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관상동맥 질환에서 CD14 유전자형에 따른 세균 및 Heat Shock Protein에 대한 반응의 차이
한주용,최수연,조현주,김화평,강현재,구본권,김남중,김효수,손대원,오병희,박영배,최윤식 대한감염학회 2007 감염과 화학요법 Vol.39 No.1
Background : CD14 is the receptor for lipopolysaccharides and heat shock protein (HSP), which has been suggested being associated with increased risk of coronary artery disease (CAD). We investigated whether the response to infectious agents or HSP is different according to CD14 polymorphism in Koreans. Materials and Methods : Antibody titers to Helicobacter pylori, Chlamydia pneumoniae, and human HSP60 (hHSP60) were measured in 48 patients with stable CAD and in 41 healthy controls by ELISA. CD14 genotype was determined by PCR and high-sensitivity C-reactive protein (hs-CRP) was measured. Results : Seropositivity to C. pneumoniae and H. pylori, and antibody titer to hHSP60 were not significantly associated with the presence of CAD. CD14 genotype distribution was 31 TT (35%), 43 CT (48%), and 15 CC (17%). To compare the response to the infectious organism and hHSP60, we divided study population into 3 groups; CAD patients with non-TT genotype (group I, n=30), CAD patients with TT genotype (group II, n=18), and normal controls (group III, n=41). Seropositivity to C. pneumoniae and H. pylori, and antibody titer to hHSP60 were not significantly different among 3 groups. Though hs-CRP level was significantly different among 3 groups, post-Hoc analysis showed that hs-CRP level was not significantly different between group I and group II (group I: 1.6[1.1-3.5] mg/L and group II: 0.35[0.1-2.0] mg/L). Conclusions : This study suggests that the inflammatory responses to infectious organisms and HSP do not differ according to the CD14 genotype in Koreans. 목적 : 만성적인 세균 감염이나 자가 면역 반응이 동맥경화와 연관되어 있다는 주장이 제기되어 왔다. CD14은 lipopolysaccharides (LPS)와 heat shock protein(HSP)의 수용체로 C(-260)→T 다형성이 관상동맥 질환의 위험과 관련되어 있다고 제안되어 왔다. 본 연구에서는 한국인에서 CD14 다형성에 따른 LPS와 HSP에 대한 반응성을 염증표지자를 측정하여 살펴보고자 하였다. 재료 및 방법 : 안정형 관상동맥 환자 48명과 정상 대조군 41명을 대상으로 Chlamydia pneumoniae, Helicobacter pylori 항체 및 인체 HSP60 (hHSP60) 항체 역가를 enzyme-linked immunosorbent assay (ELISA) 방법으로 측정하였다. CD14 유전자형은 중합효소연쇄반응을 이용하여 결정하였고 hs-CRP를 측정하였다. 결과 : C. pneumonias 및 H. pylori 항체 양성 여부 및 항체 역가, 그리고 hHSP60에 대한 항체 역가는 안정형 관상동맥 질환의 유무와 유의한 상관관계는 없었다. CD14 유전자형의 분포는 TT 30명(39%), CT 31명(40%), 그리고 CC 16명(21%)이었다. 관상동맥 질환 군에서 TT 유전자형은 38%, 대조군에서는 32%로 TT 유전자형과 관상동맥 질환의 유무와는 유의한 상관관계가 발견되지 않았다(P>0.05). CD14 유전자형에 따라 C. pneumonias와 H.pylori 감염 및 hHSP60에 따른 반응에 차이가 있는지 여 부를 알아보기 위해, 관상동맥 질환 군을 다시 TT 유전자형 군과 non-TT 유전자형 군으로 나누어, 전체적으로 세군에서 항체 양성률과 역가를 비교하였다(I군: CD14 TT 유전자형을 가진 안정형 관상동맥 환자, II군: CD14 TT 유전자형을 가진 안정형 관상동맥 환자, III군: 정상 대조군). 세 군에서 C. pneumonias와 H. pylori 항체 양성률 및 hHSP60 항체 역가에는 유의한 차이가 없었다. 세 군사이에 hs-CRP 값에 유의한 차이가 있었지만, post-Hoc분석에서 II군의 hs-CRP 값이 I군에 비해 유의하게 높지는 않았다(0.35 [0.1-2.0] mg/L in group II vs. 1.6 [1.1-3.5]mg/L in group I, P>0.05). 결론 : 본 연구는 한국인에서 CD14 유전자형에 따라 LPS나 HSP에 대한 반응이 유의하게 다르지 않음을 시사한다.
