음성 인식 헬스케어 시스템

신진우,조우승,조성빈,김재훈,정지은,사예지,백경동,박동규 순천향대학교 부설 산업기술연구소 2021 순천향 산업기술연구소논문집 Vol.27 No.2

As modern people's interest in health grows, wearable healthcare-related technologies that can collect biometric information and receive health-related services regardless of time and place are developing. This paper proposes the healthcare system based on voice recognition function. Unlike conventional wearable healthcare systems, the proposed system provides real-time telemedicine and diagnosis and the direct connection with doctors is possible through it. And almost all functions of the application in it are operated with voice commands to lower user access barriers. Because it deals with personal information including medical information, encryption algorithms have been applied between all data movements. Finally, the healthcare system proposed in this paper is expected to increase convenience in health care and reduce the medical gap.

다중센서 환경에서 공중표적 데이타의 연계

정진영,우영운,고봉홍,김재희,홍인표,조동래 연세대학교 산업기술연구소 1994 논문집 Vol.26 No.2

In the system using one sensor, to describe accurate situation or conclude from information of one source in difficult. Moreover, sensor noise degrades the belief of decision. Multisensor information system, however, can increase the belief of date by imploying more than one source of information simultaneously. Another advantage of the system is that it can accomplish its task with other sources of information when one source malfunctions. In this paper, we implemented data association methods to identity moving flight targets using distance, probability theory, Dempster-Shafter theory for the low level process in the information fusion system. Data association is to classify information from various sources into data groups depending for the same flight object. Times and errors of these data association methods are analyzed.

하수방류수의 자외선 살균을 위한 설계인자 최적화에 관한 연구

신동호,김진현,김정민,고승민,모효원,이용택 한국공업화학회 2004 응용화학 Vol.8 No.2

피부 양성 혈관 병변의 임상 및 병리 조직학적 연구

고재향,진훈,신동환,이광길 대한병리학회 1995 Journal of Pathology and Translational Medicine Vol.29 No.3

BioSMACK: a Linux Live CD for genome-wide association analyses

( Chang Bum Hong ),( Young Jin Kim ),( Sang Hoon Moon ),( Young Ah Shin ),( Min Jin Go ),( Dong Joon Kim ),( Jong Young Lee ),( Yoon Shin Cho ) 생화학분자생물학회 (구 한국생화학분자생물학회) 2012 BMB Reports Vol.45 No.1

Recent advances in high-throughput genotyping technologies have enabled us to conduct a genome-wide association study (GWAS) on a large cohort. However, analyzing millions of single nucleotide polymorphisms (SNPs) is still a difficult task for researchers conducting a GWAS. Several difficulties such as compatibilities and dependencies are often encountered by researchers using analytical tools, during the installation of software. This is a huge obstacle to any research institute without computing facilities and specialists. Therefore, a proper research environment is an urgent need for researchers working on GWAS. We developed BioSMACK to provide a research environment for GWAS that requires no configuration and is easy to use. BioSMACK is based on the Ubuntu Live CD that offers a complete Linux-based operating system environment without installation. Moreover, we provide users with a GWAS manual consisting of a series of guidelines for GWAS and useful examples. BioSMACK is freely available at http://ksnp.cdc. go.kr/biosmack. [BMB reports 2012; 45(1): 44-46]

동계 서해의 해황과 기상인자와의 관계

고우진,김상우,김동선,Go Woo-Jin,Kim Sang-Woo,Kim Dong-Sun 해양환경안전학회 2006 해양환경안전학회지 Vol.12 No.1

