구강내 연조직 질환과 구강점막 각화도와의 관계

송주종,김병국,최홍란 전남대학교 치과대학 2000 전남치대논문집 Vol.12 No.1

To investigate the relationship between several intraoral soft tissue lesions(hairy tongue, lichen planus, recurrent aphthous stomatitis, oral candidiasis, glossitis and oral herpetic lesion) and oral mucosal keratinization, exfoliative cytological smear on intraoral mucosal surfaces were performed on each number of patients and 25 controls keratinization cell(yellow-stained cell) ratio was then measured. In hairy tongue, there was no significant difference between patient group and control group in all kind of cells. Only blue cell ratio of wemen was more than of men in patient group. In inchen planus, there was no difference between patient and control group in yellow cell ratio. Red cell ratio in the control group was more than in the patient group. Blue cell ratio in the patient group was more than that in control group. But there was no sex predilection between both groups in the ratio of all kind of cells. In recurrent aphthous stomatitis, Yellow cell ratio in the control group was more than that in the patient group. Red cell ratio in the control group was more than that in control group. Blue cell ratio in the patient group was more than that in control group. But there was no sex predilection between both groups in the ratio of all kind of cells. In oral candidiasis, Yellow cell ratio in the control group was more than that in the patient group. Red cell ratio in the control group was more than that in control group. Blue cell ratio in the patient group was more than that in control group. There was no sex predilection between both groups in yellow cell ratio. Red cell ratio of wemen was more than of men in patient group. Blue cell ratio of men was more than of wemen in patient group. In herpetic lesions, there was no difference between patient and control group in yellow cell ratio. Red cell ratio in the control group was more than in the patient group. Blue cell ratio in the patient group was more than that in control group. Yellow cell ratio of wemen was more than of men in control group. Red cell ratio of men was more than of wemen in control group. Blue cell ratio of men was more than of wemen in patient group. In glossitis, Yellow cell ratio in the control group was more than in the patient group. There was no difference between patient and control group in red cell ratio. Blue cell ratio in the patient group was more than that in control group. Yellow cell ratio of wemen was more than of men in control group. Red cell ratio and blue cell ratio of men were more than of wemen in control group. According to above results, the ratio of keratinized cell in atrophic, ulcerated, or pseudomembranous lesions was lowered than in control, but the ratio of keratinized cell in keratotic, vesicular or lesions on keratinized surface lesions had no difference to control group. Thus, keratotic, vesicular or lesions on keratinized surface lesions have not closely relation to mucosal keratinization. And, there was a little sex predilection between men and wemen in mucosal keratinization.

항암화학요법 중 호중구감소증이 발생한 저위험군 발열 환자들을 대상으로 한 경구 항균제 요법의 임상적 유용성 및 안정성에 대한 연구

김연숙,이혁,기현균,김춘관,김신우,김성민,백경란,김원석,윤성수,이홍기,강원기,박찬형,박근칠,송재훈 대한화학요법학회 2000 대한화학요법학회지 Vol.18 No.1

