화농성 슬관절염이 동반된 수막구균성 수막염 1예

김태연,유진홍,박성환,김연식,임상현,신완식,강문원,정창훈,최문구,강지민 대한화학요법학회 1997 대한화학요법학회지 Vol.15 No.2

저자들은 최근 화농성 슬관절염과 병발한 수막구균성 수막염 1예를 체험하였고, 이는 국내에서 아직 보고되지 않은 드문 예로 사료되어 문헌고찰과 함께 보고하는 바이다. We recently experienced a case of meningococcal meningitis associated with pyogenic arthritis in a 37-year old male patient. Pyogenic arthritis developed in right knee joint during treatment for meningococcal meningitis. He was treated successfully by appropriate antibiotics and arthroscopic irrigation. To our knowledge, such a rare case has not ever been reported in Korea, Hence we report this case with a review of related literatures.

소아에서 출혈을 동반한 단일 연소성 용종의 내시경적 절제술

김준기,조상욱,신성하,고영춘,최정영,서강석,강명원,임연근,여향순,김경수 全南大醫大 2001 전남의대학술지 Vol.37 No.3

The Oncologic Implications of Tumor Multiplicity in Intrahepatic Cholangiocarcinoma: Its Prognostic Value Might be Underestimated

So Jeong Yoon,Hyun Jeong Jeon,HyeJeong Jeong,Soo Yeun Lim,Sang Hyun Shin,Jin Seok Heo,In Woong Han 대한외과학회 2022 대한외과학회 학술대회 초록집 Vol.2022 No.11

동종 골수이식 후 만성 이식편대숙주질환과 동반되어 신증후군으로 발현된 IgA 신병증 1예

정철권,김현수,박준성,정성현,조도연,최진혁,남동기,임호영,김명성,신규태,임현이,김효철 대한조혈모세포이식학회 1999 대한조혈모세포이식학회지 Vol.4 No.2

동종 골수이식 후 발생하는 신기능부전은 원인이 다양하여 감별에 어려움이 있다. 만성 GVHD는 흉선의 기능저하에 따른 면역관용의 실패로 발생되는 자가면역현상에 의해 발생되는 것으로 알려져 있으며 드물게 신장을 침범하여 신증후군을 일으키기도 한다. CaA의 용량을 줄이거나 투약중지 후 발생한 만성 GVHD에 동반된 신증후군의 경우 조기에 신조직검사를 시행하여 감별진단하고 CsA의 용량을 증량하거나 재투약하여 좋은 치료 결과를 보일 것으로 기대된다. 저자들은 문헌고찰을 통해 동종 골수이식 후 발생된 신증후군이 유사한 임상양상을 보이며 발생기전에 만성 GVHD와 자가면역현상이 연관되어 있음을 확인하였으며 동종 골수이식 후 신증후군의 임상양상을 보이는 환자에서 병리조직학적으로 lgA 신병증을 진단하고 이러한 lgA 신병증이 발생기전에 만성 GVHD와 자가 면역현상이 연관되어 있을 가능성을 최초로 확인하였으며 CsA를 이용하여 성공적으로 치료한 경험을 하였기에 보고하는 바이다. Renal insufficiency is occasionally encountered in allogeneic bone marrow transplantation and its cause is difficult to ascertain. Chronic graft-versus-host disease (GVHD) related to thymic dysfunction is immune-mediated and involves autoreactivity of T-lymphocytes derived from donor marrow to recipient's major histocompatibility complex(MHC) minor antigens. The clinical mainifestations of chronic GVHD are similar to those of autoimmune disease but kidney involvement is rare. Few cases of nephrotic syndrome with membranous nephropathy or minimal change nephrotic syndrome have been reported to be associated with chronic GVHD in allogeneic bone marrow transplant recipient especially after cyclosporine A(CsA) withdrawal, and these cases have responded well to CsA. Therefore, it is prudent to differentiate the cause of post-transplant renal insufficiency using renal biopsy and to start CsA in a case of nephrotic syndrome associated with chronic GVHD as early as possible. We report a case who had a massive proteinuria during the post-allogeneic marrow transplantation period. The cause of nephrotic syndrome was diagnosed as IgA nephropathy by renal biopsy. The patient was successfully treated with reintroduction of CsA.

