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      • Effects of <i>Ginkgo biloba</i> Extract on Promotion of Neurogenesis in the Hippocampal Dentate Gyrus in C57BL/6 Mice

        YOO, Dae Young,NAM, YoonYi,KIM, Woosuk,YOO, Ki-Yeon,PARK, Jaeil,LEE, Choong Hyun,CHOI, Jung Hoon,YOON, Yeo Sung,KIM, Dong-Woo,WON, Moo-Ho,HWANG, In Koo Japanese Society of Veterinary Science 2011 The Journal of veterinary medical science Vol.73 No.1

        <P><I>Ginkgo biloba </I>leaf extract (Gb) has been known to improve blood flow and preclude the tissue from free radical damage. Effects of Gb were examined by using Ki67, a specific proliferative marker for cellular proliferation, and doublecortin (DCX), a marker for immature neurons, indicating degree of neuroblast differentiation in the hippocampal dentate gyrus (DG) of adult C57BL/6 mice. The mice were fed with Gb at 40 and 100 mg/kg once daily for 28 days. The increase of Ki67- and DCX-immunoreactive cells in the DG was increased in a dose-dependent manner. Especially, the group having 100 mg/kg Gb showed a significant increase of DCX-immunoreactive neuroblasts with well-developed tertiary dendrites. Expression of DCX protein in the Gb groups was also significantly increased upon compared with the vehicle group. The results suggested that repeated intake of Gb would enhance cell proliferation and neuroblast differentiation in the mouse DG.</P>

      • KCI등재후보

        조혈모세포이식 환자에서 침습성 진균 감염에 대한 이트라코나졸 액과 플루코나졸 시럽의 예방 효과 : 전향적, 무작위, 비교 임상시험

        최수미,이동건,최정현,박선희,엄기성,김유진,김희제,민창기,유진홍,김동욱,이종욱,민우성,신완식,김춘추 대한감염학회 2005 감염과 화학요법 Vol.37 No.2

        목적 : 조혈모세포이식 환자에서 호중구 감소 기간 동안 이트라코나졸 액(ITZS)과 플루코나졸 시럽(FCZS)의 진균 감염에 대한 예방 효과를 전향적으로 비교해 보고자 하였다. 재료 및 방법 : 2001년 8월부터 2002년 6월까지 가톨릭 조혈모세포이식센터에 입원하여 동종 조혈모세포이식을 받은 만 18세 이상의 환자들을 각각 ITZS와 FCZS군으로 무작위 배정하여 침습성 진균 감염 발생과 약제 관련 부작용을 전향적으로 조사하였다. 결과 : ITZS군에 40명, FCZS군에 38명이 배정되었고, FCZS군 환자의 평균 나이가 더 많았다. 시험 약제 평균투여기간은 ITZS군 16.4일, FCZS군 21.9일로 ITZS군이 더 짧았다. 이는 ITZS군에서 소화기 부작용으로 인한 약제 중단이 더 많았기 때문으로 보인다. 시험 약제 투여 후 총 빌리루빈 수치의 유의한 증가가 관찰되었으나, 약제 관련 부작용은 모든 환자에서 가역적이었다. 호중구감소 기간동안 표재성 진균 감염은 두 군에서 모두 발생하지 않았고, 침습성 진균 감염은 ITZS군 5명(12.5%), FCZS군 8명(21.1%)으로 FCZS군에서 많았으나, 통계학적으로 유의하지 않았고, 사망률에도 유의한 차이는 없었다. 결론 : 침습성 진균 감염에 대한 이트라코나졸 액과플루코라졸 시럽의 예방 효과에 유의한 차이는 없었으나, 앞으로 더 많은 환자를 대상으로 잘 짝지어진 대조군 연구가 필요할 것으로 보인다. 부작용 중 간독성과 관련하여 이식시 투여되는 여러 약제들과의 상호작용에 대한 연구도 필요할 것이다. Background : Though fluconazole is widely used for antifungal prophylaxis, it is ineffective against mould infections including Aspergillus species. Itraconazole has a broader spectrum than fluconazole but the capsule form shows erratic bioavailability in neutropenic patients. In this study, we compared itraconazole oral solution (ITZS) with fluconazole syrup (FCZS) for the prevention of invasive fungal infection (IFI) in allogeneic hematopoietic stem cell transplant recipients. Materials and Methods : Adults receiving allogeneic hematopoietic stem cell transplantation (HSCT) from september 2001 to June 2002, were randomly allocated to either the ITZS group or the FCZS group. We prospectively evaluated the safety and efficacy of each drug. Results : Out of 78 patients (40 patients in the ITZS group and 38 patients in the FCZS group) who were eligible for this study, 37 patients completed the course of prophylaxis without any evidence of IFI. The mean duration of prophylaxis was 16.4 days for the ITZS group and 21.9 days for the FCZS group (P<0.006). Drug-related adverse events occurred in 28 patients (70.0%) and 19 patients (50.0%) in the ITZS group and the FCZS group, respectively. Common adverse events of ITZS were nausea, vomiting, and diarrhea. Drug-related reversible hepatotoxicity occurred in 4 patients in the ITZS group. There was a significant elevation of total bilirubin level in the ITZS group. The incidence of suspected IFI occurred in 5 patients (12.5%) who received ITZS, compared with 8 (21.1%) who received FCZS (P=0.372). There were no proven IFIs or superficial (oral/vaginal) fungal infections in both groups. Overall mortality was not different between the two groups (2.5% in the ITZS group versus 5.3% in the FCZS group, P=0.610). Conclusion : ITZS and FCZS showed similar protection against IFI during pre-engraftment period. Poor tolerability due to gastrointestinal troubles of ITZS might limit its success as prophylactic therapy. Well matched controlled study with large number of patients will be required in the future.

