적외선 체열촬영을 이용한 온천요법에 관한 임상적 연구

이정민 ( Jung Min Lee ),뱍인선 ( In Sun Park ),안택원 ( Taek Won Ahn ),홍서영 ( Seo Young Hong ) 한방재활의학과학회 2012 한방재활의학과학회지 Vol.22 No.1

Objectives :The purpose of this study was to investigate the influence of balneotherapy on the changes of DITI(digital infrared thermal imaging). Methods :This study was carried out on 27 patients. They went through balneotherapy with high pressure under water shower(15 min.) and whole body bathing in neutral or hot water between 32 to 40 ℃(15 min.). DITI was measured at before and after the treatment. And then the data was analyzed. Results :1. In cold hypersensitivity of hands group, temperature on PC8 rose and difference between LU4 and PC8 decreased(p<0.05)(Fig. 1, Table Ⅱ). 2. In cold hypersensitivity of feet group, temperature on LR3 rose and difference between ST32 and LR3 decreased(p<0.05)(Fig. 2, Table Ⅱ). 3. In shangrexiahanzheng(上熱下寒證) group, there were no significant changes on CV17, CV6 and difference between CV17 and CV6(Fig. 3, Table Ⅱ). Conclusions :These results demonstrated that balneotherapy has clinical effects on cold hypersensitivity of hands and feet. And further studies are required to apply the balneotherapy in order to cure various diseases in the future.

측정장치의 compliance 유무가 복합레진의 중합수축응력의 측정에 미치는 영향

서덕규,민선홍,이인복 대한치과보존학회 2009 Restorative Dentistry & Endodontics Vol.34 No.2

본 연구에서는 측정장치의 compliance 유무가 복합레진의 중합수축응력 측정에 미치는 영향을 알아보았다. 변위센서, cantilever load cell과 부궤환 (negative feedback) 시스템을 적용하여 compliance를 허용하는 것과 허용하지 않는 두 가지 모드로 중합수축응력의 측정이 가능한 stress-strain analyzer를 제작하였다. 한 종의 flowable (Filtek Flow: FF) 복합레진과 두 종의 universal hybrid (Z100: Zl and Z250: Z2) 복합레진이 사용되었다. Load cell의 끝과 base pIate에 고정된 직경 3.0 mm의 금속 막대에 silane을 처리하였다. 1.0 mm의 거리로 고정한 두 개의 금속 막대 사이에 복합레진을 적용한 후 광중합을 하였다. 복합레진의 수직 중합수축률과 중합수축응력을 10 분 동안 기록하였고 인장탄성계수도 구하였다. 통계처리는 일원분산분석과 paired t-test를 시행하였고 95% 유의수준에서 Tukey's test로 사후 검정하였다. 측정된 중합수축 응력은 재료와 compliance의 유무에 따라 큰 차이를 보였다. Compliance를 허용한 모드에서 중합수축응력은 FF: 3.11 (0.13)이 가장 컸으며 Z1: 2.91 (0.10), Z2: 1.94 (0.09) MPa의 순서였다. 측정장치의 compliance를 허용하지 않은 경우에는 Z1: 17.08 (0.89)이 가장 컸고 FF: 10.11 (0.29), Z2.9,46 (1.63) MPa의 순이었다. 또한 Z1, Z2, FF의 인장탄성계수는 각각 2,31 (0.18), 2.05 (0.20), 1.41 (0.11) GPa 이었다. 중합수축응력은 compliance mode에서는 복합레진의 수직 중합수축률이 주요 영향 요인이었으며, compliance를 배제한 모드에서는 탄성계수의 효과가 지배적이었다. The purpose of this study was to evaluate the effect of instrument compliance on the polymerization shrinkage stress measurements of dental composites. The contraction strain and stress of composites during light curing were measured by a custom made stress-strain analyzer, which consisted of a displacement sensor, a cantilever load cell and a negative feedback mechanism. The instrument can measure the polymerization stress by two modes with compliance mode in which the instrument compliance is allowed or without compliance mode in which the instrument compliance is not allowed. A flowable (Filtek Flow: FF) and two universal hybrid (Z100:ZI and Z250: Z2) composites were studied. A silane treated metal rod with a diameter of 3.0 mm was fixed at free end of the load cell and other metal rod was fixed on the base plate. Composite of 1.0 mm thickness was placed between the two rods and light cured. The axial shrinkage strain and stress of the composite were recorded for 10 minutes during polymerization and the tensile modulus of the materials was also determined with the instrument. The statistical analysis was conducted by ANOVA paired t-test and Tukey's test (α<0.05) There were significant differences between the two measurement. modes and among material. With compliance mode, the contraction stress of FF was the highest: 3.11 (0.13) followed by Zl: 2.91 (0.10) and Z2: 1.94 (0.09) MPa. When the instrument compliance is not allowed the contraction stress of Zl was the highest: 17.08 (0.89) followed by FF: 10.11 (0.29) and Z2: 9.46 (1.63) MPa. The tensile modulus for Zl, Z2 and FF was 2.31 (0.18), 2.05(0.20), 1.41 (0.11) GPa respectively. With compliance mode the measured stress correlated with the axial shrinkage strain of composite while without compliance the elastic modulus of materials played a significant role in the stress measurement.

