Poster Session : PS 0831 ; Upper GI Tract : Clinical Factors to Predict Angiographically Detectable Non-Variceal Upper Gastrointestinal Bleeding in Patients Refractory to Endoscopic Treatment

( Tae Hwan Ha ),( Tae Hoon Oh ),( Sung In Yu ),( Min Kim ),( Jong Wook Kim ),( Won Ki Bae ),( Jae Hyung Kim ),( Seung Suk Baek ),( Mi Jin Ryu ),( Ye Na Choi ),( Ji Young Park ),( Eileen L Yoon ),( Tae 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: Non-variceal upper GI bleeding (NVUGIB) is a common medical problem that has signifi cant association with morbidity and mortality. Angiographic detection and subsequent transarterial embolization (TAE) is a primary treatment option when medical and endoscopic treatments fail. We investigated clinical factors that could affect the success of the angiographic detection and prognosis after TAE in patients with NVUGIB refractory to endoscopic therapy. Methods: A retrospective analysis of the clinical data was done in patients with failed endoscopic treatment who underwent angiography for the treatment of acute NVUGIB between May 2002 and May 2013. Patients were divided into detection or non-detection groups according to the presence of bleeding stigmata in angiographic fi nding. Rebleeding defi ned as subsequent bleeding event within 7 days and mortality within 30days were analyzed as outcome parameters after TAE following detection in angiography. Results: A total 45 patients 37 (male, mean age, 65.9±14.9 years) were analyzed and classifi ed as a detection group (n=25, 55.5%) and non-detection group (n=20, 44.6%). Peptic ulcers were the most common cause of refractory NVUGIB. Larger transfusion amount (5.7±3.9 unit vs. 3.5±2.8 unit; P=0.03), prolonged aPTT level (34.2±17.3 sec vs. 21.8±13.8 sec; P=0.01) and short time interval between last endoscopy and angiography (17.5±25.9 hours vs. 34.3±59.5 hours; P=0.04) were found to be signifi cant factors for predicting angiographic detection. TAE was performed in all patients detected in angiography. Rebleeding (44%) was significantly associated with higher Rockall score (8.3±1.5 vs. 6.6±2.4; P=0.046) and mortality (12%) was signifi cantly associated with higher Rockall score (9.3±0.6 vs. 7.1±2.2; P=0.002) and higher level of BUN (55.3±47.4 vs. 27.6±17.4; P=0.01). Conclusions: Clinical characteristics associated with angiographic detection in patients with NVUGIB refractory to endoscopic therapy were severe bleeding, bleeding tendency and early angiographic intervention. The Rockall score is useful parameter for predicting rebleeding and mortality after TAE.

한의진단명과 진단요건의 표준화 연구 III : 3차년도 연구결과 보고

최선미,양기상,최승훈,박경모,박종현,심범상,김성우,노석선,이인선,정진홍,이진용,김달래,임형호,김윤범,박성식,송태원,김종우,이승기,최윤정,신순식 한국한의학연구원 1997 한국한의학연구원논문집 Vol.3 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the third year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows : - analyzing and differentiating of epidemic febrile disease - analyzing and differentiating in accordance with the Sasang constitution medicine based on four-type recognition - differentiation of disease according to pathological changes of Chong and Ren channels - standards for diagnosis of women's disease - standards for diagnosis of children's disease - standards for diagnosis of motor and sensor disturbance (-muscle. born, joint, etc.) - standards for diagnosis of neuropsychiatric disease - standards for diagnosis of five sense organ disease - standards for diagnosis of external disease The indivisual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name, notion of diagnosis pattern, index of differentiation of symptoms and signs, the main point of diagnosis, analysis of diagnosis pattern, discrimination of diagnosis pattern, prognosis, a way of curing a disease, prescription, herbs in common use, disease appearing the diagnosis pattern, documents. The standards for diagnosis of each disease was arranged by the diagnostic requirements in the following order : another name, notion of disease, the main point of diagnosis, analyzing and differentiating of disease, analysis of disease, discrimination of disease, prognosis, a way of curing and prescription of disease, disease in western medicine appearing the disease in oriental medicine, documents.

