Comparison of Proliferative Activity in Each Histological Subtypes of Benign and Atypical Intracranial Meningiomas by PCNA and Ki-67 Immunolabeling

최승진,장은덕,권성오,계대곤,박춘근,이상원,강준기,Choi, Seung Jin,Chang, Eun Deok,Kwon, Seung Oh,Kye, Dae Kon,Park, Choon Keun,Lee, Sang Won,Kang, Joon Ki The Korean Neurosurgical Society 2000 Journal of Korean neurosurgical society Vol.29 No.9

목 적 : 양성 뇌수막종에 비하여 이형성 및 악성 뇌수막종이 나쁜 임상적인 예후 및 양상을 보이는 것은 잘 알려져 있으나, 양성 뇌수막종에 있어서 각각의 병리조직학적 아형에 따른 생물학적 양상의 차이에 대해서는 잘 알려지지 않거나 일부 논란이 되고있다. 본 연구에서는 이형성 뇌수막종 및 양성 뇌수막종의 각각의 병리조직학적 아형에 따른 증식능의 차이여부를 알아보고자 PCNA와 Ki-67표지지수를 분석하였다. 방 법 : 본원에서 뇌수막종으로 수술을 시행하여 얻은, 재발을 보여 재수술을 시행한 2례를 포함하여, 파라핀에 포매시킨 27개의 조직을 대상으로 병리학적인 증식능을 분석하기 위해, PCNA에 대한 단일항체 및 MIB-1 단일항체를 이용한 면역조직화학적 염색을 시행하였다. 조직학적 분류상 meningothelial type이 8례, transitional type이 9례, fibroblastic type이 5례였으며, 이형성 수막종이 5례였다. 결 과 : PCNA표지지수의 평균값은 양성 수막종에서 meningothelial type이 $4.82{\pm}5.10%$, transitional type이 $9.01{\pm}4.25%$, fibroblastic type이 $5.66{\pm}5.32%$를 보였으나 이형성 수막종에서는 $27.62{\pm}19.67%$의 높은 지수를 나타냈고, Ki-67 표지지수의 평균값은 양성 수막종의 아형에서 각각 $0.43{\pm}0.85%$, $0.44{\pm}1.08%$, $0.24{\pm}0.18%$를 보이고, 역시 이형성 수막종에서는 $0.84{\pm}0.59%$의 높은 지수를 보였다. 즉, 양성 수막종에서 각각의 아형에 따른 PCNA 및 Ki-67 표지지수는 통계학적으로 의미있는 차이는 없었으나(p>0.05), 이형성 수막종에서는 의미있는 높은 표지지수를 보여(p<0.05) 양성 수막종에서 보다 높은 증식능을 보임을 알 수 있었다. 결 론 : PCNA 및 Ki-67 표지지수를 이용한 증식능의 비교결과, 양성 뇌수막종에서는 각각의 아형에 따른 생물학적 양상이나 예후는 차이가 없을것으로 생각되나, 이형성 수막종에서는 높은 증식능을 보여 이에 대한 예후를 예상할 수 있을것으로 생각되며, 또한 이러한 표지지수가 병리조직학적으로 양성과 이형성의 감별에 많은 도움이 될것으로 사료된다. Objective : The clinical prognosis and biological behavior of atypical and especially malignant meningiomas are well known to be worse than benign meningioma, but the degree of biological aggressiveness in each classical subtypes of benign meningioma is controversy. This study was performed to see whether there is a difference in the proliferative activity between each different histological subtypes of benign meningioma as well as atypical meningioma. Methods : Paraffin-embedded surgical specimens of 27 meningiomas, including two recurrent tumors, were studied to evaluate proliferative activity by immunohistochemical method with monoclonal antibodies to proliferating cell nuclear antigen(PCNA) and MIB-1. The specimens consisted of 8 cases of meningothelial, 9 cases of transitional, 5 cases of fibroblastic subtypes and 5 cases of atypical meningiomas. Results : Mean PCNA labeling indices of meningothelial, transitional and fibroblastic meningiomas were $4.82{\pm}5.10%$, $9.01{\pm}4.25%$ and $5.66{\pm}5.32%$, but that of atypical meningiomas was $27.62{\pm}19.67%$, noting a higher value compared to all three subtypes of benign meningiomas. Mean Ki-67 labeling indices of the above 3 subtypes were $0.43{\pm}0.85%$, $0.44{\pm}1.08%$ and $0.24{\pm}0.18%$, and that of atypical meningiomas was also revealed to be of higher value ($0.84{\pm}0.59%$). PCNA and Ki-67 labeling indices were not statistically different between histological subtypes of benign meningioma(p>0.05), but the differences of both immunolabeling between benign and atypical meningiomas were statistically significant(p<0.05). Conclusion : Immunolabeling of PCNA and Ki-67 in intracranial meningiomas reveals no prognostic difference between meningothelial, transitional and fibroblastic subtypes in classical benign meningiomas by measuring expression of PCNA and Ki-67, but it seems to be helpful in differentiating benign and atypical meningioma, later showing more proliferative activity and biological aggressiveness.