목적 : 항암화학요법 중 호중구감소증을 동반한 발열이 발생하는 암환자들을 치료하기 위한 다양한 항균제와 여러 가지 방법들이 시도되고 있는 가운데, 합병증과 사망률의 발생가능성이 적은 저위험군 환자들을 대상으로 초기 72시간동안 정주 항균제를 투여한 이후 경구 항균제로 전환하는 요법의 유용성과 안정성을 평가해보고자 본 연구를 시행하였다. 방법 : 1998년 2월부터 1999년 9월까지 본원에서 항암화학요법 중 호중구감소증과 발열이 발생한 환자들 가운데 기저 암질환이 고형암이거나 림프종이고, 입원당시 패혈증의 증후가 없으며 입원 72시간이내에 해열되고 백혈구수치가 증가 추세인 환자들을 대상으로 하여 72시간 동안 정주 항균제를 투여한 이후 경우 ciprofloxacin 750㎎을 하루 2회씩 투여하여 총 4일간 투여하였다. 모든 환자들은 열이 떨어지고 호중구감소증이 회복될 때까지 입원하도록 하였다. 결과 : 총 38명 환자의 40예가 등록이 되었고, 환자들의 기저암 질환은 고형함이 72.5%, 림프종이 27.5%였다. 입원당시 평균 호중구치수는 156/㎕였고, 호중구수치가 100/㎕미만인 경우는 65%였으며, 호중구감소증이 지속된 기간의 평균은 2.4일이었다. 40예 중 39예가 항균제의 변형이나 추가 없이 호중구감소증과 발열로부터 회복이 되어 97.5%의 성공율(95% 신뢰구간: 86.8-99.9%)을 보였다. 부작용으로 피부발진이 있었던 경우가 한 예 있었는데, 증상이 경하여 경구 항균제를 지속할 수 있었다. 심와부의 동통으로 복용을 지속할 수 없어서 대상에서 제외된 예가 또 한 예 있었다. 결론 : 항암요법 중 호중구감소증과 발열을 동반한 환자들 가운데 저위험군 환자들에서 항균제 72시간정주 이후 경구 항균제로의 전환요법은 효과적이고도 안전한 치료방법이라고 할 수 있다. Background : Oral antibiotic therapy following empirical intravenous antibiotics may be effective and safe for febrile neutropenic patients with lowrisk for complications. Methods : We conducted a prospective clinical trial of oral antibiotic therapy in the patients with neutropenia and fever during chemotherapy for cancer. Underlying malignancies were solid tumor or lymphoma with short duration of neurtropenia and the patients had no evidence of clinically or microbiologically documented infections. Oral ciprofloxacin was given to the patients who lacked signs of sepsis on admission, had a rising tendency of neutrophil count (ANC >100 /㎕ ) at 72 hours, and were afebrile at 72 hours. All patients were hospitalized until neutropenia and fever resolved. Results : A total of 40 episodes of 38 patients were enrolled from February 1998 to September 1999. The mean neutrophil counts on admission were 156/㎕ and the mean duration of neutropenia was 2.4 days. The episodes which had neutrophil count below 100 /㎕ were 26 (65%). Treatment was successful in 39 of 40 episodes (97.5% : 95 % confidence interval, 86.8% to 99.9%). Adverse reactions of oral ciprofloxacin were skin rash and epigastric soreness in two cases, respectively. There were no deaths during the study. Conclusions : For low-risk febrile patients with neutropenia during cancer chemotherapy, switch therapy to oral ciprofloxacin at 72 hours following intravenous broad-spectrum antibiotics is effective and safe,

6-Hydroxydopamine induces nuclear translocation of apoptosis inducing factor in nigral dopaminergic neurons in rat

Hong-Il Yoo,Gil-Yeong Ahn,이은진,Eu-gene Kim,Sung-Young Hong,Sang-Jin Park,Ran-Sook Woo,Tai-Kyoung Baik,Dae-Yong Song,T.-K. Baik,D.-Y. Song 대한독성 유전단백체 학회 2017 Molecular & cellular toxicology Vol.13 No.3

Parkinson’s disease (PD) is a progressive neurodegenerative disorder, characterized by relatively selective death of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc). 6-Hydroxydopamine (6-OHDA), a neurotoxin that causes the death of DA neurons, is commonly used to produce experimental PD model in rodents. Accumulating evidences suggest that caspase-independent apoptotic programmed cell death (PCD) could also be involved in the progression of various neurodegenerative diseases in addition to caspase-dependent neuronal PCD. Apoptosis-inducing factor (AIF), a mitochondrial intermembrane oxidoreductase, has been identified as a key protein implicated in caspase-independent apoptosis. However, little is known about the role of AIF in death of nigral DA neurons in PD. Therefore, we undertook this study in an effort to clarify the involvement of AIF in DA neuronal death by 6-OHDA administration. Ten and twenty micrograms of 6-OHDA was infused into the medial forebrain bundle (MFB) unilaterally, and the experimental rats were sacrificed at various time point. The DA neuronal loss was identified in the ipsilateral SN in the dose-dependent manner by using NeuN and tyrosine hydroxylase immunohistochemical staining and western blot assay. Numerous degenerating neurons, showing apoptotic features which are characterized by the shrunken nuclei with eosinophilic perikarya were observed in the ipsilateral SNpc. Activating transcription factor 3 (ATF3), the specific marker for neuronal damage, was expressed in the ipsilateral DA neurons only. Immunohistochemistry and immunofluorescence staining demonstrated that nuclear localization of AIF in the ipsilateral degenerating DA neurons. These results suggest that AIF could induce DA neuronal death by caspase-independent apoptosis in 6-OHDA treated model, although other cell death cascades should not be rule out.