홍민어 Sciaenops ocellatus에서의 바이러스성 신경괴사증 viral nervous necrosis

김진도,김석렬,정성주,김영진,정태성,최태진,박성우,오명주 한국어병학회 2001 한국어병학회지 Vol.14 No.2

1999년 10월에서 11월 사이에 남해안 일대의 홍민어 종묘 생산장에서 20~30열령의 치어가 척추만곡 및 이상유영을 하며 대량 폐사하였다. 병어는 특이 외부 증상이 없었고, 높은 누적폐사량이 바이러스 질병으로 의심되어, 조직학적 및 분자생물학적인 검사를 행하여 폐사원인을 확인하였다. 폐사개체의 조직을 H-E 염색하여 관찰한 결과 뇌와 안구의 신경세포에서 공포와 괴사가 관찰되었고, 전자현미경 관찰에서는 안구와 뇌에서 바이러스 입자가 관찰되었다. RT-PCR 결과에서는 ≒426 bp의 DNA 단편을 확인할 수 있었다. 이러한 결과로 홍민어에서 발생한 대량폐사는 바이러스성 신경괴사증(VNN)으로 진단되었다. Mass mortalities occurred among red drum lavae, 20 to 30 days old, culturing at hatcheries on southern costal area. No specific external signs were observed except abnormal swimming and spinal deformity. It was, however, suspected as a viral etiology due to high mass mortalities so that histopathological and molecular biological study was performed to evaluate the agent. Both vacuoles and necrosis were observed on nerve cells of brain and eye by H-E staining, and viral particles were observed on electronmicroscopic examination. On the other hand, DNA fragment, approximately 426 bps, was amplified with RT-PCR. The above results were able to diagnosis the etiological agent of mass moralities in red drum larvae as VNN(viral nervous necrosis)virus.

(±)-Camphor가 ICR 마우스 수컷의 간 cytochrome P450 효소 활성에 미치는 영향

오은경,박형건,배기현,최옥진,최은경,최창근,한진희,정태천 한국환경독성학회 2002 환경독성보건학회지 Vol.17 No.4

Effects of (±)-camphor on liver cytochrome P450 enzymes were investigated in male ICR mice. Mice were treated intraperitoneally with 0, 200, 400 and 800 mg/kg of (±) -camphor in corn oil for 3 consecutive days. Twenty four hr after the final treatment, the animals were subjected to necropsy. The activities of serum aspartate aminotransferase and serum alanine aminotransferase were slightly changed by the treatment with (±)-camphor at the doses used. Administration o(±)-camphor to mice significantly induced the hepatic activities of pentoxyresorufin O-depentylase and benzyloxyresorufin O-debenzylase and weakly induced ethoxyresorufin O-deethylase in dose-dependent manners. The present results suggested that (±)-camphor might act as a relatively specific inducer of hepatic cytochrome P450 213 in male ICR mice.

논토양 유형별 토양검정에 기초한 질소 적정 시비량

최용조,이영한,이성태,강진호 한국환경농학회 2006 한국환경농학회지 Vol.25 No.1

Serratia liquefaciens AL-11이 생산하는 Alkaline Lipase의 특성 및 작용양상

최청,김태완,안봉전,김영활,손준호,김성,최희준 한국미생물생명공학회 ( 구 한국산업미생물학회 ) 1996 한국미생물·생명공학회지 Vol.24 No.1