역행적 골수정 삽입술을 이용한 대퇴골 과상부 골절의 치료

권진우,신승호,조원호,성기호,김기환,손경태,이상훈,박세원,배종문,권태우 대한골절학회 2003 대한골절학회지 Vol.16 No.4

3분과 : 가선집재작업에서의 작업 생산성 및 비용 분석

한원성 ( Won Sung Han ),한한섭 ( Han Sup Han ),김남훈 ( Nam Hun Kim ),차두송 ( Du Song Chu ),조구현 ( Koo Hyun Cho ),민도홍 ( Do Hong Min ),권기철 ( Ki Cheol Kwon ) 한국임학회 2014 한국산림과학회지 Vol.103 No.1

본 연구에서는 임목수확작업에 사용되는 집재기계의 작업효율성을 분석하여 경사가 급한(20° 이상) 작업조건에 적합한 가선계 집재기계를 선정하는데 기초 정보를 제공하고자, 타워야더(RME-300T), 트랙터부착형 집재기(일명: 춘천집재기), 트랙터윈치(FARMI) 등에 의한 집재작업에서의 작업생산성 및 비용을 비교 분석하였다. 평균 흉고직경이 20 cm, 집재거리 60 m, 가로집재거리 10 m, 그리고 기계이용률이 70%인 동일한 작업 조건에서 작업이 이루어질 경우, 타워야더의 1일 집재작업 생산성은 33.04 m3/일, 트랙터부착형 집재기는 38.47 m3/일, 그리고 트랙터윈치는 14.17 m3/일으로 분석되었으며, 이에 따른 집재작업비용은 각각 25,105원/m3, 20,520원/m3, 37,835원/m3으로 나타났다. 동일한 작업조건에서 집재거리에 따른 각 집재기계별 작업효율성을 비교하였을 경우, 집재거리가 40 m 이내로 짧을 경우에는 트랙터윈치에 의한 집재작업이 효율적이며, 40~140 m의 집재거리에서는 춘천집재기가, 140 m 이상의 장거리 집재작업에서는 타워야더가 가장 효율적인 것으로 나타났다. This study was conducted to provide field-based harvesting study information which can be used to select an optimal cable system for certain work conditions on steep grounds (>20° ground slope) in Korea. Toaccomplish this study objectives, we evaluated three cable yarding systems (RME-300T tower-yarder, Chuncheontower-yarder, FARMI tractor winch) working in typical work conditions for their yarding productivity and operational efficiency. Those yarders are commonly used for removing logs or trees on steep grounds in Korea. Under the same work conditions (average DBH of tree to be cut, 20 cm; yarding distance, 60 m; lateral yardingdistance, 10 m; and machine utilization rate, 70%), the average productivities were 33.04 m3/day, 38.47 m3/day, and 14.17 m3/day for RME-300T, Chuncheon tower-yarder, and FARMI, respectively. Our standardized cost comparison study also showed that the yarding cost was highest at 37,835 won/m3 with FARMI, followed byRME-300T at 25,105 won/m3 for the same work conditions. We found the lowest yarding cost with the Chuncheon tower-yarder at 20,520 won/m3 which was resulted primarily from high yarding productivity at theyarding distance (60 m). Our analysis suggested that a small machine such as FARMI could be a low-costyarding machine option for a cable yarding job with a short yarding distance (40 m or less). The Chuncheontower-yarder is well suited for a mid-range yarding distance job in Korea, ranged between 40 to 140 m. Ifyarding distance were longer than 140 m, the RME-300T tower yarder appears to be most cost-effective.

