폐쇄성 담관질환에서 관찰되는 담소관증식의 기원에 관한 면역조직화학적 연구

성현정,안병철,이재태,금윤섭,박재복,박관규 대한병리학회 2009 Journal of Pathology and Translational Medicine Vol.43 No.2

Background : The relationship between bile duct proliferation and portal fibrosis in obstructive liver diseases remains unclear. The purpose of this study is to analyze the relationship between hepatic stellate cells (HSC), hepatocytes and bile ductule proliferation in obstructive liver disease using immunoreactivity for α-SMA (α-smooth muscle actin), CK7, and CK19. Methods : We used 20 human tissue samples with hepatic fibrosis due to intrahepatic stones and liver cirrhosis. Immunohistochemical staining was performed using the streptavidin-biotin method. Results : Proliferations of bile ductules at the periphery of the hepatic lobules, and diffuse HSC activation in the perisinusoidal spaces were observed in all cases. Immunoreactivity of the hepatocytes for CK7 and CK19 suggested a possible phenotypic transformation into bile duct epithelium during fibrogenesis. Immunohistochemical-analyses of α-SMA expression profiles showed that intralobular HSCs and some hepatocytes underwent early phenotypic changes, and that the accumulation of collagen coincides with that of α-SMA-labeled myofibroblasts around portal/septal ductular structures. Conclusions : Our results showed the possibility of a phenotypic transformation of hepatocytes into bile ductular epithelium. It is suggested that hepatocytes might play a role in bile ductule proliferation in obstructive liver disease.

The Treatment Road for Gastric Antral Vascular Ectasia in the Setting of Systemic Sclerosis

성현정,이영규,이경언 대한내과학회 2023 대한내과학회 추계학술대회 Vol.2023 No.2

코로나19 팬데믹과 중소기업의 공급망 회복탄력성에 관한 체계적 문헌 고찰: 국내외 중소기업의 글로벌 공급망 관리를 중심으로

성현정,김석수 한국국제경영관리학회 2023 국제경영리뷰 Vol.27 No.1

This study conducted systematic literature review on supply chain resilience in SMEs in the context of the COVID-19 Pandemic and provided a comprehensive understanding of insight gained, knowledge gap identified, and suggested potential areas of furture research. Based on this purpose, using a systematic research strategy, 68 articles were seleceted for this study. Each of these articles was reviewed, classified and analysed to focus on the development of literature in supply chain resilience fied and figure out the significant focal research area in this domain. The major findings are as follows : (1) the classification of articles indicated a rapidly growing number of studies in the last three years with significant focus on general industries and survey-based empirical research design. (2) This study also suggested that literature on supply chain resilience in SMEs was categorized into 4 dimensions: 1) supply chain resilience principle; 2) impact of COVID-19 pandemic on supply chain in SMEs, 3) supply chain resilience strategies in the context of the COVID-19 pandemic, 4) application of Industy 4.0 for resilience. Also, the knowledge gap was identified and the directions for future studies to inspire research at the interface of SMEs, supply chain resilience and COVID-19 pandemic. This study offers research questions and directions for further investigation, and the findings will be of great value for SMEs to enhance supply chain resilience during the uncertain business environment. 본 연구는 코로나19 팬데믹과 중소기업의 공급망 회복탄력성에 관해 2012년 1월~2022년 12월까지 게재된 중소기업 중심의 공급망 회복탄력성과 관련된 국내외 선행연구를 고찰한 후 기존연구의 한계점을 파악하여 연구범위를 설정하고 새로운 연구영역을 확장하는 데 그 목적을 둔다. 체계적인 자료선정 절차를 거쳐 최종 선택된 68편의 국내외 논문을 바탕으로 코로나19 팬데믹 이후 중소기업의 공급망 회복탄력성과 관련하여 다음과 같이 4개의 주요 연구영역인 (1) 공급망 회복탄력성의 원칙; (2) 코로나19 팬데믹이 공급망 회복탄력성에 미친 영향; (3) 코로나19 팬데믹을 통해 본 공급망 회복탄력성 구축 방법; (4) 공급망 회복탄력성과 4차 산업혁명 기술로 구분하여 정리하였다. 그 결과 현재까지 진행된 코로나19 팬데믹과 중소기업이 공급망 회복탄력성 관련 이론 연구 및 실증 연구 모두 2019년 12월 코로나 발병 이후 빠르게 진척되었고 특정 산업을 대상으로 진행한 일부 연구도 있지만, 대부분은 전체 산업에 적용 가능한 일반적인 시사점을 도출하였음을 확인하였다. 또한 코로나19 팬데믹이 중소기업 공급망에 미친 악영향을 평가하기 위해 국가별 중소기업의 코로나19 영향과 그 결과를 정리한 결과, 폐업, 대규모 해고와 원자재 부족 등 연쇄적이고 다발적인 문제가 발생하였으며 이에 대응하기 위해 혁신적인 비즈니스 모델을 채택하거나 공급망 회복탄력성을 위한 유연성과 완충 재고 보유, 디지털 전환 추진 등 공급망 복원을 위한 전략 개발연구가 주로 진행되었음을 파악하였다. 본 연구는 중소기업은 제한된 자원과 제약으로 급변하는 상황에 적극적으로 대응하기 어려워 코로나19 악영향에 직격탄을 맞을 가능성이 크지만 이를 중심으로 한 회복탄력성 전략 개발연구는 초기 단계에 불과하고 국내연구는 소수에 불과하다는 점에서 후속 연구를 통해 연구영역을 확장하기 위한 토대로 활용할 수 있을 것으로 판단된다.

