서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)

김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1

In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.

혈액투석 환자의 가성 고칼륨혈증

최창렬,조형도,강태영,이준수,한호,정청일,이동규,유준호,한상웅,김호중 대한신장학회 2001 대한신장학회잡지 Vol.20 No.5

기저질환이 없는 사람에서 발생한 Campylobacter fetus에 의한 재발성 심내막염 1예

전재범,정진원,김성혜,송문희,오형철,안성기,최상호,김남중,김양수,우준희,류지소 대한감염학회 2004 감염과 화학요법 Vol.36 No.6

C. fetus 심내막염은 드물게 발생하는 질환으로 주로 면역능이 저하된 환자에서 발병하고 대동맥판을 침범하는 경우가 많으며 적절한 치료가 되지 않을 경우 치사율이 높다. 저자들은 기저질환이 없던 69세 남자에서 C. fetus 심내막염을 경험하였기에 문헌고찰과 함께 보고하는 바이다. 환자는 발열로 내원하여 시행한 혈액배양 검사상 C. fetus가 동정되었고 경식도 초음파 검사상 삼첨판에 증식증이 발견되어 심내막염 진단하에 ceftriaxone에 이어 meropenem으로 총 4주간 항생제를 투여받고 호전되었다가 한달 후 다시 재발하였고 판막부전 소견 진행하여 삼첨판 치환술을 시행받고 전신상태 호전되어 퇴원하였다. Campylobacter fetus is a rare cause of endocarditis. To date, only about 30 cases of C. fetus endocarditis have been reported mainly in the elderly with chronic underlying illnesses. Most cases showed tendency to involve aortic valve. This report describes a case of native tricuspid valve infective endocarditis in a 69-year-old man without any underlying disease. Despite adequate antibiotic therapy for 4-weeks, endocarditis recurred and leading to surgical valve replacement.

구내 접근법에 의한 하악골 골절 치료에 대한 임상적 고찰

정성훈,박형식,권준호 大韓顎顔面成形外科學會 1989 Maxillofacial Plastic Reconstructive Surgery Vol.11 No.1

This is a retrospective study on the transoral approach to open reduction of the Mandibular fractures. Our study was based on a series of 64 patients with mandibular fractures among 99 patients of facial bone fractures who had been treated by transoral approach with or without extraoral approach at Department of Oral and Maxillofacial Surgery, Yonsei Medical Center, Yonsei University from January 1981 to October 1988. We studied favorite sites of open reduction, fixation methods, results and prognosis related to transoral approaches of Mandibular fractures, and which compared with extraoral approaches. The results obtained are as follows : 1. The transoral open reduction was used more frequently in Mandibular fractures(64.6%) than Midfacial bone fractures(35.4%). Among 64 patients of mandibular fractures, 47 patients(73.4%) were treated only by transoral approach and others(26.6%) were treated by both trans and extraoral approach. Among 92 sites of mandibular fractures 75 sites(81.5%) were treated by transoral approach and 17(18.5%) were treated by extraoral approach. 2. The most favorite site for transoral approach compared with extraoral approach was symphysis(100%), and Angle(62.5%) was next in order of frequency on Mandibular fractures. 3. Direct Interosseous Wiring(DIW) was most commonly used for fixation(64.6%) and Miniplate osteosynthesis was used next in 28.1%. 4. Simple(39.1%) and Compound(52.2%) fractures were frequently indicated for transoral approach, however comminuted fractures were rarely indicated. 5. The direction of fracture lines on Angle of the mandible did not influence to determine whether transoral approach should be selected or not. However this area seemed to be more difficult to reduce exactly by transoral procedure than other areas because simultaneous superior and inferior fixation was applied predominantly on this area. 6. The success rate of reduction and fixation analyzed from us was more excellent in Direct Interosseous Wiring(29/53=54.7%) than in Rigid Internal Fixation(9/29=31.0%). But it might be depended upon various factors as like as sugeon's skill. 7. The postoperative complication due to transoral open reduction of mandible was not high(12.0%) and this rate was similar with other published reports.