CASE REPORT : Pulmonary Langerhans Cell Histiocytosis in an Adult Male Presenting with Central Diabetes Insipidus and Diabetes Mellitus: A Case Report

( Yeun Seoung Choi ),( Jung Soo Lim ),( Woocheol Kwon ),( Soon Hee Jung ),( Il Hwan Park ),( Myoung Kyu Lee ),( Won Yeon Lee ),( Suk Joong Yong ),( Seok Jeong Lee ),( Ye Ryung Jung ),( Jiwon Choi ),( 대한결핵 및 호흡기학회 2015 Tuberculosis and Respiratory Diseases Vol.78 No.4

Pulmonary Langerhans cell histiocytosis is an uncommon diffuse cystic lung disease in adults. In rare cases, it can involve extrapulmonary organs and lead to endocrine abnormalities such as central diabetes insipidus. A 42-year-old man presented with polyphagia and polydipsia, as well as a dry cough and dyspnea on exertion. Magnetic resonance imaging of the hypothalamic-pituitary system failed to show the posterior pituitary, which is a typical finding in patients with central diabetes insipidus. This condition was confirmed by a water deprivation test, and the patient was also found to have type 2 diabetes mellitus. Computed tomographic scanning of the lungs revealed multiple, irregularly shaped cystic lesions and small nodules bilaterally, with sparing of the costophrenic angles. Lung biopsy through video-assisted thoracoscopic surgery revealed pulmonary Langerhans cell histiocytosis. On a follow-up visit, only 1 year after the patient had quit smoking, clinical and radiological improvement was significant. Here, we report an uncommon case of pulmonary Langerhans cell histiocytosis that simultaneously presented with diabetes insipidus and diabetes mellitus.

Synthesis of Selective Butyrylcholinesterase Inhibitors Coupled between α-Lipoic Acid and Polyphenols by Using 2-(Piperazin-1-yl)ethanol Linker

Yeun, Go Heum,Lee, Seung Hwan,Lim, Yong Bae,Lee, Hye Sook,Won, Moo-Ho,Lee, Bong Ho,Park, Jeong Ho Korean Chemical Society 2013 Bulletin of the Korean Chemical Society Vol.34 No.4

In the previous paper (Bull. Korean Chem. Soc., 2011, 32, 2997), the hybrid molecules between ${\alpha}$-lipoic acid (ALA) and polyphenols (PPs) connected with neutral 2-(2-aminoethoxy)ethanol linker (linker-1) showed new biological activity such as butyrylcholinesterase (BuChE) inhibition. In order to increase the binding affinity of the hybrid compounds to cholinesterase (ChE), the neutral 2-(2-aminoethoxy)ethanol (linker 1) was switched to the cationic 2-(piperazin-1-yl)ethanol linker (linker 2). The $IC_{50}$ values of the linker-2 hybrid molecules for BuChE inhibition were lower than those of linker-1 hybrid molecules (except 9-2) and they also had the same great selectivity for BuChE over AChE (> 800 fold) as linker-1 hybrid molecules. ALA-acetyl caffeic acid (10-2, ALA-AcCA) was shown as an effective inhibitor of BuChE ($IC_{50}=0.44{\pm}0.24{\mu}M$). A kinetic study using 7-2 showed that it is the same mixed type inhibition as 7-1. Its inhibition constant (Ki) to BuChE is $4.3{\pm}0.09{\mu}M$.

