결핵성 육아종에서 Thioredoxin peroxidase-2 의 발현

박근호,유형륜,정영진,윤기중,한원철,유대열,문형배 圓光大學校 醫科學硏究所 1999 圓光醫科學 Vol.15 No.2

Background: Thioredoxin peroxidase(TPX) is a kind of recently discovered antioxidant enzyme which react as rapid hydrogen ion donor for the removal of hydroperoxide. The action and distribution of the TPX was poorly understood in the human diseases. This experiments were designed for the study about the distribution of the TPX in the chronic granulomatous inflammation and about the correlation between the expression of TPX and the site of inflammation, histological activities of tuberculous inflammation or existence of mycobacterium in the inflammatory foci. Methods: The immunohistochemical stains were performed for the localization of the TPX-2 in the epithelioid cells, giant cells and lymphocytes in the chronic granulomatous inflammation. The tissue sections were obtained from the paraffin blocks of the 54 cases of tuberculosis (lung 21 cases, lymph node 12 cases, bone and soft tissue 12 cases, kidney 9 cases; active 33 cases, inactive 21 cases by the histologic classification; presence of mycobacterium 15 cases, no mycobacterium 39 cases by PCR reaction). Results: The expression of TPX-2 was 16.7% in the giant cells, 27.8% in the epithelioid cells and 100% in the lymphocytes of tuberculous inflammations. The expression of TPX-2 in the giant cells and epithelioid cells of the tuberculosis were 28.6% and 57.1% of the pulmonary tuberculosis; 33.3% in each cells of the renal tuberculosis; 0% in each cells of the lymph node or bone and soft tissue tuberculosis. The expression of TPX-2 in the giant cells and epithelioid cells were 9.1% in each cells of the active tuberculosis and were 28.6% and 57.1% in each cells of the inactive tuberculosis by histologic classification. The expression of TPX-2 in the giant cells and epithelioid cells was 40% in each cells of tuberculosis which mycobacteria were detected and the expression of TPX-2 was 7.7% and 23.1% in each cells which mycobacteria were not detected by PCR reaction in the paraffin embedded tissue. Conclusions: The above results were summarized that the TPX-2 in the giant cells and epithelioid cells were more frequently expressed in the inactive tuberculosis than in the active tuberculosis. These results suggest that the TPX-2 is a kind of regulating or suppressing factors in the activity of the tuberculosis.

아세톤-물혼합용매에서 trans-[Co(en)_2Cl_2]^+ 및 trans-[Co(1,3-pn)_2Cl_2]^+ 이온의 가용매 분해 반응에 미치는 압력과 용매조성의 영향

朴裕哲,卞鍾轍,金京美,趙靈濟 慶北大學校 物理化學硏究所 1985 硏究論文集 Vol.6 No.-

The rates of solvolysis of trans-[Co(en)_2Cl_2]^+ and trans-[Co(1,3-pn)_2Cl_2]^+, in which en and 1,3-pn are ethylenediamine and 1,3-propylenediamine resepectively, have been investigated using conductometric and spectrophotometric methods at various pressures up to 2,000 bar in acetone-water mixture. The activation volumes obtained from the pressure effect on rate constants were small and positive values in both complexes of trans-[Co(en)_2Cl_2]^+ and trans-[Co(1,3-pn)_2Cl_2]^+. These results are discussed in terms of dissociative mechanism (S_NI) for the solvolysis of both complexes. The importance of solvent composition on the reaction is further confirmed by application of a free energy cycle. It is concluded from the free energy cycle that the effect of solvation of transition state in the solvolysis of both complexes is more dominant than that of initial state. In addition to that, it is shown that the character of S_NI is further increased with increasing the content of acetone.

