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        • KCI등재

          생맥산(生脈散)의 방사선 보호효과 : 생쥐 소낭세포 재생과 Apoptosis에 미치는 영향

          김현경,윤상협,류봉하,김진성,Kim, Hyun-Kyung,Yoon, Sang-Hyub,Ryu, Bong-Ha,Kim, Jin-Sung 대한한방내과학회 2006 大韓韓方內科學會誌 Vol.27 No.2

          Backgrounds & Objects: The aim of this study was to investigate the radioprotective effect of Shengmai-san(SMS), a herbal medicine, on mice jejunal crypt cell survival and Apoptosis. Methods: Mice were devided into 4 groups according to radiation dose and SMS treatment: Normal was the group without irradiation. Control was the group treated with D.W before 10 Gy irradiation. SMS 2.9 was sample group treated with 2.9 mg/10 g of SMS extract before 10 Gy irradiation and SMS 29 was sample group treated with 29 mg/10 g of SMS extract before 10 Gy irradiation. And Each group were sacrificedat 24 hours and 72 hours after irradiation. To analyze the crypt survival, hematoxylin-eosin staining was used and to analyze the apoptosis, the TUNEL assay was done. Results: 1. From the microcolony survival assay, the SMS 2.9 and SMS 29 showed the radioprotective effect with a statistical significance compared to the control group at 24 hr (P < 0.01) and 72 hr (p < 0.001) after 10 Gy irradiatien. And the differences of radioprotective effect between SMS 2.9 and SMS 29 were net significant. 2. The results of the TUNEL assay showed that the apoptotic index in SMS 2.9 and SMS 29 was significantly decreased, as compared to the control group at both 24 hr ( p < 0.01) and 72 hr (SMS 2.9 : p < 0.001. SMS 29 : P < 0.01) after 10Gy irradiation And the differences of between SMS 2.9 and SMS 29 were not significant. Conclusions: It could be suggested that the Shengmai-san has a prominent Protective effect in mice intestines against the radiation damage. And the radieprotective effect seems to be related to inhibition of the apoptosis.

        • KCI등재

          소갈전변증(消渴傳變證)에 관한 고찰(考察) - 중풍 병리(病理)와의 상관성을 중심으로 -

          고경덕,정승현,신길조,이원철,Koh, Kyeong-Deok,Jeong, Sung-Hyun,Shin, Gil-Cho,Lee, Won-Chul 대한한방내과학회 1997 大韓韓方內科學會誌 Vol.18 No.2

          1. Xiaoke(消渴) had been defined symptoms as polyuria with polydysia in Han and Dang Dynasty(漢唐時代), diagnosed variable disease as to the region of typical symptoms in Jin and Yuan Dynasty(金元時代) and classified into Upper-jiao(上消), Middle-jiao(中消), Lower-jiao(下消) by typical symptoms in Ming and Qing Dynasty(明淸時代). 2. The complications of Xiaoke(消渴) consist of carbuncle and phlegmon(癰疽), hemorrhoid and diarrhea(痔疾), an eye disease(眼病) such as nyctalopia(雀目) and cataract(內障) without Zhongman and Guzhang(中滿鼓脹) resulted from wrong medical treatmentis considered the pathology of Huore(火熱) 3. The pathology of Xiaoke(消渴) has been taken an instance of Shen-zao(腎燥), Five zang-organs's ganzao(五臟乾燥), Zao-re(燥熱), Shi-huo(實火) and Xu-huo(虛火), and since Jin and Yuan Dynasty(金元時代) generally cosidered Zao-re(燥熱). 4 The complications of Xiaoke(消渴) are explained the pathology of Huore(火熱), in the an opinion that the the pathology of Huore(火熱) changed into Zao-re(燥熱), and then Zao(燥), the pathology of Xiaoke(消渴) is similar to Huo(火), the pathology of Jungpung(中風).

        • KCI등재
        • KCI등재

          청열막성방(淸熱膜性方)이 Cationized Bovine Serum Albumin투여로 유발된 Mouse의 Membranous Nephropathy에 미치는 영향

          최인구,조충식,김철중,Choi, In-Gu,Cho, Chung-Sik,Kim, Cheol-Jung 대한한방내과학회 2008 大韓韓方內科學會誌 Vol.29 No.1

          Objective : Membranous nephropathy (MN) is the most common cause of adult nephrotic syndrome worldwide. MN has been defined as granular subepithelial deposition of IgG immune complexes along the glomerular basement membrane (GBM). We aimed to identify the effects of Chungyeolmaksungbang (CYMSB) treatment on cBSA-induced in MN mouse model. Methods : The effect of Chungyeolmaksungbang treatment was studied on the morphology and protein excretion in the cationized bovine serum albumin (cBSA)induced mouse chronic serum sickness nephritis model. One group of mice was given intra-peritoneal (i.p.) immunizing doses of cBSA and complete Freund's adjuvant. One week later, these animals began a single i.p. injection of cBSA for 4 weeks. A second group followed the same injection protocol, but was given CYMSB p.o. Results : Proteinuria significantly was decreased and serum albumin was increased in the group treated with cBSA and CYMSB extract compared with the control. Serum BUN was significantly decreased on CYMSB compared with control. CD3e+/CD19 cells ratio of peripheral blood was decreased and CD4+/CD8 cells was increased. Level of $IL-1{\beta}$ was significantly decreased, and $IFN-{\gamma}$ was significantly increased. Concentration of IgG and IgM was significantly decreased compared with control. Thickness of GBM was decreased on histological analysis of kidney. Deposition of CD4 and CD8 was decreased on immunohistochemical staining of kidney. Conclusions : We conclude that CYMSB treatment may could be a useful remedy agents for treating the MN with cBSA.

