Contribution of small phytoplankton to total primary production in the Chukchi Sea

Lee, S.H.,Sun Yun, M.,Kyung Kim, B.,Joo, H.,Kang, S.H.,Keun Kang, C.,Whitledge, T.E. Pergamon Press ; Elsevier Science Ltd 2013 Continental shelf research Vol.68 No.-

Given a projection of thriving small phytoplankton in the Arctic Ocean under climate-induced environmental changes, it is important to estimate the contribution of small phytoplankton (0.7-5μm) to the total primary production in the Chukchi Sea, which is an important conduit of organic matter from the North Pacific to the Arctic Ocean. Based on a <SUP>13</SUP>C-<SUP>15</SUP>N dual isotope tracer technique, small phytoplankton productivity measurements were taken during two consecutive cruises in the Chukchi Sea in 2004. The total phytoplankton carbon uptake rates ranged from 0 to 25.38mgCm<SUP>-3</SUP>h<SUP>-1</SUP>, whereas the uptake rates of small phytoplankton ranged from 0 to 2.87mgCm<SUP>-3</SUP>h<SUP>-1</SUP>. In comparison with the carbon uptake rates, total phytoplankton nitrate uptake rates ranged from 0 to 4.40mgNm<SUP>-3</SUP>h<SUP>-1</SUP> while small phytoplankton nitrate uptake rates ranged from 0 to 0.39mgNm<SUP>-3</SUP>h<SUP>-1</SUP>. Ammonium uptake rates ranged from 0 to 8.34mgNm<SUP>-3</SUP>h<SUP>-1</SUP> and from 0.01 to 2.18mgNm<SUP>-3</SUP>h<SUP>-1</SUP>, for total and small phytoplankton, respectively. Small phytoplankton contributed 24.80% (S.D.=+/-23.0%) to the total chlorophyll-a concentration, and 59.41% (S.D.=+/-52.12%) to the total carbon biomass due to its higher particulate organic carbon per chlorophyll-a unit during the two cruises in 2004. In the Chukchi Sea, the average contributions of small phytoplankton to carbon and total nitrogen (nitrate+ammonium) uptake rates were 31.72% (S.D.=+/-23.59%) and 37.31% (S.D.=+/-26.06%), respectively.

원발성 간암에서 PIVKA-II 및 Lens Culinaris Agglutinin-A 반응성 Alpha-fetoprotein(AFP-L3)의 임상적 유용성

배시현,박두호,양진모,박영민,차상복,최종영,성광용,조세현,정규원,선희식,김부성,최상욱,변병훈,한남익 대한간학회 2000 Clinical and Molecular Hepatology(대한간학회지) Vol.6 No.2

Background/Aims: Des-γ-carboxy prothrombin(DCP), a protein induced by vitamin K absence or antagonist-II(PIVKA-II), and Lens culinaris agglutinin-A reactive AFP-L3 have been reported to be useful markers for the diagnosis of hepatocellular carcinoma (HCC). In the present study, both the PIVKA-II and AFP-L3 were analyzed and compared with a conventional AFP to determine its usefulness, specificity and sensitivity in the diagnosis of HCC. Methods: Sera were collected from 108 patients consisting of 17 patients with chronic hepatitis, 22 patients with liver cirrhosis and 69 patients with HCC. The AFP-L3 was determined by an lectin affinity electrophoresis coupled with an antibody-affinity blotting. Level of DCP was measured by an enzyme immunoassay with an anti-DCP monoclonal antibody. Results: The sensitivity and specificity of PIVKA-II and AFP L3 were 49.3% and 89.5%, and 32.5% and 85.7%, respectively. No significant correlation was found between the PIVKA-II or AFP L3 and serum AFP. No correlation was found etween the PIVKA-II or AFP L3 and the characteristics of HCC. Conclusion: The determination of plasma DCP and AFP L3 levels combined with AFP levels may be useful especially for the differential diagnosis between HCC and chronic liver diseases without HCC.(Korean J HepatoBackground/Aims: Des-γ-carboxy prothrombin(DCP), a protein induced by vitamin K absence or antagonist-II(PIVKA-II), and Lens culinaris agglutinin-A reactive AFP-L3 have been reported to be useful markers for the diagnosis of hepatocellular carcinoma (HCC). In the present study, both the PIVKA-II and AFP-L3 were analyzed and compared with a conventional AFP to determine its usefulness, specificity and sensitivity in the diagnosis of HCC. Methods: Sera were collected from 108 patients consisting of 17 patients with chronic hepatitis, 22 patients with liver cirrhosis and 69 patients with HCC. The AFP-L3 was determined by an lectin affinity electrophoresis coupled with an antibody-affinity blotting. Level of DCP was measured by an enzyme immunoassay with an anti-DCP monoclonal antibody. Results: The sensitivity and specificity of PIVKA-II and AFP-L3 were 49.3% and 89.5%, and 32.5% and 85.7%, respectively. No significant correlation was found between the PIVKA-II or AFP-L3 and serum AFP. No correlation was found etween the PIVKA-II or AFP L3 and the characteristics of HCC. Conclusion: The determination of plasma DCP and AFP-L3 levels combined with AFP levels may be useful especially for the differential diagnosis between HCC and chronic liver diseases without HCC.(Korean J Hepatol 2000;6:205-214)l 2000;6:205-214)