아세톤-물혼합용매에서 trans-[Co(en)_2Cl_2]^+ 및 trans-[Co(1,3-pn)_2Cl_2]^+ 이온의 가용매 분해 반응에 미치는 압력과 용매조성의 영향

朴裕哲,卞鍾轍,金京美,趙靈濟 慶北大學校 1984 論文集 Vol.38 No.-

The rates of solvolysis of trans-[Co(en)_2CL_2]^+ and trans- [Co(1,3-pn)_2CL_2]^+, in which en and 1,3-pn are ethylenediamine and 1,3-propylenediamine resepectively, have been investigated using conductometric and spectrophotometric methods at various pressures up to 2,000 bar in aceton-water mixture. The activation volumes obtained from the pressure effect on rate constants were small and positive values in both complexes of trans- [Co(en)_2Cl_2]^+ and trans- [Co(1,3-pn)_2CL_2]^+. These results are discussed in terms of dissociative mechanism (S_NI) for the solvolysis of both complexes. The importance of solvent composition on the reaction is further confirmed by application of a free energy cycle. It is concluded from the free energy cycle that the effect of solvation of transition state in the solvolysis of both complexes is more dominant than that of initial state. In addition to that, it is shown that the character of S_NI is further increased with increasing the content of acetone.

참당귀의 흰쥐 4-Vessel Occlusion 전뇌허혈에 대한 신경방어효과

김영옥,하니나,부영민,박선영,박주영,유영법,신준식,안덕균,김호철 대한본초학회 2002 大韓本草學會誌 Vol.17 No.2

Objectives : Angelicae Radix, the root of Angelica gigas N_AKAI (Umbelliferae) , which has been used to nourish the blood(補血), regulate menstruation(調經), relieve pain and promote bowel movements(崩漏) and activate blood circulation for the treatment of fatigue, headache, constipation and blood troubles in traditional Korean medicine. It's flavour and channel tropism is sweet(甘), pungent(辛), warm(溫), acting on the lung, heart and spleen(肺, 心, 脾). The purpose of study we report here was to determine the neuroprotective effect of Angelica gigas on global ischemia induced by 4-vessel occlusion in Wistar rats. Methods : Angelica gigas extracts was lyphilized after extraction with 85% methanol. We induced 4-VO for 10 minutes and reperfused again. The number of CA1 pyramidal neurons were counted after 7 days of reperfusion under the cresyl violet staining. Results : The results showed that Angelica gigas had significantly neuroprotective effects (100, 250 and 500mg/kg of AR extracts, p<0.001) compared with control group. Each neuroprotective ratio was about 66.1, 79.3 and 78.6% respectively. Immunohistochemical data partially explained the protective effects of Angelica gigas via attenuation of COX-2 induction in hippocampus. Conclusion : Angelica gigas gas neuroprotective effects on the global ischemia induced by 4-vessel occlusion in Wistar rats and the attenuation of COX-2 induction is thought to be its possible mechanism.

TiO₂를 이용한 아세틸렌, 프로필렌, 프로판 가스의 광촉매 산화반응

정대일,변석인,이도훈,이용균,박유미,최순규,김동현 동아대학교 환경문제연구소 2002 硏究報告 Vol.25 No.1

Photocatalyzed degradation of acetylene, propylene, and propane gases were carried out over precoated titanium dioxide(anatase) illuminated UV light in a flow reactor. photocatalytic oxidation of acetylene, propylene, and propane gases respectively indicated high conversion rates (78.0%) to CO₂gas. And photocatalytic oxidation of three gases according to a fold, twofold, and threefold of titanium dioxide(anatase) respectively gave high conversion rate. The longer reaction time was, the higher conversion rate to CO₂gas showed.

