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      • Combination treatment for onychomycosis using 1,064 Nd:YAG laser and efinaconazole 10% topical solution

        ( Sang Ju Lee ),( Dong Woo Suh ),( Won Soon Chung ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.2

        Background: Onychomycosis is one of the most common nail disease around the world. No specific treatment other than drug therapy and surgery was suggested till present. Systemic antifungal drugs for onychomysosis are effective. However, they require a long treatment time and not suitable for people with other systemic disease. Furthermore, they may cause many side effects such as liver disease. Also, many patients prefer topical drugs or physical treatment. Objectives: The objective of this study was to evaluate the efficacy of combination treatment with a 1064 Nd:YAG laser and efinaconazole 10% Topical Solution. Methods: Ten patients with onychomycosis were treated with 1064 Nd:YAG laser (PinPointe FootLaser, Cynosure, Westford, MA, USA) once a month with application of 10% eifnaconazole solution(Jublia, Dong-A EST) once a day. The effectiveness of treatment were evaluated with before and after photographs. Results: Improvement were shown in 90% of patients after the treatment. However, 10% of patients had no response. Conclusion: This clinical study suggests that combination treatment of a 1064 Nd:YAG laser and efinaconazole 10% Topical Solutionis an effective, safe, and convenient treatment method for onychomycosis.

      • Combination treatment for onychomycosis using 1,064-Nd:YAG laser and efinaconazole 10% topical Solution

        ( Sang Ju Lee ),( Dong Woo Suh ),( Won Soon Chung ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1

        Onychomycosis is one of the most common nail disease around the world. No specific treatment other than drug therapy and surgery has been suggested till present. Systemic treatment with antifungal drugs for onychomysosis is effective. However, a long treatment time is required and it is not suitable for people with other systemic disease. Furthermore, it may cause many side effects such as liver diseases. For that reasons, topical drugs or physical treatments are preferred by many patients. Recently laser treatment for onychomycosis has been proposed. The efficacy of treatment is less than systemic drugs but, laser is more convenient, safe and accessible in treatment. As a result, the combination therapy using 1064 Nd:YAG laser and efinaconazole 10% topical solution was performed. Two patients with onychomycosis were treated with 1064 Nd:YAG laser (PinPointe FootLaser, Cynosure, Westford, MA, USA) once a month with application of 10% eifnaconazole solution(Jublia, Dong-A EST) once a day. All three patients were treated successfully. We considered a combination treatment of a 1064 Nd:YAG laser and efinaconazole 10% topical solutions would be an effective, safe, and convenient treatment method for onychomycosis.

      • Alkylhalide가 Mouse의 LDH isozyme 분포에 미치는 영향 : Cellulose Acetate Electrophoresis Method

        권미경,김영옥,박은주,이동화,이명미,이문희,이양자 曉星女子大學校 藥學大學 學生會 1988 曉星藥誌 Vol.4 No.-

        The effect of Carbontetrachloride administration on Lactatedehydrogenase isozyme patterns were analyzed by cellulose acetate electrophoresis for the brain, heart, kidney, lung, liver and mouse muscle. Each other tissue was found to have a characteristic distribution of these isozymes. At normal condition, aerobic tissue such as brain, heart, kidney, and lung were found to have all five isozymes from LDH_1 to LDH_5, while anaerobic tissues such as liver and muscle were found to have superiorly LDH_5 The toxicity of Carbontetrachloride administration was most prominence in the liver, and lung toxicity was occured also.