A case of hypopigmented parapsoriasis en plaque

( Joo Ran Hong ),( Ji Youn Hong ),( Jin Hee Kim ),( Hye In Cheon ),( Min Seok Hur ),( Byung Gon Choi ),( Song Hee Han ),( Yang Won Lee ),( Yong Beom Choe ),( Kyu Joong Ahn ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1

Parapsoriasis en plaque (PSEP) belongs to the cutaneous T-cell lymphoproliferative disorder. PSEP is clinically benign and typically presents as slightly scaly red-brown patches. However, when PSEP presented as a rare hypopigmented lesions, it can be easily be misdiagnosed as other diseases such as vitiligo, pityriasis alba, or hypopigmented mycosis fungoides. Therefore, suspicious skin lesions should be biopsied to make appropriate diagnosis. A 5-year-old girl visited our clinic with hypopigmented macules and patches developing gradually over the past four years. The lesions were covered with scanty scales. Superficial perivascular infiltrate of lymphocytes and histiocytes as a band-like pattern were observed in histologic examination. Immunohistochemistry showed that T-cell lymphocyte stained positively for CD3, whereas T-cell receptor gamma gene rearrangement study was negative in the clonal population. On the basis of the above findings, a diagnosis of PSEP was made. The hypopigmented lesions were improved after 308-nm excimer laser twice a week for 12 weeks. We herein report a 5-year-old child with hypopigmented PSEP lesions who has been successfully treated with 308-nm excimer laser.

The synergistic effect of antihistamines and topical corticosteroids on the treatment of atopic dermatitis: a meta-analysis

( Joo Ran Hong ),( Ji Youn Hong ),( Jin Hee Kim ),( Hye In Cheon ),( Min Seok Hur ),( Byung Gon Choi ),( Song Hee Han ),( Yang Won Lee ),( Yong Beom Choe ),( Kyu Joong Ahn ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.2

Background: H1-antihistamines have been used widely to treat pruritus in atopic dermatitis (AD). Although the evidence for H1-antihistamine monotherapy for pruritus in AD is inconclusive, combination therapy with topical glucocorticoids are particularly considered as to be effective as both short-term intensive therapy and maintenance treatment in patients with frequent relapse. Objectives: We conducted a meta-analysis for confirming the efficacy of antihistamine as an adjunct to topical corticosteroid application in the treatment of AD. Methods: We identified 1,206 studies through systematically searching Medline, Embase, and CENTRAL databases for articles published from 1967 to 2015. Random effects meta-analysis was used to calculate mean differences (MD) with 95% confidence intervals (CI). Results: Two studies satisfying the inclusion criteria of antihistamine therapy with mandatory topical steroid use were selected. Comparing antihistamine monotherapy with combination therapy, patients treated with the addition of antihistamine to topical corticosteroids showed a statistically significant clinical improvement (standard MD, -0.24; 95% CI, -0.42 to -0.05; p = 0.01). Conclusion: This meta-analysis based on two studies suggests that antihistamine therapy as an adjunctive therapy for pruritus in AD may have beneficial effects in combination with topical corticosteroid treatment.