양 족부 열감을 호소하는 하지불안증후군 환자 치험 1례

김경묵,서원주,김수빈,정우상,문상관,권승원,조기호,Kim, Gyeong-muk,Suh, Won-joo,Kim, Su-bin,Jung, Woo-sang,Mun, Sang-kwan,Kwon, Seung-won,Cho, Ki-ho 대한한방내과학회 2018 大韓韓方內科學會誌 Vol.39 No.2

Objectives: The purpose of this study is to evaluate the effectiveness of electroacupuncture on heat sensation of the feet of a 61-year-old female patient with restless leg syndrome. Methods: Electroacupuncture was performed at four acupoints (KI3 (太谿), KI6 (照海), LR3 (太衝), LR2 (行間)) selected to reduce heat sensation in both feet. The patient's symptoms were assessed using the VAS (Visual Analogue Scale), the SF-MPQ (short-form McGill Pain Questionnaire), and the IRLS (International Restless Legs Scale). The treatment was performed from April 20, 2010 to April 24, 2010. Results: During five sessions of electroacupuncture treatments, the VAS, SF-MPQ, and IRLS scores improved throughout the treatment period and afterwards. Conclusions: The results suggest that electroacupuncture at KI3(太谿), KI6(照海), LR3(太衝), LR2(行間) can be effective for reducing hot flush in both feet.

교과 목표에 기초한 공업계 고등학교『기계설계』교과서 분석 연구

권윤원,김기수 충남대학교 공업교육연구소 1999 論文集 Vol.22 No.1

The purpose of this study is to analyze the 「Mechanical Design」 textbook in the present curriculum(the sixth) of high school, to find its problems and to suggest the basic data for showing the direction of its development in the seventh school curriculum. The results of this study are as follows. 1) The 「Mechanical Design」 subject in technical high school has been from the first school curriculum to the seventh one and will be maintained and improved even in the new millenium. 2) The size of characters and illustrations are too small and their composition is too complicated in the editing structure of the textbook. 「Mechanical Design」 textbook is also at a burden on the students, for there are too many formulas for designing the mechanical elements. 3) Many problems, presented in the textbook, consist of simple ones of calculating type rather than explanatory ones requiting creatively thinking power. The contents of the textbook is much removed from graduates' job after leaving high school. 4) 「Mechanical Design」 textbook in the seventh school curriculum should be developed after due consideration about the contents, teaching and learning method, the structure, and the direction for developing.

忠南 錦山部의 綠地自然度 實態組査

權琦遠 忠南大學校 環境問題硏究所 1984 環境硏究 Vol.2 No.2

The census of the Degree of Green Naturality, indicating minus human interference against natural environment, was carried out in the region of Geumsan as a part of national programme towards nature conservation. The field survey was accomplised in the summer of 1983 by 1×1㎢ mesh in all the region of Geumsan. The Degree of Green Naturality of the region surveyed ranged from the lowest value of 3.06 in Geumsung- myoun to the highest value of 5.99 in Namee- myoun. The average D. G. N. of all the region was estimated to be about 5.1. The reforested stands of D. G. N. (6) were estimated to be 60.9% of all the region. The green naturality of Namee- myoun and Jinsan- myoun etc. contributed greatly to improving the average D. G. N. of all the region surveyed. If the naturality is fully restored within the range of possibility in the future, the potential best D. G. N. shall be attained to be about 7.0- 7.5.