유전치의 polyethylene fiber-post를 이용한 심미수복에 관한 증례 보고
서영주,조태식,김효석,고승백,정현구,이난영 조선대학교 구강생물학연구소 2002 口腔生物學硏究 Vol.26 No.2
In clinical practice, restoration of primary incisors severely affected by caries continues to be a challenge. Not only are these teeth difficult to restore. but the behavior of the patient can affect treatment negatively. An acceptable restoration for maxillary anterior incisors should have matching material color, durability, adhesive cementation that is biocompatible with the pulp, easily and rapidly placed. This Paper describes two cases showing an alternative technique for the construction of completely destroyed upper incisors with polyethylene ribbons for retention and stability for the resin crowns.
박정란,강진형,구효정,노지영,류형철,박상욱,고동현,조일환,이주영,황다니엘,김인경 한국약제학회 2003 Journal of Pharmaceutical Investigation Vol.33 No.2
Selective COX (cyclooxygenase)-2 inhibitors including celecoxib have been shown to induce apoptosis and cell cycle changes in various tumor cells. New inhibitors are recently being developed as chemomodulating agents. We evaluated celecoxib and screened 150 synthetic compounds for anti-proliferative activities in vitro. Effects of celecoxib on COX activity, cell growth, cell cycle distribution, and apoptosis induction were determined in A549 COX-2 overexpressing human non-small cell lung cancer (NSCLC) cells. The COX inhibition of celecoxib increased with concentration up to 82% at 1μM after 24 hr exposure. Forty μM and 50μM of celecoxib induce G_1 arrest, and TUNEL-positive apoptotic cells, respectively. Among 150 compounds, several compounds were selected for having greater COX-2 inhibitory activity and higher selectivity than celecoxib with growth inhibitory activity. Celecoxib showed concentration-dependent COX inhibitory activity, and ability to induce cell cycle arrest and apoptosis in human NSCLC cells in vitro. Among synthetic analogues screened, several compounds showed promising in vitro activity as COX-2 inhibitory anticancer agents, which warrant further evaluation in vitro and in vivo.
Original Article : Serum transferrin as Liver fibrosis biomarkerin patients with chronic hepatitis B
( Hyo Jung Cho ),( Soon Sun Kim ),( Seun Joo Ahn ),( Joo Han Park ),( Dong Joon Kim ),( Young Bae Kim ),( Sung Won Cho ),( Jae Youn Cheong ) 대한간학회 2014 Clinical and Molecular Hepatology(대한간학회지) Vol.20 No.4
Background/Aims: Transferrin and alpha-1 antitrypsin are reportedly associated with liver fibrosis. We evaluated the usefulness of serum transferrin and alpha-1 antitrypsin as new liver fibrosis markers in patients with chronic hepatitis B. Methods: The study included 293 patients with chronic hepatitis B who underwent a liver biopsy between October 2005 and June 2009, and who had no history of hepatocellular carcinoma. Serum markers and liver fibrosis stages were compared. Results: Univariate analysis revealed that age (P<0.001), serum platelet count (P<0.001), and serum alkaline phosphatase level (P=0.003) differed significantly between the patients with and without liver cirrhosis. Serum transferrin levels were significantly lower in advanced fibrosis than in mild fibrosis in both univariate analysis (P=0.002) and multivariate analysis (P=0.009). In addition, the serum transferrin level was significantly lower in cirrhotic patients than in noncirrhotic patients (P=0.020). However, the serum level of alpha-1 antitrypsin was not significantly associated with liver cirrhosis in patients with chronic hepatitis B. Conclusions: Serum transferrin could be promising serum marker for predicting advanced liver fibrosis in patients with chronic hepatitis B.