패션 전문점의 점포 이미지 차별화에 대한 소비자 인식연구

박선영,석유경,성현정,오설영,오창배,유수연,유혜선,윤성희,조영호 연세대학교 생활과학대학 1995 婦學 Vol.28 No.-

GG-25 : Validity and reliability of Korean version of female sexual function index (FSFI-6)

( Yu Mi Lee ),( Myong Cheol Lim ),( Dong Ock Lee ),( Suji Lee ),( Soo Jin Park ),( Kib Yung Park ),( Jung Nam Joo ),( Sang Yon Park ) 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.99 No.-

This study is to verify the validity and the reliability of Korean version of FSFI-6 (FSFI-6K) which is the short version of FSFI-19. This study has been approved by NCC IRB (NCCNCS-12-685). This study had been performed at outpatient department of National Cancer Center, from February 2013 to July 2013. Inclusion criteria were women 1) who are not diagnosed as cancer, 2) are above 18 years old, 3) are able to speak and understand Korean, and 4) have sexual activity within 3 months. Of 267 women who were asked to be responded whether they have sexual activity within 3 months, 47 women are disqualified. Total 220 female out-patients have participated in this study. The first primary survey was conducted and then retest was conducted 3 weeks (± 1 week) after primary survey. Of 220 women, 199 women (90.45%) responded for the retest, 18 women (8.18%) had no contact and 3 women (1.36%) refused to respond. FSFI-6 is a tool invented by Isidori et al. (2010) for measuring female sexual function and it consists of 6 domains; desire, arousal, lubrication, orgasm, satisfaction and pain. A statistics was analyzed through collecting information of 220 women (82.40%) who completed the primary survey. The result of reliability The Cronbach`s alpha which is for measuring internal consistency of each domain is 0.888 and its reliability of test-retest is 0.606. The LoevH which is for measuring homogeneity of domain is 0.652. The result of validity The translated survey questions are conducted to 30 participants as a pilot test. As there are no cases of misunderstanding of questions, translated 6 survey domains were used as it is. It appears that all of 6 domains have correlation as its correlation coefficient is 0.432-0.722 (p<.001). Korean version of FSFI-6 which has more concised questions and simpler methods of calculating points has been developed and validated. Therefore it could be used in evaluating sexuality on clinical and research field in Korean women.

블록기반 정규화 된 이미지 수 표현자

박유영(Yu-yung Park),조상복(Sang-bock Cho),이종화(Jong-hwa Lee) 大韓電子工學會 2012 電子工學會論文誌-SP (Signal processing) Vol.49 No.2

본 논문에서는 이미지 밝기와 명암을 명확하고 객관적으로 평가하기 위한 정규화된 수 표현자를 제안한다. 제안하는 수 표현자는 이미지를 구성하는 각각의 픽셀 데이터 값을 확률밀도함수(PDF)의 가중치로 사용하고 이를 정규화하여 객관적으로 표현되도록 정의되었다. 제안된 정규화 된 이미지 수 표현자는 감마보정 처리 시에 객관적인 감마 값 선택 기준을 제시하므로 적응형 감마보정처리가 가능하다. This paper describes a normalized numeric image descriptor used to assess the luminance and contrast of the image. The proposed image descriptor used the each pixel data as weighted value of the probability density function (PDF) and defined by normalization in order to objective represent. The proposed image numeric descriptor can be used to the adaptive gamma process because it suggests the objective basis of the gamma value selection.

김해신공항 정책과정의 문제점과 입지 재검토의 필요성

문유석 ( Moon Yu-seok ),박영강 ( Park Yung-kang ) 동의대학교 지방자치연구소 2017 공공정책연구 Vol.34 No.1

