우리나라 사람면역결핍바이러스(Human Immunodeficiency Virus) 감염환자에서 발병한 악성종양

최평균,송진수,조재현,김성한,박경화,방지환,박완범,김홍빈,김동완,김태유,허대석,오명돈,김남중,최강원 대한감염학회 2006 감염과 화학요법 Vol.38 No.6

Background : Since highly active antiretroviral therapy has lengthened the life span of individuals infected with human immunodeficiency virus (HIV), the importance of malignancy associated with HIV has been increased. The relative frequencies of malignancies in HIV infected patients may vary in different race and region. The aim of this study is to determine the prevalence and characteristics of malignancies in patients with HIV infection in South Korea. Materials and Methods : To identify HIV patients with malignancy, we reviewed the electronic database of pathological reports for all HIV-infected patients seen from January 1986 to December 2005 at the Seoul National University Hospital. We retrospectively reviewed the medical records of them. Results : Among 850 patients infected with HIV, 33 episodes of malignant diseases were diagnosed in 32 patients (3.76%). Thirty were males, and median age was 46 years (range 29-70). At the time of the diagnosis of malignancy, median CD4^(+) lymphocytes count was 100/uL (range 5-620) and in 27 (82%) patients, CD4^(+) lymphocytes count were less than 200/uL. For 13 patients (40%), malignancy was initial presentation of HIV infection. Excluding patients initially diagnosed as malignancy, median follow-up duration from the first visit to diagnosis of malignancy was 36 months (range 3-96). Non-Hodgkin's lymphoma was the most frequent malignancy (13 patients), followed by Kaposi's sarcoma (7), Hodgkin‘s disease (3), acute myeloid leukemia (1), and other solid cancer (9) including one case of anal cancer associated with human papillomavirus. Among 13 patients with non- Hodgkin's lymphoma, 4(31%) achieved the complete remission after chemotherapy and/or radiation therapy, and had been followed without evidence of recurrence. Conclusion : Malignancy was diagnosed in 3.76% of patients infected with HIV. Non-Hodgkin‘s lymphoma is the most prevalent malignancy in HIV patients in South Korea. 목적 : 효과적인 항레트로바이러스 다제요법이 도입됨에 따라, HIV 감염환자들의 수명이 증가되었고, 이에 따라 HIV 감염환자에서 악성종양의 중요성 또한 증가하고 있다. 본 연구의 목적은 우리나라 HIV 감염환자에서 악성종양의 유병률과 호발하는 악성종양의 특성을 밝히는 것이다. 재료 및 방법 : 1986년부터 2005년까지 서울대학교병원에서 치료를 받은 HIV 감염환자의 의무기록을 후향적으로 분석하였고, 병리학적 검사 결과를 검토하여 악성종양이 진단된 환자들을 대상으로 연구를 시행하였다. 결과 : 총 850명의 환자 중, 32명(3.76%)에서 33예의 악성종양이 진단되어, 악성종양의 발병률은 1,000인년 당13.0명(95% 신뢰구간: 8.6∼17.4명)이었다. 그 중 남자는 30명이었고, 악성종양 진단 당시 연령의 중간값은 46 (29-70)세이었다. 악성종양 진단받을 당시, CD4 림프구 수의 중간값은 lOO/uL (5-620 uL) 이었고, CD4 림프구수가 200/ uL 미만인 환자가 27명(82%)이었다. 악성종양에 대한 검사 도중에 HIV 감염사실이 밝혀진 환자가 13명(40%)이었다. HIV를 진단 받은 후 악성종양이 발병한 환자들에서, HIV 진단 후 악성종양의 발병까지는 평균 36개월(3-96개월)이 걸렸다. 13명의 HIV 감염 환자에서 진단된 비호지킨림프종이 가장 흔한 악성종양이었고, 이외에 카포시육종이 7명, 호지킨병이 3명, HPV와 연관된 항문암이 1명의 HIV 환자에서 진단되었다. 그 밖에 급성백혈병, 방광암, 췌장장, 폐암, 진행성위암, 갑상선암, 간세포암, 후두암이 각각 1예씩 진단되었다. 비호지킨림프종이 진단된13명 환자 중, 4명(31%)은 항암치료 및 방사선치료를 받아 완전관해가 되었고, 현재 재발의 증거 없이 외래에서 경과 관찰 중이다. 결론 : 우리나라 HIV 감염환자에서 악성종양의 유병률은 3.76%이었고, 비호지킨림프종이 가장 흔한 악성종양이었다.

