새로운 알랄아민 항진균제의 합성과 생물학적 평가

정병호,박은주,문현주,유진철 朝鮮大學校 1997 藥學硏究誌 Vol.18 No.2

Some allylamine compounds which are benzothiazole substituants in stead of naphthylring in naftifine, antifungal agents, were sythesized as potential antimycotics. The intermediate Schiff bases that were obtained by condensation of 2-aminobenzothiazole and trans-cinnamaldehyde, were reduced to imine compounds to give allylamines(5a-5d) after mrthylation. These compounds which were tested in vitro against five fungal cell lines containing Trichophyton mentagrophytes. showed no activity in 0.1∼100 μg/ml range.

스포츠센터 소비자의 고객충성도에 영향을 미치는 요인에 관한 연구 : 서비스 품질과 서비스 가치를 중심으로 Centered on the quality and value of services

정의권,최영진,조현철 중앙대학교 스포츠과학연구소 2002 體育硏究 Vol.- No.17

This study centers on the quality and value of services perceived by consumers regarding factors that affect customer loyalties of sport center consumers. Study has been administered by a questionnaire survey of 200 male and female adult members of four sport centers in Seoul area. Following is the results: 1. Analyzing the relationship between demographic characteristics of sport center consumers and factors of their selection of those sport centers, there is significant difference in consumers' schooling and their family income. 2. Service quality perceived by sport center consumers appears to have a positive influence on service value. 3. Service value of sport center consumers appears to have a positive influence on customer loyalties. 4. Service quality perceived by sport center consumers appears to have a direct influence on customer loyalties. 5. Assessing the causal relationship between the service quality and value perceived by sport center consumers and customer loyalties, direct influence that the perceived service quality has on customer loyalties is stronger than indirect influence that mediated by service value.

콘택트렌즈 보존 용기 유래 Acanthamoeba lugdunensis KA/L5주의 내공생세균

정동일,공현희,김태호,황미열,유학선,윤호철,설성용 경북대학교 의학연구소 1999 경북대학교병원의학연구소논문집 Vol.3 No.1

콘택트렌즈 보존 용기 유래 가시아메바 KA/L5주의 세포질 내에 존재하는 bacterial endosymbiont(내공생세균)를 투과전자현미경으로 관찰하여 확인하였다. 숙주인 가시아메바 KA/L5주는 형태학적으로 제2군에 속하였고, rDNA PCR-RFLP 결과 A. lugdunensis로 동정되었다. 미토콘드리아 DNA RFLP와 동위효소 분석상 이 충주는 국내 콘택트렌즈 보존용기에서 가장흔히 분리되는 type인 KA/Ll주, 국내 임상 분리주 중 하나인 KA/E2주, 내공생세균을 가지는 것으로 보고된 병원 냉각수 유래 KA/W4주 및 L3a주와 동일하거나 매우 유사한 성적을 보였다. 내공생세균은 약 1.38× 0.507㎛의 크기였고, 아메바 세포질 내에 불규칙하게 분포하고 있었으며. 그 표면에 아메바의 ribosome이 부착되어 있었다. 내공생세균을 둘러싼 lacunae나 막과 같은 구조는 관찰되지 않았다. Legionella 특이 primer를 이용한 효소중합반응(PCR)에서 내공생세균의 염색체 DNA는 증폭되지 않았다. A. lugdunensis의 우리말 이름을 담수가시아메바로 제안한다. Transmission electron microscopy of an Acanthamieba isolate (KA/L5) from a contact lens case revealed bacterial endosymbionts within cytoplasm of the amoebae, The Acanthamoeba isolate belonged to the morphological group II. Based on the polymerase chain reaction (PCR) - restriction fragment length Polymorphism (RFLP) of 18S ribosomal RNA coding DNA (rDNA), the Isolate was identified as A. lugdunensis. Strain typing by isoenzyme analysis using isoelectric focusing (IEF) and mitochondrial (Mt) DNA RFLP revealed that the isolate was closely related with KA/Ll , the most predominant type of isolates from contact lens storage cases, KA/E2, a clinical isolate, KA/W4, preciously reported to host endosymbionts, and L3a strains of A. lugdunensis. The endosymbionts were similar to those of KA/W4 In aspects that they were randomly distributed in both trophozoites and cysts, and were rod-shaped bacteria measuring approximately 1.38x 0.50㎛. But the number of endosymbionts per amoeba was significantly lower than that of KA/W4. They were neither limited by phagosomal membranes nor included In lacunae- like structure.

