2003년 국내 중증급성호흡기증후군 진료 현황 및 문제점 분석

이진수,김은실,정문현,백제중,정선화,안주희,최영화,이선희,고철우,김성범,김민자,박승철,기현균,송재훈,최상호,김양수,이상오,조용균,박영훈,정숙인,김연숙,이흥범,손창희,장성희,정희진,김우주 대한감염학회 2004 감염과 화학요법 Vol.36 No.3

목적 : 2002년 말 중국에서 SARS가 발생한 이후 국내에서도 2003년 10월까지 총 3명의 추정환자, 17명의 의심환자가 보고되었다. 향후 추가적인 SARS의 유행이 우려되는 상황에서, 그간의 SARS 환자 진료에 있어서의 실질적인 준비사항, 진료 현황 등에 대한 조사를 통해 문제점을 파악하여, 향후 더 나은 대비가 될 수 있도록 개선점을 제시하고자 하였다. 재료 및 방법 : SARS로 의심되는 환자를 진료 경험이 있는 병원의료진을 대상으로 2003년 10월에 설문조사를 실시하였다. 설문에는 SARS 환자 진료 시의 실질적인 조치, 진료 현황, 병실, 응급실 및 외래에서의 격리 시설과 준비사항, 보건당국의 관리와 지원에 관한 사항을 포함하였다. 결과 : 대상이 되는 22개 병원 중 17개(17/22, 77.2%) 병원이 설문에 응하였다. SARS 환자를 위한 격리실은 응급실, 외래, 일반병실 및 중환자실에서 각각 9개(9/17, 52.9%), 5개(5/17, 29.4%), 15개(15/16, 93.7%), 4개(4/16, 25%) 병원에서 음압처리가 되어있지 않은 일인실 혹은 다인실이 사용되었고, 1개(1/16, 6.3%) 병원에서만 일반병실에서 음압격리실이 운영되었다. 입원환자의 진찰 시 개인보호구의 착용은 거의 모든 의료기관에서 이루어졌다. 보건당국에서 SARS지정병원의 시설 등을 사전에 확인한 곳은 1곳(1/12, 8.3%)이였고, 14개 병원(14/15, 93.3%)에서는 보건당국에 의뢰한 검사결과를 통하 받지 못하였다. 결론 : 의료기관에서 SARS 환자용 격리실뿐만 아니라 기존의 격리실 설비 등이 미흡하였으며, 특히 중환자실 및 외래의 준비가 더욱 부족하였다. 보건당국의 의료기관에 대한 종합적인 지원이 부족하였고, 병원과의 원활한 연계가 잘 이루어지지 않았다. SARS 만이 아닌 격리를 필요로 하는 질환의 적절한 진료를 위해 향후 병원 시설의 정비와 정부차원에서의 보다 구체적이고 실질적인 대책마련이 필요하다. Background : There was an worldwide outbreak of the Severe Acute Respiratory Syndrome (SARS) originated from China in late 2002. During that period three cases of suspected SARS and 17 cases of probable SARS were reported in Korea. With the concerns about the reemergence of SARS-coV transmission, it is important to be prepared for any possibility. So, this study is aimed to analysis the past measures in managing SARS and propose the amendatory plans to improve the preparedness. Materials & Methods : Questionnaires were collected among clinicians with any experience in managing the probable or suspected SARS cases in Oct. 2003. 17 out of 22 hospitals responded to the questionnaire. The contents in the questionnaire were practical activities, personal equipments, response plans, isolation facilities in emergency centers, outpatient clinics, general wards and intensive care units, and relationship with the public health department. Results : The dedicated isolation rooms in emergency centers, outpatient clinics, general wards, and intensive care units were prepared in 9 (9/17, 52.9%), 5 (5/17, 29.4%), 15 (15/16, 93.7%), and 4 (4/16, 25.0%) hospitals, respectively. Except for one hospital that newly made negative pressure room for SARS, single or multi-bed rooms without airborne infection control were used in all the other hospitals. The personal precaution principles were kept quite well in general wards. Before the designation of SARS hospital by the public health department prior evalution to see if the hospital was suitable for managing SARS was conducted in only 1 (1/12, 8.3%) hospital. The results of laboratory diagnosis were reported back in 1 (1/15, 6.6%) hospital. Conclusions : The isolation facilities which can control airborne infection were almost deficient not only for SARS but also for other respiratory transmissible diseases. For the infection control of transmissible diseases including SARS, more investment is needed on medical facilities and comprehensive support from the public health department required.