흡연이 성인남자의 폐기능에 미치는 영향

김태우,박철민 경희대학교 체육과학연구소 1996 體育學論文集 Vol.24 No.-

To study effect of smoking on pulmonary function in adult man. Smoker groups 70 men who aged 40-65yrs and non-smoker groues 84 men who 40-65yrs were checked by medical process and pulmonary testing. Smoker groups were divided into four groups by smoking history and its divided three groups by number of cigarettes smoked per-day, control is non-smoker. The relationship of age of smoker and non-smoker with , levels of pulmonary function testing, 1.Relationship of duration of smoking with mean levels of pulmonary function test. 1)Vital Capacity is 3.93L in control groups, 3.64L in 〈10yrs smoking group, 3.77L in 11-20yrs smoking group, 3.76L in 21-30yrs smoking group, 2.93L in 〉30yrs smoking group. 〉30yrs is significantly leaner than control groups.(p〈0.01). 2)%FEVI is 91.78% in control groups, 84.95% in 〈10yrs group, 90.34% in 11-20yrs group, 88.49% in 21-30yrs group,83.88% in 〉30yrs. 〉30yrs smoking group is significantly leaner than control groups(p〈0.05). 3)MVV is 115,95L/M in control groups, 113.5L/M in 〈10yrs smoking group, 97.17L/M in 11-20yrs smoking group, 101.24L/M in 21-30yrs smoking group, 76.17L/M in 〉30yrs smoking group. 〉30yrs smoking group is significantly leaner than control groups.(p〈0.01). 2.Relationship of number of cigarettes smoked per day with mean levels of pulmonary test. 1)VC is 3.93L in control groups, 3.97L in 1-10NCPD smoking group, 3.64L in 11-20NCPD smoking group, 3.90L in 〉20NCPD smoking group. 2)%FEVI is 91.78% in control groups, 91.01% in 1-10NCPD smoking group, 88.14% in 11-20NCPD smoking group, 86.54% in 〉20NCPD smoking group. 3)MVV is 115.95L/M in control groups, 108.95L/M in 1-10NCPD smoking group, 108.4L/M in 11-20NCPD smoking group. 3.Relationship of age of smoker and non-smoker with levels of pulmonary function test. 1)VC 40-50 age is 3.94L in non-smoker groups and 3.89L in smoker groups. Smoker groups 3.42L is significantly leaner than non-smoker groups(p〈0.05) in 50-60 age, smoker groups is significantly leaner than non-smoker groups(p〈0.05) in 〉60 age. 2)%FEVI is 91,6% in non-smoker groups and 88.61% in smoker groups in 40-50 age, 91.95% in non-smoker groups and 92.09% in smoker groups in 50-60 age, 79.20% in non-smoker groups and 87.32% in smoker groups in 〉60 age. 3)MVV 40-50 age is 116.6L/M in non-smoker groups and 99.4L/M in smoker groups. smoker groups is significantly leaner than non-smoker groups(p〈0.01) in 40-50 age. 117.L/M in non-smoker groups, 95.90L/M in smoker groups in 50-60 age. smoker groups is significantly leaner than non-smoker groups(p〈0.01) in 50-60 age. Result this indicate that pulmonary function induces significantly change of smoking in middle and elderly men. And according to increase of age with respiratory muscle weakly, airway resistance increase in smoker than non-smoker. Conclunsionally, middle and elderly smoker is pulmonary function test with VC, %FEV1, MW its must decrease.

