[무용(4)] 제4회 ‘전문무용인의 날’ 기념공연과 윤수미 춤

김효빈 현대미학사 2009 공연과 리뷰 Vol.- No.67

소아 천식 환자에서 집먼지진드기 항원을 이용한면역요법의 3년 장기 추적관찰

김효빈,이소연,김자형,김봉성,서희정,홍수종 대한 소아알레르기 호흡기학회 2005 Allergy Asthma & Respiratory Disease Vol.15 No.1

Purpose:Immunotherapy(IT) with Dermatophagoides farinae(D.f) or Dermatophagoides pteronyssinus(D.p) has proven to be clinically effective treatment for patients with asthma, but the mechanism and prognostic index of IT are not completely understood. We evaluated the long-term effect of conventional IT with D.f or D.p, and also investigated whether IT could prevent new sensitizations to other new allergens. Methods:The patient group included 23 asthmatic patients with D.f- and D.p-sensitivities who visited Asan Medical Center and were treated with conventional IT(Allergopharma, Germany). The control group contained 27 asthmatic patients with D.f- and D.p-sensitivities who were not treated with IT. We compared skin test reactivity, total IgE, specific IgE, total eosinophil counts, eosinophils fraction and bronchial hyperreactivity before and three years after IT. Results:The skin test reactivity to D.p and total eosinophil counts were decreased significantly three years after IT. But total IgE, D.f- and D.p-specific IgE, and eosinophils fraction were not changed three years after IT. The bronchial hyperreactivity by methacholine was decreased in both groups after three years. In addition, development of sensitization to new allergens happened in 13.0 percent of the IT group and 22.2 percent of the control group, but did not reach statistical significance. Conclusion:The conventional IT with D.f and D.p could change the allergic responsiveness of the target organs, such as skin, but it could not prevent the development of new sensitizations in asthmatic children. 목 적 : 집먼지진드기 항원에 감작된 소아 천식 환자에서 집먼지진드기 항원을 이용한 고식적 면역요법이 천식의 치료에 효과적이나 그 기전은 명확히 밝혀지지 않은 상태로, 저자들은 3년간의 장기 추적관찰로 면역요법이 천식환자에게 미치는 효과와 새로운 항원에의 감작을 예방하는 효과가 있는지 알아보고자 하였다.방 법 : D.f와 D.p를 이용하여 고식적 면역요법을 시행한 환자 23명인 치료군과 대조군으로는 D.f와 D.p에는 감작되어 있으나 면역요법을 시행받지 않은 환자 27명을 대상으로 하였다. 면역요법을 시행하기 전과 3년 후에 피부단자시험과 말초혈액내 총 호산구 수, 백혈구 중 호산구 분율, 총 IgE, D.f- 및 D.p-특이 IgE 농도를 측정하였다. 그리고 기도과민성을 평가하기 위해 메타콜린 유발검사에 의한 PC20을 측정하여 비교하였다. 또한 집먼지진드기에만 감작되어 있었던 환아들에서 면역요법으로 새로운 알레르기 항원에 대한 감작의 발생이 예방되는지도 관찰하였다.결 과 : 치료군에서 면역요법 시행 3년 후에 D.p에 대한 피부반응도와 총 호산구수가 감소하였다. 그러나 백혈구 중 호산구 분율과 총 IgE, D.f- 및 D.p-특이 IgE는 면역요법 시행 전후에 차이가 없었다. 기도과민성은 치료군과 대조군 모두에서 3년 후 호전을 보였다. 새로운 항원에 대한 감작은 치료군에서는 13.0%, 대조군에서는 22.2%에서 발생되었으나 두 군 사이에 통계적으로는 차이가 없었다. 결 론:면역요법으로 피부반응도와 기도과민성이 호전되는 것으로 보아 면역요법은 작동기관에 변화를 유도하여 그 효과가 지속되지만, 새로운 항원에 대한 감작이 발생하는 것을 예방하지는 못하였다.

