대장게실염 -18 예-

김광연,차귀현,이영희,유경수 대한대장항문학회 1986 Annals of Coloproctolgy Vol.2 No.1

중학교 과학 분야(과)에 대한 7차 교육 과정 중 화학 단원의 비교 분석에 관한 연구

유광식,이동현 울산대학교 2003 자연과학논문집 Vol.13 No.1

제7차 교육 과정에 대한 중학교 과학과의 교육 목표와 과학 교과서 및 교사용 지도서의 화학 단원에 대한 학습 목표를 Klopfer의 과학 교육 목표 분류 체계를 이용하여 비교 분석하였고, 본 과정의 개선 및 시행에 필요한 자료를 얻고자 하였다. 분석 결과는 다음과 같았다. 1. 제7차 교육 과정의 중학교 과학과 교육 목표는 Klopfer의 과학 교육 목표 분류 체계의 범주에서 G.0을 제외한 전 범주에 걸쳐 그 목표를 설정하고 있으며, 범주 A.0~E.0과 F.0, H.0, I.0의 비중 등은 높게 나타났다. 2. 제7차 교육 과정의 중학교 과학 교과서는 1, 2학년 모두 과학적 태도 및 흥미(H.0)에 관한 요소나 목표가 전혀 언급되고 있지 않기 때문에 과학에 대한 흥미를 잃게 하지 않을까 우려 된다. 과학에 대한 경향성(I.0)의 목표 역시 언급되어 있지 않아서 정의적 영역의 목표가 소외되어 있음을 알 수 있었다. 지식과 이해(A.0)에 관한 목표는 84.8%로 지나치게 편중되어 있는 반면에 과학 지식과 과학적 방법의 적용(F.0)에 관한 목표는 5.9%로서 낮았으므로 중학교 과학 교과서의 화학 단원이 실생활과 관련이 적은 내용으로 구성되어 있음을 알 수 있었다. 3. 제7차 교육 과정의 중학교 과학과 교사용 지도서의 지식과 이해에 관한 목표 비율은 83.0%로서 47% 정도를 제안하고 있는 미국 NSTA(National Science Teachers Association, 1982)의 권장 비율보다 월등 높은 것을 알 수 있었다. 과학적 탐구 과정(B.0~E.0)에 관한 목표 비율은 11.0%로서 NSTA(1982)의 권장 비율 30%에 비해 낮음을 알 수 있었다. The educational objectives of science on the 7th curriculum and the learning objectives for the chemistry domain of the middle school science textbooks and teacher's guides on the 7th curriculum were comparatively analyzed by use of Klopfer's Taxonomic system. This study tries to obtain data for improving and operating of the 7th curriculum. The analytical results are as follows. 1. The educational objectives of middle school science on the 7th curriculum include all of the categories of Klopfer's Taxonomic system except G.O. A.0~E.0, F.0, H.0, and I.0 were shown in high level. 2. Attitudes and interests(H.0) wasn't described at all in the middle school science textbooks on the 7th curriculum for 1 and 2 year course of middle school and it showed responsible for losing the interest of science. Orientation(I.0) wasn't also described. It showed that the affective domain was alienated. It seems to be overemphasized that knowledge and comprehension (A.0) are 84.8%. Scientific knowledge and methods(F.0) was contained only 5.9% in the textbook. This fact showed that the chemistry domain of the middle school science textbooks consists of some irrelevant contents to the actual life. 3. Knowledge and comprehension of the middle school science teacher's guides on the 7th curriculum was described 83.0% which is higher than 47% of NSTA(National Science Teachers Association, 1982). Processes of scientific inquiry(B.0~E.0) was only 11.0% which is lower than 30% of NSTA.

다발성 말초신경병증으로 발현한 Churg-Strauss 증후군 1예

이지현,김종국,유봉구,김민정,김광수 KOSIN UNIVERSITY COLLEGE OF MEDICINE 2006 高神大學校 醫學部 論文集 Vol.21 No.1

Churg-Strauss syndrome (CSS) is defined by eosinophil-rich and granulomatous inflammation of the respiratory tract and necrotizing vasculitis affecting small to medium-sized vessels, associated with asthma and eosinophilia. It is strongly associated with antineutrophil cytoplasmic antibodies, especially the anti-myeloperoxidase type (p-antineutrophil cytoplasmic antibodies) are most often found in CSS. Neurologic involvement is common and may develops early in patients with CSS, usually manifestings as peripheral neuropathy especially mononeuritis multiplex. We report a 58-year-old woman of Churg-Strauss syndrome presented with distal asymmetric polyneuroapthy, which has been reported rarely.