정신분열증 환자와 우울증 환자의 MMPI-2 프로파일

고윤화,손용훈,윤정흠,오상우,이귀행,박민철 圓光大學校 醫科學硏究所 2008 圓光醫科學 Vol.23 No.2

Background: Minnesota multiphasic personality inventory-2(MMPI-2) is superior to its predecessor in differential diagnosis. this study was to investigate MMPI-2 profiles of the patients with schizophrenia and depression and to discriminate among two groups. Methods: The sample consisted of 35 patients with schizophrenia(male 24, female 11), 35 patients with depression(male 18, female 17) diagnosed by the diagnostic and statistical manual of mental disorders(DSM-IV) for schizophrenia & depression at department of neuropsychiatry in WonKwang University from January 2005 to December 2007. The data from the results were analyzed statistically by t-test and discriminant analysis. Results: The results were as follows. First, according to t-test results the comparison of schizophrenia patients and depression patients in MMPI-2 among two groups showed significant differences; the validity scales: F, F(P); The clinical scales: D, Pa; The restructured clinical scales: Rcd(dem), RC4, RC6, RC8; The content scales: ANX, DEP, BIZ; The supplementary scales: AGGR, PSYC, Mt, GF, O-H. Second, as a results discriminant analysis, BIZ, D were significant predictors in distinguishing patients with schizophrenia from patients with depression. Third, probability to be discriminated schizophrenia in schizophrenia was 91.4%, probability to be discriminated depression in depression was 85.7%. Conclusion: Finally, we remind readers that although the MMPI-2 may prove to be useful in the task of differential diagnosis, it should be used only in combination with other patient information. 배경: MMPI-2는 감별진단에서 기존의 MMPI 보다 더 우수하다. 본 연구는 정신분열증 환자와 우울증 환자의 MMPI-2 프로파일과 두 집단을 판별하는 연구를 하였다. 방법: 2005년 1월부터 2007년 12월까지 원광대학교 병원 신경정신과에서 정신분열증과 우울증으로 진단된 정신분열증 환자 35명(남성 24명, 여성 11명), 우울증 환자 35명(남성 18명, 여성 17명)이 본 연구에 참여하였다. 자료는 t-검증과 판별분석으로 분석하였다. 결과: 결과는 다음과 같다. 1. t-검증 결과, 두 집단간 유의미한 차이를 보인 척도들로는 타당도 척도에서 F, F(P) 척도, 임상척도에서 D, Pa, 척도, 재구성 임상척도에서 Rcd(dem), RC4, RC6, RC8척도 였다. 내용척도에서는 ANX, DEP, BIZ척도 였으며 보충척도에서는 AGGR, PSYC, MT, GF O-H척도 였다. 2. 판별 분석 결과로서, 정신분열증과 우울증을 구별하는데 가장 유의한 예언요소는 BIZ, D척도로 나타났다. 3. 판별함수를 통한 진단율은 정신분열증을 정신분열증으로 판별해주는 정확도는 91.4%였고, 우울증을 우울증으로 판별해주는 정확도는 85.7%였다. 결론: 본 연구 결과를 통해서 MMPI-2가 두 집단을 감별하는데 유용하다고 증명되었을지 모르지만 더욱 정확하게 감별하기 위해서 환자의 기타 정보를 사용해야 할 것이다.

