe는 4.5, 7.0, 10.5 dS m<SUP>-1</SUP>에서 각각 0.39, 0.39, 0.28 cm³ cm<SUP>-3</SUP> 였고, 미사질양토의 경우에는 ECe는 4.3, 7.8, 11.4 dS m<SUP>-1</SUP>에서 각각 0.48, 0.62, 0.50 cm³ cm<SUP>-3</SUP> 였다. 해당 수분 함량에서 EC<SUB>b</SUB>와 EC<SUB>e</SUB>는 매우 강한 상관관계를 보였는데, 회귀식은 사양토와 미사질양토가 각각 EC<SUB>b</SUB>=EC<SUB>e</SUB> 0.80 x + 1.3, EC<SUB>b</SUB>=EC<SUB>e</SUB> –0.27 x² + 4.7 x - 9.8 였다. 본 연구결과는 염농도 자동계측기에서 측정하는 EC<SUB>b</SUB>가 토양 수분함량이 높을 때는 염농도 희석, 그리고 수분함량이 낮을 때는 이온 활동도 감소에 의해 크게 변하는 것을 보여준다. 따라서, EC<SUB>b</SUB>가 EC<SUB>e</SUB>와 유사한 토양 수분 함량 조건에서만 EC<SUB>b</SUB>를 직접 활용할 수 있는 것으로 나타났다. 따라서, 향후 염농도 자동계측기의 활용도를 높이기 위해서는 토양수분함량에 따른 EC<SUB>b</SUB> 변화를 정량화하여 토양수분함량의 영향을 제거할 수 있는 방법 개발이 필요하다.
( Jae Yang Song ),( Young Bin Seo ),( Soon Kwang Hong ),( Yong Keun Chang ) 한국미생물 · 생명공학회 2013 Journal of microbiology and biotechnology Vol.23 No.2
Heterologous expression of a putative K+/H+ antiporter of Streptomyces coelicolor A3(2) (designated as sha4) in E. coli and Streptomyces hygroscopicus JCM4427 showed enhanced tolerance to K+ stress, acidic-pH shock, and/or geldanamycin production under K+ stress. In a series of K+ extrusion experiments with sha4-carrying E. coli deficient in the K+/H+ antiporter, a restoration of impaired K+ extrusion activity was observed. Based on this, it was concluded that sha4 was a true K+/H+ antiporter. In different sets of experiments, the sha4-carrying E. coli showed significantly improved tolerances to K+ stresses and acidic-pH shock, whereas sha4-carrying S. hygroscopicus showed an improvement in K+ stress tolerance only. The sha4-carrying S. hygroscopicus showed much higher geldanamycin productivity than the control under K+ stress condition. In another set of experiments with a production medium, the secretion of geldanamycin was also significantly enhanced by the expression of sha4.