지역사회치위생학 현장(보건소)실습 실태

김연주 ( Yeun Ju Kim ),한양금 ( Yang Keum Han ),김영경 ( Young Kyung Kim ),임현주 ( Hyun Ju Lim ),권양옥 ( Yang Ok Kown ),김한미 ( Han Mi Kim ),박정란 ( Jeong Ran Park ),김남희 ( Nam Hee Kim ) 한국치위생학회 2015 한국치위생학회지 Vol.15 No.1

Objectives: This study was obtained to identify current education status of the community dental hygiene practice. Methods: It was designed cross section and self-reported on-line questionnaire(Survey monkey). It was performed probability sampling by targeting 82 dental hygiene schools(each one faculty member) in charge of community dental hygiene curriculum and 254 community health centers``s community dental hygienists whom was working at oral health section. The response rate was 60% and 53%, respectively. The questionnaire consisted of time, duration, practice group, evaluation method, and practice contents including 63 learning objectives of dental hygiene. Results: Nearly half of these schools conduct such community field work practice in the spring semester of the junior year. This practice was mainly progressed based on average 4 students as one team per each one school for 7-8 hours a day during the period of more than 5 weeks(p<0.05). However, in case of both school and community health center, almost half of feedback after practice was not achieved and there was a difference in needs for practice education between schools and community health center. Conclusions: We should be considered that a sufficient consultation for the practice environment and its contents between schools and community health centers. It was considered that development of a standardized practice manual reflecting such requirement.

Effect of Hominis Placenta on cutaneous wound healing in normal and diabetic mice

Ji-Yeun Park,Jiyoung Lee,Minsu Jeong,Seorim Min,Song-Yi Kim,Hyejung Lee,Yunsook Lim,Hi-Joon Park 한국영양학회 2014 Nutrition Research and Practice Vol.8 No.4

BACKGROUND/OBJECTIVES: The number of diabetic patients has recently shown a rapid increase, and delayed wound healing is a major clinical complication in diabetes. In this study, the wound healing effect of Hominis placenta (HP) treatment was investigated in normal and streptozotocin-induced diabetic mice. MATERIALS/METHODS: Four full thickness wounds were created using a 4 mm biopsy punch on the dorsum. HP was injected subcutaneously at the middle region of the upper and lower wounds. Wounds were digitally photographed and wound size was measured every other day until the 14th day. Wound closure rate was analyzed using CANVAS 7SE software. Wound tissues were collected on days 2, 6, and 14 after wounding for H/E, immunohistochemistry for FGF2, and Masson"s trichrome staining for collagen study. RESULTS: Significantly faster wound closure rates were observed in the HP treated group than in normal and diabetes control mice on days 6 and 8. Treatment with HP resulted in reduced localization of inflammatory cells in wounded skin at day 6 in normal mice and at day 14 in diabetic mice (P < 0.01). Expression of fibroblast growth factor (FGF) 2 showed a significant increase in the HP treated group on day 14 in both normal (P < 0.01) and diabetic mice (P < 0.05). In addition, HP treated groups showed a thicker collagen layer than no treatment groups, which was remarkable on the last day, day 14, in both normal and diabetic mice. CONCLUSIONS: Taken together, HP treatment has a beneficial effect on acceleration of cutaneous wound healing via regulation of the entire wound healing process, including inflammation, proliferation, and remodeling.

나이관련황변변성 환자들의 항산화 영양제 복용에 대한 설문조사

나정호(Jeong Ho Na),임재완(Jae Wan Lim),방종욱(Jong Wook Bang),박강윤(Kang Yeun Pak),김현웅(Hyun Woong Kim) 대한안과학회 2021 대한안과학회지 Vol.62 No.11