동계 서해에서 해황과 기상인자와의 상호 관련성에 대해서 조사하였다. 수온의 수평분포는 수심이 얕은 연악역이 외해역보다 저수온으로 12월과 2월사이에 외해역에서 $3^{\circ}C$, 연안역에서는 $6^{\circ}C$ 정도의 큰 수온 하강을 보였다. 염분의 분포는 북쪽해역이 연안역과 남쪽해역보다 저농도를 보였다. 또한, 하계에 남북방향으로 형성되었던 등염선이 동계에는 북서에서 남동 방향으로 형성한다. 한국 서해연안의 기온과 연안의 표층수온 사이에는 기온이 상승하면 수온이 상승하고 기온이 하강하면 수온도 하강하는 정의 상관관계를 보인다. 서해 외해의 표층수온은 잠열속과 현열속에 의한 해양에서의 방출열량과 역의 상관관계를 보인다. 동계 서해 연안지역 기온과 연안역 표층염분과의 관계는 기온이 상승하면 연안역의 염분이 증가하고, 수온이 하강하면 염분이 낮아지는 정의 상관관계를 보인다. 또한 서해의 하계($6{\sim}9$월) 강수량은 10월과 12월보다 다음해 동계 2월의 염분분포에 크게 영향을 미치고 있다. This study was conducted to find out the effects of meterological factors on oceanic conditions when cold and dry continental air mass passes through the western sea of Korea The change of ocean conditions during the winter season were more obvious in coastal area than open sea And sea surface temperature (SST) during February is lower by $3^{\circ}C$ than December but in coastal area SST dropped by $3^{\circ}C$. As for the salinity, there was not much difference between areas except southern area of Mokpo. In the coastal regions, air temperature(AT) and SST showed a positive correlation; as the air temperature goes up with the increase of SST and when the former goes down the latter decrease. SST of open sea seems to be changed by latent (Qe) and sensible heat (Qs), when the open sea lose its heat by Qe and Qs then SST goes down And when they get the heat then the SST goes up. 1here was a positive correlation between the AT of the coastal region and sea surface salinity (SSS), when the AT goes up then SSS increase and when the former goes down the latter decrease. Precipitation during the summer seasons (June$\sim$September) appeared to the more closely related with salinity of February of the following year than those of October and December.

Pivotal factors for successful withdrawal of nonsteroidal anti-inflammatory drugs in rheumatoid arthritis patients in remission or with low-disease activity

Go, Dong Jin,Shin, Kichul,Baek, Han Joo,Kang, Seong Wook,Kang, Young Mo,Jun, Jae Bum,Lee, Yun Jong,Park, Sung Hwan,Song, Yeong Wook AMB ACTA MEDICA BELGICA 2018 CLINICAL RHEUMATOLOGY Vol.37 No.2

<P>The purpose of this study is to examine the patient-reported outcomes (PRO) after discontinuing nonsteroidal anti-inflammatory drugs (NSAIDs) and clinical factors associated with a favorable outcome in patients with rheumatoid arthritis (RA) in remission or with low-disease activity (LDA). A 16-week prospective open-label trial was conducted at eight rheumatology clinics in Korea. RA patients with 28-joint disease activity score based on erythrocyte sedimentation rate (DAS28-ESR) < 3.2 who were on NSAIDs for more than a month were enrolled, and NSAIDs were discontinued. Acetaminophen (AAP) was used as the rescue medication, and NSAIDs were restarted when joint pain was intolerable with AAP. The endpoint was to analyze the group of patients who continued to withdraw NSAIDs. Among 109 enrolled patients, 105 completed the 16-week follow-up. Eighty-nine (84.8%) patients remained without restarting NSAIDs. In these patients, there was a slight increase in their pain levels compared with baseline (median 14.0 versus 19.0 using the pain-visual analog scale, p = 0.010). However, changes in DAS28-ESR (p = 0.638) and routine assessment of patient index data 3 (RAPID-3) (p = 0.128) were insignificant. Moreover, 66 (62.9%) patients showed sustained effectiveness on PRO without restarting NSAIDs. In the multivariate regression models, joint swelling was the detrimental factor in NSAID withdrawal (odds ratio [OR] 0.149, 95% confidence interval [CI] 0.033-0.680, p = 0.014) and sustained effectiveness (OR 0.284, 95% CI 0.091-0.883, p = 0.030). Joint pain in RA patients in remission or with LDA can be well managed without NSAIDs, especially in those without swollen joints at the time of cessation.</P>

Effect of Genetic Predisposition on Blood Lipid Traits Using Cumulative Risk Assessment in the Korean Population

Go, Min-Jin,Hwang, Joo-Yeon,Kim, Dong-Joon,Lee, Hye-Ja,Jang, Han-Byul,Park, Kyung-Hee,Song, Ji-Hyun,Lee, Jong-Young Korea Genome Organization 2012 Genomics & informatics Vol.10 No.2