폐경 후 여성의 골다공증 및 심혈관계질환 위험도에 따른 영양소 및 식품섭취상태: 제5기 국민건강영양조사(2010-2011) 자료를 이용하여

김효빈,김혜숙,권오란,박희정 대한지역사회영양학회 2019 대한지역사회영양학회지 Vol.24 No.2

Objectives: The purpose of this study was to investigate the food, nutrient intake, and diet quality of postmenopausal women at high risk of osteoporosis (OP) and cardiovascular disease (CVD) compared with those of control subjects. Methods: A total of 1,131 post-menopausal women aged over 45 years, who took the 2010-2011 Korean National Health and Nutrition Examination Survey (KNHANES), were included for analysis. These participants were classified into the following groups: the OP group, with a risk of OP (n=135); the CVD group, with a risk of CVD (n=373); the OP+CVD group, with a risk of OP and CVD concurrently (n=218); and the control group (n=405) according to bone mineral density (BMD) and CVD risk. Anthropometric measurements, blood profiles, dietary intake, and dietary quality indices were measured and compared among the four groups. Results: Waist circumference, total body fat percentage, blood pressure, fasting plasma glucose, total cholesterol, triglyceride, and LDL-cholesterol were higher, and HDL-cholesterol and BMD were lower in the OP+CVD group than in the control group. In the food frequency questionnaire, the OP+CVD group had significantly higher frequencies of grain (except for multi-grain) and lower frequencies of fruit and dairy product. The frequency of consumption of red meat, processed meat, and carbonated beverages was higher in OP+CVD group. In nutrient density analysis, proteins and vitamin B2 levels were significantly lower in the OP+CVD group than in the control group. The nutritional quality index (INQ) values of calcium were in the order of 0.63, 0.58, 0.56, and 0.55 in each group, and it was urgent to improve the dietary intake for calcium in postmenopausal women. In addition, vitamin B2 was inadequately consumed by all groups. Conclusions: These results suggest that it is necessary to increase the intake of vitamin B2 and calcium and decrease the frequency of intake of red meat, processed meat, and carbonated beverages in postmenopausal women with the risk of OP and CVD.

항경련제 투여로 발작이 조절된 소아 간질 환자에서 투약 중단 후의 효과에 대한 연구 : 재발률과 이와 관련된 위험인자 Recurrence and Related Risk Factors

김효빈,유수정,고태성 대한소아과학회 2004 小兒科 Vol.47 No.1

The Effect of Rush Immunotherapy with House Dust Mite in the Production of IL-5 and IFN-γ from the Peripheral Blood T Cells of Asthmatic Children

김효빈,이소연,김자형,박성종,홍수종,김봉성,진현승 대한의학회 2009 Journal of Korean medical science Vol.24 No.3

Although the mechanisms are unclear, rush immunotherapy (RIT) may be effective to treat allergic diseases. We investigated the long-term modifications of cellular immunity as a mechanism of RIT. The RIT group, included 15 house dust mite (HDM)-sensitized asthmatic children, received RIT only with Dermatophagoides farinae (Der f) and Dermatophagoides pteronyssinus (Der p), whereas the control group, consisted of 10 HDM-sensitized asthmatic children, did not receive RIT. The asthma symptom scores and the skin reactivities to Der f were measured. The cellular proliferative responses and intracellular interleukin (IL)-5 and interferon (IFN)-γ productions from peripheral blood T cells were also measured before, 8 weeks and 1 yr after RIT. The symptom scores, skin reactivity to Der f and cellular proliferative responses to Der f were decreased significantly after 8 weeks and maintained until 1 yr of RIT. The IFN-γ/IL-5 ratio of the CD3(+) and CD4(+) cells were increased significantly after 8 weeks and maintained until 1 yr of RIT, while there were no changes in the control group. These data indicate that the continuous functional modification from Th2 to Th1 phenotype of the CD4(+) T cells are developed after RIT in the asthmatic children sensitized with HDM.

A Case Report of a Patient with Miller Fisher Syndrome Treated with Traditional Korean Medicine

김효빈,정정교,김명관,김재익,이예지,전주현,김은석,김정호,김영일 대한침구의학회 2018 대한침구의학회지 Vol.35 No.3

The aim of this report is to describe improved symptom changes in eye movement disorders and dizziness of a patient with Miller Fisher syndrome after receiving combined Korean medicine treatment (CKMT). A 24-year-old male was diagnosed with MFS accompanied by eye movement disorder, diplopia, and dizziness. For 6 weeks, the patient received acupuncture, electro-acupuncture, pharmacopuncture, herbal medicine, and physical therapy treatment. Visual analogue scale were checked and other outcomes (the range of eye movement, the distance that diplopia appears, diplopia questionnaire) were measured. Following CKMT, the movement of both eyes improved in both the horizontal and vertical direction. Also for diplopia and dizziness, there was a decrease in the visual analogue scale and the distance that diplopia appeared. The present case report suggests that CKMT may have a role in treating eye movement disorders and dizziness in patient diagnosed with MFS.

