소양인(少陽人) 부종(浮腫) 환자(患者) 치험례(治驗例)

안택원,배나영,Ahn, Taek-Won,Bae, Na-Young 사상체질의학회 2005 사상체질의학회지 Vol.17 No.3

1. Objectives The purpose of this study is to evaluate the effectivity of the Korean herbal medicine therapy which is based on the Sasang constitutional medicine for the Soyangin Edema Patient 2. Methods Patient who diagnosed as Soyangin by physical characteristic, posture and symptoms is evaluated with length of patient' Lt. calf, ankle, foot circumference after medication 3. Results After medicine, 1) Length of patient' Lt. calf was on the decrease from 37.2cm to 34.4cm 2) Length of patient' Lt. ankle was on the decrease from 27.8cm to 25.4cm 3) Length of patient' Lt. foot was on the decrease from 28.0cm to 25.7cm Edema of a Soyangin patient responded well to the treatment with Dojeokgangki-tang 4. Conclusions The case study shows an efficient results by using Dojeokgangki-tang in treatment of Soyangin edema patient.

형방패독산(荊防敗毒散)과 독활지황탕(獨活地黃湯)이 Wistar rat의 노화(老化)에 미치는 영향(影響)

안택원,이수영,Ahn, Taek-Won,Lee, Soo-Young 사상체질의학회 2005 사상체질의학회지 Vol.17 No.3

1. Objectives The purpose of this study is to find out effects of Hyeongbangpaedok-san(HBPDS) and Dokhwaljihwang(DHJH) against decline of physical function as aging. 2. Methods Administrating HBPDS and DHJH to 40-week-old Wistar rat for 10 weeks so, I researched weight change, weight change of internal organs, and hematological and serological changes. 3. Results & Conclusions 1. Both examining groups, which were taken HBPDS and DHJH, got more weight than control group. But that was regardless. 2. Both examining groups got more weight on internal organs than control group. But that was regardless, too. 3. Both examining groups decreased in amount of MDA in serum, as contrasted with control group. But it was regardless. 4. Both examining groups improved on hematological condition. WBC, RBC, Hgb, monocytes and eosinophil rates were decreasing and HCT and PLT were increasing. Especially monocytes(p<0.001) and eosinophil(p<0.05) rate of DHJH taken group was decreased remarkably. 5-1. Both examining groups show decline in each item of functional examination of liver, such as ALT, AST, T-bilirubin, T-protein, ALB, A/G. T-chol, TG, etc. HBPDS taken group showed meaningful decline in Albumin(p<0.01) and A/G(p<0.01) and DHJH taken group showed meaningful decline in T-bilirubin(p<0.01). 5-2. Both examining groups showed decline in items of functional examination of kidneys. Specially HBPDS taken group showed meaningful decline in CRN rate(p<0.05) and DHJH taken group showed meaningful decline in BUN rate(p<0.05). As those results, HBPDS and DHJH are effective against decline of physical function as aging.

청심연자탕(淸心蓮子湯)과 태음조위탕(太陰調胃湯)이 Wistar rat의 노화(老化)에 미치는 영향

안택원,이현,주입산,Ahn, Taek-Won,Lee, Hyun,Chou, Li-Shan 사상체질의학회 2005 사상체질의학회지 Vol.17 No.2