      • KCI등재후보

        경기 일부지역 육용 양돈작업장의 분진 및 내독소 농도

        유동호,김형아,허용,성재혁,이한기,박용규 한국산업위생학회 2003 한국산업보건학회지 Vol.13 No.1

        The aim of this study was to evaluate exposure to dust and endotoxin produced while working at swine confinement buildings. The dusts and endotoxin may cause adverse health effects on humans. Fourteen swine farms located at Yong-In, I-Cheon and Yeo-Ju of onggi-do were investigated. Husbandry workers form the farms were requested to wear personal sampler to measure respirable dust levels. Area samplings for total and respirable dust were also conducted at swine confinements buildings by season (summer under window open, winter under window close.) Gravimetric analyses and Limulus Amebocyte Lysate assay for measu- rement of dust level and endotoxin, respectively. The highest geometric mean (GM) concentration of airbome dusts was 7.47mg/㎡ for area respirable dust. and 10.35mg/㎡ for personal respirable dust. For respirable dust levels, seven farmers exceeded level of ACGIH, 3mg/㎥. The highest GM of endo- toxin was 5745.40 EU/㎥ for personal respirable dust. Significantly increased level of total dust (p〈0.001) and endotoxin in area total dust was observe with winter samples compared with those of summer. Area total dust and area respirable dust (r-0.622, p〈0.0001) was very significantly correlated in winter. Swine husbandry worker may have a considerable risk of ill health whenexposed to level of dust or endotoxin demonstrated at this study.

