http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1
연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.
김조천,김기준,홍지형,선우 영,임수길 한국대기환경학회 2004 한국대기환경학회지 Vol.20 No.1
In order to compare the NVOC (Natural Volatile Organic Compound) emission rates from oak trees, the emission rates of isoprene were quantitatively measured in situ based on tree species and region. As a result, the emission rates from Quercus serrata T. were found to be 1000 times greater than those from Quercus acutissima C. However, the emission rates at the Chiri and Gumsung mountain sites did not show any significant differences in summer. Cuvette tests using four different oak species also supported that there was a tremendous difference in emission rates between Quercus serrata T. and Quercus acutissima C. It was found that the emission rates from the trees were highest on the order of Quercus serrata T., Quercus aliena B., Quercus acutissima C. and Quercus variabilis B.
침엽수로부터 발생되는 방향성 테르펜의 배출속도 비교 연구
김조천,홍지형,강창희,선우영,김기준,임준호 한국대기환경학회 2004 한국대기환경학회지 Vol.20 No.2
In order to investigate the composition ratio and the emission rate of monoterpenes emitted from coniferous trees during summer, the enclosure chamber experiments were carried out for two tree species (Pinus densiflora and Pinus rigida). The major monoterpenes from the pine trees were α-pinene, β-pinene, myrcene and β-phellan-drene. There was no difference of the composition ratio between two sites for P. densiflora, but the difference was observed for P.rigida, Clearly, the ratio of β-pinene (26.1%) for P.rigida was higher than that of β-phellandrene (12%) at the Gumsung mountain site, but the ratio of β-phellandrene (22.2%) was higher than that of β-pinene (9.9%) at the Chiri mountain site. Particularly, the composition ratio of β-phellandrene was higher than that of β-pinene for P.densiflora, and the opposite trend was found for P.rigida at the Gumsung mountain site. The characteristics of the composition ratio between two species were similar at the Chiri mountain site. As a result of the emission rate measurements, it was observed that both sites did not show any significant β value (slope between emission rate and temperature) and ERs (Standard Emission rate at 30℃) difference. However, the β value and ERs at the Chiri mountain site were slightly greater than those of Gumsung mountain site for both pine species. P.densiflora(1.703 and 1.971㎍C/gdw/hr) showed the higher monoterpene ERs than those of P.rigida (0.572 and 0.698 ㎍C/gdw/hr) at both sites.
Comparison of Physicochemical and Functional Traits of Hanwoo Steer Beef by the Quality Grade
Lim, Dong-Gyun,Cha, Ju-Su,Jo, Cheorun,Lee, Kyung Haeng,Kim, Jong-Ju,Nam, Ki-Chang Korean Society for Food Science of Animal Resource 2014 한국축산식품학회지 Vol.34 No.3
The physicochemical and functional traits for loin muscles of Hanwoo steers were compared by quality grade (QG). A total of 500 Hanwoo steers were slaughtered, their carcasses were categorized into four groups (QG 1++, 1+, 1, and 2), and the longissimus dorsi muscles were analyzed. QG 1++ group had the highest fat and lowest moisture content (p<0.05). QG 1++ showed higher $L^*$ and $b^*$ color values, higher cooking loss, and lower shear force values, compared with the other groups (p<0.05). The flavor, tenderness, juiciness, and preference scores by sensory evaluation were highly ranked for premium QG groups (1++ and 1+). Regarding the micro compounds, QG 1 and QG 2 had greater amounts of inosine monophosphate, and QG 2 had greater amounts of anserine, carnosine, and creatine, than QG 1++ (p<0.05). QG 1++ and 1+ had higher percentages of oleic acid (C18:1) than QG 2 (p<0.05). Within premium QG 1++ and 1+, the results of the nucleotides, free amino acids, dipeptides, and fatty acids did not show any distinctive differences. Hanwoo beef as determined by the current grading system was not significantly different in terms of functional components; the only significant difference was in intramuscular fat content.
Estimation of Liquidity Cost in Financial Markets
Lim, Jo-Han,Lee, Ki-Seop,Song, Hyun-Seok The Korean Statistical Society 2008 Communications for statistical applications and me Vol.15 No.1
The liquidity risk is defined as an additional risk in the market due to the timing and size of a trade. A recent work by Cetin et ai. (2003) proposes a rigorous mathematical model incorporating this liquidity risk into the arbitrage pricing theory. A practical problem arising in a real market application is an estimation problem of a liquidity cost. In this paper, we propose to estimate the liquidity cost function in the context of Cetin et al. (2003) using the constrained least square (LS) method, and illustrate it by analyzing the Kellogg company data.