간장 허혈 및 재관류시 vitamin C와 E가 간장기능에 미치는 영향

서민영,김순애,조태순,이선미 성균관대학교 약학연구소 1995 成均藥硏論文集 Vol.7 No.1

Abstract - This study was done to investigate the effect of vitamin C and E on hepatic biliary and microsomal function during ischemia and reperfusion. Rats were treated with vitamin C, E or with vehicle(saline) and then subjected to 60 min no-flow hepatic ischemia in vivo. Control animals were time-matched sham ischemic animals. After 1 or 5 hr of reperfusion, bile was collected, blood was obtained from the abdominal aorta, and liver microsomes were isolated. In vehicle-treated ischemic rats, serum ALT levels peaked at 5 hr and were significantly attenuated by vitamin C, E individually and combination of vitamin C and E treatment. Similarly hepatic wet weight-to-dry weight ratio was increased in the vehicle-treated ischemic group. Vitamin C and E combination minimized the increase in this ratio. Lipid peroxidation was elevated in vehicle-treated ischemic group, but this elevation was also inhibited by vitamin C or E, respectively. Bile flow and cholate output, but not bilirubin output, were markedly decreased by ischemia/reperfusion. Vitamin C treatment restored the secretion. Cytochrome P-450 content was decreased by ischemia/reperfusion and restored by vitamin E treatment to the level of sham operated group. Aminopyrine N-demethylase activity was decreased and aniline p-hydroxylase activity was increased by ischemia/reperfusion. These changes were prevented by vitamin C or E treatment, but not by vitamin C and E combination treatment. Our findings suggest that vitamin C or E individually significantly ameliorates these ischemia/reperfusion-induced hepatic damages and there is no evidence of synergism between vitamin C and E in our system.

전통 떡류에 대한 대학생들의 이용 현황에 관한 연구

정효선,서경화,신민자 한국조리과학회 2004 한국식품조리과학회지 Vol.20 No.1

The purpose of this study was to investigate the consumption patterns of traditional Korean rice cake among college students. Self administered questionnaires were collected from 512 college students in the Seoul, Kyunggi, Chungchung, Kyungsang, Junla and Gangwondo areas. The data were statistically analysed using frequency analysis, chi-squared and t-tests and a one-way ANOVA. By examining the results of the student's perceptions of traditional Korean rice cake, it was found that most knew little, or only a moderate amount, about this type of food. Meanwhile, more than half the students liked traditional Korean rice cake, as this type of food satisfied their need for a traditional Korean taste, while the reason for disliking was that they were more familiar with western-style confectionary. Most students answered that they only ate traditional Korean rice cake on special occasions, such as big holidays or ceremonies for the dead ancestors. Most answered that they bought those foods at conventional markets, the mile in the neighborhood, (Eds note: I don't understand, do you mean, "within a mile of their neighborhood"?) or atbig malls. The factor they considered the most important at the time of purchase was the quality(taste), which demonstrates the need for the development of traditional Korean rice cakes, with new tastes and shapes, which still satisfy the Korean's taste, whilemaintaining the traditional taste. For the questions that asked about the problems faced by the traditional Korean rice cake manufacturing industry, and the reasons for low consumption, the students responded that buying this type of food was difficult as the outlets selling themwere not easy to find. Our results seem to suggest that there are almost no specialty stores for the sale of traditional Korean rice cake compared to the other types of cakes that are scattered all over the country. (Eds note: this is only my opinion, and I maybe wrong, but I would have though that trying to market traditional Korean rice cakes at local convenience stores, rather than specially stores, would make them more available to the general public. Their marketing at speciality stores will maintain the status quo, i.e. people will go to the speciality stores to purchase product for holidays and special occasions, wheras they will go to the local convenience stores to buy general everyday snacks etc.)