지속가능발전지표의 지수화 연구

정영근,강상목,여준호 한국환경경제학회 한국자원경제학회 2004 자원·환경경제연구 Vol.13 No.3

본 연구에서는 사회·환경·경제·제도 4개 부문의 지속가능한 발전지표들을 통합하여 지속가능발전지수 작성을 위한 방법론을 제시하고 한국의 지속가능발전 상태를 종합적으로 평가할 수 있는 지속가능발전지수를 1990~2001년간 실증적으로 계측해 보았다. 한국의 지속가능발전지수는 기준년도인 1995년을 중심으로 완만한 U자형 형태를 보이고 있는 것으로 나타났다. 지속가능발전지수가 1990년대 중반까지 하락한 주된 요인은 경제와 환경 부문의 하락에 기인하고 그 이후 상승은 사회와 제도 부문의 급격한 상승에 기인한 것으로 분석되었다. 지속가능발전지수가 주는 정책적 시사점은 첫째, 한국은 지속가능발전 측면에서 점차 긍정적인 추세를 보인다는 점과, 둘째, 지속가능발전지수의 상승과 하락이 4개 부분에 따라 사이하므로 하락하거나 보합적인 추세를 보이고 있는 부문에 대한 세심한 정책적 고려가 필요하다는 점이다. This paper develops the methodology for the indexation of Sustainable Development Indicators (SDIs) in 4 sectors (social, environmental, economic, and institutional sectors), and provides the empirical results of Sustainable Development Index (SDI) for Korea from 1990 to 2001. Given 1995 as the basic year. the trend of SDI for Korea displays a slowly curving U-shape. The down trend of SDI until mid-90's results from the decline of SDI in economic and environmental sectors, and the uptrend of SDI after mid-90's results from the sharp rising of SDI in social and institutional sectors. The implication of the results is that Korea generally shows a positive trend toward the sustainable development. However, there should be a careful consideration about partly downward trend in individual SDIs, because of the different trend of SDI in each sector.

Cadmium Chloride가 Mouse 의 췌장도 β-세포에 미치는 영향

전영희,백태경,정호삼,이규식,김영호 한양대학교 의과대학 1993 한양의대 학술지 Vol.13 No.1

As the industrial use of cadmium has become more common, the question of its toxicity has become more important. The present was undertaken to study effects of cadmium on the structure of β-cells in the Langerhans islet of the mouse pancreas. Healthy mice of ICR strain weighing around 39gm were used in this experiment. The each animal of the experimental group was interperitoneally administrated cadmium chloride 5.0mg/kg diluted in the water for injection. The experimental animals were sacrified at 3, 6, 12, 24, 48 and 72 hours after administration of cadmium chloride and pancreatic tissues was excised. Some specimens were stained with Halmi stain to observe the morphological changes in the endocrine portion of the pancreas, the islet of Langerhan, and the others were prefixed in the 2.5% glutaraldehyde-2% paraformaldehyde phosphate buffer solution (pH7.0) and postfixed in the 1% osmic acid. Ultrathin sections were made and double strained with uranyl acetate and lead citrate. These preparations were observed with light microscope and electron microscope as well. The results obtained were as follow; 1. The number of β-cells throughout the pancreatic islets were markedly reduced in the 12 hours group and the β-cells were increased slowly in the 24 hours group. 2. The cristae of mitochondria disappeared and electron-density of matrix in mitochondria is decreased in the 3 hours after treatment of animals with cadmium chloride. The mitochomdria appeared almost like normal group, in the 12 hours group. 3. The cisternae of rough endoplasmic reticulum were dilatated in the 3hours group and change in rough endoplasmic reticulum were completely restored to normal in the 24 hours group. 4. The Golgi complexes were very hypertophied in the 3 hours. The Golgi complexes were observed like normal group, in the 12 hours group. 5. The sectetory granules were hypertrophied a halo and loss a dense core and the electron dense core and the electron dense of core in secretory granules decreased in the 3 hours, 12 hours group. But the secretory granules were slightly restored in the 48 hours group and appeared almost like normal group in the 72 hours group. Consequently, it is concluded that cadmium chloride exerts several toxic effects to β-cells of Langerhan's islet, especially, the damage to secretory granule in mouse.

