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Locoregional recurrence is the most common type of recurrence in surgical operation of gastric adenocarcinoma, and peritoneal dissemination is one of the most difficult problems in advanced gastric adenocarcinoma treatment. Because the peritoneal cavity is the most common site of the first recurrence after gastric cancer resection, intraperitoneal chemotherapy seems a logical choice for cancer chemotherapy. In this study, Mitomycin C (MMC)-activated charcoal (CH)-alginate (ALG) beads were prepared by the mixtures of CH particles adsorbed with MMC as an anti-cancer drug and aqueous alginate solution. The alginate is recognized as biodegradable, nontoxic, and biocompatible. The release of MMC from the beads in 0.1 M Tris buffer was stable and continuous until about 1 week. The MMC-CH-ALG beads can be applied in the peritoneal cavity for intraperitoneal chemotherapy since they provide a good adhesiveness on the tissue and controlled release pattern of the drugs.
Loxoprofen sodium[sodium (±)-2-[4-(2-oxocyclopentylmethyl)phenyl]propionate] is non-steroidal anti-inflammatory drug in the propionic acid derivatives group. To develop a novel transdermal drug delivery system of loxoprofen sodium, the effects of various vehicles and penetration enhancers on the skin permeation of loxoprofen sodium from solution formulations were investigated. The permeation rate of loxoprefen sodium through excised Sprague-Dawley rat skin was measured using a franz diffusion cell and keshary-chien diffusion cell at 32 ± 0.5oC. The solubilities of loxoprofen sodium in various vehicle for enhancer were determined by the equilibrium solubility method. The solubility of loxoprofen increased in the rank order of tween80 > labrasol > tween20 > cremophor > lauroglycol90 > capryol90. In addition, transdermal patch containing loxoprofen sodium provides continuous drug delivery over 24 hours and similar efficacy to the highest recommended dose of oral route drug with improved tolerability.
Drug delivery system(DDS) has been extensively applied the various areas as (1) novel methods for drug administration through several route, (2) development of novel polymeric carrier, and (3) tissue engineering and regenerative medicine. The aim of this review is to report the recent progress of "Development of controlled drug delivery system" supported by Korean Intellectual and Economy(KOIE) for 2004~2009. This project is composed by 5 subproject as (1) development of novel osmotic pump, (2) development of liposome delivery system, (3) development of DDS by bile acid transporter, (4) protein drug delivery system using thermo-sensitive hydrogel, and (5) development of novel transdermal drug delivery system. DDS system might be the core and platform technology for the application of diagnosis, bioinstrument, tissue engineering, regenerative medicine and pharmaceutical industries.