항경련제 투여로 발작이 조절된 소아 간질 환자에서 투약 중단 후의 효과에 대한 연구 : 재발률과 이와 관련된 위험인자 Recurrence and Related Risk Factors

김효빈,유수정,고태성 대한소아과학회 2004 小兒科 Vol.47 No.1

大學 自然系科目 敎授方法에 관한 硏究

任洪彬,金澤基,金振淳,盧泰天 충남대학교 공업교육연구소 1984 論文集 Vol.7 No.1

In order to find the effective teaching method of the natural science subjects in the university level, the project method wsa applied to the actual university classes as a experimental basis. The experimented subjects were "Teaching Method in the Industrial Education"of 3 classes, and "Manufacturing Practices"of 2 classes. The findings of this study are summarized as follows; 1. The project method gives the students much learing motivations and cooperative working habits. 2. The project method gives the students problem solving abilities through creativity and thinking power. 3. The project method is better than the course method in terms of learning content understanding and time utilization of the students. 4. The projet method is not suitable to the class which has a large number of students. 5. The problem level of project should be fitted to the time duration and the level of student' s ability. 6. The more studies are needed in order to generalize the project method to the other subjects.

전국교도관 무도대회의 역할과 성과

빈우성(Bin, Woo-Seong),김진태(Kim, Jin-Tae),곽낙현(Kwak, Nak-Hyun) 한국사회체육학회 2014 한국사회체육학회지 Vol.0 No.58

The purpose of this study is to examine the role and outcome of the National martial art competition of correctional staff. The results of the examination are as follows. First, we can find out the fact that ‘The martial match of prison guard’ was held every year through the article of the newspaper‘Chosun ilbo’and ‘Maeil sinbo which wered aily newspapers at that time. That match is origin of the National martial art competition of correctionasl taff during the Japan’s reign. After the independence in 1945, the first competition with the same name of previous one was held in the gym of prison guard academy only with Judo, July 4th in 1949, And the second compeittion was hosted in the same place, May 14th in 1955. Kumdo is included to the match officially, since then. Tae-kwondo is added at 16th competition in 1978. Since then, there have been three kinds of martial a, rtJudo, Kumdo, Taekwondo, which are officially recognized and implemented annually until the 48th competition in 2013. Second, Each martial art performance of Kumdo, Judo, Taekwondo, has been shown before the main event. Judo performance was shown in the gym of the correctionl aofficer academy in 1949 at the first competition, and bon- standard posture of each martial art - was eprformed in Judo, Kumdo. Moreover the performance of slicing a sheaf of straw by real sword was included in Kumdo performance. It was good opportunity to impress the staff members of ministry of justice and civilian about martial art spirit of correctional officer. At present, the organizing and preliminary practice of the peorfrmance is executed by the hand of martial art professors who are dispatched to the institute of justice. Th ispractice maintains for one month, based on the scenario and teaching by them. Third, the annual match became a good chance to improve jobk isll and organizational capability, during the preparation of the competition. Especifically, there are alo t of resource for the impovement. So to speak, the martial art curriculum of institute of justice, hiring maestr level employees, activate martial art club in correction facility, friendly match with Japan correction service ,chance for the promotion are good base for the improvement. There are currently about 4,100 martial art trainees which are divided into 1,300 Judo trainees, 1,300Kumdo trainees, 1,500 Taekwondo trainees that are affiliaetd with national correctional centers. Furthermore, there are about 350senior experts that have a master level, fourth-degree black belt or higher. The martial art clubs of the 50 correction facilities contribute t oimprove martial art skill for the correctional staffs and make positive image about correctional service in their community through providing martial art lecture and exchanging their skill.

CE 환경하에서 디지탈 설계 자료 관리에 관한 연구

明台植,金泰圭,高準彬 大田産業大學校 1996 한밭대학교 논문집 Vol.13 No.1

This study is a system development of CMP (Computer Management Program) that concurrently take care of related task, referencing geometry information that engineer designed a model digital geometry information and that constructs a integrated database on apply at each other group in concurrent engineering environment. This study laid emphasis on a concept of CE(Concurrent Engineering) and can be can out related task seeing designed geometry model. It can be certification that development system is very useful to introduce a concept of CE.