슬개골 골절에서 관절경을 이용한 정복 및 내 고정술

고상훈,조성도,나화엽,김우석,정유영,곽창렬,김범수 대한골절학회 2003 대한골절학회지 Vol.16 No.4

2004학년도 재학생 의식조사에 관한 연구

고강호,김두화,김성현 濟州大學校 學生生活硏究所 2005 學生生活硏究 Vol.26 No.-

This study is to understand views and opinions of students on the general policy of Cheju National University (CNU) and ultimately provide basic data which can help university authorities establish policy and improve guidance and educational programs for students. For this survey, 105-item questionnaire was distributed to 1,117 students of the university. Data was analyzed by college, by academic year, and by sex using SPSS Method. The results are as follows. 1. About personal life and views of life As the most important thing in life, stable life (22.1%), exertion of one's ability (17.7%) and happy family life (13.8%) were picked. The most important attitude as a college student is trying to become a well-educated intellectual (31.9%) and laying the foundation to become an able member of society (44.5%). Daily computer use time is 1-2 hours on average (39.7%). Monthly reading volume is one book (45.5%) and two books (14.6%). Given the result, students think leading a stable life and preparing building blocks to become a member of society are very important, but they do not spend enough in reading. The authorities need to open and run programs to encourage reading, and students also should realize themselves. 2. About scholastic performance 61.3% of the students are satisfied with the study of their major. About the reasons for the dissatisfaction with their major, they answered subjects do not live up to their expectations (16.8%) and the major does not fit their aptitude and interest (14.1%) and they lack learning ability (11.7%). Questioned about whether to transfer to other department, 53.6% want transfer. The reasons for transfer are to extend chances of job seeking (31.2%), much interest in other studies (19.4%) and to complement the current study (15.3%). This result indicates that students think their major does not matchtheir aptitude. So, students should be more careful to decide their major considering one's aptitude and future career. 3. As for campus life What they are interested in regarding the university are the easiness of employment (22.5%), the prospect for the future (13.9%), commute distance (10.8%) and the possibility of university development (10.0%). The results show that students relate the meritsof the university to whether they can get a job or not. So, relevant programs should be carried out in line with their demands. 4. About administrative service and university development Questioned about in-campus facilities for students, 46.3% expressed their satisfaction and 40.8% said so-so. As to hat should be improved in the cafeteria, they replied not tasty food (29.3%), not wide menu (28.5%), and poor quality (9.0%). So, food quality and menu should be improved. 5. As to course and career after graduation Most students (74,8%) want to have a job, and some (12.7%) want to study abroad. The most important factors to get employment are foreign language ability (47.8%), certificates of qualification (23.2%). They get information on employment on the internet (41.3%) or from friends or relatives (28.5%); it turned out that job information provided by CNU is not delivered well to students. 6. About social problems CNU students think the most serious social problems are wealth discrepancy (42.5%), corruption and irregularities (12.9%). As to equal opportunity, 22.5% said think so, 37.7% said not so. As for legal justice, 17.6% said laws are fair and 37.0% said not fair largely negative about the fairness of laws. 7. About Consultation and Service Center Questioned bout the center, 56.2% said they heard about the center but never used it and 24.3% answered they neither heard about nor visited it. This means the center has yet to get familiar with students. The center should promote itself to attract more students.

