원발성 유방암에서 Sodium Iodide Symporter의 발현과 ^(99m)Tc-MIBI 유방스캔의 관계

석주원,김성장,곽희숙,이창훈,김인주,김용기,배영태,김동수 대한핵의학회 2002 핵의학 분자영상 Vol.36 No.6

목적: hNIS는 갑상선 조직 외에 다른 조직들에서도 발현된다고 알려져 있다. 유방암 세포는 그런 조직들 중에 하나이며, 그에 의한 유방암의 방사성옥소치료의 가능성이 제시되고 있다. 본 연구에서는 유방암 조직에서 hNIS의 발현정도를 알아보고, ^99mTc-MIBI 유방스캔과 hNIS의 발현 정도와의 관계를 조사하여 보았다. 대상 및 방법: 본 연구에서는 유방암으로 수술을 시행했던 56명의 환자를 대상으로 하였다. hNIS의 발현은 면역조직화학염색에 의해서 평가되었으며, 그 결과를 ^99mTc-MIBI 유방스캔의 판정 결과와 비교하였다. 결과: 전체 56명의 환자에서 hNIS의 발현율은 41.1%였다. 병리학적 진단에 의해 침윤성관상피암종이었던 49명에서의 발현율은 42.9%, 관상피내암종이었던 7명에서의 발현율은 28.6%였다. ^99mTc-MIBI 유방스캔에서 국소섭취 소견이 관찰되었던 41명에서의 hNIS의 발현율은 31.7%였다. 비정상적인 섭취 소견이 관찰되지 않았던 15명의 환자에서의 hNIS의 발현율이 의미있게 높게 관찰되었다(66.7%, p>0.05). 결론: 유방암 환자에서의 hNIS의 발현율은 그다지 높지 않았다. ^99mTc-MIBI 유방스캔에서 섭취증가 소견이 없을 때 hNIS의 발현율이 더 높았다. Purpose: Human Na^+/I- symporter (hNIS) is known to be expressed in many tissues other than thyroid gland. The breast cancer cells are one of them and the possibility of radioiodine therapy in treatment of the breast cancer may be suggested. We investigated the expression rate of hNIS and the relationship between the expression of hNIS and the finding of 99mTc-MIBI scintimammography in the breast cancer. Materials and Methods: Surgically proved 56 patients with breast cancer were the subjects of this study. The expression of hNIS were evaluated by immunohistochemistry and the results were compared to the findings of 99mTc-MIBI scintimammography. Results: Overall expression rate of hNIS was 41.1% in 56 patients. According to the pathologic diagnosis, it was 42.9% in 49 patients with invasive ductal carcinoma and 28.6% in the 7 patients with ductal carcinoma in situ. The expression rate of hNIS in the 41 cases with a focal increased uptake at he breast lesion on 99mTc-MIBI scintimammogram was 31.7%. That in the 15 cases without any abnormal uptake on the scan was significantly higher(66.7%, p<0.05). Conclusion: The expression rate of hNIS in the patients with breast cancer was not so high. The rate was higher in the patients with no increased uptake at the breast lesion on 99mTc-MIBI scintimammography. (Korean J Nucl Med 2002;36;325-32)

탄산가스를 이용한 아아크 용접에서 국소배기설비의 제어 속도가 용접성에 미치는 영향에 관한 연구

김병철,홍석주,김기형 조선대학교 동력자원연구소 1996 動力資源硏究所誌 Vol.18 No.2

It was studied the effects of control velocity of local exhaust installation in CO_2-Gas Arc Welding by using the SS41 in the process of car boby production. The properties of the specimens after welding were observed and analysed It was concluded as follows : (1) The trensile strength and tensile load was apparently lowered when the control velocity was above 1.0m/sec (2) The hardness was increased when the control velocity of hood was above 1.0m/sec in the welede metal. (3) When the control velocity was above 1.om/sec, the base metal was not completely melted. (4) In the bending test when the control velocity was above 1.0m/sec, weld zone was brittle. (5) When the control velocity was above the 1.0m/sec, the shielding effect was lowered and weld zone was found to be defective.