프롤린 함량 증가 및 내건성 강화 관련 새로운 RING-Type E3 유비퀴틴 리가아제 애기장대 atrzf1 돌연변이체의 생리적 기능 연구

주현우,민지희,정문수,김철수 전남대학교 농업과학기술연구소 2021 농업생명과학연구동향 Vol.59 No.-

The covalent attachment of ubiquitin to proteins plays a fundamental role in the regulation of cellular function through biological events involving abiotic of biotic stress responses, immune responses, and apoptosis, Here, we characterize the biological function of the Arabidopsis thaliana RING Zinc Finger 1 (AtRZF1) in dehydration response. AtRZF1 was significantly reduced by drought stress. The atrzf1 mutant was less sensitive to osmotic stress than the wild-type during early seedling development, wheareas transgenic pants overexpressing AtRZF1 were hypersensitive, indicating that AtRZF1 megatively regulates drought-mediated control of early seedling developmeng. Moreover, the ectopic expression of the AtRZF1 gene was very significantly influential in drought sensitiv parameters including proline content, water loss, membrance ion leakage and the expression of dehy-dration stress-relat genes. ARZF1 is a functional E3 ubiquitin ligase, and its conserved C3H2C3-type RING domain is likely important for the biological function of AtRZF1 in drought response. Together, these results suggest that the E3 ligase AtRZF1 is an important regulator of water deficit stress during early seedling development.

수종의 치과용 수복재료 및 시멘트의 radiopacity

정현주,강병철,오원만,양홍서 大韓口腔顎顔面 放射線學會 1994 Imaging Science in Dentistry Vol.24 No.1

The radiopacity of six composite resins, three resin luting cements and ten filling materials were studied. The purpose was to obtain an indication of radiopacity value of different brands within each of these groups of materials and to show differences in radiopacities of filling materials and natural tooth structures. On radiographs, the optimal densities of standardized samples were determined by computer imaging system and radiopacity values of the materials were expressed in millimeter equivalent aluminum. Within the groups of materials studied, there was considerable variation in radiopacity. The composite resins of P-50, Z100 and Prisma AP.H displayed much higher radiopacities than aluminum. Panavia resin cement was shown to be similarly radiopaque to aluminum. Generally, the radiopacity of base and filling materials appeared to be higher than that of the enamel and dentin. If materials with substantial difference in radiopacity are used in combined applications for restorative treatment of teeth, lower radiopacity can interfere with the diagnosis and detection of gaps near the restoration.

국외 먹는 물 자외선 소독 법규

염철민,김도겸,정광열,유양수,조창현 대한상하수도학회 2003 상하수도학회지 Vol.17 No.6

過蓋咬合, 開咬合 및 正常咬合의 咬筋沈默期에 關한 硏究

문철현,정현수 대한치과교정학회 1987 대한치과교정학회지 Vol.17 No.1

The present study was carried out to investigate the relationships between the depth of overbite and the masseteric silent period. Normal subjects of 44 were selected, which consisted of 9 open bites, 24 normal overbites and 11 deep bites, all were 19-29 years of age. EMG activity was recorded on the bilateral masseteric muscles and craniofacial radiography was done. The following results were obtained. 1. The mean duration of masseteric silent period was 18.58±4.50 msec in open bite, 17.37±7.05 msec in normal overbite and 19.30±7.62 msec in deep bite groups. 2. There were no significant differences on masseteric silent period among open bite, normal overbite and deep bite groups. 3. There were no significant correlations between masseteric silent period and craniofacial variables.

산청군 산림지가 형성요인에 관한 연구

권철현,이상태,신현철,최재채,정영관 경상대학교 농업생명과학연구원 2003 농업생명과학연구 Vol.37 No.1

본 연구는 산청군 남부와 북부지역 361개소의 공시지가와 일반시가에 대하여 분석하였다. 지가 형성요인에 대하여 단계별 회귀분석을 실시하였으며, 그 결과는 다음과 같다. 남부지역에 대한 공시지가와 관련된 5변수 모형에 의한 추정식은 Y = 332.1973 +0.0099X_26 - 0.3577 X_8+ 0.0291X_24 - 2.6768X_2 - 26.1452X_3 이며, 회귀식에 대한 설명력은 90%로 높게 나타났으며, 일반시가에 대한 추정식은 Y = 1035.7976 -185.8280X_21 -3.3937X_1 + 405.6658X_19 -0.4703X_8 이며, 추정식에 대한 설명력은 92%롤 비교적 높게 나타났다. 북부지역에 대한 지가 형성요인에 의한 공시지가 추정모형은 Y = 176.7875 + 0.0205X_25 -0.1168X_8 + 0.0015X_26 -46.3447X_21 로 추정되었으며, 회귀식에 대한 설명력은 96%, 일반시가의 추정 모형은 Y = 203.0697 + 0.0430X_25 + 0.0027X_26 -28.8276X_4 -46.7856X_21 -0.0007X_23 으로 추정되었으며, 회귀식에 대한 설명력은 90%로 나타났다. 이상과 같이 접근요인은 부의 영향을, 그 외 다른 요인들은 지가에 양의 영향을 미치는 것으로 나타났다. This study was carried out to analyze the publicly announced land price and actual land price compared to the northern and southern region of 361 forest land place in Sanchung county. To decipher factors for making forest land price it used the stepwise regression analysis. And the result of analysis are followings; Y = 332.1973 +0.0099X_26 - 0.3577 X_8+ 0.0291X_24 - 2.6768X_2 - 26.1452X_3 (R^2=90%) and the estimation equation of actual price analyze the publicly announced and actual price compared to the northern and southern regions of Sanchung county of price was obtained as Y = 1035.7976 -185.8280X_21 -3.3937X_1 + 405.6658X_19 -0.4703X_8(R^2=92%). In the northern region, the estimation equation of publicly announced land price by the factors for making forest land price was obtained Y = 176.7875 + 0.0205X_25 -0.1168X_8 + 0.0015X_26 -46.3447X_21(R^2=96%) and the estimation equation of actual price was obtained as Y = 203.0697 + 0.0430X_25 + 0.0027X_26 -28.8276X_4 -46.7856X_21 -0.0007X_23(R^2=90%). In the result of the stepwise regression analysis, it was a showed negative effect of the proximity factor and the positive effect between others factor and land price.