Cation-Dependent Intrinsic Electrical Conductivity in Isostructural Tetrathiafulvalene-Based Microporous Metal–Organic Frameworks

Park, Sarah S.,Hontz, Eric R.,Sun, Lei,Hendon, Christopher H.,Walsh, Aron,Van Voorhis, Troy,Dincă,, Mircea American Chemical Society 2015 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.137 No.5

<P>Isostructural metal–organic frameworks (MOFs) M<SUB>2</SUB>(TTFTB) (M = Mn, Co, Zn, and Cd; H<SUB>4</SUB>TTFTB = tetrathiafulvalene tetrabenzoate) exhibit a striking correlation between their single-crystal conductivities and the shortest S···S interaction defined by neighboring TTF cores, which inversely correlates with the ionic radius of the metal ions. The larger cations cause a pinching of the S···S contact, which is responsible for better orbital overlap between p<SUB><I>z</I></SUB> orbitals on neighboring S and C atoms. Density functional theory calculations show that these orbitals are critically involved in the valence band of these materials, such that modulation of the S···S distance has an important effect on band dispersion and, implicitly, on the conductivity. The Cd analogue, with the largest cation and shortest S···S contact, shows the largest electrical conductivity, σ = 2.86 (±0.53) × 10<SUP>–4</SUP> S/cm, which is also among the highest in microporous MOFs. These results describe the first demonstration of tunable intrinsic electrical conductivity in this class of materials and serve as a blueprint for controlling charge transport in MOFs with π-stacked motifs.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/2015/jacsat.2015.137.issue-5/ja512437u/production/images/medium/ja-2014-12437u_0005.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ja512437u'>ACS Electronic Supporting Info</A></P>

Rational Design of Low Cost and High Energy Lithium Batteries through Tailored Fluorine-free Electrolyte and Nanostructured S/C Composite

Agostini, M.,Lim, D.-H.,Sadd, M.,Hwang, J.-Y.,Brutti, S.,Heo, J. W.,Ahn, J. H.,Sun, Y. K.,Matic, A. Wiley (John WileySons) 2018 ChemSusChem Vol.11 No.17

<P>We report a new Li-S cell concept based on an optimized F-free catholyte solution and a high loading nanostructured C/S composite cathode. The Li2S8 present in the electrolyte ensures both buffering against active material dissolution and Li+ conduction. The high S loading is obtained by confining elemental S (approximate to 80%) in the pores of a highly ordered mesopores carbon (CMK3). With this concept we demonstrate stabilization of a high energy density and excellent cycling performance over 500 cycles. This Li-S cell has a specific capacity that reaches over 1000 mA hg(-1), with an overall S loading of 3.6 mg cm(-2) and low electrolyte volume (i.e., 10 mu L cm(-2)), resulting in a practical energy density of 365 Wh kg(-1). The Li-S system proposed thus meets the requirements for large scale energy storage systems and is expected to be environmentally friendly and have lower cost compared with the commercial Li-ion battery thanks to the removal of both Co and F from the overall formulation.</P>