본 효소의 최적 반응온도는 약 45℃이고, 최적 pH는 10.0 정도였고, pH 7.0~10.0 범위와 30~50℃의 범위에서 안정하였다. 금속이온중 Mn^2+, Ca^2+ 등에 의하여 활성이 증대되었으나 Fe^2+, Pb^2+와 Zn^2+ 등에 의해서는 효소 활성이 저해되었고, 효소활성 저해제 중 ethylenediaminetetraacetic acid(EDTA)에 의해 강한 저해작용을 나타내어 본 효소는 효소분자 중 금속이온이 관여하는 것으로 추정되었다. 효소반응 처리한 olive oil 가수분해물을 박충크로마토그래피 분석한 결과 Serratia liquefaciens AL-11이 생산하는 지방분해효소는 기질특이성이 비특이적이었으며, sodium cholate, sodium edoxychol-ate, sodium taurocholate 등의 담즙산염에 의해 효소활성이 증대되었다. The optimum temperature and pH for the enzyme activity were 45℃ and 10.0, respectively. The enzyme was stable in a pH range of 5 to 10, and 62% of its activity was lost on heat treatment at 60℃ for 20 min. The activity of the purified enzyme was inhibited by Fe^2+, Zm^2+ and Pb^2+, and slightly activated by Mn^2+ and Ca^2+. γ-Chloromercuribenzoic acid, 2,4-dinitrophenol and H_2O_2 did not show inhibitory effect on the lipolytic activity of the alkaline lipase but ethylenediaminetetraacetic acid inhibited the enzyme activity. This suggested that the enzyme have metal group in its active site. Sodium salts of bile acids stimulated the enzyme activity. Analysis of hydrolyzates of olive oil after the lipase reaction revealed that Serratia liquefaciens AL-11 produced non-specific lipolytic enzyme.

高에너지 電子線治療時 Air Gap의 影響에 關한 實驗的 考察

崔泰珍 대구보건대학 1984 대구보건대학 論文集 Vol.8 No.-

In high energy electron beam, alteration in dosimetry occur as a result of air space between the end-of-treatment applicator and skin surface. CLINAC-l8(Varian) has a 5cm. nominal air gap cause to reduce the bremsstrahlung from shielding materials and to get the good dose distribution in radiation field. But it sometimes has more large air gap from curvatured skin surface or anatomical structure. In this case, We determined the Effective Source Skin Distance (76~82cm. in variable electron energy) to correct the dose and distributions by experimental data. In a comparison of calculated and measured dose, they are very closed within ±1 % of uncertainty in all electron energies. Particularly ESSD depends on the incident electron energy, field size and measuring depth.

自然科 實驗學習指導方法의 硏究 : 탐구학습의 효율화를 위한 재료개발

최수안,오진태,옥치율 부산교육대학교 과학교육연구소 1985 科學敎育硏究 Vol.10 No.-

It may be said that the mainpost of natural science study is the inquring study and as for the point of observation and experiment which is a kind of inquiring process, the success of natural science study is dependent upon study materials. Therefore, in order to develop more effective inquring activities, successive studies such as the ploblem solution, improvement and development of study materials are needed. Several units is the field of chemistry and biology are selected, and several study materials improved and developed are examined as followers: 1. Several experiment methods for the game in order to observe the presence of air are tried. 2. In order to observe the solution phenomena of air easily, new experiment designe is devised, ammonia is soluble in the water including two drops of phenolphthalein and the solution phenomena of air changing into red. 3. In the experiment of the generation of carbon dioxide using every kind of shelfish instead of lime, the amount of the generation of carbon dioxide from the concentration of hydrochloric acid and the amount of shelfish is compared and the effort of substitute materials is examined. 4. The utility factor or the inquring study is devised through the utilization of waste materials, the development of substitute materials and the productive activities of instrument observation using study materials used separated units of materials. 5. It is found that a tadpole, a mud-snail and a killifish substitute for a planaria with a living thing material in the field of biology is available for the revival experiment.

티타늄의 NaOH 수용액 침적 및 열처리가 유사체액 중에서의 인산칼슘 석출에 미치는 영향

최진용,정회웅,이민호,배태성 대한치과기재학회 1999 대한치과재료학회지 Vol.26 No.4

This study was performed to examine whether the precipitation of calcium phosphate on titanium surface is affected by the immersion in NaOH solution and heat treatment. Titanium plates of 10×10×1㎜ in dimensions were polished sequentially from #240 to #2,000 emery paper and one surface of each specimen was received an additional polishing sequence through 0.1㎛ alumina paste. Polished specimens were soaked in 1, 3, 6, 10M-NaOH aqueous solutions at 60℃ for 24 hrs, and 6M-NaOH-treated group were heated to 400, 600, 800℃ for 1 h. After the alkali treatment in the NaOH aqueous solution and heat treatment, specimens were soaked in the Hanks solution with pH 7.4 at 36.5℃ for 7 days in the NaOH-treated groups and for 30 days in the NaOH and heat-treated groups. The results obtained were summarized as follows; 1. The precipitation of calcium phosphate on titanium was accelerated by the immersion in NaOH solution and heat treatment. 2. The precipitation of calcium phosphate was densified with the increase of molar ratio of NaOH. 3. The heat-treated titanium surface at 600℃ showed the precipitation of dense and fine apatite crystals.

