정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

Analysis of the Motion of a Harmonic Oscillator Coupled to Faraday's Law

KIM*, Se-Hun,KO, Tae-Eon,LEE, Se-Hyun,KIM, Kwang-Sun,OH, Seung-Won,KIM, Hyun-Seok Korean Physical Society 2018 새물리 Vol.68 No.1

분말야금법으로 제조된 2124AI 합금의 빠른변형률속도 초소성 거동

金祐塡,張勝彦,南勝義,金亨駿 弘益大學校 科學基術硏究所 1999 科學技術硏究論文集 Vol.10 No.2

Ceramic whisker or particulate reinforced aluminum based metal matrix composites show high room temperature strength, but their low formability makes it difficult to form into desired shapes. By superplastic deformation, their formability can be improved and it is possible to produce complex parts for automotive aerospace simultaneously instead of many near-net-shape forming operations. This study has been carried out to investigate the high temperature mechanical and superplastic properties in 2124Al alloy. SRC(Strain Rate Change) tests show that the value of n(stress exponent) is around 3 at high strain rate and above 5 at low strain rate. It was turned out that 212Al matrix alloy exhibited reasonably high tensile elongation above 250% with the broad range of temperature and strain rate. Especially, at 550℃, both materials showed very high elongation failure up to 700% for 2124Al alloy. The strength comparison is lower strength then 2124Al composites were obtained that the composite is lower strength than 2124Al alloy at superplastic region.

호닝 가공에 사용되는 다이아몬드 공구의 성능평가에 관한 연구

김민주,이승수,전언찬 한국공작기계학회 2002 한국생산제조학회지 Vol.11 No.1

This study is to evaluate the tool performance in honing using diamond reamer and present grounds whether the localized products are sufficiently competitive comparing with the existing imported ones. The heads of the tool performance evaluation are roundness, roughness, tool life of the workpiece and so on. When evaluating the tool performance, cutting process is divided by three areas which are rough, semi-finish and finish cut. Honing improves the accuracy such as boring and reaming after manufacturing the inside diameter, and finishing directly by boning is a recent trend. This honing is used greatly in hard cutting materials like cemented carbides and it is the CBN and diamond that is used in hard cutting materials. Both of them are expensive and most of them are imported.

BAF Annealing에서 저온점의 온도변화에 관한 연구

김순경,이승수,김문경,전언찬 동아대학교 공과대학부설 생산기술연구소 1997 生産技術硏究所硏究論文集 Vol.2 No.2

As demand for various kinds and small lot products has been increasing, batch annealing has been appreciated for its small restriction for the operation. The cold spot of the coil is very inportant in the BAF(Batch annealing furnace) annealing process. Because of the annealing cycle time in the BAF, annealing was decided on the cold spot of the coil. So, we tested the effect, variation of cold spot, for hydrogen contents of atmospheric gas at the annealing furnace. As a result of several investigations. We confirmed the following characteristics ; after the heating and soaking, the cold spot of coil moved to 1/3 of coil thickness in the HNx atmospheric gas, but the mid point of the coil thickness is the cold spot in the Ax or H₂atmospheric gas. Therefore, the use of hydrogen instead of nitrogen as the protective gas, combined with high convection in batch annealing furnaces, has shown that considerable increases in furnace output and material quality are attainable. Owing to the low density, high diffusion and reducing character of hydrogen, a better transfer resulting in uniform material temperatures and improved coil surfaces can be achieved.

건축물 건설단계에서의 에너지소비량 및 CO₂배출량 원단위 산출

김종엽,이승언,손장열 대한건축학회 2004 대한건축학회논문집 Vol.20 No.10

The purpose of this study is to establish the database that could be applied to the building LCA Firstly, in this paper, the methodologies of building LCA and energy based I/O model for estimating embodied energy of building materials were examined Then, the intensity of energy consumption and CO₂ emission for building materials and construction stage were estimated The intensity database for building materials calculated by the I/O table published in 2000 was compared with the database by the I/O table published in 1995 According to the result of comparison, there were a little differences between the results calculated by the new and the previous data, and two results showed nearly the same patterns So, it could be said that the industrial activity change has little effect on the energy intensity of building materials during the past 5 years For the calculation of the energy intensity in the construction stages, the payment documents of an ad and electricity consumptions during construction for the sample buildings were surveyed and the intensity per a building gross area were calculated The database presented in this paper could be applied to the building LCA process as the basic data for analysing global worming effect caused by building construction

자동차용 냉연강판의 풀림방법이 성형성에 미치는 영향

김순경,이승수,전언찬 동아대학교 공과대학부설 생산기술연구소 1998 生産技術硏究所硏究論文集 Vol.3 No.1

The formability of an automobile body panel is very important. So, we performed an annealing condition change for the development of annealing condition with temperature, atmospheric gas and the annealing cycle. Formability was changed under the influenced of the mechanical properties of steel sheet for the automobile body panel. Thwerfore, it is important in the BAF(Batch annealing furnace) annealing process. Because mechanical properties were decided on the heat treatment method of the coil. So, we tested the development of mechanical properties according to the heat treatment method at the annealingfurnace using the Ax atmospheric gas and the HNx atmospheric gas. As a result of several investigations, we confirmed the following characteristics ; mechanical properties change under the influence of the annealing cycle and atmospheric gas.

저탄소강의 풀림 사이클에 대한 예측 프로그램 개발

김순경,이승수,김문경,전언찬 동아대학교 공과대학부설 생산기술연구소 1997 生産技術硏究所硏究論文集 Vol.2 No.2

The cold spot of the coil is very important in the BAF(Batch annealing furnace) annealing process. Because of the annealing cycle time in the BAF, annealing was decided on the cold spot of the coil. So, we tested the temperature variation of cold spot and the correctness of computer simulation at the annealing furnace using the Ax atmospheric gas. As a result of several investigations. We confirmed the following characteristics ; Annealing cycle was changed under the influence of the strip surface condition and the strip tension. The cold spot of coil was the mid point of the B coil in the Ax atmospheric gas. And, the power of recirculation fan is very important in the high convection annealing furnaces.

자동차용 강판의 열처리 특성에 관한 연구

김순경,이승수,전언찬 동아대학교 공과대학부설 생산기술연구소 1998 生産技術硏究所硏究論文集 Vol.3 No.1

Development on the mechanical properties of steel for the automobile body panel is very important in the BAF(Batch annealing furnace) annealing process. Because of the heat treatment in method the BAF, mechanical properties was decides on the heat treatment method of the coil. So, we tested on the development of mechanical properties according to heat treatment method at the annealing furnace using the Ax atmospheric gas and the HNx atmospheric gas. As a result of several investigations. We confirmed the following characteristics ; mechanical properties was changed under the influence of the annealing cycle and the atmospheric gas. The coil spot of coil was the mid point of the B coil in the Ax atmospheric gas. And, atmospheric gas is very important in the high convection annealing furnaces.

래칫 휠의 자동설계와 유한요소해석을 이용한 검증에 관한 연구

김민주,이승수,전언찬 한국공작기계학회 2002 한국생산제조학회지 Vol.11 No.3

This study is an investigation for the ADS optimum design using FEA. We write out program which express ADS perfectly and reduce the required time for correcting of model to the minimum in solution and manufacture result. We complete algorithm which can plan optimum forming of model by feedback error information in CAE. Then we correct model by feedback date obtaining in solution process, repeat course following stress solution again and do modeling rachet wheel for optimum forming. That is our aim. In rachet wheel, greatest equivalence stress originates in key groove comer and KS standard is proved the design for security.