1. Objectives The purpose of this study is to find out effects of Choeongsimyeonja-tang and Taeumjowi-tang on the against decline of physical function as aging. 2. Methods In Wistar rat 10, 30, 50 week and 40 week Choeongsimyeonja-tang & Taeumjowi-tang between 10 weeks form condition change of weight, change of intestine weight, hematology, blood chemistry, research result about serum content following conclusion get. 3. Results and Conclusions 1. Observed gain in weight than control group form of Cheongsimyeonja-tang & Taeumjowi-tang to aged Wistar rat. 2. Is thought to promote activation of living body action gaining intestine weight along with gain in weight. 3. Displayed decrease of MDA's content of serum than control group form of Cheongsimyeonja-tang & Taeumjowi-tang to aged Wistar rat. 4. Change that is Wistar rat's hematological value by aging according to 10, 30, 50 week WBC, RBC, Hgb, monocyces, eosinophil ere. increase, and HCT, PLT ere. showed tendency that decrease accorcling to old-week, and observed improvement that is hematological value than control group form of Cheongsimyeonja-tang & Taeumjowi-tang.5. Change that is Wistar rat's biochemical value by aging was measured highest in 50 week because ALT, AST, BUN, CRN, T-bili., T-chol., TG, TP, ALB, A/G. P ete. increase according to 10, 30, 50 week, and observed improvement that is biochemical value than control group form of Cheongsimyeonja-tang & Taeumjowi-tang. Is considered by being effect that Cheongsimyeonja-tang & Taeumjowi-tang living body function decline by aging by this result.

녹용대보탕(鹿茸大補湯)이 AAPH로 유발된 산화병태(酸化病態)모델 흰 쥐의 항산화(抗酸化) 작용(作用)에 미치는 영향

배나영,안택원,Bae, Na-Young,Ahn, Taek-Won 사상체질의학회 2007 사상체질의학회지 Vol.19 No.2

1. Objectives This study aimed to investigate the anti-oxidative effect of Nocyongdaebo-tang (NYD) decoction in oxidized rats induced by AAPH. 2. Methods AAPH (2.2-azobis-2 aminodinopropane-hydrochloride) was injected intraperitoneally to induce oxidization and NYD was orally administered to the rats. To observe the anti-oxidative effect of NYD, we performed blood chemistry analysis, histological analysis, and evaluated the levels of SOD, catalase, glutathione, NO and MDA in liver. 3. Results & Conclusions 1) Serum Albumin level was increased significantly in the NYD group as compared with the control group and the saline group. 2) Serum LDL-cholesterol level was reduced significantly in the NYD group as compared with the control group. 3) GPT level in liver was reduced significantly in the NYD group as compared with the control group. 4) SOD, catalase activity and glutathione levels were increased significantly in the NYD group as compared with the control group and the saline group. 5) The levels of NO and MDA were reduced significantly in the NYD group as compared with the control group. 6) The degenerative change of liver tissue of NYD group was decreased in comparison with the control group. In conclusion, NYD decoction is considered to have an anti-oxidative effect in rats.

("동의수세보원(東醫壽世保元)"과 "상한론(傷寒論)"의 연관성(聯關性)에 관한 연구 - 상한육경(傷寒六經)을 중심으로 -

손덕칭,안택원,Sun, Teh-Cheng,Ahn, Taek-Won 사상체질의학회 2007 사상체질의학회지 Vol.19 No.1

1. Objectvies The study is purposed to find the role of the six-channels of shanghan(傷寒六經) on the relation between ${\ulcorner}$Dongyisusaebowon(東醫壽世保元)${\lrcorner}$ and ${\ulcorner}$Shanghanlun(傷寒論)${\lrcorner}$ 2. Methods The study is compared ${\ulcorner}$Euiwonleun(醫源論)${\lrcorner}$ with the process of study on the ${\ulcorner}$Shanghanlun(傷寒論)${\lrcorner}$, origin and theorys of the Shanghan six-channels(傷寒六經). 3. Results and Conclusions Just as Dong-mu fully understood the concepts of ${\ulcorner}$Shanghanlun(傷寒論)${\lrcorner}$ through the six of Shanghan(傷寒六經) proposed by Chu-gueng(朱肱), the ideas of Differential Diagnostic System(辨證體系) of ${\ulcorner}$Shanghanlun(傷寒論)${\lrcorner}$ had much influence on ${\ulcorner}$Dongyisusaebowon(東醫壽世保元)${\lrcorner}$. Therefore a new medical theory could be born.