발모제가 발모효과에 미치는 영향에 관한 연구

최경임,이진태,안봉전,최은영,박찬익 경산대학교 생명자원개발연구소 2002 생명자원과 산업 Vol.6 No.-

지금까지의 발모관리는 의학적인 차원에서 원형탈모, 남성형 탈모증 및 약제에 의한 병리학적인 연구가 있었으나 미용적인 관리에 대한 연구가 거의 없었다. 따라서 본 논문에서는 약품을 사용하지 않고 순수한 발모촉진 화장품과 두피관리 프로그램을 중심으로 발모관리를 통해 탈모개선 효과를 비교검토하였다. 탈모자를 여러 그룹으로 선발하고 발모제를 달리 처방하여 모발의 굵기, SEM 촬영, 수분측정, 정상인의 모발상태와 탈모자의 모발상태를 TEM 촬영하여 비교 분석하였다. 먼저 두피관리 전과 후의 수분함량의 차이는 평균 16% 상승하였다. 발두께 비교실험에서는 정상모에 비해 탈모자의 모발이 최대 38.6%가 작은 것으로 나타났으며, 모유두와 모간의 촬영사진에서는 탈모자의 모유두는 덜 발달되어 있었고, 변형된 모유두 형태가 많았다. 전자현미경을 통한 모표피의 SEM촬영에서는 탈모자나 정상모나 표면적으로 큰 차이는 없었다. 오히려 탈모자의 경우에는 모발이 약하고 건강하지 못하기 때문에 화학적인 처방을 하는 염색이나 펌 등을 하지 않아서 모발의 큐티클 층은 정상인의 모발보다 건강한 상태로 보였다. 두피측정에서는 관리 후 A, B, C 군의 비교에서 세 그룹 모두 두피의 현저한 개선효과를 보였다. 육모제를 사용한 A, B, Group과 영양제를 사용하지 않고 스캘링과 관리를 한 C군 모두 발모효과가 있었으며, 두피관리를 전혀 하지 않는 D군은 발모효과나 두피의 개선효과는 전혀 없었다. 전자 현미경을 통한 모발의 단면 촬영에서는 정상모발이 탈모자의 모발보다 피질이 부드럽고 풍성하게 잘 형성되어 있었다. 탈모자의 경우는 매우 심각한 고민거리인데 본 실험의 결과 가장 효과적인 발모 관리는 육모제로 두피의 혈액순환을 도와주고 평소생활에서 Brushing으로 모공이 막히지 않도록 꾸준한 손질을 함으로써 발모 및 두피개선이 될 수 있다는 것을 확인할 수 있었다. Twenty working people from 30s to 50s whose hairs were in the process of losing were selected for this study. They were divided into four groups as A, B, C and D. Their hairs were sampled to compare the thickness of the hairs through a optical microscope. Using hair care products from two marketing companies, once a week, Group A and B were treated scalp scaling and steam treatment during ten minutes. After applying vitamin cream the scalp was examined using a bio-beam every 5 minutes. Group C did not receive any vitamin cream but had the same treatment as A and B. Group D used no vitamin cream and receives no treatment. The results were as follows: In Comparison losing hair surface with healthy hair surface by electronic microscope, losing hair took place when the scalp has keratin or too much fat. After comparing the amount of moisture before and after care by a moisture measurement instrument, the amount of moisture has been outstandingly increased. As a result of observing hair root and hair shaft, hair root appeared to be less developed than healthy hair. These results showed that hair care is need to be constantly research and illuminate with regard to the proper care.