Dyslipidemia, mainly characterized by high triglyceride (TG) and low high-density lipoprotein cholesterol (HDL-C) levels, is an important etiological factor in the development of cardiovascular disease (CVD). Considering the relationship between childhood obesity and CVD risk, it would be worthwhile to evaluate whether previously identified lipid-related variants in adult subjects are associated with lipid variations in a childhood obesity study (n = 482). In an association analysis for 16 genome-wide association study (GWAS)-based candidate loci, we confirmed significant associations of a genetic predisposition to lipoprotein concentrations in a childhood obesity study. Having two loci (rs10503669 at LPL and rs16940212 at LIPC) that showed the strongest association with blood levels of TG and HDL-C, we calculated a genetic risk score (GRS), representing the sum of the risk alleles. It has been observed that increasing GRS is significantly associated with decreased HDL-C (effect size, $-1.13{\pm}0.07$) compared to single nucleotide polymorphism combinations without two risk variants. In addition, a positive correlation was observed between allelic dosage score and risk allele (rs10503669 at LPL) on high TG levels (effect size, $10.89{\pm}0.84$). These two loci yielded consistent associations in our previous meta-analysis. Taken together, our findings demonstrate that the genetic architecture of circulating lipid levels (TG and HDL-C) overlap to a large extent in childhood as well as in adulthood. Post-GWAS functional characterization of these variants is further required to elucidate their pathophysiological roles and biological mechanisms.

Poster Session : PS 0694 ; Rheumatology ; Appearance of Psoriasis after TNF-a Blocker and Use of Ustekinumab or Tocilizumab for Refractory Monoarthritis

( Jin Young Moon ),( Dong Jin Go ),( Jae Hyun Lee ),( Jin Kyun Park ),( Eun Bong Lee ),( Yeong Wook Song ),( Jai Il Youn ),( Eun Young Lee ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Nowadays, tumor necrosis factor-a (TNF-a) blockers are used for the treatment of RA, infi ammatory bowel diseases (IBD), ankylosing spondylitis (AS), psoriatic arthritis (PsA), and psoriasis. Paradoxically, there are some reports of appearance of psoriasis after TNF-a blockers. We report a patient who have seronegative mono-rheumatoid arthritis (mono-RA) on knee joint that experienced psoriasis after TNF-a blocker therapy (adalimumab and etanercept). For the patient, oral medication is not available due to intolerance; thus, we tried ustekinumab which is an anti-IL-12/23 monoclonal antibody that has been used to treat psoriasis. After ustekinumab injection, psoriatic skin lesions and joint symptoms were much improved in the patient. But in the following period, joint pain and swelling aggravated and synovial fi uid cytokine levels such as IL-6 and IL-17 were elevated. Treatment was changed to tocilizumab, humanized monoclonal antibody against IL-6 receptor. After injection, knee joint swelling rapidly subsided without worsening of psoriatic skin lesion.

Poster Session : PS 0751 ; Rheumatology ; Erythrocyte Sedimentation Rate Elevation Predicts Pulmonary Impairment and Overall Mortality in Dermatomyositis

( Dong Jin Go ),( Hyun Mi Kwon ),( Eun Ha Kang ),( Maximilian Konig ),( Jin Kyun Park ),( Eun Young Lee ),( Eun Bong Lee ),( Yeong Wook Song ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: Interstitial lung disease (ILD) is a major cause of death in patients with dermatomyositis (DM). Patients with clinically amyopathic dermatomyositis (CADM) in particular have an unfavorable outcome due to ILD, which is often refractory to corticosteroid therapy. Here, we defi ne the utility of the erythrocyte sedimentation rate (ESR) as a powerful marker of ILD and increased overall mortality in patients with classic DM and CADM. Methods: 114 patients with DM (28/114 with CADM) receiving clinical care from January 2004 through June 2013 were analyzed. Patients who presented with respiratory symptoms or abnormal fi ndings on chest radiography underwent high resolution computed tomography (HRCT) and pulmonary function testing. ILD was diagnosed based on HRCT. Baseline ESR and C-reactive protein (CRP) determined at presentation were correlated with markers of pulmonary function. Results: The mean age of patients at DM diagnosis was 49. 4 ± 12. 3 years. ILD was present in 53 (46. 5%) patients. Among 28 patients with CADM, 14 (50%) had ILD. Themean ESR was signifi cantly higher in patients with ILD compared to patients without ILD (49. 9 ± 23. 3 vs. 34. 4 ± 24. 1 mm/hr, p=0. 001). This difference was even more pronounced in CADM patients with ILD vs. without ILD (56. 3 ± 23. 8 vs. 25. 4 ± 22. 9 mm/hr, p=0. 002). ESR was inversely correlated with forced vital capacity (r=-0. 303, p=0. 007) and carbon monoxide diffusing capacity (r=-0. 319, p=0. 006). Baseline ESR = 30mm/hr was strongly associated with mortality (p=0. 002, by log rank test), and invariably observed in patients that died during follow-up. Conclusions: Baseline ESR elevation is associated with pulmonary impairment and increased mortality in patients with DM. Evaluating ESR should be an integral part of clinical care of DM.