2003학년도 재학생 의식조사에 관한 연구

고강호,김두화,김성현 濟州大學校 學生生活硏究所 2005 學生生活硏究 Vol.26 No.-

This study is to understand views and opinions of students on the general policy of Cheju National University (CNU) and ultimately provide basic data which can help university authorities establish policy and improve guidance and educational programs for students. For this survey, 105-item questionnaire was distributed to 1,121 sophomores, junior and senior students of the university. Data was analyzed by college, by academic year, and by sex using SPSS Method. The results are as follows. 1. About personal life and views of life As the most important thing in life, stable life (19.0%) and exertion of one's ability (17.7%)were picked. Questioned about the most important attitude as a college student, 39.7% answered trying to become a well-educated intellectual, and 38.5% said laying the foundation to become an able member of society. About reading, 48.0% of the respondents read one book a month. Given the result, it is thought that students regard a stable life as most important, but they do not spend enough in reading. The authorities need to open and run programs to encourage reading, and students also should realize themselves. 2. About scholastic performance 60.7% are satisfied with the study of their major. On the other hand, the reasons for the dissatisfaction with their major, they think, are unpromising major (24.7%) and their lack of learning ability (24.7%). Questioned about whether to transfer to other department, six out of ten respondents (55.3%) want transfer. This result indicates that students consider their major unsuitable for their aptitude and future job. Thus, students should be more careful to decide their major considering one's aptitude and future career. 3. Campus life What they want to do most in university is to build a wide range of human relationships (32.4%), to study their major (22.8%) and to experience a lot (19. 1%). The biggest problem is setting the career to pursue. Therefore, the Consultation and Service Center need to strengthen the program for mental state test and consultation to help students. 4. About in-campus service and university development Questioned about in-campus facilities for students, 42.0% expressed their satisfaction and 41.3% said so-so. The frequency of the use of cafeteria is 3-4 times a week (27.7%) and 1-2 times (26.6%). As dissatisfactory factors to be improved, they said not wide menu (31.9%) and not tasty food (23.3%). 5. As to course and career after graduation Most students want to have a job and some want to study abroad. What they think of as obstacles to getting a job is the lack of confidence in their aptitude (43.9%), followed by insufficient information on job openings. So, the center should offer active advice and information. 6. About social problems CNU students think the most serious social problems are corruption and irregularities (32.0%) and unemployment (28.9%). As to equal opportunity, a majority of students thinks offering opportunities according to one's ability is not conducted fairly. As for legal justice, 38.0% said not bad and 30.2% not fair largely negative about the fairness of laws. 7. About Consultation and Service Center If they take a consultation in the center, they want to consult about their course after graduation (28.9%) and study problems (11.4%). We can infer that many students are worried about their career and job seeking. Therefore, the center should conduct a survey on students' aptitude and offer advice and help to them.

대장암 근치적 절제술후 재발양상에 관한 임상적 연구

이길연,홍성화,고석환,윤충,고영관,이기형,박주철 대한대장항문학회 1996 Annals of Coloproctolgy Vol.12 No.2

高品質 豚肉 生産을 위한 고구마 사일리지의 開發에 關한 硏究 : 3. 肥肉豚에 대한 고구마 사일리지 給與가 豚肉의 品質에 미치는 影響 3. Effects of Supplementing the Sweet Potato Silage on Pork Quality