본 연구에서는 2017년도 조기대선이 예상되는 시점에서 대통령 공약으로 가덕도 신공항을 재검토 하는 것이 바람직한가의 여부를 밝히는데 초점을 두었다. 이를 위하여 김해신공항이 지닌 정책적 함의를 살펴보고, 부산시민을 대상으로 한 설문분석 결과를 토대로 정책제안을 시도하였다. 또한 이러한 설문분석결과를 토대로 대선이 지난 현 시점에서 바람직한 신공항의 건설을 위한 정책제안도 시도하였다. 언론기사의 분석이나 김해신공항을 둘러싼 소음문제 등을 감안할 때 박근혜 정부의 김해신공항 결정은 정책의 내용적, 절차적 측면에서 실패일 뿐만 아니라, 실제적 측면에서도 실패일 가능성이 높은 것으로 나타났다. 시민설문조사에 의하면 외국용역기관을 통한 정책결정의 신뢰성이 낮은 것으로 나타나 이러한 정책실패의 논리를 보강해주고 있다. 대선공약을 통하여 가덕도 신공항을 재추진하는 방안에 대해서는 필요 35.2%, 불필요 39.6%로 근소한 차이를 보이지만 유보의견도25.2% 수준으로 높아 공약의 필요성은 높은 것으로 나타났다. 가덕도 신공항 재추진에 대한 어려움에 대해서는 대구·경북 측에서 이의 제기나 중앙정부 혹은 정치권 등의 반대보다는 신공항 결정 이후 변화된 부산시의 도시계획 변경 등과 같은 내부적 요인이 중시되었다. 이상의 논의에 의하면 김해공항 확장 안은 박근혜 정부의 정치적 상황 하에서 이루어진 정책실패로 규정될 수 있으므로 제19대 대선 이후 정치적 상황이 바뀐 시점에서 새로운 방식의 재검토가 요청된다. 재검토에 대한 구체적인 논의는 최근 착수된 전략환경영향평가 용역과 기본계획 용역의 결과가 나타날 시점이 되겠지만, 정부로서는 더 이상 시행착오를 겪지 않도록 관련 용역절차를 공개하고 부산시와 김해시를 비롯한 이해관계자들의 의견을 충분하게 수렴해야 할 것이다. 동시에 부산시로서는 이러한 용역과정을 면밀히 살펴보고, 24시간 운항에 치명적인 문제점이 발견될 경우에는 신공항 입지의 재검토를 주장해야 할 것이다. 또한 신공항의 원활한 추진과 교통망 정비를 위해서는 부산시와 경상남도 및 울산시의 긴밀한 협력이 필요할 것이다. This study focuses on whether it is desirable to review the Gadeokdo New Airport by the Presidential pledge at the time of early presidential election in 2017. This study proposes a policy alternative through examining the policy process of the issue and the citizen survey was conducted among the airport passengers at Gimhae Airport. Given the analyses of the media reports and the noise problem surrounding the new airport in Gimhae, it is clear that the Gimhae New Airport decision by Park Geunhye government is a failure in terms of the policy content and procedure. The low credibility of the policy decision through the foreign service organization(ADPi) at the citizen survey also justifies the conclusion of this policy failure. Since the Gimhae Airport Expansion Plan can be defined as a policy failure under the political situation of the Park Geun-hye government, it is necessary to reconsider the issue under the new political situation changed since the 19th presidential election. After the Gimhae Airport Expansion Plan was decided, the internal factors of the city of Busan became more important than the external factors and the re-launch of the Gadeokdo New Airport became an policy alternative. A specific discussion of the review will begin with the outcome of the recently launched government decision. The government should disclose relevant policy procedures to avoid trial and error, and should gather opinions of stakeholders including the cities of Busan and Gimhae sufficiently. At the same time, the city of Busan should closely examine the policy process and insist on reviewing the location of the new airport if fatal problems are found with the Gimhae Airport Expansion Plan in operating 24-hours.

Case Reports : A Case of Cushing`s Syndrome in ACTH - secreting Mediastinal Paraganglioma

Hyeong Kwan Park,Chang Min Park,Kyung Heng Ko,Myung Soo Rim,Yu II Kim,Jun Hwa Hwang,Sung Chul Im,Yung Chul Kim,Kyung Ok Park 대한내과학회 2000 The Korean Journal of Internal Medicine Vol.15 No.2

Paragangliomas are unusual neuroendocrine cell tumors arising from paraganglia, of which ACTH-secreting cases in the mediastinum are exremely rare. A 51-year-old woman was admitted for generalized edema and weakness which began 5 months ago. Chest X-ray an