자가 말초혈액 조혈모세포 이식술의 임상적용

김혁,안명주,오석중,이영열,김인순,정태준,최일영,오미란,임호준,이항,김신규 한양대학교 의과대학 1999 한양의대 학술지 Vol.19 No.1

Responses to chemotherapy correlate with the increased dose of chemotherapeutic agents in some cancers, e.g. breast cancer, Ewing's sarcoma, Hodgkin's disease(HD) and non-Hodgkin's lymphoma(NHL), then for the improvement of the chemotherapy responsiveness, high-dose chemotherapy(HDCT) was proposed. But, it's application was limited due to complications, especially bone marrow suppression. HDCT and succeeding autologous peripheral blood stem cell transplantation(APBSCT) was introduced to overcome this problem. This study was designed to determine the clinical pictures including clinical parameters and the responsiveness of HDCT followed by APBSCT in Hanyang University Hospital. Ten patients were enrolled. They were 8 adults (3 breast cancers, 3 multiple myelomas, 1 HD, 1 NHL) and 2 children (1 acute myelogenous leukemia (AML), 1 neuroblastoma). Mobilization chemocherapy(MCT) followed by Granulocyte Colony Stimulating Factor(G-CSF) was administered to mobilize stem cells from bone marrow to peripheral blood. The stem cells were collected by using CS-3000 and cryopreserved at -196℃ with programmed controlled rate freezer as the mixture with 10% dimethyl sulfoxide(DMSO). HDCT was administered and cryopreserved peripheral stem cells were infused on day 0 as planned. Patients' mean age was 41 years old. After induction chemotherapy three patients achieved complete response and 5 partial response. The median time for bone marrow recovery after MCT was 11.5 days for neutrophil(〉500/㎣) and 4.8 days for platelet(〉20,000/㎣). There were three cases of neutropenic fever and one case of gingivitis. After HDCT with APBSCT, one patient was converted partial response to complete response, and one patient achieved complete response after HDCT without induction chemotherapy. The median time for bone marrow recovery was 12.7 days for neutrophil(〉500/㎣) and 14.7 days for platelet(〉20,000/㎣). Eight patients developed neutropenic fever and required systemic antibiotics. Transfusion was required 1.6 pints for packed red cell and 23.4 pints for platelet concentrates. Toxicity consisted mainly of vomiting, diarrhea, and mucositis which were mild. HDCT with APBSCT can be performed safely with minimal complications. For the evaluation of the exact role of HDCT with APBSCT in malignant diseases, further studies are required as a large scale of patients and lung-term follow up.

공구형상이 칩유동에 미치는 영향에 관한 연구

김경우,김우순,윤주식,채왕석,김동현 한국공작기계학회 2000 한국공작기계학회 추계학술대회논문집 Vol.2000 No.-

A new methodology is presented to evaluate material properties at high strain rates and high temperatures based on orthogonal metal cutting experiments and FEM simulations. Average strain rate and average temperature found in the deformation zone are computed and flow stress data at these conditions are modified until cutting forces calculated in simulations match those determined in experiments. Material properties obtained from this method were verified by additional metal cutting simulations. Derivation from cutting forces measured in experiments was less than 10%. The feasibility of tool design using FEM simulations is also demonstrated.

과학 수행 평가 문항의 선정 및 제작을 위한 평가 준거의 개발

김은진,박현주,강호감,노석구 한국과학교육학회 2003 한국과학교육학회지 Vol.23 No.1

본 연구에서는 과학교육에서 수행평가의 올바른 사용과 정착을 위하여 과학 수행평가문항의 선정과 제작을 위한 평가준거를 개발하였다. 이를 위하여 과학과 평가목표 및 수행평가에 대한 이론적 논의를 통해 평가준거의 대범주로 평가 목표의 충실도(Fidelity), 수행평가의 특징과 구성 요소에 대한 만족도(Satisfaction), 문항의 내용 타당도(Content Validity), 학습자에 대한 내용의 적합도 및 공정성(Suitability & Fairness), 문항의 신뢰도와 객관도(Reliability & Objectivity), 사용상의 편의성 및 실용성(Usability)의 6가지 범주를 개발하였고, 각 대범주별 하위항목을 선정하여, 총 25개의 하위 항목을 가진 평가준거표를 개발하였다. 그리고 개발된 평가준거표의 타당도는 과학교육 연구자 5명의 안면타당도로 보았고, 신뢰도는 3가지 종류의 과학 수행평가문항을 과학교육 전문가 2명과 초등예비교사 6명이 평가하교, 그 결과를 Kendall계수를 통한 평가자간 합치도로 검증하였다. 그 결과 합치도는 통계적으로 유의한 수준으로 나타났다. 이상의 과정을 통하여 최종적인 평가준거표를 완성하여 제시하였다. We have developed of a criterion that would help to select and develop performance assessments in science education. There are six categories of a criterion: Fidelity, satisfaction, content validity, fairness & suitability, reliability & objectivity, and usability. There are the total of 25 sub-categories under the six categories. Five science educators evaluated the validity of the criterion. For reliability of the criterion, Kendall's tau-b was used. Eight science educators and elementary teachers evaluated three performance assessment tasks for the correspondence of the criterion. This study also discuss the implications of this criterions as well.