Porter의 산업구조분석모형을 이용한 TFT-LCD 사업매력도 분석

이선규,이웅희,서명지,허연호,홍민정 금오공과대학교 산업기술개발연구원 2001 産業技術開發硏究 Vol.17 No.-

This study examined the key success factors and the degree of industry attractiveness in the TFT-LCD industries. The five competitive force factors include: barriers o entry, industry rivalry, threat of substitutes, supplier power and buyer power. As the result of this study, it was found that the key success factors were customer needs, high screen quality, low price, high performance, convenience and stability concerning with display device. This study provides another link in the chain of understanding of the industry attractiveness and key success factors in the TFT-LCD markets.

컴퓨터 시각과 입자 추적 방법을 이용한 복합레진의 선형중합수축 측정의 새로운 방법

이인복,민선홍,서덕규,김선영,권영철 大韓齒科保存學會 2010 Restorative Dentistry & Endodontics Vol.35 No.3

수복용 복합레진이 도입된 이후 많은 물성의 향상이 이루어졌으나 중합수축은 아직 해결되지 않은 주요 단점으로 남아있다. 중합수축이 적은 복합레진을 만들기 위한 많은 노력이 이루어져 최근에 silorane 기질의 저수축 복합레진이 개발되었고, 정밀하게 중합수축을 측정하기 위한 여러 방법들이 시도되었다. 본 연구에서는 컴퓨터 시각(computer vision)을 이용하여 시편에 직접 접촉하지 않으며 광중합 복합레진의 선형중합수축을 측정할 수 있는 입자 추적 시스템을 개발하였고 이를 이용하여 silorane (P90) 및 methacrylate (Z250과 Z350) 기질의 광중합 복합레진의 중합수축 거동을 측정하여 다음과 같은 결론을 얻었다. 1. 복합레진의 선형중합수축은 0.33-1.41% 였으며 silorane기질의 복합레진인 P90이 가장 낮았고 Z250, Z350의 순으로 증가하였다. 2. 본 장비는 선형중합수축을 시편의 형태에 민감하지 않고 복잡한 과정없이 실시간으로 측정할 수 있었다. Since the introduction of restorative dental composites, their physical properties have been significantly improved. However, polymerization shrinkage is still a major drawback. Many efforts have been made to develop a low shrinking composite, and silorane-based composites have recently been introduced into the market. In addition, many different methods have been developed to measure the polymerization shrinkage. In this study, we developed a new method to measure the linear polymerization shrinkage of composites without direct contact to a specimen using a particle tracking method with computer vision. The shrinkage kinetics of a commercial silorane-based composite (P90) and two conventional methacrylate-based composites (Z250 and Z350) were investigated and compared. The results were as follows: 1. The linear shrinkage of composites was 0.33-1.41%. Shrinkage was lowest for the silorane-based (P90) composite, and highest for the flowable Z350 composite. 2. The new instrument was able to measure the true linear shrinkage of composites in real time without sensitivity to the specimen preparation and geometry.

위암 환자의 복강내 투여를 위한 Activated Charcoal-Alginate Bead 제형으로부터 Mitomycin C의 용출 거동

이진호,최선웅,서중기,김동민,정경수,오정연,김진향,노승무,민병무,김용백,김창식,박근성,강대영,송규상,양준묵,조준식,정현용,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

Locoregional recurrence is the most common type of recurrence in surgical operation of gastric adenocarcinoma, and peritoneal dissemination is one of the most difficult problems in advanced gastric adenocarcinoma treatment. Because the peritoneal cavity is the most common site of the first recurrence after gastric cancer resection, intraperitoneal chemotherapy seems a logical choice for cancer chemotherapy. In this study, Mitomycin C (MMC)-activated charcoal (CH)-alginate (ALG) beads were prepared by the mixtures of CH particles adsorbed with MMC as an anti-cancer drug and aqueous alginate solution. The alginate is recognized as biodegradable, nontoxic, and biocompatible. The release of MMC from the beads in 0.1 M Tris buffer was stable and continuous until about 1 week. The MMC-CH-ALG beads can be applied in the peritoneal cavity for intraperitoneal chemotherapy since they provide a good adhesiveness on the tissue and controlled release pattern of the drugs.