        • KCI등재

          일중음의 인체 전립선암 세포에 대한 성장억제 효과

          손기정,박양춘,Son, Gi-Jung,Park, Yang-Chun 대한한방내과학회 2008 大韓韓方內科學會誌 Vol.29 No.1

          Objectives : The study was intended to investigate whether Iljoong-eum (IJE) significantly affects proliferation and growth of prostate cancer cells. Materials and Methods : In vitro, after the treatment of DU-145 and PC-3 cells with IJE, we performed Sulforhodamine B (SRB) method. In vivo, a total of 8 male nude mice subcutaneously transplanted with the PC-3 cell line were divided in 2 groups. An experimental group was given IJE orally at a dose of 4.29ml/kg per day from the 8th to 31st day following tumor injection. All mice were observed for 31 days, and sacrificed by CO2 gas asphyxiation at the end of the experiment. The mean tumor volume and body weight of both groups were compared using Student's t-tests. Results : In vitro, IJE inhibited significantly proliferation and growth of DU-145 cells and PC-3 cells. In vivo, IJE inhibited significantly proliferation and growth of PC-3 cells xenografted into athymic nude mice. Conclusions : Our data has shown that IJE is effective in suppressing the growth rate of prostate cancer cells.

        • KCI등재

          강황(薑黃)이 고환절제술 및 testosterone으로 유발된 rat의 전립선비대증에 미치는 영향

          이상헌,안영민,안세영,김영옥,이병철,Lee, Sang-Hun,Ahn, Young-Min,Ahn, Se-Young,Kim, Young-Ock,Lee, Byung-Cheol 대한한방내과학회 2009 大韓韓方內科學會誌 Vol.30 No.2

          Objectives : Benign prostatic hyperplasia (BPH) is one of the most common diseases among elderly men. Though medicines such as 5${\alpha}$-reductase inhibitor (finasteride) have recently been developed for treating BPH, their adverse effects and low efficacy should not be overlooked. Curcuma longa has a long history of use in traditional medicines of Asian countries. Many reports conclude the component curcumin in Curcuma lonfa, has the potential to treat various diseases including prostate cancer. In this study, we investigated the therapeutic effects and action mechanism of Curcuma longa with a BPH rat model. Methods : Sprague-Dawley rats were used with subcutaneous injection of testosterone after castration, which were histologically similar to human BPH. A total of 30 rats were equally divided into five groups: Group 1 served as control (sham-operated group): Group 2 was the model group: Group 3 and Group 4 animals were administered Curcuma longa at dose levels of 0.5g/kg and 1.0g/kg: Group 5 served as a positive control group and was treated with finasteride at a dose of 1 mg/kg. The drugs were administered orally once a day for 30 days consecutively. After 31 days, the prostates were removed, and analyzed for their prostatic weight and histological examination. Results : The oral Curcuma longa ingestion group showed statistically significant decreases in their prostatic weights compared with the BPH-induced group and the oral finasteride ingestion group (p<0.05). Curcuma longa is also very safe in liver and kidney up to a dose of lg/kg. Injected testosterone histologically led to prostatic hyperplasia in rats, but oral Curcuma longa ingestion decreased this change. Conclusions : These results suggest that Curcuma longa has a definite inhibitory effect on BPH and might be an alternative medicine for treatment and prevention of human BPH.

        • KCI등재

          급성기 뇌졸중 환자에 대한 임상적 고찰

          장인수,유경숙,이진구,윤희식,이영구,강현철,손동혁,Jang, In-Soo,Yu, Kyung-Suk,Lee, Jin-Goo,Yun, Hee-Sik,Lee, Young-Goo,Kang, Hyon-Chel,Son, Dong-Hyug 대한한방내과학회 2000 大韓韓方內科學會誌 Vol.21 No.2

          Objective : We studied only patients at the acute stage but existing studies on stroke didn't almost classify the stage. We examined 243 patients admitted to the Woo Suk university oriental medical hospital from January 1998 to December 1999 for 2 years. Methods : We analyzed patients into sex, Sasang constitution, the incidence and lesion according to the stroke types, post and family history, onset time, period to admission and physical treatment from onset, and symptom, blood pressure, cholesterol level and herb medicine at entry. Results : Our study was similar to existing studies in the distribution of sex, age and the lesion of stroke, post and family history, and symptoms at entry. But it differed in the constitution, incidence of cerebral infarction and intracranial hemorrhage, attack time, period to admission and physical treatment from onset day, and the symptoms, blood pressure, cholesterol level and herb medication. In comparison between infarction and hemorrhage patients, there was some difference in the distribution of onset time, but wasn't in the cholesterol level. Conclusions : Our study on the acute stage of stroke was similar to existing studies in the general characteristics. But it showed some differences in the herb medicine at entry. In particular, there were much differences in the blood pressure at entry and the incidence of infarction and hemorrhage. We hoped that stroke patients would be synthetically studied in western and oriental medicine.

