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일측성 질폐쇄 및 동측 신장 무발생을 동반한 중복자궁 2예
윤일영,여소진,김형문,김정식,김태희,이해혁,남계현,이권해,김준모,김민의 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2
Uterus didelphys with unilateral obstructed hemivagina and ipsilateral renal agenesis usually presents after menarch with progressive abdominal pain during menses secondary to hematocolpos, and indeed a very rare congenital anomaly due to Mullerian duct malformation. An accurate and prompt diagnosis is of importance to permit treatment and to assure the future fertility of the patient. Pelvic ultrasound, physical examination and pelvic MRI established a diagnosis of hematometracolpos secondary to uterus didelphys with unilateral imperforate hemivagina. An incision in the vaginal septum allowed drainage of the hematocolpos, providing relief of the patients symptoms. We report two case of uterus didelphys with obstructed hemivagina with brief review of the literature.
오영애,하귀현,박인경,김미향,김미정,김미경,정자림,이명숙,김순동 대구효성가톨릭대학교 식품과학연구소 1992 식품과학지 Vol.4 No.-
This paper showed the summarization of the preservative method of wild vegetables in the house and the precessing method of Japanese pickles. The preservative methods of wild vegetables were explained devided into long, short term, fresh state, heat treatment and drying. Salt, soybean fermented sauce, soybean fermented paste, lees of refined rice wine and residue in the preparation of bean curd were used as the materials of Japanese pickles.
Paclitaxel 및 Apo-2L/TRAIL이 자궁경부암 세포주 아포토시스에 미치는 영향
김주영,남계현,김태희,이권해,이해혁,배동한 순천향의학연구소 2003 Journal of Soonchunhyang Medical Science Vol.9 No.2
Objective: TRAIL(also called Apo-2L) is a member of the tumor necrosis factor(TNF) family of cytokines which induces apoptosis cell death in a variety of tumor cell lines. It mediates its apoptotic effects through one of two receptors, DR4 and DR5, which are members of the TNF receptor family, and whose cytoplasmic regions contain death domains. TNF and Fas ligand induces apoptosis in tumor cells; however, their severe toxicity toward normal tissues hampers their application to cancer therapy. We examed if paclitaxed and/or Apo-2LTRAIL induces apoptosis of cervical cancer HeLa, SiHa, ME-180, and CaSki cells. Mehods : We have demonstrated that paclitaxel and Apo-2L/TRAIL induces apoptosis of cervical cancer HeLa, SiHa, CaSki and ME-180 cell lines in a dose-dependent manner. HeLa, SiHa, ME-180 and CaSki were obtained from American Type Culture Colection. Recombinant Human TRAIL(Chmicon). DR4 and DR5 were purchased from Santa Cruz. Paclitaxel, MTT assay Kit, Acridine orange and Ethium bormide were purchased from Sigma. HeLa and SiHa were grown in DMEM. ME-180 and CaSki were grown in RPMI. Tripan blue stain and MTT assay were done for cytotoxicity. Annexin V-FITC and PI(propidium iodide) flowcytometry for apoptosis assay. DR4 and DR% were expressed by Western Blot. Fluorescent Microscopy used Acridine orange(AO) and Ethium bromide(EB). Results : Importantly, concurrent treatment of cervical cancer cells with paclitaxed and Apo-2L/TRAIL induces significantly more apoptosis than Apo-2L/TRAIL alone. Conclusion : We need further studies which reveals possible therapeutic potential in the women with cervical cancer by suing Apo-2L/TRAIL.
한국판 Edinburgh Postnatal Depression Scale의 임상적 적용
김용구,허지원,김계현,오강섭,신영철 大韓神經精神醫學會 2008 신경정신의학 Vol.47 No.1
Objectives : The EPDS (Edinburgh Postnatal Depression Scale) is a lO-items self-report scale designed as a specific instmment to detect postnatal depression by Cox et al. (1987). This study was to determine the optimal cut-offpoint ofthe K-EPDS for postpartum depression in Korea. Methods : The 239 pregnant women assessed their own psychiatric features with the Korean version of the Edinburgh Postnatal Depression Scale (K.-EPDS), Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), Rosenberg Self-Esteem Scale (RSES) and Marital Satisfaction Scale (MSS) at 6 months ofpregnancy, 1 week after delivery, and 6 weeks after delivery. Subjects above 9 points of K-EPDS at 6 week after delivery were interviewed with Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I) to confirm postpartum depression. Results : The prevalence of postpartum depression was 12.6% (30/239 pregnant women) in our study. The total scores of K-EPDS at 6 weeks after delivery were higher significantly than those of nonnal group. The score gap of K-EPDS between the depressed pregnant group and the normal pregnant group was increased after the delivery. However, there were no differences in the epidemiological characteristics and the BDI scores at 6 weeks after delivery between groups. Using the AUC (area under the curve), the optimal point to assess the postpartum depression was revealed as 6 weeks after delivery (AUC=85.8%) or 24 weeks of pregnancy (83.7%). The cut-offpoint of K-EPDS to detect postpartum depression among pregnant women was 9/10score of K-EPDS (AUC= 81.8%). Conclusion : In the K-EPDS, cut-off score of 9/10 was optimal to assess the postpartum depression, and K-EPDS at 6 weeks of delivery was more useful than any other point of time. K-EPDS administrated during pregnancy may be a useful tool to find the vulnerability on the postpartum depression.