安瑛敏,高永杜,文勝式,陳詳根,鄭孟和 진주산업대학교 농업기술연구소 1999 農業技術硏究所報 Vol.12 No.-

육에 대한 소비자들의 욕구는 계속해서 증가하고 다양해지고 있어 이러한 욕구에 부응하기 위해 육의 풍미 및 육색을 증진시키는 것으로 알려진 고구마 사일리지를 급여한 돈육 일반성분과 물리적인 성질 및 도체특성을 조사하였다. 고구마 사일리지 제조는 고구마의 외부에 부착된 흙을 수세하여 마쇄한 후 고구마 사일리지 1은 고구마 70%, 맥강 20%, 대두박10%를 혼합하여 제조하였으며, 고구마 사일리지 2는 고구마 70%, 맥강 30%를 혼합하여 제조하였다. 일반성분으로는 수분, 조지방, 조단백, 조회분을 조사하였고, 물리적 성질로는 pH, 보수성, 연도, 육과 지방색, 관능검사, 도체특성을 조사하였다. 일반성분에서 수분은 고구마 사일리지 2 급여구가 다른 처리구에 비하여 유의적으로 높게 나타난(P<0.05) 반면에 조지방 함량과 조단백질 함량은 유의적으로 낮은 함량을 보였으며, 그리고 조회분 함량은 처리구간에 유의적인 차이가 없었다. 물리적 성질인 pH의 변화는 대조구와 고구마 사일리지 급여구간에는 유의적인 차이가 없었다. 보수성은 고구마 사일리지 급여구가 대조구보다 유의적으로 높게 나타났으며(P<0.05), 연도는 고구마 사일리지 급여구가 대조구에 비하여 좋은 결과를 보였다. 육색의 변화는 고구마 사일리지 급여로 명도가 유의적으로 낮게 나타났으며, 적색도와 황색도는 측정부위에 따라 값의 변화가 심하였다. 지방색은 고구마 사일리지 급여가 대조구에 비하여 황색도가 낮아 좋은 결과 였다. 관능검사 결과는 고구마 사일리지 급여가 대조구에 비하여 풍미는 유의적으로 높은 성적을 보였지만(P<0.05), 다즙성, 견고성, 탄력성에는 유의적인 차이가 없었다. 전체적인 관능검사 성적은 고구마 사일리지 2 급여구가 가장 좋은 성적을 얻었다. 도체특성에 미치는 변화를 측정한 결과 도체중은 유의적으로 낮게 나타났으나(P<0.05), 지육율은 차이가 없었다. 그러나 고구마 사일리지 급여로 등지방 두께가 유의적으로 감소하는 결과를 보였다(P<0.05). 본 실험 결과 보수성과 연도는 대조구에 비해 고구마 사일리지 급여구가 더 나은 결과 나타내었으며, 육색과 관능검사, 도체특성 결과도 대조구에 비교해 고구마 사일리지 급여구가 유의적으로 더 나은 것으로 나타나 고구마 사일리지를 급여시 특히 고구마 사일리지 1 급여구의 경우 돈육의 육질을 크게 향상시킬 수 있을 것으로 사료된다. The present study was conducted to investigate the effect of supplementary feeding of sweet potato silage on carcass and its meat quality in finishing gilts. Two sweet potato silages containing same ingredients with different ratios(silages 1 and 2; 70 and 70% sweet potato, 20 and 30% barley bran, 10 and 0% soybean meal, respectively) were fermented for 21 days in 500 kg-capacity silos. Finishing gilts were fed a commercial finishing diet(CONT), or the same basal diet plus 0.4kg silage 1(TRT 1) or silage 2(TRT 2)/head/day beginning from 90kg of body weight, 18 heads per group, up to approximately 110kg of final weight and slaughtered. After measuring carcass traits, loin eye sections were removed and their physicochemical characteristics were analyzed. The sensory evaluation on the fresh and cooked meat was performed by the panel test and the whole experiment was repeated 3 times. Backfat thickness was reduced in TRT 1 and TRT 2 compared with CONT, but carcass weight and dressing percentage were not different between the feeding regimens. Compared with CONT, TRT 1 and TRT 2 had greater water holding capacity, tenderness, fat color and palatability scores including flavor and reduced brightness, with no difference in pH, juiciness, firmness and gumminess. Overall, TRT 2 exhibited the greatest sensory evaluation score.

高品質 豚肉 生産을 위한 고구마 사일리지의 開發에 關한 硏究 : 2. 肥肉豚에 대한 고구마 사일리지 給與가 生産形質과 經濟性에 미치는 影響 2. Effects of Feeding the Sweet Potato Silage on Performances and Production Cost of Finishing Pigs