흡연에 의한 급성 호산구성 폐렴 2예

박종빈,김학렬,주현준,유태양,신성남,신정현,송정섭,황기은,김소영,양세훈,정은택 圓光大學校 醫科學硏究所 2008 圓光醫科學 Vol.23 No.2

최근 흡연을 시작한 젊은 성언에서 급성 호산구성 폐렴의 발생에 대한 증례가 보고되고 있다. 급성 호산구성 폐렴은 대개 발열을 동반하기 때문에 초기에는 감염성 폐렴으로 잘못 진단, 치료되는 경우가 많다. 아직 정확한 병태 생리 및 조직학적 소견은 밝혀져 있지 않지만 병력 청취 및 임상 양상, 방사선 소견의 관찰을 통해 급성 호산구성 폐렴을 의심하고, 진단을 위해 기관지 폐포 세척액 검사를 시행한다면 좀 더 쉽게 진단 내릴 수 있을 것이다. 본 저자들은 최근 처음 시작한 흡연에 의해 발생한 급성 호산구성 폐렴을 진단하고, 스테로이드를 투여하여 성공적으로 치료한 환자 2예를 경험하였기에 이를 문헌 고찰과 함께 보고하는 바이다. Acute eosinophilic pneumonia(AEP) is characterized by acute febrile respiratory illness associated with diffuse pulmonary infiltration and pulmonary eosinophilia. The specific etiology for acute eosinophilic pneumonia is elusive. By some investigators, cigarette smoking is suggested as a causative substance which can cause AEP. In recent, the authors experienced two cases of AEP following cigarette smoking. Both cases had characteristic features including age around 20 years, new onset smoking before occurance of AEP, diffuse infiltration on chest radiography, pulmonary eosinophilia based on bronchoalveolar lavage and acute improvement after steroid therapy. These clinical features are resemble with previous smoking induced AEP case reports. Base on these clinical features, cigarette smoking associated AEP could be diagnosed more easily.

진행성 폐 종양 환자에서 종양 내 OK-432 주입술의 효과

정수현,김성빈,박진희,탁희상,옥철호,장태원,정만홍,천봉권 고신대학교 의과대학 2009 고신대학교 의과대학 학술지 Vol.24 No.2

Background: Intratumoral injection of OK-432 produced significant antitumor effects. There are reports that OK-432 was injected directly into tumor tissue on gastrointestinal tracts and HCC tissue, producing decrease in serum alpha-fetoprotein level. We adopted this technique for treating locally advanced lung cancer. The object of this study is to evaluate the local therapeutic efficacy, side effects of injection for treating symptomatic mass. Methods: Twenty lung cancer patients (13 males and 7 females) underwent sonography guided OK-432 injection. We analyzed relationships between response of OK-432 and response of skin test, histology and age. Pain that patients feel was evaluated by VAS (Visual Analog scale). Results: A significant decrease of tumor size was observed. The mean pre-injection diameter of the lesions was 54.7±11.3mm, PR rate were 15.0% (3/20) and minimal change (50%<tumor size decreased.) patients were 35.0% (7/20). The VAS score before injecting OK-432 into the lesion was 5±3, this was decreased to 2.5±1.5 (p=0.04). Object response was significantly correlated with skin response, adenocarcinoma, and age. Conclusion: A significant decrease of tumor size and pain was observed. So OK-432 is a valuable treatment option for patients with symptomatic lesion from advanced lung cancer who are not amenable to further therapy.