A case of self-healing juvenile cutaneous mucinosis
( In Hyuk Kwon ),( Dae Yeon Kim ),( Dong Won Lee ),( Tae Hyung Ryu ),( Jae Eun Choi ),( Soo Hong Seo ),( Young Chul Kye ),( Hyo Hyun Ahn ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1
Self-healing juvenile cutaneous mucinosis is a very rare, self-limiting disease characterized by transient cutaneous lesions that affects the young. This disorder is characterized by rapid onset of asymptomatic papules and nodules on the face, periarticular regions, abdomen, and thigh. As implied by the name, the lesions spontaneously resolve over weeks to months. In contrast to mucinoses affecting adults, Self-healing juvenile cutaneous mucinosis has not been associated with systemic disorders such as paraproteinemia, bone marrow plasmacytosis, or thyroid diseases. A 7-year-old male presented with erythematous papules, multiple subcutaneous nodules on trunk and both arms that began 6 days before. Aside from pruritus of lesions no other symptoms were manifested. Histopathology showed microabscess in epidermis, superficial perivascular lymphocytic infiltration, and mucin deposition in dermis On follow up visit, although new lesions were present, previous lesions were subsiding. In consideration of the clinicopathological features, the diagnosis of self-healing juvenile cutaneous mucinosis was made. The patient is under close observation with no specific treatment. Herein, we report a rare case of self-healing juvenile cutaneous mucinosis. Knowledge of this entity may prevent unnecessary diagnostic testing and aggressive treatment in the pediatric population with this self-limited disease.
( Hyun Jung Lee ),( Young Joo Jin ),( Jin Woo Lee ),( Hyun Jung Chung ),( Byung Wook Bang ),( Seok Jeong ),( Kye Sook Kwon ),( Don Haeng Lee ),( Hyung Gil Kim ),( Yong Woon Shin ),( Young Soo Kim ) 대한간학회 2013 춘·추계 학술대회 (KASL) Vol.2013 No.1
Background: Patients with liver cirrhosis frequently undergo secondary prophylactic endoscopic band ligation (EVL), and these patients can suffer from EVL with non-sleep endoscopy. Given the impaired metabolism of drugs administered for sedation in cirrhotic patients, we investigated the safety of sleep endoscopy for secondary prophylactic EVL in those patients who had a previous history of variceal bleeding Methods: A total of 59 cases with secondary prophylactic EVL that were performed at our institution between August, 2010 and April, 2013 were consecutively recruited. We compared the frequency of hepatic encephalopathy (HEP) between patients with sleep endoscopy and non-sleep endoscopy. Midazolam was intravenously injected for conscious sedation, and flumazenil was always used as antidote after sleep endoscopy. Results: The median patient`s age was 55 years (range, 29-89 years). The most common causes of liver cirrhosis were hepatitis B virus infection (44.1%) and alcohol (42.4%). Of the 59 cases, 39 (66.1%), 13 (22.0%), and 7 (11.9%) had Child-Tur- Turcotte- Pugh class A, B, and C, respectively. Sleep endoscopy was performed in 52 (88.1%) of the 59 cases [CTP class A (n=35, 67.3%), B (n=13, 25.0%), and C (n=4, 7.7%), respectively], and the remaining 7 (11.9%) underwent non-sleep endoscopy. Median dosage of midazolam was 5 mg (range, 2-10 mg). None of the patients had experienced HEP after sleep endoscopy for secondary prophylactic EVL, and this result was same to those with non-sleep endoscopy. Conclusions: Our data showed that intravenous midazolam may be used safely in cirrhotic patients, even in those with CTP class C undergoing secondary prophylactic EVL for conscious sedation, but large scaled prospective randomized studies should be performed to confirm our results.