목적: 중등도 이상의 황반변성을 진단받고 AREDS2 formula를 복용하고 있는 환자들의 복용 실태에 대해서 조사해 보고자 하였다. 대상과 방법: 2019년 12월부터 2020년 7월까지 황반변성 환자를 대상으로 전향적으로 설문조사를 시행하였다. 설문지는 인구학적 특성, 질병에 대한 인식, 영양제 복용 실태 등에 대해 총 24문항을 조사하였다. 결과: 총 100명의 환자가 포함되었으며, 남자가 56%였고 연령은 60대 이상이 89%였다. 질환에 대한 이해도, 금연의 필요성, 항산화 영양제의 필요성에 대해 안다고 대답한 비율은 66%, 84%, 93%였다. 복용 실태 조사에서 복용 중인 약을 정확히 알고 있는 환자는 58%였고, 이 중 AREDS2 영양제를 제대로 복용하고 있는 환자는 63.8% (전체 환자의 37%)였다. 또한, 영양제 성분에 대해서 알고 있는 환자는 8%, 영양제를 매일 복용한다고 답한 환자는 91%였다. 복용 실태와 인식에 영향을 미치는 인자로 유병 기간이 길어질수록 황반변성 영양제를 복용하는 빈도가 줄어드는 경향이 있었으며(p<0.05), 연령이 높고 저학력일수록 황반변성질환에 대한 인지가 낮았다(p<0.05). 결론: 황반변성 영양제 복용 실태 조사에서 정확한 AREDS2 formula를 복용하지 않는 환자들이 있어 이에 대한 보완책이 필요할 것으로 생각된다. Purpose: To investigate the use of second AREDS2 formula in patients with intermediate or advanced age-related macular degeneration. Methods: A prospective survey was conducted between December 2019 and July 2020. The questionnaire consisted of 24 questions on demographics, disease perception, and formula intake. Results: The survey included 100 patients (males, 56%; age [>60 years], 89%). We found that 66%, 84%, and 93% of patients had a good understanding of their disease, had stopped smoking, and were aware of the need for antioxidant supplements; 58% of patients were aware of the supplement they were prescribed, and 63.8% (37% of total) were using the AREDS2 formula. Only 8% of patients had knowledge regarding the supplement ingredients, and 91% consumed the supplement daily. Patients with long disease duration used supplements less frequently (p < 0.05). Older patients and those with a low education level had a limited perception of the disease (p < 0.05). Conclusions: In this prospective survey, some patients consumed supplements other than the AREDS2 formula. Further studies are required to determine ways to increase the use of the AREDS2 formula.

증례 : 성인에서 발견된 단독 심실 비치밀화증 1예

임연정 ( Yeun Jung Lim ),김정순 ( Jeong Soon Kim ),김인환 ( In Hwan Kim ),박상순 ( Sang Soon Park ),조성욱 ( Seong Wook Cho ),김동진 ( Dong Jin Kim ),조상균 ( Sang Kyoon Cho ) 대한내과학회 2007 대한내과학회지 Vol.73 No.1

단독 심실 비치밀화증은 태아기에 심근의 치밀화 과정이 정지됨으로서 과도한 육주(trabecula)가 형성되고 그 육주 사이에 깊은 함몰이 생기는 선천성 심근병증이다. 진단을 위해 심초음파는 가장 중요한 검사이며, 심초음파로 진단이 확실하지 않을 때에는 비침습적인 방법으로 다중단면 컴퓨터 단층촬영(MD CT), 자기공명단층촬영(MRI)을 통해 도움을 받을 수 있다. 임상양상은 매우 다양하여 무증상인 경우부터 심장이식이 필요하거나 사망할 수도 있는 전격성 심부전까지 나타날 수 있으며, 부정맥, 혈전 색전증이 발생할 수 있다. 저자들은 성인남자에서 심계항진 및 호흡곤란을 주소로 내원하여 단독 심실 비치밀화증으로 진단받고 심부전, 심방 세동 및 심첨부의 혈전에 대한 치료를 하였으나 결국 난치심부전 및 다발성 장기부전으로 사망한 1예를 경험하였기에 보고하는 바이다. Noncompaction of the ventricular myocardium is a rare congenital cardiomyopathy that is thought to be caused by arrest of normal endomyocardial embryogenesis. It is usually diagnosed via echocardiography. The three major clinical manifestations of noncompaction are heart failure, arrhythmia and embolic events. We report here on a case of isolated noncompaction of the ventricular myocardium, and the patient was admitted due to palpitation and dyspnea. Sadly, he died of intractable heart failure despite that we administered intensive medical treatment.(Korean J Med 73:96-102, 2007)