기억력 저하를 호소하는 노인들을 대상으로 INM176를 3개월간 임상시험한 후의 치료성적 및 부작용 평가 보고

김지혜,고선규,고효정,권영아,김성환,김재경,김태은,박재우,서민영,송영란,이인수,김도관 大韓神經精神醫學會 2003 신경정신의학 Vol.42 No.2

Objectives : We examined the effects of INM 176 (K-l107) compared with placebo on the cognitive functions of 92 old aged subjects with cognitive impairment. Methods : This was a prospective, 12 week, double-blind, Placebo-controlled clinical trial. The elderly who achieved a score of less than 25 points on the K-MMSE or showed a high risk of Alzheimer's disease from the 7-Minute Neurocognitive Screening Battery were considered to have objective impairment and were selected as subjects for this study. The subjects were randomized to placebo or INM 176 group. The outcome measures were from the Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-Cog), the Instrumental Activities ofDaily Living (IADL) and the Korean Geriatric Depression Scale (KGDS) and two kinds of computerized priming tests. After setting the total error score in the Alzheimer's Disease Assessment Scale-Cognitive section (ADAS-cog) as the repeated measurement factor, an analysis of variance of the combined factor design was done between the placebo and INM 176 group. Results : The interaction effect of time (pre- and post-trial) and group (placebo and INM 176 group) was significant in the analysis of the ADAS-cog's total error score. The INM 176 group's total error score in the ADAS-cog decreased significantly (p<0.01), whereas the placebo group showed a slight increase. The mean changes in IADL and GDS from baseline scores favored in the INM 176 group than in the placebo group. Outcome changes ofADAS-cog, IADL, KGDS scores during the 12 week clinical trail ofINM 176 and placebo demonstrated favorable responses in the INM176 administered group. Conclusions : This is a preliminary clinical trial result of INM176 as a memory pill. Based on these results, INM176 may be a candidate molecule for the improvement of cognitive functions, including memory, Further clinical trial should demonstrate its efficacy.

뇌동맥류의 진단에 대한 전산화단층촬영 뇌혈관조영술과 고식적 뇌혈관조영술의 비교

송상현,윤수한,안영환,안영민,조기홍,조경기,김선용,서정호 대한신경외과학회 1996 Journal of Korean neurosurgical society Vol.25 No.10

Cerebral angiography has been essential for the diagnosis of the intracranial aneurysms but. is sometimes accompanied by serious complications. Resolution of CT angiography was up-graded greatly to represent the three-demensional structure of vesseles since helical CT had been introduced. We have compared 26 cases of CT angiography and 28 cases of conventional angiography in terms of specificity and sensitivity for the diagnosis detectable aneurysm diameter. configurational diagnosis and diagnostic confidency. All results showed no statistical difference between CT angiography and conventional angiography. These should suggest that CT angiography could be replaced with conventional angiography for the diagnosis of ruptured aneurysms and even of unruptured aneurysms. resulting in the introduction of first screening modality of unruptured aneurysms.