막성 및 연골성 탈회골기질에 의한 골유도와 재생에 관한 연구

김호철,정현대 전남대학교 치과대학 1995 전남치대논문집 Vol.7 No.1

Since bone matrix is konwn to contain osteoinductive substance to form bone by endochondral ossification, there are much clinical interests concerning it. But there are still controversies about clinical effects, the methods of osteoinduction and preparations of bone matrix. About 700㎛ demineralized endochondral and intramembranous bone matrix particles, which have different origin in development were made from long bone and calvaria of rabbit respectively. They were allografted into the artificial defects of medial surface of tibia. The mode of bone formation and regeneration are stuided by microscopic and fluorescent observation. 1. A lot of fibrin network formed among the demineralized bone particles after 3 days of graft. 2. Lots of spindle shaped cells appeared around the particles and begin to bone formation 7 days after graft. Bone formation was mainly taking place from the host bone in control group. 3. Active bone induction by endochondral and intramembranous bone formation from both kinds of the matrix particles, which were being resorbed by multinucleated cells, was noted. 4. More rapid bone regeneration and maturity were seen in demineralized bone grafted groups than in control in grinding preparations and fluorescent microscopy. 5. There is no considerable difference of osteoinductivity between the membranous and endochondral bone matrices. These results suggest that endochondral bone formation is not critical in osteoinduction by demineralized bone matrices and both types of matrices can be applicated clinically in bone graft.

발달지연 아동 및 뇌성마비 아동의 평가실태와 물리치료사들의 평가에 대한 인식도 조사

박혜정,이충휘,조상현,권혁철 한국전문물리치료학회 2000 한국전문물리치료학회지 Vol.7 No.1

The purpose of this study were to research the current stat of evaluation of children with delayed development and cerebral palsy and determine pediatric physical therapists's knowledge of assessment tools and their use. The subjects were 130 pediatric physical therapists (general hospitals, university-related hospitals, rehabilitation centers, etc.). Data was obtained form August 24, 1999 to October 18, 1999 by means of a survey questionnaire. The results were as follows: 1. the current state of pediatric physical therapist evaluation of children with delayed development and cerebral palsy. 1) Tools used to assess functional areas of children with cerebral palsy were: subjective description format-128 (47.1%); the GMFM-58 (21.3%); facility-generated tool-51 (18.8%); and DDST-15 (5.5%) 2) Tools used to assess developmentally delayed children were: subjective description format-121 (50.6%); the GMFM-43 (18.0%); facility-generated tool-41 (17.2%); and DDST-14 (5.9%). 3) After their college or university study, therapists who had attended lectures on evaluation were 113 (86.9%); 13 (10.0%) therapists had not attended any lectures on evaluation. 2. Test scores of physical therapists' professional knowledge of evaluation procedures: high (more than 36 points)-74 (56.9%); moderate (18~35 points)-39 (30.0%); and low (below 17 points)-none. 1) For therapists treating cerebral palsied children, 73 (65.2%) were in the high range, 39 (34.8%) were in the moderate rage and none were in the low range. 2) For therapists treating children with delayed development, 71 (65.7%) were in the high range, 37 (34.3%) were in the moderate range and none were in low range. Although the general degree of professional knowledge of evaluation was quite high, there was a lack of variety in the assessment tools used with a large number of therapists depending on subjective description. Possible reasons for the low rate of objective assessment tool use: 1) Poor clinical environment: Too many clients and limited treatment time. 2) Lack of any medical insurance fee category for specific assessment tools. 3) Lack of continuing education opportunities in pediatric evaluation skills during or after either college-based(3 year) or university-based(4 year) education programs. Based on the study results, provision of more extended educational opportunities would promote the use of a greater variety of objective assessment tools by pediatric physical therapists.