韓方藥의 藥理

김공수,유광석,한종현 圓光大學校 韓醫學硏究所 1993 원광한의학 Vol.3 No.1

Western medical science places the highest priority on scientific analysis and research. Therefore, Western medicine has obtained good results by estabilishing specific countermeasures against individual diseases, with causes thoroughly analysed and positively diagnosed. On the other hand, Oriental medical science has been particular about intergrating the part into the whole, in general. The superiority and/or inferiority of one approach over the other cannot be determined by either of the two medical sciences, due to the fundamentally different bases. Therefore, the two medical schools must now be combined, by distinguishing and isolating the respective characteristics in treatment, first seperatly and then combined, during a transition period. If Western medical science may be likened to a piece of brick, as its substance can be easily defined, Oriental medical science may be likened to cement. If one were to build a medical science house for the 21st century, a comfortable house could be built using either to the medical sciences as building material, Western medical science, corresponding to brick, or Oriental medical science, corresponding cement. Bricks are easily dimensioned and standardized, whereas cement is not only fixed in from, but requires a great deal of experience for its successful use. Howerever, both items are essential as building materials. It may be held that we can successfully treat the complicated pathogens of diseases afflicting the aged and chronically ill patients by making full and intelligent use of both medical sciences.

급성 뇌경색 환자에서 경색 위치가 심근 효소치 상승에 미치는 영향

윤경호,박현영,박성욱,장혁,김요식,조광호,유남진,김남호,오석규,정진원 圓光大學校 醫科學硏究所 2003 圓光醫科學 Vol.18 No.2

圓光醫大 附屬 第2病院 神經精神科 患者에 對한 統計的 考察(Ⅱ)

박민철,장광철,김상원,김한주,유미경,김훈,유용진,김현정,박남진,오상우,이귀행,노승호,백영석 圓光大學校 醫科大學 神經精神科學敎室 1992 圓光精神醫學 Vol.8 No.1