용육조위탕(龍肉調胃湯) 경구투여가 노화 흰쥐의 면역활성에 미치는 영향

이한얼,안택원,Lee, Han-Eol,Ahn, Taek-Won 사상체질의학회 2012 사상체질의학회지 Vol.24 No.4

Objectives : The purpose of this study is to investigate the effect of oral administration of Yongyukjowi-tang(YJT) on the immune activity in aged Sprague-Dawley rat(SD rat). Methods : SD rats were divided into three groups: Yongyukjowi-tang groups(YJT groups), distilled water groups(control groups) and Vitamin C groups(positive control groups) which were administered an oral dose(1ml/1day) to 6, 48 and 68 weeks old SD rats for four weeks. After four weeks, the number of total leukocyte, CD3+, CD4+, CD8+, and the level of cytokine (IL-2, IL-4, IL-10, IFN-${\gamma}$) were measured in spleen tissue of each SD rats. Results and Conclusions : 1) The number of total leukocyte significantly increased in 52 weeks old YJT group and 72 weeks old YJT group in comparison with those of the control group. 2) The number of CD3+ cell significantly increased in 72 weeks old YJT group in comparison with those of the control group and the positive control group. 3) The number of CD8+ cell significantly increased in 52 weeks old YJT group in comparison with those of the control group. 4) The level of IL-2 significantly increased in 72 weeks old YJT group in comparison with those of the control group and the positive control group. 5) The level of IL-4 significantly increased in 52 weeks old YJT group in comparison with those of the positive control group. These results suggest that oral administration of YJT has an effect on increase of immune activity in aged rat.

태음조위탕 엑스과립이 비만을 포함한 대사증후군 위험인자에 미치는 영향에 대한 연구: 단일군, 전향적, 다기관 임상연구

곽진영,안택원,Kwak, Jin-Young,Ahn, Taek-Won 사상체질의학회 2020 사상체질의학회지 Vol.32 No.2

Objective The purpose of this study is to study the effects of Taeeumjowi-tang extract granule on metabolic syndrome with obesity in Taeeumin. Methods We studied 206 subjects who diagnosed metabolic syndrome with obesity and classified Taeeumin by a Sasang constitution analysis tool. The subjects were administered by Taeeumjowi-tang for 12 weeks. We investigated the changes of body mass index, abdominal circumference, the number of risk factors for metabolic syndrome, lipid, fasting blood sugar, Hemoglobin A1c, free fatty acid, insulin, and blood pressure. Results Body mass index and abdominal circumference, systolic and diastolic blood pressure were significantly reduced after 4 weeks, 8 weeks, and 12 weeks of administration compared to before administration. Triglyceride significantly decreased after 8 weeks and 12 weeks of dosing compared to before taking. Low density lipoprotein cholesterol, fasting blood sugar were significantly increased after 8 weeks of administration compared to before administration. High density lipoprotein cholessterol was decreased significantly after 4 weeks of administration compared to before administration. The number of risk factors for metabolic syndrome, Hemoglobin A1c increased significantly after 12 weeks of administration compared to screening. Conclusions In this study we knew that Taeeumjowi-tang extract granule is very efficient in metabolic syndrome, especially in obesity and hypertension, triglyceride, insulin resistance.

온천요법이 비만 아동의 비만지수와 체성분에 미치는 영향

강기연,안택원,한재경,Kang, Ki Yeon,Ahn, Taek Won,Han, Jae Kyung 대한한방소아과학회 2013 대한한방소아과학회지 Vol.27 No.3