Mild Cognitive Impairment 노인군의 점화효과 특성

박재우,김도관,고선규,고효정,김성환,김재경,서민영,이인수,김지혜 大韓神經精神醫學會 2002 신경정신의학 Vol.41 No.3

연구목적 : 이 연구에서는 K-MMSE에서 25점 이하를 받은 50대 이상 노인들을 MCI(Mild Cognitive Impairment) 군으로 보고 이들의 인지 기능 특성을 점화 효과를 중심으로 살펴보고자 하였다. 먼저, 점화 효과가 MCI 노인군에서 있어서도 유지되고 있는지를 알아보고, 인지 기능의 손상 정도에 따라 점화 효과가 유의미하게 변화하는 지를 살펴보고자 하였다. 방 법 : 본 연구에서는 K-NAME 점수 25점 이하의 노인 96명으 대상으로 ADAS-Cog와 일종의 간접 기억 검사 도구인 지각적 파악 과제를 제작하여 점화 효과를 측정하여 인지 기능의 퇴행이 시작된 고연령군이 나타내는 암묵 기억 능력 특성을 알아보았다. 점화효과는 컴퓨터 상에 사전 노출된 자극과 그렇지 않은 자극을 순간 노출시켜 미리 노출된 자극에 대해 반응 시간이 줄어들고 정확 반응이 증가하는 정도로써 측정하였다. 이 때 지능이나 연령, 학력 수준과 같은 변인이 미치는 영향을 통제하기 위해 한국판 웩슬러 지능 검사의 <어휘>, <토막> 소검사를 실시하였고, 인구통계학적 변인에 관한 면접을 실시하였다. 통계적 분석 과정에서는 먼저, 연구에서 측정된 점화효과의 특성을 알아보기 점화 효과 측정치의 기술 통계치를 구하였으며 다른 측정 변인들과의 상관 분석을 실시하였다. 마지막으로 측정된 점화효과가 인지 기능의 퇴행 수준에 비례하는 지의 여부를 파악하기 위해 ADAS-Cog 및 나이, 교육 연한 및 지능 수준을 독립변인으로 회귀분석을 실시하였다. 결 과 : 먼저 기술 통계 분석 결과에 의하면 본 연구에 참여한 피보험자들의 경우 점화효과에 의해 미리 노출된 자극을 평균 3.6개 더 정확히 파악하였으며 평균 59ms 더 빠르게 반응한 것으로 나타나 이들 집단에서도 점화효과가 유지되고 있음을 알 수 있었다. 다음으로 변인들 간의 상관 분석 결과에 따르면, 정확 파악 반응 점수에 따른 점화효과는 전반적인 인지 기능을 평가하는 K-MMSE 및 ADAS-Cog와 정적인 상관이 있는 것으로 나타났으며 반응 속도로 측정한 점화효과의 경우에는 나이와는 정적인 상관이, KWIS의 <어휘> 소검사 점수와는 부적인 상관이 있는 것으로 나타났다. 또한, 본 연구에서 사용된 점화 효과 측정치를 종속 변인으로 ADAS-Cog와 KWIS의 어휘 및 코막 소검사로 측정한 지능 수준, 나이와 교육 연한과 같은 인구 통계학적 변인을 독립 변인으로 회귀 분석을 실시한 결과에 따르면 정화간응 점수로 측정한 점화 효과의 경우 상관 분석 결과에서와 같이 ADAS-Cog 변인만이 유의미한 효과를 갖는 것으로 나타났으며 반응 속도로 측정한 점화 효과의 경우 나이의 효과만 유의미한 것으로 나타났다. 결 론 : 이러한 결과는 경미한 인지 기능의 손상이 진행되고 있는 고연령군의 경우에는 외현 기억 능력은 손상이 시작되지만 점화효과로 측정된 암묵 기억이 전반적으로는 유지되다가 인지 기능의 퇴행이 진행됨에 따라 노출된 자극을 더 정확히 파악하는 능력이 저하되고 점화 효과에 의해 인출 속도가 빨라지는 현상이 연령이 증가함에 따라 함께 증가하는 것으로 나타남을 말해 준다. Objectives : In this study, the cognitive characteristics, especially priming effect, of above 50 years old age group who had less than 25 points in K-MMSE were investigated. Methods : In this study, an implicit memory test measuring priming effect was made and administered ti old age people who had less than 25 points in k-MMSe in screening session. To control the effect of age, educational level and intelligence, demograohic variables were measured, and the subjects of KWIS, vocabulary and block design were administered. Descriptive statistical analysis of the two priming measures and correlational analysis between variables were done. To test the effect of cognitive functioning on priming effect multiple regression analysis was done. Results : Correlational analysis revealed priming score obtained from correct identification response was positively correlated with K-MMSE and ADAS-Cog. And priming score obtained from mean reaction time was positively correlated with age and negatively correlated with vocabulary substest of KWIS. The regression analysis results indicated from correct identification response, whereas age has significant effect on priming score obtained from mean reaction time. Conclusions : The results revealed that as cognitive deterioration progresses priming effect which identify primed stimulus correctly diminish, and as one grow older within age 50 to 70, priming effect which identifies primed stimulus quickly increase.