      • 일부 도시지역 성인들의 혈중지질치의 참고치 및 저콜레스테롤혈증에 미치는 요인 분석

        유기하,이동배,이태용,조영채,김수영 충남대학교 의과대학 지역사회의학연구소 2000 충남의대잡지 Vol.27 No.1

        Data from 3.982 adults participating in a health examination in a university hospital were analysed to determine the reference values of hyperlipidemia and hypolipidemia, and those were compared with American data. Also health related behaviors affecting hypocholesterolemia were investigated. 29.3% of the males diseased subjects, and as were 25.6% of the females in their twenties, 69.5% of the males in their 60s and 78.6% of the females in their 50s. The rate of diseased subjects tended increase with increasing age. The rates of the diseased were 60.1% for males and 55.2% for females. Among cardiovascular risk factors, the proportion of hyperlipidemia was 46.6%, fat liver 42.2%, hypertension 21.8%, glucose intolerance 13.7%, abnormal EKG 11. 0%, obesity 2.9% and anemia 1.7% for male subjects and hyperlipidemia was 31.2%, fat liver 29. 5%, anemia 27.5%, hypertension 21.1%, abnormal EKG 15.7%, obesity 7.3% for females in that order. The rates of cardiovascular risk factors were higher in males than in females except for anemia, abnormal EKG and obesity. The total cholesterol levels of 95 percentile for males and females were 227.0 mgldl, 226.0 mg/dl and the 5 percentile levels for males and females were 134.0 rag/dl, 131.0 mgldl, respectively. The LDL cholesterol level of 95 percentile for males and females were 150.0 mg/dl, 147.0 mgldl, and the 5 percentile were 53.0 mgldl, 51.0 mg/dl, respectively. The HDL cholesterol 95 percentile levels for males and females were 82.0 mg/dl, 83. 0 mg/dl, and those of 5 percentile were 36.0 mg/dl and 39.0 mg/dl, respectively. These data show that the mean levels of total cholesterol, triglyceride, LDL cholesterol were related to increased age in both sexes, and were slightly higher in the females than in the males over all ages, but those of HDL cholesterol decreased. The high cholesterol level group was associated with age, the amount of alcohol consumption, smoking and body mass index. But that was not associated with meat intake and regular exercise. No significant difference were found among the rates of all diseases except for diseases and anemia up to 160 mg/dl of cholesterol level in both sexes. Sex, regular exercise and glucose intolerance were revealed as influencing factors in the low serum cholesterol levels, but disease and abnormal EKG had a lowing effect for the low cholesterol risks. In conclusion, the reference values of Korean serum lipids were 5-25 mg/dl lower than Americans. The cut-off value to diagnosis hypolipidemia for the Korean is recommended as below 140 mg/dl of serum total cholesterol. The hyperlipidemia cut-off value should above 220 mg/dl of serum total cholesterol.

      • 한국프로야구 관중 유인을 위한 야구장 시설의 개선 방안

        전익기,유동현 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.6

        This research sought to present measures for improving a ballpark facilities to increase the number of spectators of Korean professional baseball matches. To this end, the research surveyed the status and trends of spectators of Korean professional baseball matches, and compared Korean situations with those of the United States and Japan where professional baseball matches are activated. Since its launching in 1982, Korea's professional baseball have been seeing its spectators steadily rising until the figure reached a record high of 5.4 million in 1995, before it plummeted. Korea's professional baseball tournaments reap most of their revenues from admission fees, unlike the United States and Japan. To bolster revenues from admission fees, ballpark facilities need to be expanded and improved. Thus, in consideration of the fact that a rise in spectators leads to an increase in revenues, the research sought to analyze causes of increasing spectators, address current problems surrounding Korea's professional baseball, and thus activate professional baseball matches.

      • 體育의 名稱 및 槪念에 대한 考察

        朴起東,柳根直 江原大學校附設 體育科學硏究所 1990 江原大學校附設體育科學硏究所論文集 Vol.- No.15

        It we consider terminological problems of "Physical Education" and merits or demerits of sports which is to be changed into P.E, because the term "P.E" itself has many problems, we can find some suggestions that it has limitations in its change of term and also, actual problems that it can not be changed into its new term "sports". Meamwhile, the concept that "Education through the physical introduced by early scholars researching on P.E, who have the thought that we must pursuit something more than "to be physical" in order for P.E to be valuable, made a great contribution to its securing a momentous position as one of valuable courses by emphasizing the function of P.E in the area of intellect and emotion. But, the questions not only on its educational effect but also on its impracticable measurement and management weakened its status. Studies and discussions on the academic discipline of P.E, since 1960, have presented the concept "Human Movement" as the subject of research, afterwards the discussion of academic discipline of P.E has become heated much more than ever.

      • 체육교사의 직업적 사회화에 관한 조사(Ⅱ) : -경기도내 체육교사를 중심으로-

        부기원,박기동,유근직 江原大學校附設 體育科學硏究所 1990 江原大學校附設體育科學硏究所論文集 Vol.- No.15

        This study aimed at analyzing on the basis of actual proof the occupational socialization of physical education teacher. The investigation was made on all of 292 physical education teachers both of 80 middle schools and 67 high schools in Kyungki province. The results gained from the investigation were as follows : (1) The initiation of their becoming physical education teacher were generated more by the experiences of play and sports than by those of physical education class they took. This data showed that the occupational socialization of physical education teacher closely related to the socialization of sports. (2) The most influential others on the physical education teachers were turned out to be their physical education. (3) The main motivations of becoming physical education were their major in physical education at college, self-confidence in their own physical competence and perspectiveness in further development of their special talent in specific sport. Compared with the first survey of local people of Kangwon province, they replied in the same tendency. This fact demonstrates that regardless of region there is a closs affinity between physical education teacher and sports.

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