Ethionine의 시간투여로 인한 Rat의 간과 신장의 지질과산화와 지질량의 변화 연구

김은석,김현아,이주연,이주현,한정희 曉星女子大學校 藥學大學 學生會 1990 曉星藥誌 Vol.5 No.-

The present studies were undertaken to evaluate the effect of Schedule administration of ethionine on the change of lipid peroxidation, total lipid, phospholipid, total cholesterol, and triglycerides of liver and kidney in male rats. The result obtained were summarized as follows ; 1) Hepatic and renal lipid peroxidation were significantly increased 18hr and 24hr after ethionine I.P. injecion. The change of hepatic and renal lipid peroxidation was maximal 18hr after ethionine I.P. injection. 2) Hepatic total lipid and triglycerides were significantly increased 12hr, 18hr, and 24hr after ethionine I.P. injection. The accumulation of total lipid and triglycerides was maximal 18hr after ethionine I.P. injection.

Lutembacher 증후군 환자 증례 보고

김성범,서정주,곽철훈,김상민,이보라,민선경,황은구,김용인,조욱현,최석구 인제대학교 2008 仁濟醫學 Vol.29 No.-

Lutembacher's syndrome is rare combination of mitral stenosis (MS) and atrial septal defect (ASD). The hemodynamic interplay between the MS and ASD leads to wide variation of clinical presentation. Here we describe a 43-year-old female with Lutembacher's syndrome and tricuspid regurgitation with pulmonary hypertension, who underwent direct closure of ASD and tricuspid valvuloplasty successfully. We also reviewed other literatures in an effort to increase awareness of this condition.

一部 美容業 從事者들의 織責別 腰痛 有病率과 關聯要因

김춘일,박종,류소연,김석산,김기순,하상호,변주남 조선대학교 부설 의학연구소 1999 The Medical Journal of Chosun University Vol.24 No.1

To find the prevalence and related factors of low back pain experienced by some beauticians. a survey was made toward 252 beauticians in Kwangju City from March 1st to April 1st, 1998. The results were as follows; 1. The prevalence rate of low back pain among the respondents for the last week was 59.5%. 2. The aid group and staff group with low back Pain had significantly longer duration of work than those without low back pain. Managers who had bad posture with twisted or too much extended back showed a significantly higher prevalence of low back pain than those with good posture during work(P<05). 3. Aid group with low back pain showed significantly higher points at total stress score, depression score, general health score and vitality score than those without low back Pain. The staff group with low back pain showed significantly higher points for total stress score, sleep disorder and anxiety score, depression score, general well-being and vitality score than those without low back pain. Managers with low back Pain showed significantly higher points of stress at social performance and self confidence (P<05) than those without low back pain. The above results suggest that low back pain is related to different jobs and work environments for beauticians. So effective measures and further studies against risk factors must be made considering their jobs. To prevent or reduce low back pain, appropriate management of stress for beauticians is necessary.

남서울대학교 교직교육과정 개편 방안

허영주,김원곤,전창석,이석열 남서울대학교 2009 남서울대학교 논문집 Vol.15 No.1

The purpose of this study is to search for method that Teacher's curriculum of Namseoul University is been active. For success of this purpose, we analyze strengthening on Teacher's education of Ministry of Education & Science, and analyze Kindergarten and Middle & High School's curriculum. And we examined the present managerial conditionand the problem of Teacher's curriculum in this university. Also analyze curriculum, support system and existing facilities of other universities.According of this analysis, for acting of Teacher's curriculum through the enlargement of advance into the teaching profession, we found alternate Teacher's curriculum. Key Words : alternate, Teacher's curriculum, teaching profession, survey

交通事故患者에 對한 精神醫學的 考察

金錫柱 大韓神經精神醫學會 1967 신경정신의학 Vol.6 No.1

The author studied 38 cases of traffic accident through psychiatric interview with 30 cases under control and acquired the following conclusions. 1. Higher accident rate could be observed in those 25 cases (65.7%) who had responsibility to support their families than those who had not. 2. It was observed that the more environmental problems the person had or the less adaptable the person was to his environment, The more tendency to give in to accidents was he subject to. 3. A considerable number of accident cases could be described as heavy drinkers. Six of them were found to have been drunken on accident. 4. It was proved that 21 of all cases had succumbed to compensation neurosis (55.3%) 5. Two in accident group had attempted suicide and other two had once involved in an accident. 6. Rorschach test was applied to both the accident group (38) and the control group(30), and the former in comparison with the latter showed the following findings: (1) Decrease of R (2) Frequent Rejection (3) Increase of Dm% (4) Decrease of F+% (5) Decrease of Σc (6) Increase of Destructive Index (Sex. blood, fire. explosion,) (7) Decrease of P The author can state that these Rorschach responses may identify results obtained by psychiatric evaluation through individual interview.