외상성 간손상과 비장손상시 CT분류의 의의

정준영,이창현,김현정,도호석,이삼범,도병수 大韓應急醫學會 1997 대한응급의학회지 Vol.8 No.1

The Organ Injury Scaling Committee of the American Association for the Surgery of Trauma recently published a consensus classification of hepatic and splenic injuries. The hepatic and splenic injury scales, based on parenchymal laceration and intrahepatic hematoma, include grade 1 to 6 and grade 1 to 5 respectively, representing the least to most severe injury. Forty-eight patients with hepatic and splenic injury were evaluate by abdominal CT from January 1995 to May 1996 and we compared abdominal CT grading with operative grading. Four CT grades did not correlate with operative finding. CT grading showed a sensitivity of 80%, specificity 80% in regard to operative grading. We conclude that 1) CT is an accurate technique to determine the extent of hepatic and splenic injury. 2) CT grading of hepatic and splenic trauma has a high correlation with operative grading.

2인과 3인의 기본 심페소생술 비교

정준영,이창현,김현정,도호석,이삼범,도병수 大韓應急醫學會 1997 대한응급의학회지 Vol.8 No.1

Study objectives: To compare the quality of CPR provided by medical students and pre-EMTs perfoming three-rescuer CPR with that achieved by same students trained to provide standard two-rescuer CPR and to find the most effective method of resuscitation and to educate this methods to students. Material and methods: From July 1 to September 30, 1996, we had trained 60 groups consisted of the medical students, students of EMS technology and pre-EMT. Each group practiced two-rescuer CPR and three-rescuer CPR for 120 minutes with Resusci? Anne and perfomed CPR for at least 3 minutes without feedback. To eliminate any visual cues of perfomance the mannequin's recorder was hidden. Each actions were recorded by Resusci? skillmeter and Laerdal printer. To compare the quality of two-rescuer CPR and three-rescuer CPR, we analyzed the data by SPSS with paired t-test. Results: Three-rescuer teams delivered a mean minute ventilation and a mean minute cardiac compression substantially greater than that produced by two-rescuer teams(11.30±1.85 vs 9.09±2.22, p<0.001; 99.22±12.42 vs 95.12±15.75, p<0.001). Three-rescuer teams produce the more correct actions in chest compression and ventilation(93.84±7.56% vs 83.49±16.94%, 90.90±9.33% vs 77.00±17.06%). Conclusion: Three-rescuers can produce better CPR than two rescuers when a bag-valve-mask devices is used and the technique is easily learned and readily retrained, so we think that repeated education and training of this CPR methods to students is needed.