China Spallation Neutron Source: Accelerator Design Iterations and R&D Status

J. Wei,C.-D. Deng,C.-H. Wang,C.-T. Shi,H. Sun,H.-F. Ouyang,H.-M. Qu,H.-Y. Dong,J. Li,J. Zhang,J.-S. Cao,J.-Y. Tang,L. Dong,L.-L. Wang,Q. Qin,Q.-B. Wang,S. Wang,S.-N. Fu,S.-X Fang,T. -G. Xu,W. Kang,Y.- 한국물리학회 2007 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.50 No.I

The China Spallation Neutron Source (CSNS) is a high-power, accelerator-based project currently under preparation. The accelerator complex consists of an H$^-$ ion source, an H$^-$ linac, a rapid-cycling proton synchrotron, and the transport lines. During the past year, the design of most accelerator systems went through major iterations, and initial research and developments was started on the prototyping of several key components.

Effects of phosphorus on the δ-Ni₃Nb phase precipitation and the stress rupture properties in alloy 718

Sun,W.R.,Lee,J.H.,Guo,S.R.,Yoo,Y.S.,Choe,S.J.,Park,N.K.,Hu,Z.Q. 창원대학교 공작기계기술연구센터 1999 연구업적집 Vol.1 No.1

The effects of phosphorus on the phase transformation and stress rupture properties of alloy 718 were investigated. The nucleation of δ- phase, which does not contain phosphorus, was suppressed by the enrichment of phosphorus at grain boundaries. A low level of phosphorus resulted in the formation of faults-containing film-like δ- phase along the grain boundaries, while a higher level of phosphorus favored the long lath-like δ- phase precipitation. Phosphorus greatly prolonged the stress rupture life of the alloy in the range of 0.0008-0.013 wt.% while it reduced the stress rupture life in the range of 0.013-0.049 wt.% The effect of phosphorus in the stress rupture properties was closely related to its interaction with oxygen. Phosphorus atoms, in the range of 0.0008-0.013 wt.%, enhanced the resistance to oxygen intrusion along the grain boundaries, protected the grain boundaries from decohesion by oxygen atoms and oxidation, and subsequently prolonged the rupture life of the alloy. The protection effect of p is clearly demonstrated by the phenomenon that the crack initiation site was shifted from the surface to the center in the stress-ruptured samples with increasing addition of P. Over 0.013 wt.%, the protection effect of phosphorus is excessive and phosphorus began to display its inherent effect of damaging the grain boundary strength ; the stress rupture life of the alloy was reduced accordingly. Maximum stress rupture life was thus obtained at ∼0.013 wt.% P ⓒ 1998 Elsevier Science S.A. All rights reserved.

INFLUENCE OF ENDOGENOUS SOMATOSTATIN ON LACTATION IN RATS

Sun, S.S.,Myung, K.H.,Spencer, G.S.G. Asian Australasian Association of Animal Productio 1996 Animal Bioscience Vol.9 No.3

The role of endogenous somatostatin on lactation in rats was examined by passive immuno-neutralization of Wistar rats. In one study, the rats were given either immunoglobulin raised in sheep against somatostatin, or non-specific sheep immunoglobulins by daily s.c. injection from parturition through the first two weeks of lactation. The growth of the pups was recorded by weighting every second day, and the milk yield calculated from the pup weight and weight gain. Immunoneutralization of maternal somatostatin during pregnancy had a slight effect (p < 0.05) on the mean birth weight of the pups but no subsequent effect on postnatal growth rate of the pups or milk yield ($25.32{\pm}0.88g/day$) compared with young control rats given normal sheep serum ($25.55{\pm}1.04g/day$). Similarly, passive immunization against somatostatin during lactation ($21.96{\pm}1.57g/day$) also did not affect milk yields compared with controls ($24.85{\pm}1.03g/day$). These data do not support a significant role for endogenous somatostatin in regulating milk production in lactating rats.