Exhaled NO: Determinants and Clinical Application in Children With Allergic Airway Disease

김효빈,Sandrah P. Eckel,김정희,Frank D. Gilliland 대한천식알레르기학회 2016 Allergy, Asthma & Immunology Research Vol.8 No.1

Nitric oxide (NO) is endogenously released in the airways, and the fractional concentration of NO in exhaled breath (FeNO) is now recognized as a surrogate marker of eosinophilic airway inflammation that can be measured using a noninvasive technique suitable for young children. Although FeNO levels are affected by several factors, the most important clinical determinants of increased FeNO levels are atopy, asthma, and allergic rhinitis. In addition, air pollution is an environmental determinant of FeNO that may contribute to the high prevalence of allergic disease. In this review, we discuss the mechanism for airway NO production, methods for measuring FeNO, and determinants of FeNO in children, including host and environmental factors such as air pollution. We also discuss the clinical utility of FeNO in children with asthma and allergic rhinitis and further useful directions using FeNO measurement.

롤즈의 정의론을 통해 본 교육기회 균등에 관한 연구

김효빈 윤리문화학회 2011 윤리문화연구 Vol.7 No.-

혈액투석 환자의 질병대처경험 : With a Grounded Theory Approach

김효빈,백경선,최경숙 중앙대학교 의과대학 간호학과 간호과학연구소 2003 중앙간호논문집 Vol.7 No.2

This study dealt with the grounded theory which was applied to Hemodialysis patients The subjects were 8 hemodialysis patients, and they were interviewed directly by the present writer. The data were collected and analysed from April through September 2003. They were analysed immediately after the interviews and new data were continually coded into categories according to Strauss & Corbin's methodology. In the process of data analysis 81concepts and 22sub-categories were identified and then finally 7categories were confirmed. They are such as suffering, powerlessness, attachment of life, love and concern, acknowledge of disease and improvement/deterioration of quality of life. Among those 7categories control of powerlessness was found to be the core phenomenon. The coping experiences of hemodialysis patients can be summarized as the process of "control of powerlessness". It is a process of a series of interaction which includes 4 stage, several hypothetical statements were developed in relation with cause & result relationship between before and after, strategy and result of interaction. These hypothetical statements were narrowed down to four types as the result of continuous comparison with the data and confirmation of the repetitious relationship between categories. Those four types of hypothetical statements are Religious Devotion Type, Social Pursuit Type, Self-initiative Type, Others-dependence. This study shows, in the area of nursing education the need of education of nurses about providing hemodialysis patients away how to cope with the difficult situations. In the study of nursing, it provides a grounded theory which can be applied to the coping experiences of hemodialysis patients. In the area of clinical practices, it can be used as a basic material to develop a series education of nursing intervention for hemodialysis patients.

Analysis of Traditional Medical Disputes: Data from the Korean Acupuncture and Moxibustion Medicine Society (2013-2017)

김효빈,김재익,이예지,전주현,김은석,김영일 대한침구의학회 2019 대한침구의학회지 Vol.36 No.3

Background: The purpose of this study was to analyze the medical dispute cases in Acupuncture and Moxibustion treatment, and present the guidelines of treatment to prevent medical disputes. Methods: Korean Acupuncture and Moxibustion Medicine Society medical dispute cases from January 2013 to September 2018 were collected and analyzed. Results: There were 80 cases, which included acupuncture treatment (54 cases), cupping treatment (7 cases), local infection / inflammation (17 cases), and neurological symptoms (13 cases). Analysis of the correlation between types of medical accidents and the treatment methods, showed that local infection and inflammation (12 cases) were the most reported in acupuncture treatment. Conclusion: This study was performed to analyze the current status of medical disputes in the field of acupuncture and moxibustion, and provide basic data for guidelines to prevent them. Further study preparing for clinical guidelines to prevent medical disputes in specific departments are warranted in the future.