A case of reactive angioendotheliomatosis following varicose vein surgery by unlicensed non-medical personnel

( Joo Ran Hong ),( Ji Youn Hong ),( Jin Hee Kim ),( Hye In Cheon ),( Min Seok Hur ),( Byung Gon Choi ),( Song Hee Han ),( Yang Won Lee ),( Yong Beom Choe ),( Kyu Joong Ahn ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1

Reactive angioendotheliomatosis (RAE) is a rare benign angioproliferative condition of the skin. RAE manifests as diverse and nonspecific cutaneous lesions such as macules, papules, plaques and ulceration. Although the pathogenesis has not been fully elucidated, various diseases that cause vascular occlusion and hypoxemia are related to RAE. However, RAE after varicose vein surgery is rarely reported. A 26-year-old man visited our clinic with a 2-year history of painful skin lesions affecting the left lower limb. The lesions were poorly delimited, with deep purple colored plaques and macules. He had a varicose vein surgery by unlicensed non-medical personnel 5 years ago. Prominent proliferation of endothelial cells within the lumina of dermal vessels was observed in histologic examination. Immunohistochemistry showed that endothelial cells stained positively for CD31 and CD34. On the basis of the above findings, the patient was diagnosed with RAE. We referred the patient to rehabilitation center in order to alleviate the chronic leg edema worsening after varicose vein surgery.

난소 복합기형종의 갑상샘증에서 발생한 유두암

홍란 ( Ran Hong ),임성철 ( Sung Chul Lim ),송창훈 ( Chang Hun Song ),기근홍 ( Keun Hong Kee ),이미자 ( Mi Ja Lee ) 대한산부인과학회 2007 Obstetrics & Gynecology Science Vol.50 No.11

Benign or malignant tumors that arise in a benign cystic teratoma are rare. Malignant transformation in mature cystic teratoma of ovary is reported to occur in 1~3%. Several types of malignancy can occur from any of three germ-cell layers, but the most common malignancy is a squamous cell carcinoma derived from ectoderm. We experienced a papillary carcinoma arising in a struma ovarii of the complex teratoma. 74-year-old female presented with an abdominal discomfort. A pelvic ultrasonograph and computed tomography detected a 7×6 cm-sized and well-circumscribed cystic mass at the anterior to the uterus. The inner part of the mass was filled with cystic fluid showing low-density, however, solid portion including fat and soft tissue accompanied by calcification was identified in more than half of the entire tumor volume. The patient underwent a bilateral salpingo-oophorectomy. On histopathologic examination, the lesion was consistent with papillary carcinoma with squamoid features arising in a struma ovarii of the mature cystic teratoma. We herein report a case of the very rare papillary carcinoma arising in a struma ovarii of the complex teratoma and review the available literature.

Clinical and immunological characteristics of psoriasis patients with latent tuberculosis infection

( Joo Ran Hong ),( Ji Youn Hong ),( Jin Hee Kim ),( Hye In Cheon ),( Min Seok Hur ),( Byung Gon Choi ),( Song Hee Han ),( Yang Won Lee ),( Yong Beom Choe ),( Kyu Joong Ahn ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.2

Background: Latent tuberculosis infection (LTBI) is a growing concern for the treatment of psoriasis, as the use of biologics has recently increased. LTBI may also be associated with chronic inflammatory status that results in a change in immune status. Objectives: To investigate the association between the clinical comorbidities of psoriasis and the expressions of inflammatory cytokines induced by LTBI. Methods: We conducted a retrospective analysis for 300 patients with psoriasis using clinical information, including the comorbidities and presence of LTBI. Serum cytokine levels were measured for immunological analysis. Results: The prevalence rates of psoriatic arthritis (p = 0.001) and nail psoriasis (p = 0.014) were significantly higher in patients with LTBI than in those without LTBI. The serum levels of interleukin (IL) 6, IL-8, and IL-23A were greater in the LTBI-positive group than in the LTBI-negative group (p = 0.014 for IL-6, p = 0.025 for IL-8, and p = 0.004 for IL-23A). Conclusion: LTBI may be a risk factor for the development of clinical comorbidities in psoriatic patients through an increase in the levels of inflammatory cytokines, including IL-6, IL-8, and IL-23A.