코칭리더십이 창의적 행동에 미치는 영향: 심리적 임파워먼트의 매개효과

성현정,탁진국 한국산업및조직심리학회 2017 한국심리학회지 산업 및 조직 Vol.30 No.3

본 연구는 리더의 코칭 리더십과 부하의 창의적 행동의 관계를 검증하는데 목적이 있다. 또한 코칭 리더십과 창의적 행동 간의 관계에서 심리적 임파워먼트의 매개효과를 검증하였다. 연구 대상은 국내 기업의 직장인 429명을 대상으로 실시하였다. 연구 결과, 코칭 리더십은 부하의 창의적 행동에 정적인 영향을 미쳤다. 또한 심리적 임파워먼트는 코칭 리더십과 창의적 행동의 관계를 부분매개하였다. 본 연구 결과를 토대로 연구의 학문적 의의와 실무적 시사점, 제한점, 연구 제안에 대해 논의하였다.

Breast Carcinoma with Choriocarcinomatous Features: A Case Report

성현정,맹영인,김민경,이선재,강성민,봉진구,오훈규 한국유방암학회 2013 Journal of breast cancer Vol.16 No.3

Nongestational choriocarcinoma differentiation is extremely rare in breast neoplasms. It is characterized by tumor cells similar to chorionic trophoblastic cells, which react with human placental lactogen and human chorionic gonadotropin (hCG). A 56-yearold woman presented with a palpable right breast mass without past history of trophoblastic tumors. An F-18 fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) scan revealed one focus with low accumulation of FDG in the right breast (maximum standardized uptake value, 1.98). The patient underwent a right mastectomy and biopsy of sentinel nodes. Microscopically, the tumor was a typical invasive ductal carcinoma with multiple foci of choriocarcinoma features. Immunohistochemistry showed that the tumor cells resembling choriocarcinoma were positive for hCG antibody, but negative for HER2/neu, estrogen receptor, and progesterone receptor. A pathologic diagnosis of breast carcinoma with choriocarcinomatous features was made. To our knowledge, this is the first report of invasive carcinoma with choriocarcinomatous features and an unusual finding of low accumulation in an F-18 FDG PET/CT scan in Korea.

Enzymatic defluorination of fluorinated compounds

성현정,권성우,서동철,김진효,장유신 한국응용생명화학회 2019 Applied Biological Chemistry (Appl Biol Chem) Vol.62 No.5

Fluorine-containing compounds are widely used because they have properties required in textiles and coatings for electronic, automotive, and outdoor products. However, fluorinated compounds do not easily break down in nature, which has resulted in their accumulation in the environment as well as the human body. Recently, the enzymatic defluorination of fluorine-containing compounds has gained increasing attention. Here, we review the enzymatic defluorination reactions of fluorinated compounds. Furthermore, we review the enzyme engineering strategies for cleaving C–F bonds, which have the highest dissociation energy found in organic compounds.