보리잎의 色素, 蛋白質含量 및 光系Ⅱ 活性에 미치는 Sulfite의 影響

權炳奎,鄭華淑,朴基元 慶北大學校 師範大學 1985 敎育硏究誌 Vol.27 No.-

Sulfur dioxide, a major atmospheric pollutant, influences to photosynthesis and causes some damages such as chlorosis, necrosis etc. When SO_2 enters into leaf tissue through the stomata, it produces H^+, HSO_3^- and SO_3^-2 as it is dissolved in the water of cells. On the basis of a report that sulfite (SO_3^-2) serves as the most toxic material to SO_2 phytotoxicity, we treated sodium sulfite at the indicated concentrations and treatment time to barley leaves. Then the leaf disks were illuminated at 30,000 lux and placed in darkness. This study was carried out to investigate the effects of sulfite on pigments, protein content, and photosystem Ⅱ activity in barley leaves. With sulfite treatement of barley leaf disks, pigment and protein content were decreased in light but not in darkness. The rate of DCIP photoreduction was inhibited in light-dependence of sulfite. It was inhibited to 78% with sulfite (10mM) treatment for 1 hour.

광주광역시 도시기능의 공간분포패턴에 관한 연구

권준오,원열,강기수 조선대학교 국토개발연구소 1997 국토개발연구 Vol.17 No.1

This study has been carried out in order to offer basic data necessary to effective planning in space structure of city by examining the concentration degree of city functions in administrative parts through analyzing space distribution of Kwangju City. This study has been resulted in ; First, service works are mostly distributed in down areas(43.2%), and particularly high in Dong-Ku which has least space for administrative part and Seo-Ku, Puk-Ku and Kwangsan-Ku was in order. It showed that the functions of the city is preponderated. Second, the area with high rate of population allotment is relatively far from downtown areas and one with high rate of indusrtrial allotment is relatively near from downtown areas. It showed us the internal space structure in Kwangju shaping a concentric circle. Third, the following areas show specialization in particular works ; ⓐ Ariculture; Tae-Ye, Ssang-Chon2, Nong-Seong, ⓑ Mining Industry; Tae-Kum, ⓒ Manufacturing Industry; Ha-Nam, You-Deuk, Bon-Chon, ⓓ Elecrical Industry; Yong-Bong, Seo-San, So-Chon, ⓔ Construction; Tae-Kum, ⓕ Wholesacle and detail; Chung-Kum, Tae-Kum, ⓖ Transportation business; Shin-An, Tae-Kum, ⓗ Financial business; Chung-Kum, Tae-Kum, ⓘ Social works; Seo-Seuk, Fourth, manufacturing industry was concentrated in industrial complex area and transportation industry in the area of gateway to Kwangju and social works in the area of educational facilities respectively.

한국인 관상동맥의 변화양상에 대한 형태학적 연구

권태정,이상용,이한영,고영창,권기석,조재홍,김태공,김유훈,조갑래,서중석,이원태 內務部 國立科學搜査硏究所 2001 國立 科學 搜査 硏究所 年報 Vol.33 No.-

中學 科學敎育의 探究學習에 대한 評價問項 開發(Ⅰ)

奇宇恒,權炳奎,朴德圭,이병교,鄭遠佑,金裕漢 경북대학교 과학교육연구소 1984 科學敎育硏究誌 Vol.8 No.-

The purpose of this study is to achieve the individualized inquiring learning which is centered on students by improving the method of the evaluation of the inquiry learning in the science class in a multi-student class. Therefore the author made the table of specification for scientific achievements of the abilities of inquiring by analyzing the abilities of inquiring according to the content of science and five basic experiments of each unit inthe first grade of of middle school, ant then made the paper and pencil and performance test items for the evaluation of the abilities of inquiring. The paper and pencil test was taken after the experimental and observational class, and performance test was taken in the way of the students' self evaluation, peer evaluation and Tester evaluation. The results are as follows: 1) In operation of the inquiry learning by two experiments, performance test items and 13 the paper and pencil test items made for evaluation of the abilities of inquiring could be applied usefully. 2) Correlation coefficient between paper and pencil test and performance test is .362 and it is very low. Therefore it is desirable that performance test be used for the evaluation for the abilities of inquiring which cannot be evaluated by paper and pencil test. 3) In evaluation of the abilities of inquiring by performance test on five basic experiments, it is more desirable that 'the use of microscope' is presented in the way of peer evaluation or peer and Tester evaluation, 'the observation on epidermis of onion cell' in the way of peer evaluation, and self-evaluation. 4) Skill of the abilities of inquiring in experimental and observational class can be evaluated correctly through performance test.