        • KCI등재

          간손상 관련 한약 안전성 연구의 개선을 위한 한약인성 간손상 조사표 제안

          윤영주,신병철,신우진,장인수,Yun, Young-Ju,Shin, Byung-Cheul,Shin, Woo-Jin,Jang, In-Soo 대한한방내과학회 2009 大韓韓方內科學會誌 Vol.30 No.1

          It is important to establish the safety of herbal medicine because of its frequent and widespread use in Korea. Several studies on the safety of herbal medicine have been performed and there have been rare serious adverse drug reactions from those reports in Korea. However, the results are not strongly supported because of not adopting appropriate enough research methodology as to make the safety issue clear. For improving the quality of the safety research on herbal medicine. including investigations of drug induced liver injury (DILl). the aim of this study was to suggest herbal medicine-induced liver injury investigation forms for performing reasonable safety research. After a systematic review of the preceding studies regarding herbal safety in Korea was performed in 2008, we assessed the quality and the limitations of the primary studies. Two investigation forms for herbal safety research were made as a following step. one a basic investigation form for herbal safety research and the other an advanced investigation form for suspected DILl cases, Those forms include the essential informations and data needed to make an appropriate assessment of whether DILl occurred during or after the use of herbal medicine. Guidelines for using those forms and other recommendations were also suggested. More rigorous studies are required for answering the safety issue of herbal medicine as well as the efficacy issue. We hope for wide use and improvement of those investigation forms in the study of herbal safety by many researchers for establishing better evidences in Korea.

        • KCI등재

          기능성 소화불량증 환자의 두통은 위 운동성 장애에 의한 증상이 될 수 있는가?

          박영선,윤상협,Park, Young-Sun,Yoon, Sang-Hyub 대한한방내과학회 2009 大韓韓方內科學會誌 Vol.30 No.3

          Objectives : The aim of this study was to investigate the relationship between headache and gastric dysmotility in patients with functional dyspepsia by using electrogastrogram and bowel sounds analysis. Methods : 127 patients(male 40, female 87) with functional dyspepsia were enrolled. By using inquiry and the questionnaire, we examined whether each patient had headache and abdominal pain. All patients were divided into 4 groups according to the above symptoms. Gastric motility was measured during the fasting-postprandial state by using electrogastrogram and bowel sounds analysis. Results : 33 patients complained of headache. There was a significant difference between headache patients and non-headache patients in gastric arrhythmia of the fasting state. Moreover, in headache patients without abdominal pain, postprandial improvement of gastric arrhythmia was poorer than the other groups. So, headache patients without abnormal pain had more severe gastric myoelectrical rhythm disorder than headache patients with abdominal pain. Conclusion : Headache could be one of symptoms induced by gastric dysmotility in patients with functional dyspepsia. Especially, headache in functional dyspepsia was related to gastric arrhythmia.

        • KCI등재

          중풍환자의 구강건조증에 대한 생맥산의 효과 : 무작위배정 이중맹검 연구

          이대현,한현진,김락형,강세영,장인수,Lee, Dae-Hyun,Han, Hyun-Jin,Kim, Lak-Hyung,Kang, Sei-Young,Jang, In-Soo 대한한방내과학회 2011 大韓韓方內科學會誌 Vol.32 No.4

          Objectives : The present study was made to evaluate the clinical effectiveness of Saengmaeg-san (生脈散) extract to treat xerostomia in stroke patients. Methods : The study design was a double-blind randomized controlled trial. Subjects were stroke patients with xerostomia. They were allocated to either the Saengmaeg-san (n=12) or placebo group (n=12). Saengmaeg-san extract or a placebo in similar opaque capsules was given three times a day for a week. The improvement of xerostomia was measured by the xerostomia-evaluating questionnaire, developed by the school of dentistry in Seoul National University, before baseline and one week later. Eleven of the Saengmaeg-san group and ten of the placebo group finished the trial and were analyzed. Paired samples t-test and Mann-Whitney test were applied to statistical analysis. Results : On three of the six questions, the Saengmaeg-san group improved significantly. On two of the six questions, the Saengmaeg-san group improved significantly more than the placebo group. On the other questions, the Saengmaeg-san group improved more than the placebo group, although significance was not reached. Conclusions : These results demonstrate that Saengmaeg-san extract is effective for treating xerostomia in stroke patients, and further studies should be conducted to provide more valuable information.

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