최고경영자 팀(TMT)의 해외경험과 다양성이 기업 국제화에 미치는 영향: TMT의 직무요구 조절효과를 중심으로

성현정 한국국제경영관리학회 2019 국제경영리뷰 Vol.23 No.3

Based on Upper Echelons theory, this study considered the Top Management Team (TMT) as one of important determinations to pursue firm internationalization. Thus, we focused on the TMT's international experience and its diversity, and examined the relationship with firm internationalization, Moreover, the level of competitive pressure and the ratio of outside directors as determinants to increase the level of the TMT's job demands was used as moderating factors to demonstrate that existing relationships among TMT’s characteristics -international experience and diversity- and firm internationalization can be changed. This study organized the panel data set consisting of companies in the Korean’s electronics and automobile industries from 2013 to 2017 and conducted the GLS analysis. The result are as follows. First, the TMT’s international experience and age diversity had positive impacts on firm internationalization, whereas the diversity of the educational background had a negative impact. Second, If the level of competitive pressure is high, the relationship between the TMT’s international experience and firm internationalization has been strengthened, but rather the relationship with age diversity has been weakened. In addition, if the ratio of outside directors is high, the relationship between the TMT’s international experience and firm internationalization has been strengthened. Based on these findings, this study can provide meaningful implications in that it explains the strategic decision process on firm internationalization using the TMT’s characteristics and its job demands. 본 연구는 최고경영자 이론을 바탕으로 기업이 국제화를 추진하는 다양한 배경 중 최고경영자(CEO)나 최고경영자 팀을(TMT) 하나의 요인으로 간주하였고 특히 TMT의 해외경험과 다양성에 주목하여 기업국제화 간의 관계를 살펴보았다. 더욱이 이러한 TMT의 특성과 기업 국제화 간의 관계가 상황 요(contingent factor)인에 의해 변화될 수 있다는 전제 하에서 TMT의 직무요구 수준을 조절변수로 활용하여 실증 분석하였다. 2013년부터 2017년까지 전자산업 및 자동차 산업에 속한 기업을 대상으로 패널 데이터를 구성하여 GLS분석을 실시하였고 그 결과를 다음과 같이 정리하였다, 1) TMT의 해외경험과 연령 다양성이 기업 국제화에 긍정적인 영향을 미쳤지만 반면 교육배경의 다양성은 부정적인 영향을 미쳤다. 2) TMT의 직무요건 조절효과 검증결과, 경쟁강도가 높은 경우, TMT의 해외경험과 기업 국제화 간의 관계를 강화시키지만 오히려 연령 다양성과의 관계는 약화시켰다. 3) 또한 사외이사 비율이 높은 경우, TMT의 해외경험과 기업 국제화 간의 관계는 강화되었다. 이러한 연구결과를 바탕으로 본 연구는 TMT의 특성과 직무요구 수준을 중심으로 기업의 국제화 의사결정을 설명하였다는 점에서 의미 있는 시사점을 제시할 수 있을 것이다.

Therapeutic Trial of Bee Venom Acupuncture for Idiopathic Facial Paralysis in a Dog

성현정,박희명 한국임상수의학회 2013 한국임상수의학회지 Vol.30 No.2

A 6-year-old, castrated male Shih-tzu dog was presented due to left side facial paralysis with head tilt. Neurological examination revealed absence of facial sensation, menance response, and palpebral reflex on the left side. On magnetic resonance imaging (MRI), intracranial intra-arachnoid cyst (IIAC) was noted. The dog was poor response to steroid and dieuretic therapy. Based on characteristic historical and clinical findings, and excluding of other causes of acute facial nerve dysfunction, the dog was tentatively diagnosed as idiopathic facial paralysis. The clinical signs were improved gradually after acupuncture therapy with bee venom. Eight weeks after initial acupuncture with bee venom, the patient recovered sensory and neurological facial signs. This case report demonstrates that bee venom acupuncture for an idiopathic facial paralysis could be useful in a dog.

Primary hepatic mixed germ cell tumor in an adult

성현정,김지훈,김규래,윤신교,이재훈,강효정 대한병리학회 2021 Journal of Pathology and Translational Medicine Vol.55 No.5

Primary hepatic mixed germ cell tumor (GCT) is very rare, and less than 10 cases have been reported. We report a case of mixed GCT composed of a choriocarcinoma and yolk sac tumor, which occurred in the liver of a 40-year-old woman. A large mass was detected by computed tomography solely in the liver. Serum β-human chorionic gonadotropin (hCG) was highly elevated, otherwise, other serum tumor markers were slightly elevated or within normal limits. For hepatic choriocarcinoma, neoadjuvant chemotherapy was administered, followed by right lobectomy. Histologic features of the resected tumor revealed characteristic choriocarcinoma features with diffuse positivity for hCG in the syncytiotrophoblasts and diffuse positivity for α-fetoprotein and Sal-like protein 4 in the yolk sac tumor components. Primary malignant GCT in the liver is associated with a poor prognosis and requires specific treatment. Therefore, GCT should be considered during a differential diagnosis of a rapidly growing mass in the liver.

우리나라 기업의 국제화 수준과 경영성과에 관한 연구

성현정(Hyun-Jung Sung),정태숙(Tae-suk Jung),김석수(Seog-soo Kim) 한국무역연구원 2013 무역연구 Vol.9 No.3

In recent global market, International diversification is one of the most decisive strategies in Multinational enterprises. However MNEs now encounter a number of difficulties in internationalization diversification according to high risk of managing the overseas subsidiaries and inherent cost of foreignness. This study examined the relationship between the degree of internationalization(DOI) and the firm performance by analysing 120 Korean top manufacturing companies which went publicly listed in the KOSPI as of 2011. In this regard, this study was conducted with following objectives: (1) to examine the variables of Degree Of Internationalization -structure dimension, performance dimension, behavior dimension- by Reliability analysis and Factor analysis for deriving DOI factor. (2) to explore the relationship between DOI factor and firm performance by multiple regression analysis. (3) to verify positive moderate effects of the corporate capabilities on the relationship between the DOI and performance. As a result of this research, three hypotheses were adopted. First, Structure variable of DOI(FATA), Performance variable of DOI(FSTS) are partially selected the explanatory variable. Second the relationship between DOI and firm performance is expected to be inverted U-shape. Third, moderate effect of the corporate capabilities will affect the corporate performance.