주요 우울증에서 종양괴사인자-베타 유전자의 다형성

전태연,배치운,김영호,장계호,이정태,박원명,김광수 대한신경정신의학회 2000 신경정신의학 Vol.39 No.6

연구목적 : 주요 우울증은 역학적 유전연구 등을 통하여 유전적 영향이 높은 것으로 알려져 있으며 최근에는 분자 유전학적 연구로 유전자 다형성과 질병의 연관성을 밝히는 것이 정신질환의 유전학적 연구에서 중요한 부분을 차지하고 있다. 이에 본 연구는 중추신경계와 면역계간의 상호작용에 관여하는 싸이토카인 중 TNF-β 유전자의 다형성을 분석하여 주요 우울증과의 유전학적 관련성을 알아보고자 하였다. 방 법 : DSM-IV에 의하여 주요 우울증으로 진단된95명을 환자군으로 선정하였고 가톨릭조혈모세포정보은행에서 보유하고 있는 정상 한국인 202명의 자료를 정상 대조군으로 사용하였다. 전혈에서 DNA를 추출하고 TNF-β 유전자 부위를 증폭한 후 제한효소 Nco Ⅰ으로 절단하여 555bp와 185bp의 절편을 갖는 TNFB*1과 Nco Ⅰ절단부가 없는 740bp의 절편 TNFB*2등 2가지 대립유전자의 제한효소절편길이 다형성을 조사하였다. 모든 자료의 분석은 x²검증을 이용하였다. 결 과 : 1) 주요 우울증과 정상 대조군 간에 TNFB유전자인 TNFB*1/1, TNFB*1/2 및 TNFB*2/2의 발현 빈도에는 유의한 차이가 없었다. 2) 두 군 간에 TNFB*1 과 TNFB*2 두 대립유전자의 빈도에는 유의한 차이가 없었다. 결 론 : 본 연구에서는 주요 울울증군과 정상 대조군 간에 TNFB*1과 TNFB*2의 두 대립유전자 발현 빈도에 유의한 차이를 발견하지 못하였다. 따라서 TNFB 유전자다형성과 주요 우울증과의 유전학적인 연관성이 없었다. 향후 연구에서는 다양한 임상변인을 포함하여 보다 통합적이고 체계적인 연구가 이루어져야 할 것으로 생각되었다. Objective : Major depressive disorder is known to have high genetic predisposition and the main focus of recent genetic studies in major depressive disorder has been concentrated on association studies between genetic polymorphism and disease, since molecular genetic methods have been developed. This study was designed to investigate the relationship between major depressive disorder and immunogenetic influences by analyzing polymorphism of TNFB gene, which is involved in interaction of immune system and CNS. Method : 95 persons who had been diagnosed of major depressive disorder were assigned as patient group and, 202 data obtained from Catholic hemopoietic stem cell bank, College of medicine, the Catholic University of Korea, were used as normal controls in this study. DNA was extracted from whole blood, thereafter amplified by polymerase chain reaction, and digested by Nco Ⅰ.After that procedure, we obtained and assessd restriction fragment length polymorphism of two alleles, TNFV*1 which has 555bp and 185bp fragments and carries the Nco Ⅰ restriction site, and TNFB*2 of 740 bp fragment lacks the Nco Ⅰ restriction site. All data were analyzed by x²test with two-tailed Fisher's exact test. Results : 1) The frequencies of TNFB*1/1, TNFB*1/2, and TNFB*2/2 were not statistically different between major depressive disorder patients and control group. 2) The frequencies of TNFB*2 and TNFB*1 were not statistically different between major depressive disorder patient group and normal control group. Conclusion : We did not verified the differences of frequency in TNFB*1/TNFB*2 gene between the major depressive disorder and normal controls, respectively. Consequently, there is no genetic relationship between major depressive disorder and gene polymorphism of TNFB. We do suggest that further systematic studies including various clinical variables should be conducted.

적외선 흡수 분광법 및 DPC를 이용한 치과용 수복재의 광중합 거동 분석

정찬문,김중곤,최준호,장두옥,김경남,김광만 대한치과기재학회 1998 대한치과재료학회지 Vol.25 No.1

Mechanical properties of compomers would be obtained mainly by photopolymerization by visible light irradiation. Photopolymerization behavior of two commercial compomers was investigated by FT-IR spectral analysis and differential photocalorimetry(DPC). The results obtained were as follows: 1. From FT-IR analysis, it was found that the compomer products were photocured mainly by radical polymerizations of multifunctional methacrylate monomers. Final conversion values of the polymerizations after exposure to visible light for 60 sec were 67% for Dyract and 59% for Compoglass. 2. Upon exposure the compomers exhibited autoacceleration and autodeceleration, which are usually observed in bulk polymerizations of multifunctional monomers. 3. Dyract showed higher rate of polymerization and conversion of double bond than Compoglass.