Expression of cancer-associated fibroblast-related proteins in thyroid papillary carcinoma

Sun, W. Y.,Jung, W. H.,Koo, J. S. Springer Science + Business Media 2016 TUMOR BIOLOGY Vol.37 No.6

<P>The purpose of this study was to evaluate the association between expression of cancer-associated fibroblast (CAF)-related proteins in papillary thyroid carcinoma (PTC) and clinicopathologic factors. Using tissue microarray (TMA) constructed from 339 cases of PTC (303 classic type, 36 follicular variant), we performed immunohistochemical staining for podoplanin, prolyl 4-hydroxylase, FAP alpha, S100A4, PDGFR alpha, PDGFR beta, NG2, 5-meC, and BRAF V600E and evaluated the association with clinicopathologic parameters. We classified the stroma of PTC as desmoplastic type, sclerotic type, pauci type, or inflammatory type. The expression of prolyl 4-hydroxylase (p = 0.042), FAP alpha (p = 0.044), PDGFR alpha (p < 0.001), and 5-meC (p = 0.030) in cancer cells differed according to the histologic subtype, higher in classic type than follicular type. The expression of FAP alpha (p = 0.034) and 5-meC (p = 0.021) in stromal cells was higher in the classic type than follicular type. PTC with BRAF mutation showed higher expression of podoplanin (p < 0.001), prolyl 4-hydroxylase (p = 0.013), FAP alpha (p < 0.001), S100A4 (p < 0.001), PDGFR alpha (p < 0.001), and 5-meC (p < 0.001) in the tumor cell compartment and of FAP alpha (p = 0.004), S100A4 (p < 0.001), PDGFR alpha (p = 0.002), PDGFR beta (p < 0.001), and 5-meC (p < 0.001) in the stromal cell compartment. There was also a difference in the expression of CAF-related proteins according to stromal phenotype; the expression of FAP alpha, S100A4, and PDGFR alpha was higher in desmoplastic type than in other subtypes, whereas NG2 expression was higher in inflammatory type (p < 0.001). Tumoral podoplanin negativity (p = 0.043) was associated with shorter DFS, and tumoral S100A4 positivity (p = 0.044) and stromal PDGFR beta positivity (p = 0.035) were associated with shorter OS. In conclusion, the expression of CAF-related proteins in cancer cells and stromal cells of PTC was different according to histologic subtype, BRAF V600E mutation, and subtype of stroma, and was related to prognosis.</P>

Dietary Foeniculum vulgare Mill extract attenuated UVB irradiation-induced skin photoaging by activating of Nrf2 and inhibiting MAPK pathways

Sun, Z.,Park, S.Y.,Hwang, E.,Park, B.,Seo, S.A.,Cho, J.G.,Zhang, M.,Yi, T.H. G. Fischer 2016 Phytomedicine Vol.23 No.12

<P>Background: Foeniculum vulgare Mill (FV) has long been prescribed in traditional medicine due to its antioxidant anti-inflammatory properties. However, little research has been done on the use of FV to alleviate changes in UVB-induced photoaging Purpose: This study was to investigate the photoprotective effects and mechanism of FV in vitro and in vivo. Methods: The anti-photoaging effect of FV was assessed in normal human dermal fibroblasts (NHDFs) in vitro. The secretion of reactive oxygen species (ROS), lactate dehydrogenase (LDH), GSH, matrix metalloproteinases (MMPs), procollagen type I, IL-6 and transforming growth factor-beta 1 (TGF-beta 1) were measured by kits. Additionally, the level of nuclear factor (erythroid-derived 2)-like 2 (Nrf2), p-ERK and p38 were evaluated by western blotting. In vivo, H&E and Masson's trichrome staining were employed. The expression of MMP-1, procollagen type I, TGF-beta 1 and elastin were measured by western blot. Results: FV significantly increased the production of collagen, elastin and TGF-beta 1 levels, while blocked matrix metalloproteinases (MMPs) production in UVB irradiation induced hairless mice, which were consistent with the result in NHDFs. Furthermore, FV dose-dependently decreased the production of ROS and LDH by promoting the nuclear amount of Nrf2 and enhancing the expression of cytoprotective antioxidants such as GSH. FV also significantly quenched UVB-induced phosphorylation of ERK and p38 in NHDFs. Conclusion: Our results indicate that FV is a potential botanical agent for the treatment of skin damage induced by UV irradiation. (C) 2016 Elsevier GmbH. All rights reserved.</P>

Effect of Lansoprazole on 24 Hour Intragastric pH and Acid Secretion in Peptic Ulcer Patients and Healthy Volunteers

Na, J. S 大韓臨床藥理學會 1997 臨床藥理學會誌 Vol.5 No.1