宋瑛敏,高永杜,文勝式,金斗煥,鄭孟和 진주산업대학교 농업기술연구소 1999 農業技術硏究所報 Vol.12 No.-

본 연구는 고구마 사일리지를 이용한 고품질 돈육 생산을 위하여 고구마 사일리지가 돼지에 대한 생산형질과 경제성에 미치는 영향을 조사하였다. 사양시험은 고구마 사일리지를 고구마 70, 맥강 20, 대두박 10의 비율(사일리지 1)과 고구마 70, 맥강 30의 비율(사일리지 2)로 500kg 용 사일로에 충진하여 21일간 발효시켜 제조하고, 급여시기를 각각 체중이 75kg 과 90kg부터 시작하여, 급여시간은 각각 32일과 25일로서 체중 110kg까지 사육하며, 동일한 교배조합(LYD)으로 생산된 육돈 암컷을 3반복, 반복당 18두씩 총 324두를 공시하였으며, 고구마 사일리지 급여량을 하루에 두당 0.4kg씩 공급한 결과는 다음과 같다. 1. 고구마 사일리지를 급여한 경우 개시 체중 75kg과 90kg 공히 종료시 체중, 증체량, 일당증체량 및 사료효율은 배합사료를 무제한 급여하는 대조구 보다 유의적으로 낮았고, 배합사료의 섭취량과 일당사료섭취량은 유의적으로 적게 섭취하였으나, 고구마 사일리지를 건물로 환산하여 합산한 총사료섭취량은 대조구와 고구마 급여구간에 비슷하게 나타났다. 2. 고구마 사일리지를 급여한 경우 배합사료의 섭취량은 줄어들어 배합사료비가 절감되나 고구마 사일리지를 섭취함으로서 총사료비는 비슷하다. kg 증체에 소요되는 사료비는 높게 나타났고, 배합사료급여를 기준한 생산 지수는 고구마 사일리지 급여구가 40∼50% 이상의 사료비가 추가로 소요되는 것으로 분석되었다. This study was carried out to investigate the effects of supplementing sweet potato silages on live performance and production cost in finishing gilts. Two sweet potato silages containing same ingredients with different ratios(silages 1 and 2; 70 and 70% sweet potato, 20 and 30% barley bran, 10 and 0% soybean meal, respectively) were fermented for 21 days in 500 kg-capacity silos. Finishing gilts were fed a commercial finishing diet(CONT), or the same basal diet plus 0.4kg silage 1(TRT 1) or silage 2(TRT 2)/head/day beginning from either 75kg or 90kg of body weight up to approximately 110kg of final weight and the whole experiment was repeated 3 times. 1. TRT 1 and TRT 2 were lesser than CONT in final weight, total weight gain, average daily gain, feed efficiency and total and daily basal diet intake, but not in total dry matter intake including the silage. 2. Compared with CONT, TRT 1 and TRT 2 showed a reduced basal diet cost resulting from the reduced intake of it, but total feed cost was not different between the feeding regimens. Total feed cost per kg weight gain, however, was increased 40∼50% by supplementing the silage.