본 연구는 1986년 7월 11일부터 1991년 7월 10일까지 원광의대 부속 제2병원 신경정신과에서 의래 및 입원치료를 받았던 6,072명의 환자를 대상으로 병원 역학조사를 실시하고 그 결과를 1차조사 (박민철 등1986)와 비교했다. 1.전체 환자 중 남자가 54.4%로 여자보다 많았고, 이리와 이리 인접지역이 84.0%로 대부분의 지역을 나타났다. 의료보장상태는 보험환자가 57.1%, 의료보호환자21.8%, 일반환자 21.1%였으며 연령별로는 20대 24.6%, 30대 22.8%로 20대 30대가 절반정도를 차지했다. 2.외래환자에서는 신경중성장애가 46.0%로 가장 많고 정동장애, 경련성장애 순이며, 입원환자에서는 정신분열증이 30.5%로 가장 많고 기질성정신장애, 정동장애의 순이었다. 3.남자는 신경증성쟝애(23.4%), 정신분열증, 기질성정신장애 순이고 여자는 신경증성장애(39.9%), 정동장애, 정신분열증의 순이었다. 남자가 여자보다 많은 진단은 알코올정신장애(94.6%), 기질성정신장애, 소아정신장애 순이고, 여자가 남자보다 많은 진단은 정동장애(64.5%), 신경증성장애였다. 4.진단별 연령분포에서 신경증성장에는 30대(25.3%), 20대, 40대 순이고, 정신분열증은 20대(40.5%), 30대, 40대 순이며, 정동장애는 20대, 30대, 50대 순이나 비교적 비슷한 융이었다. 5.진단별 발병연령에서 신경증성장에는 20대, 30대가 절반이고,정신분열증은 20대(51.3%), 10대, 30대 순이며 정동장애는 20대(30.7%), 30대, 50대 순이었다. 진단별 평균 발병연령은 신경증성장애 32.7세, 정동장애 36.1세, 정신분열증 23.6세였다. 6.진단별 이병기간은 2년이상이 신경증성장에 28.3%, 정신분열증 68.5% 정동장애 43.9%인데 전체적으로 41.0%였다. 진단별 평균 이병기간은 정신분열증 73.2개월, 정동장애 45.5개월, 신경증성장애 29.5개월이었다. We examined epidemiologic study of 6,072 patients who visited Wonkwang Neuropsychiatric hospital since July 11 of 1986 until July 10 of 1991 and compared this results with previous study(Park et al 1986). The study revealed as follows:1. Of total patients males visited this hosptial more than females as 57.1%, Most of them(84.0%) resided Iri and neighbouring Iri. In the point of insurance, insured patients, medicaid patients and uninsured patients were 57.1%, 21.8% and 21.1% respectively. On the distribution of age, the twenties, the thirties were 24.6%, 22.8% respectively and twenties and thirties were about half of total patients. 2. Of outpatients neurotic disorder was the most as 46.0%, secondly mood disorder and thirdly convulsive disorder, but of inpatients schizophrenia was the most as 30.5%, secondly organic mental disorder and thirdly mood disorder. 3. Of males neurotic disorder was the most as 23.4%, secondly schizophrenia, and thirdly organic mental disorder, but of females neurotic disorder was the most as 39.9%, secondly mood disorder and thirdly schizophrenia. alcoholic mental disorder(94.6%), organic mental disorder, child mental disorder were mostly found in males,but mood disorder(64.5%) and neurotic disorder were mostly found in females. 4. On the distribution of age neurotic disorder was found the most in the thirties(25.3%), next in the twenties and in the forties, and schizophrenia was found the most in the twenties(40.5%), next in the thirties and in the forties, but mood disorder was found the most in the twenties, next in the thirties and in the forties but revealed similar rates relatively. 5. On the distribution of age of onset neurotic disorder developed nearly half during the twrnties and the thirties, schizophrenia developed mostly during the twenties (51.3%), secondly the teens and thirdly the thirties, but mood disorder developed firstly the twenties(30.7%), secondly the thirties and thirdly the fifties. on the average age of onset of illness neurotic disorder, mood disorder and schizophrenia were 32.7 years, 36.1 years and 23.6 years respectively. 6. On the duration of illness more than two years was 28.3% in neurotic disorder, 68.5% in schizophrenia and 3.9% in mood disorder and on the average duration of illness schizophrenia, mood disorder and neurotic disorder were 73.2 months, 45.5 months and 29.5 months respectively.

항히스타민제의 대리결과변수로서 히스타민에 의한 피내주사반응 유용성에 대한 고찰

한나영, 송병정, 백현문, 정에벤, 유영훈, 전지현, 구성우, 윤휘열, 권광일 충남대학교 약학대학 의약품개발연구소 2017 藥學論文集 Vol.32 No.-

In this study, it is reviewed that histamine-induced wheal and flare responses are potential sur-rogate endpoints for predicting the clinical effects of antihistamines in patients with allergic skin diseases. Histamine plays an important role in allergic response by inducing degranulation of mast cells due to allergen exposure and mediating the inflammatory reaction. Thus, suppression of histamine-induced wheal and flare has been noted as surrogate markers for efficacy of Hl receptor antagonists. In addition, allergy skin prick test and intradermal test using histamine have been used to diagnose the histamin-induced allergic reaction. However, it has been well known that allergic diseases are not only mediated by histamine. but also by var-ious immunological inflammatory responses. Previous studies reported that there is a lack of evidence about the correlation between antihistamines to predict clinical efficacy and antihistamine efficacy, although hista-mine-induced wheal and flare responses may be useful indicators of the dose-response relationship. In con-clusion, the evaluation for the suppression of wheal and flare after histamine injection is reasonable for de-termining the treatment of allergic simple skin diseases, but there is a limit to evaluate the efficacy in com-plex inflammatory diseases mediated IgE or T cells, or other immune complex. Therefore, further studies are needed to identify additional surrogate endpoints to predict the therapeutic effect of antihistamines in other inflammatory diseases such as allergic rhinitis, atopic conjunctivitis, allergic asthma, and so on.