Objectives The purpose of this study is to evaluate the effect of hot spring bath in obese children. Methods The study was conducted with 20 obese children whose BMI were over 20 ($kg/m^2$). The hot spring bath program was performed in the hot-spring facilities with temperature of $32{\sim}36^{\circ}C$. The children bathed four times from June to July, 2012. Prior to their bath, their heights, weights, and body compositions were measured every time. They were also confirmed their obesity index and obesity degree during the program. Results After the bathing program, degree of obesity has changed, three obesity judgment index (BMI, RI and OI) of the children have decreased (BMI, RI, OI on the $1^{st}$ day: $25.99{\pm}3.47$, $177.63{\pm}17.43$, $37.74{\pm}13.42$; on the $4^{th}$ day: $25.06{\pm}3.08$, $168.4{\pm}14.8$, $30.60{\pm}12.12$), so have body fat mass and percent body fat (BFM, PBF on the $1^{st}$ day: $21.83{\pm}7.03$, $38.24{\pm}3.36$; on the $4^{th}$ day:$19.55{\pm}6.35$, $34.20{\pm}3.77$), but skeletal muscle mass has increased (SMM on the $1^{st}$ day: $18.37{\pm}4.24$ ; on the $4^{th}$ day: $19.80{\pm}4.44$). Conclusions This study shows that hot spring bath could be an effective way of managing and treating obesity.

승양익기탕(升陽益氣湯) 전탕액이 노화쥐의 비장, 췌장, 위장 세포의 항산화능에 미치는 영향

이주용,안택원,Lee, Joo-Yong,Ahn, Taek-Won 사상체질의학회 2010 사상체질의학회지 Vol.22 No.2

1. Objectives: The purpose of this study is to investigate the anti-aging and anti-oxidative effects of Seungyangikki-tang decoction(SY) in spleen, pancreas and stomach cells of Sprague-Dawley(SD) rats. 2. Methods: This experiment was used by the tissue of spleen, pancreas and stomach cells of 6, 52 and 68 weeks old SD rats. We devided each group by three. One group as normal group was non-treated cells, another group as control group was saline-treated cells, and the other group as experimental group was SY treated cells. After culture for 48 hours, each groups measured the level of SOD, GSH, MDA and NO in the tissue of kidney, bladder and spleen cells. 3. Results and Conclusions: SOD activity was significantly increased in spleen cell of 6, 68w-SY group, pancreas cell of 52,68w-SY group and in stomach cell of 52w-SY group compared with those of the control groups. GSH concentration was significantly increased in spleen cell of 6,68w-SY group and in pancreas cell of 6w-SY group compared with those of the control groups. MDA concentration was significantly decreased in spleen cell of 68w-SY group and in stomach cell of 68w-SY group compared with those of the control groups. NO concentration was significantly decreased in spleen cell of 68w-SY group, stomach cell of 68w-SY group compared with those of the control groups.

활성산소(活性酸素)에 의한 산화스트레스환자의 사상체질별(四象體質別) 특성(特性)에 관한 연구(硏究)

한경수,안택원,배나영,Han, Kyoung-Su,Ahn, Taek-Won,Bae, Na-Young 사상체질의학회 2006 사상체질의학회지 Vol.18 No.3

1. Objectives The purpose of this research is to find out the Constitutional difference of Oxidative stress by Free oxygen radicals. 2. Methods We enrolled 55 patients who visited our hospital for medical examination from February 1, 2006 to May 31, 2006. This research investigated the Constitutional difference of Oxidative stress by Free oxygen radicals. 3. Results and Conclusions l) The Sasang Constitutional distribution of patients have oxidatative stress by Free oxygen radicals was Taeunmin 30%(8persons of total 27persons), Soeumin 56%(9persons of total 16persons), Soyangin 33%(4persons of total 12persons). The rate of patients have oxidatate stress was high in Soeumin. The Sasang Constitution had significance relation with oxidatative stress by Free oxygen radicals. 2) Triglyceride on the average of Taeumin patients have oxidatative stress by Free oxygen radicals is ststistical significantly higher than Triglyceride on the average of controlled normal persons in Taeumin(p-value=0.010) and Soyangin(p-value=0.015). Blood uric acid level on the average of patients have oxidatate stress by Free oxygen radicals is ststistical significantly lower than Blood uric acid level on the average of controlled normal persons in Taeumin(p-value=0.004) and Soyangin(p-value=0.037). This research has shown that there is a statistical significance between the Triglyceride level, Blood uric acid level and oxidatate stress by Free oxygen radicals.