( Hyo Jung Cho ),( Sun Young Park ),( Ga Won Song ),( Seun Joo Ahn ),( Ho Joong Kim ),( Joo An Hwang ),( Soon Sun Kim ),( Sung Won Cho ),( Jae Youn Cheong ) 대한간학회 2013 춘·추계 학술대회 (KASL) Vol.2013 No.1
Background/aims: Liver biopsy remains the gold standard to assess hepatic fibrosis. To identify new candidate markers for liver fibrosis, we performed serum based proteomic approach in patients with chronic hepatitis B (CHB). Methods: Sera were obtained from 12 patients with CHB at the time of liver biopsy. Batt-Ludwig classification was used for staging liver fibrosis. Proteins in pooled sera of mild fibrosis (F1 or F2, n=6) and liver cirrhosis (F4, n=6) were compared and analyzed by using 2D gel electrophoresis. Protein spots varying among two groups were excised, digested and submitted for tandem mass spectrometry for protein identification. Validation study was done for new markers among 293 CHB patients who underwent liver biopsies. Results: We identified 147 proteins which were increased or decreased significantly in hepatic cirrhosis. Among these 147 proteins, we found 7 candidate biomarkers which were supposed to be correlated with liver fibrosis. Alpha2-macroglobulin, kininogen1, transferrin and alph1-antitrypsin (A1AT) were increased whereas inter-alpha inhibitor H2, apolipoprotein A4 and apolipoprotein A1 were decreased in patients with cirrhosis. We performed validation study for A1AT and transferrin which were suitable for quantification in 293 patients with CHB. However, A1AT and trasnferrin were not significantly associated with liver cirrhosis in validation cohort. Conclusions: We identified several candidate biomarkers for predicting liver cirrhosis in patients with CHB using proteomics technology, but could not be confirmed in large validation cohort. Further advances in proteomics techniques and establishment of simple and quantitative methods are required to identify non-invasive diagnostic marker of liver fibrosis.
( Seun Joo Ahn ),( Dong Kyu Kim ),( Soon Sun Kim ),( Chang Bum Bae ),( Hyo Jung Cho ),( Han Gyeol Kim ),( Young Jip Kim ),( Joo Ho Lee ),( Hyo Jin Lee ),( Mi Yeon Lee ),( Kee Bum Kim ),( Jin Hee Cho ) 대한간학회 2012 Clinical and Molecular Hepatology(대한간학회지) Vol.18 No.3
Background/Aims: Apolipoprotein E (ApoE) plays an important role in regulating lipid and lipoprotein metabolism, and ApoE genotypes are known to affect plasma lipoprotein concentrations. We investigated whether ApoE genotype determines the disease outcome in hepatitis B virus (HBV)-infected individuals, and verified the association between ApoE genotype and the occurrence of hepatocellular carcinoma (HCC) in patients with chronic liver diseases of various etiologies. Methods: This hospital-based, case-controlled study enrolled 156 subjects (47 healthy controls, 50 HBV-related liver cirrhosis patients, and 59 HCC patients). ApoE genotypes were determined using PCR-based ApoE genotyping kits. The biological significance of ApoE genotype was verified by measuring serum ApoE levels using an ELISA kits. Results: The ε3 allele was the most common allele, with allele frequencies among the entire cohort of 5.8%, 84.3%, and 9.9% for the ε2, ε3, and ε4 alleles, respectively. Significantly more of those patients carrying the ε3/3 genotype had developed liver cirrhosis compared to the control subjects. Being an ApoE4 carrier was associated with a lower probability of developing liver cirrhosis. The allele frequencies and genotype distribution of ApoE did not differ significantly between the liver cirrhosis and HCC patients. The serum level of ApoE was significantly higher in patients with liver cirrhosis than in the healthy controls, but did not differ significantly with the ApoE genotype. Conclusions: The ApoE ε3/3 genotype frequency was higher in patients with HBV-associated liver cirrhosis than in the controls. (Clin Mol Hepatol 2012;18:295-301)