국외 먹는 물 자외선 소독 법규

염철민,김도겸,정광열,유양수,조창현 대한상하수도학회 2003 상하수도학회지 Vol.17 No.6

난소절제후 Estrogen을 투여한 흰쥐 대동맥에서 Protein Kinase C-α와 Fas 발현의 변화

이왕수,이상엽,안지현,송영빈,김학진,이광재,유재격,김상욱,김태호,김치정,류왕성 중앙대학교 의과대학 의과학연구소 2001 中央醫大誌 Vol.26 No.3

Estrogen is believed to decrease coronary artery disease. Protein kinase C-α(PKCα)appear to be important in signal conduction pathways. Estrogen treatment increases catalytic activity of PKCα,and activation of PKCαcan modulate estrogen receptor levels and responsiveness. And it was reported that activation of PKC can protect cells from apoptosis induced by Fas ligation. But the beneficial effect of estrogen on PKCαwas not clearly demonstrated. The objective of this study was to evaluate the role of PKCαafter ovariectomy and estrogen therapy in rat aorta. The results were summarized as below: 1. The significant pathological changes were not observed in the rat aorta irrelevant to ovariectomy and estrogen therapy. 2. The expression of Fas was decreased in the aorta of estrogen-treated rats than that of ovariectomized rats without estrogen therapy. 3. Increased expression of PKCαwas more marked in the aprta of estrogen-treated rats than that of ovariectomized rat without estrogen therapy. In conclusion,PKCαmay be important in signal conduation pathway on the effect of estrogen. Activation of PKCαby estrogen reduced Fas expression, suggesting that PKCαactivation may play a role in protection against atherasclerosis. Further studies are needed to elucidate the role of PKCαafter estrogen therapy.

고빌리루빈혈증을 동반한 자가면역성 간염 1례

서영범,김성욱,장재식,강혁주,이중현,윤병구,김욱년,이광헌,이구,유석동,양창헌,이정호,이영현,이창우,서정일 동국대학교 의학연구소 2000 東國醫學 Vol.7 No.-

자가면역성 간염은 대개 만성 경과를 가지며, 혈중 자가면역항체와 혈청 글로불린치의 상승, 그리고 조직학적으로 괴사 염증성 변화를 특징으로 하는 질환으로 아직 정확한 병인이 밝혀져 있지 않은 상태이다. 발병연령은 대개 젊은 영자(15-25세)에서 호발한다. 이 질환은 급성 간염의 임상경과를 보일 수 있으나, 심한 급성 간염이나 전격성 간염으로도 나타날 수 있는데, 이 경우 아주 나쁜 예후를 보인다고 한다. 치료는 자가면역성 간염 임상 경과의 다양성이나 병인, 병리기전의 불확실성에도 불구하고 대개 steroid 치료에 반응하는 것으로 알려져 있으며 대개 80%의 관해율을 나타내며 궁극적으로 간경변으로의 진행을 막을 수 있는 것으로 보인다. 저자들은 58세 남자에서 발생한 급성의 경과를 가지고 심한 황달을 동반한 자가면역성 간염을 경험하였기에 문헌고찰과 함께 보고하는 바이다. Autoimmune hepatitis (AIH) is a chronic necroinflammatory liver disorder of unknown cause associated with circulating autoantibodies and a high serum globulin level. The age of onset of AIH show a peak between the age of 15 and 25 years. AIH can develop and be manifested as acute hepatitis, but severe form of acute hepatitis or fulminant hepatic failure has a poor prognosis. Although AIH is likely to progress from chronic active hepatitis to cirrhosis, steroid therapy can control the disease activity, prolong survival, improve the quality of life , and defer liver transplantation. In the present report we describe a 58-year-old man who admitted because of progressive jaundice and fatigue. He was diagnosed with AIH from laboratory test result showing positivity for antinuclear antibodies, anti-smooth muscle antibodies, and negativity for hepatitis viral markers and from liver biopsy. Steroid therapy, oral administration of prednisolone, was effective in improving the liver function test. Following liver biopsy 6 months after onset shows markedly improved necroinflammatory activity.