      • KCI등재

        열공형과 비열공형 피질하 혈관성 치매에서 위험인자의 차이에 관한 비교 연구

        배희준,정지향,유경호,나덕렬,김상윤,최경규,양동원,손의주,이상도,김재우,박경원,김응규,이재홍,박미영,한일우,함동석,최문성,하충건,최성혜,이애영,이병철,한설희 대한치매학회 2003 Dementia and Neurocognitive Disorders Vol.2 No.2

        Backgrounds and Objectives: Vascular dementia is a group of dementing disoders arising from various stroke syndrome. Among these. subcortical ischemic vascular dementia (SIVD) is regarded as a relatively distinct clinical entity. However, MRI patterns of SIVD are not homogenous. In some patients, lacunes are dominant, and in others, subcortical white matter changes are. This study was designed to compare risk factor profiles between SIVD with and without multiple lacunes. Methods: We divided 47 subjects (22 males, mean age. 68 years) recruited from VADAPET (Multicenter Trial For Evaluation Of The Changes In the PET Images Of Subcortical Vascular Dementia Patient) study into two groups one with more than 5 lacunes in deep gray matter (lacune group) and the other with 5 or less(non-lacune group) Clinical characteristics and laboratory findings of two groups were compared. Results: Nineteen of 47 patients (40%) belonged to the lacune group. The lacune and non-lacune groups d d not differ in the following variables: age, hypertension, diabetes mellitus, hyperlipidemia heart disease, history of stroke or TIA, history of trauma or major surgery, family history of hypertension stroke, or dementia, age at diagnosis of dementia, body mass index, white blood cell count, ESR, CRP, fibrinogen, hemoglobin A1C, total cholesterol. LDL cholesterol creatinine, proteinuria, glucosuria, and microhematuria. However, male sex, smoking alcohol. hemoglobin, and HDL cholesterol were possibly associated more with lacune group SIVD than with non-lacune group (p<0 1) Multivariate analyses revealed that smoking, hemoglobin, and HDL cholesterol were independent predictors of SIVD with multiple lacunes Conclusion: Our study suggests that SIVD with multiple lacunes may be significantly different in smoking habits hemoglobin, and HDL cholesterol from SIVD without multiple lacunes.

      • 인진쑥(Artemisia iwayomogi) 올리고당류(AIP1)의 기능성 탐색

        이동석,최현주,윤현주 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.2

        Objective: We examined the effects of the AIPI on the cell apoptosis, colonal and pathogenic microbial activities in vitro, and glycemic controls in vivo. Methods and Materials: The oligosaccharide fraction AIPI was isolated and purified from Artemisia iwayomogi by the aqueous extraction and gel filtration chromatography. Results: In the experiment of murine macrophage culture, the AIPI decreased the apoptotic cell death. In the mircrobiological experiments of the Bifidobacterium and Lactobacillus from the human intestine, the AIPI stimulated these colonal microbialactivities. However, the AIPI showed a strong inhibition against activities of the Listeria monocytogenes and Klebsiella pneumoniae in the experiments of the agar-diffusion and the estrase-FDA. In the animal experiment, the AIPI lowered the blood glucose curves of the glucose tolerance test in the diabetic rats. Conclusion: It is concluded that the oligosaccharide fraction AIPI from the Artemisia lwayomogi may have several beneficial functions as an immune booster, colonal probiotics, antimicrobial agent, and glucose intolerance alleviatin-biohealth material.

      • 미세가공 시스템을 이용한 미세 그루브 가공실험

        이선우,이동주,이응숙,제태진 한국공작기계학회 2001 한국공작기계학회 춘계학술대회논문집 Vol.2001 No.-

        The needs for precision machining of micro to milli parts have been increased as the industry require high quality products, especially for the micro-machining of IT products. The ultra-precision machining system is essential for the micro machining of fine structures, which insures machining accuracy, low systematic and random error and repeatability. In this study, we developed micro machining system, which is equipped with air bearing stage for ultra precision machining and also we present the results of V-grooving experiments, conducted by the developed system, to verify the performance of system. The results show that the machined V-grooving had good accuracy with repeatable stability.

      • 밸브 벽면과 제트의 부착효과로 인한 질량유량 감소에 관한 연구

        이성호 ; 임동주 김천대학교 1999 김천대학교 논문집 Vol.20 No.-

        Flow characteristics of a compressible gas flow through a rotating disc-type rotary valve are investigated experimentally under various conditions. It is known that the mass flow rate through poppet valves of 4-stroke cycle engines and through piston valves of 2-stoke cycle engines decrease with increase in engine speed. Rotary valve is one means by which air may be made to flow intermittently through a pipe. In this paper an exhaust system simulator of engine was used to experimentally analyze the decrease in flow rate at high rotation speeds and to determine what variables, other than rotational speed, give rise to the observed behaviour. These variables have been included in an empirical equation which is representative of the measured flow characteristics.