Cell Growth Inhibition and Induction of Apoptosis by Snake Venom Toxin in Ovarian Cancer Cell via Inactivation of Nuclear Factor κB and Signal Transducer and Activator of Transcription 3

Ju Kyoung Song,Jin Tae Hong,Mi Ran Jo,Mi Hee Park,Ho Sueb Song,Byeong Jun An,Min Jong Song,Sang Bae Han 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.5

Snake venom toxin from Vipera lebetina turanica induces apoptosis in many cancer cell lines, but there is no study about the apoptotic effect of snake venom toxin on human ovarian cancer cells. In this study, we investigated the apoptotic effect of snake venom toxin in human ovarian cancer PA-1 and SK-OV3 cells. Snake venom toxin dose dependently (0~10 μg/mL) inhibited ovarian cancer cell growth with IC50 values 4.5 μg/mL in PA-1 cells, and 6.5 μg/mL in SKOV3 cells. Our results also showed that apoptotic cell death increased by snake venom toxin in a dose dependent manner (0~10 μg/mL). Consistent with increased cell death, snake venom toxin increased the expression of pro-apoptotic protein Bax and caspase-3, but down-regulated anti-apoptotic protein Bcl-2. Untreated ovarian cancer cells showed a high DNA binding activity of nuclear factor B (NF-κB), but it was inhibited by snake venom toxin accompanied by inhibition of p50 and p65 translocation into the nucleus as well as phosphorylation of inhibitory κB. Snake venom toxin also inhibited DNA binding activity of the signal transducer and activator of transcription 3 (STAT3). Moreover, the combination treatment of NF-κB (salicylic acid, 1 or 5 μM) and STAT3 (stattic, 1 μM) with snake venom toxin (1 μg/mL) further enhanced cell growth inhibitory effects of snake venom toxin. These results showed that snake venom toxin from Vipera lebetina turanica caused apoptotic cell death of ovarian cancer cells through the inhibition of NF-κB and STAT3 signal, and suggested that snake venom toxin may be applicable as an anticancer agent for ovarian cancer.

부산·울산·경남지역 직업병 감시체계

김정일,김병권,김정원,채창호,이철호,강동묵,김지홍,김진하,김영욱,이영하,이지호,김정호,윤형렬,유철인,정백근,장태원,김운규,윤동영,강진욱,김종은,안진홍,이동준,장준호,이광영,송혜란,최영희,이용환,조병만,최홍렬,고상백,김은아,이유진,홍영습,정갑열,김정만,김준연 大韓産業醫學會 2004 대한직업환경의학회지 Vol.16 No.1

Objective: Occupational medicine specialists in the Busan, Ulsan and Kyung-Nam areas established an area-based occupational disease surveillance system and used this system to collected case information for the purpose of preventing occupational diseases Methods: l l hospital participated in this system. The authors selected five main diseases, which were hand-arm vibration syndrome (HAVS), work-related musculoskeletal disorder (WRMSD), occupational asthma, occupational skin disease and occupational and occupational lung cancer and established their case definitions. All cases were reported on the web, and real time analysis was conducted. Results: Between April 2001 and April 2003, 192 cases of HAVS, 118 cases of WRMSD, 33 cases of occupational asthma, 17 cases of occupational skin disease and 17 cases of occupational lung cancer (for a total of 377 cases of these five main diseases) were reported. most of the HAVS cases came from shipbuilding, and 172 of them (92.7%) were associated with grinding. Of the four main types of WRMSD, carpal tunnel syndrome (CTS) was the most prevalent with 46 cases and shipbuilding was also the main industry involved (83.9%). The ergonomic risk factors involved mainly associated with the hand. In 19 (57.6%) and 4 (12.1%) cases of occupational asthma, the agents involved. The causative agents of occupational lung cancer included Cr, welding fume, PAH, Ni, etc. 10(58.8%) of the cases were diagnosed as squamous cell carcinoma and 5(29.4%) as adenoma. Conclusion: This result showed that an area-based occupational disease surveillance system might provide an effective method of evaluating the prevalence of such diseases, however the Busan, Ulsan and Kyung-Nam provinces are too large to be treated as individual areas. Therefore, the authors suggest that each province should establish its own surveillance system.