간세포암에 대한 화학 색전 및 주입 요법 후에 발생한 발열과 감염성 합병증에 관한 전향적 연구

김양수,이상오,이미숙,정두련,김은옥,정영화,우준희,이영상,서동진,성규보,류지소,고기영 대한감염학회 1998 감염 Vol.30 No.3

목적 : 간동맥 화학 색전 및 주입 요법을 시행 받은 환자에서 시술 후 나타나는 발열 및 감염성 합병증의 빈도와 특성을 관찰하고, 이들 중 감염성 합병증이 발생한 환자들을 미래 예측할 수 있는 임상적 지표들이 있는 지 알고자 하였다. 방법 : 1997년 6월부터 8월까지 간세포암으로 간동맥 화학 색전 및 주입 요법을 시행받은 환자들을 대상으로 전향적으로 조사하였다. 화학 색전 및 주입 요법 시행 후 발열이 발생하였으나 감염 및 간 회 색전증의 증거 없이 자연히 소실된 경우에 한해 색전술 후 증후군이라고 정의하였다. 결과 : 284명에서 303예의 시술(화학 색전 요법 200예, 주입 요법 103예)이 시행되었다. 이중 108예(35.6%)에서 시술 후 발열이 있었다. 발열의 원인으로 감염성 합병증이 7예 (2.3%), 허혈성 담낭염이 5예(1.7%)였고 1예는 분류가 힘들어 나머지 95예(31.4%)를 색전술 후 증후군으로 분류하였다. 감염성 합병증은 배양 음성 중성구성 복수(culture-negative neutrocytic ascites)가 3예, 원발성 세균성 복막염이 2예(이중 1예는 패혈증 동반), 패혈송 쇽이 1예, 요로 감염증이 1예이었다. 색전술 후 증후군은 발열이 없었던 군에 비해 복수가 있거나(odds ratio [OR], 2.74; 95% contidence interval [CI], 1.30∼5.75) 종양이 클수록 (OR, 1/15; 95% CI, 1.06∼1.24), 도한 좌우 감동맥을 모두 막은 경우 (OR, 1.81; 95% CI, 1.00∼3.28) 빈번하게 발생하였다. 감염성 합병증일 때에는 색전술 후 발열이 있으면서 systemic inflammatory response syndrome(SIRS)의 기준을 만족하거나 (p<0.05) 시술 후 72시간 이후에 복부 동통이 발생하는 경우가 많았다.(p<0.01). 그러나 발열 시 감염을 미리 구별할 수 있는 검사실 소견은 없었다. 결론 : 간세포암에 대한 화학 색전 및 주입 요법 후 색전술 후 증후군은 31.4%, 감염성 합병증은 2.3%에서 발생하였다. 색전술 후 발열이 있으면서 SIRS의 기준을 만족하거나 시술 후 72시간 이 후에 복부 동통이 발생할 때에는 감염성 합병증을 반드시 고려해야 하겠다. Background : Transarterial chemoembolization(TACE) and chemoinfusion (TACI) are the methods used increasingly in hepatocelluar carcinoma patients. In this study, the incidence of fever and infectious complications after TACE or TACI in pateints with hepatocellular cacinoma was investigated and clinical parameters predicting such complications were evaluated. Methods : Prospective surveys were done in hepatocelluar carcinoma patients who had undergone TACE or TACI from June August, 1997. Three hundred three treatment cases with TACE (200) or TACI (103) in 284 patients were analyzed. The postembolization syndrome was defined as fever following TACE or TACI that spontaneously subsided without the evidence of infections or extrahepatic emboilizations. Results : One hundread eight (35.6%) out of 303 cases showed fever after the treatment. Regarding the etiology of the fever, after the treatment. Regarding the etiology of the fever, infections occurred in 7 cases (2.3%), and ischemic cholecystitis existed in 5 cases (1.7%). In one case the cause was not clear and 95 cases (31.4%) were classified as the postembolization syndrome. Out of the infections, three had culture-negative neutrocytic scites, two spontaneous bacterial peritonitis (one was accompanied with sepsis), one septic shock, and one urinary tract infection. The postembolization syndrome was more frequently found in the cases with ascites (odd ratio [OR], 2.74; 95% confidence interval[CI], 1.30∼5.75), with larger tumor (OR, 1.15; 95% CI, 1.06∼1.24) and with embolization both hepatic arteries (OR, 1.81; 95% CI, 1.00∼3.28). In the cases with infections, many satisfied the criteria for systemic inflammatory response syndrome (SIRS, P<0.05) or had abdominal pain 72 hours later (P<0.01) after the treatment. However, no other laboratory data predicted infection among the cases with fever. Conclusion : After TACE or TACI in hepatocellular carcinoma patients, 31.4% of cases showed the postembolization syndrome and 2.3% of cases showed infection. Infection should be considered as a cause of fever in patients satisfying the criteria for SIRS or with abdominal pain 72 hours later after the treatment.

이온화방사선에 의한 느타리버섯(Rleurotus ostreatus)의 ITS2 염기서열 변화

이영근,장화형,한갑진,고동규,이기성 한국환경생물학회 1998 환경생물 : 환경생물학회지 Vol.16 No.4

rDNA의 ITS2(internal transcribed spacer 2)부위에 대한 이온화방사선(gamma-ray)의 영향을 알아보기 위해서 감마선을 조사한 느타리버섯(Pleurotus ostreatus)의 5종의 변이중에서 ITS2의 염기서열을 결정하였다. ITS2의 염기서열은 1 kGy 조사군(PO-5, PO-6, PO-15와 PO-16)에서 변화되지 않았으나, 2kGy 조사군(PO-14)에서는 1개의 염기가 치환되었다. RAPD(ramdomly amplified polymorphic DNA) 양상에 의한 유전유사도의 변화가 다양하였고 섬유소성 고체검정 배지에서도 다양한 생장특성을 나타내었다. 본 연구결과는 ITS염기서열이 이온화 방사선에 의해 선량의존적으로 변화될 수 있음을 시사해 주었다.