      • KCI등재

        인의 흡착능 평가를 통한 인공습지 하수처리 시스템의 여재 선발

        이홍재,서동철,조주식,허종수 한국환경농학회 2003 한국환경농학회지 Vol.22 No.2

        인공습지 하수처리장이 축적되어 하수처리장 수명의 제한인자로 작용하는 인의 포화치를 조사하기 위해 여재 입경별 최대 인 흡착능을 조사하여 최적의 여재를 선정하였고, 또한 유기물과 굴패각의 인 흡착제로서 사용가능 여부를 조사하기 위해 최대 인 흡착능을 조사하였다. 그리고 인공습지 하수처리장에서 하수처리장의 수명을 연장하기 위한 방안을 검토하기 위해 여재별로 흡착제인 유기물 양을 달리하여 최대 인 흡착능을 조사하였고, 최적으로 선정된 여재에 Ca, Mg, Al, Fe 및 굴패각 첨가에 따른 최대 인 흡착능을 조사하였다. 여재 입경별 최대 인 흡착능을 조사한 결과 여재 입경이 작아질수록 최대 인 흡착능이 증가하는 경향으로 여재 대(4~10 mm), 중(2~4 mm) 및 소(0.1~2mm)의 최대 인 흡착능은 각각 8, 10 및 22mg/kg로서 여재 입경이 0.1~2 mm인 여재소(C)가 최적의 여재이었고, 유기물과 굴패각의 최대 인 흡착능을 조사한 결과 유기물이 1,000 mg/kg 및 굴패각이 833 mg/kg이었다. 입경별 여재에 유기물을 첨가하였을 경우 모든 여재에서 유기물 첨가량이 증가할수록 최대 인 흡착능이 점점 증가하였다. 따라서 인공습지 하수처리장에서 수초에 의해 쌓여 부식된 유기물은 인의 흡착능을 증가시켜 인 처리능력을 향상시킬 수 있을 것이라 사료되었다. 최적 여재인 여재 소(C)에 Ca, Mg, Al 및 Fe를 첨가하였을 경우 모든 조건에서 첨가량이 증가할수록 최대 인 흡착능도 점점 증가하였으며, 특히 Ca 0.1% 첨가시 인 흡착능이 885 mg/kg으로 급격히 증가하였다. 굴패각을 여재에 첨가하여 흡착능을 조사한 결과 굴패각을 2% 첨가시 인 흡착능이 약 22 mg/kg에서 약 36 mg/kg으로 약 14 mg/kg이 증가하였다. The phosphorus(P) adsorption capacities of various filter media were investigated in relation to the size and types of filter media to screen the optimum condition. The objective of this study was to evaluate the constructed wetland longevity by improving P adsorption capacity. The maximum P adsorption capacities of filter media A(4∼10 ㎜), B(2∼4 ㎜) and C(0.l∼2 ㎜) were 8, 10 and 22 ㎎/㎏, respectively, showing those increased as the filter media size decreased. Among the experimental media, the optimum filter media size was 0.1-2 ㎜. When the filter medium was supplemented with organic materials which were piled up and decayed in the constructed wetland, the P adsorption capacity was significantly enhanced. Under the conditions of optimum filter media size, the respective maximum P adsorption capacities of filter media C when supplemented with Ca, Mg, Al and Fe were higher than that of filter media C. However the addition of Ca, Mg, Al and Fe to constructed wetland were not recommended because of the possibility of their secondary pollution. The maximum P adsorption capacity of filter media C was 22 ㎎/㎏, but this was increased to 36 ㎎/㎏ when filter media C was supplemented with 2% oyster shell.

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