NOD/SCID 마우스 모델을 이용한 인간 제대혈 혼합이식에서의 생착 양상 분석

정양조,김동욱,조빈,강영주,박보배,김혜정,김태규,오일환 대한조혈모세포이식학회 2002 대한조혈모세포이식학회지 Vol.7 No.2

연구배경: 제대혈은 골수에 비해 많은 장점을 가지고 있음에도, 이식 후 성적에 있어 총세포수에 의해 좌우되며, 한 개의 태반으로부터 얻을 수 있는 총세포수의 한계가 있어 주로 소아에 국한되고 있다. 따라서 제대혈 응용의 확대를 위해 생착량을 늘이기 위한 방법으로 다중공여자에 의한 제대혈 혼합이식을 늘일 수 있는지 연구하기 위하여, 본 연구에서는 주조직적합성 형별로 조합된 제대혈을 NOD/ SCID 생쥐에 이식하는 방법으로, 혼합생착의 가능성을 연구하였다. 방법: 조합된 2개 공여자로부터 얻어진 제대혈들을 단일이식 및 혼합이식하여, 혼합이식된 숙주에 생착된 세포를 PCR-SSOP 방법을 사용하여 공여자 별로 추적하였다. 또한 각 공여자세포의 상대적 생착비율을 대조군인 단일제대혈 이식에서 얻어진 생착량과 비교하는 정량적 비교도 함께 하였다. 결과: 총단핵구를 혼합이식한 실험군에서는 주조직적합성의 일치도에 관계없이 한쪽공여자의 세포가 다른쪽에 비해 우세한 편향생착을 보였다. 그러나 임파구를 비롯한 Lineage 양성세포를 제거한 실험군에서는 주조직적합성의 불일치에도 불구하고 뚜렸한 생착의 공존이 관찰되었다. 결론: 본 연구는 제대혈의 생착량을 증가를 목적으로 총단핵구를 혼합이식할 경우 한쪽공여자의 세포에 의해 편중되며, 이것을 이식 후 생착과정에서의 두 종류의 세포의 경쟁에 의해 초래된다는 것을 보이고 있다. 또한 이러한 경쟁은 제대혈에 포함되어 있던 임파구들에 의한 것이며, 생착공존을 위하여는 공여자간 주조직적합성의 일치도 보다, 임파구의 제거가 더 중요하다는 것을 보여주고 있다. Background: Although umbilical cord blood (UCB) has been an attractive alternatives for bone marrow cells, application is limited to pediatric case due to limitation in total number of nucleated cells, that is a single most important factor for outcomes of UCB transplantation. Therefore, increasing overall engraftment by mixed transplantation of UCB derived from multiple donor should comprise one strategy to circumvent the posed limitation of UCB transplantation. In order to investigate the feasibility of establishing co-engraftment by multi-donor UCB cells, we carried out a xenotransaplantation study using NOD/SCID mice for systemic analysis of results on the input-based control of single unit transplantation. Methods: UCB units with various extent of HLA-matchings were co-transplanted into NOD/SCID mice along with single unit transplantation control. The relative contributions of engraftment by cells from each donor-derived were analyzed by HLA polymorphism using PCR-SSOP. Results: In all HLA-based mixed transplantation of total nucleated UCB cells, engraftment of one donor predominated over the other despite that equivalent amount of engraftments were achieved by single donor transplantation. When lineage depleted UCB units were co-transplanted, significant degree of co-engraftments were observed regardless of HLA disparity. Conclusion: Our result show that one donor cells dominate over the other in mixed UCB transplantation and that it is due to competition between donor cells during post-transplantation process. Our results suggest that immune cells contained in UCB unit mediate such competitioin and that 6 locus HLA matching would not be sufficient to prevent the competition.

풍력용 농형유도발전기 시스템의 최적제어

최선필,김영빈,노태균,김춘삼,우정인 東亞大學校 2002 東亞論叢 Vol.39 No.-

In this study, we proposed high efficiency wind power generator system for induction generator used SVPWM swiching inverter. First, we propose equivalient circuit for induction generator, it's characteristics equation, and power equation of slip. In addition, we suggest pick Power Traction Slip control methods, adapted variable wind power system. We study simulation result for the proposed system and output power by slip effect. and we identify SVPWM of suitable wind power system by comparison between SPWM and SVPWM Consequently, we show tat the system control result form variable wind power is suitable.