원위 대퇴골의 고립성 골연골종에서 발생한 속발성 연골 육종 1례 보고

정필현,황장수,강석,김용민,오형호,채동주,김종필 동국대학교 경주대학 1996 東國論集 Vol.15 No.-

연골육종은 비교적 서서히 자라며 늦게 전이하는 악성 연골 종양으로 알려져 있다. 골 연골종에서 발생한 속발성 연골육종은 발생빈도는 드물며 타부위로의 전이가 적고 악성도가 낮은 경우가 많아 적합한 수술적 치료로서 좋은 예후를 보이는 것으로 보고되고 있다. 본 동국대학교 정형외과학 교실에서는 우측 대퇴골 원위부 골간단부에 생긴 고립성 골 연골종에서 이차적으로 발생한 연골육종을 치험한 바 문헌고찰과 함께 보고하는 바이다. A case of Secondary Chondrosarcoma Arising from Solitary Osteochondroma of the Distal Femur Department of Orthopaedic Surgery, College of Medicine, DongGuk University Phil Hyun Chung M.D., Jung Su Hwang M.D., Suk Kang M.D., Yang Mln Kim M.D., Hyung Ho Oh M.D., Dong Ju Chae M.D., Jong Pil Kim M.D. Chondrpsarcoma is a malignant cartilage-forming tumor that grows slowly and metastasis of this tumor occurs in late stage. Secondary chondrosarcomas arising from a solitary osteocartilaginous exostosis are rare and those have a better prognosis than other chondrosarcomas, and they rarely metastasize. We present our experience with a case of secondary chondrpsarcoma arising in solitary osteochondroma of distal metaphysis of right femur with clinical details.

1995년도 대구지역 법의 부검 통계

채종민,이숙희,정민희,곽정식 大韓法醫學會 1996 대한법의학회지 Vol.20 No.1

This is a statistical observation by authors based on data of deaths brought to department of forensic medicine, Kyungpook National University School of Medicine for medicolegal autopsy by all of law enforcement agencies in Taegu area during the year of 1995. The report aims to reveal facts on various causes of death in Taegu area in attempt to analyse 205 cases statistically. The following are the summary of results ; 1. The total numbers of autopsy were 205 cases, of these 121 cases (58%) were males and 83 cases (40%) were females. 2. The violent deaths were 135 cases (66%) and the natural deaths were 63 cases (31%) and unknown cases were 7 (3%). 3. The percentage of autopsied cases with 30's age group was 28.2% (the most), 20's was 17.2%, 40's was 13.8%, 10's was 13.8%... in violent deaths. The percentage of autopsied cases with 30's age group was 31%, 40's was 20%, 20's was 20%, 50's was 15.5%...in natural deaths. 4. For the violent deaths, the percentage deaths due to injury was 52.9%, asphyxia was 29.8%, intoxication was 10.4% and abnormal temperature(hypothermia or fire) or electrocution was 6.7%. 5. For deaths due to injuries, the percentage of deaths due to blunt injury was 45.7%, sharp force injury was 29.5%, fall was 17.1%. and traffic accident was 7.1%. 6. For the natural deaths, 60 cases were recorded and the death due to the disese of the cardiocascular system was taking the most of the total percentage with 53%. 7. For deaths due to injuries, the percentage of accidental death was 57.3%, homicide was 22% and suicide was 14.7%. 8. 31 subjects (51.7%) of 128 violent deaths have positive blood alcohol concentrations (0.05% and above) , and 8.1% of natural deaths were associated with alcohol intake. 9. For deaths by medical dispute, 7 cases were recorded and deaths combined with operation were taking the most of the total percentage with 43%.

유량이 진공도 측정에 미치는 영향

유운종,금채,정광화,최석호 충남대학교 자연과학연구소 1989 忠南科學硏究誌 Vol.16 No.1

We extend the ranges of the vacuum standards to 10^-6 Pa by injecting the gas flow into the lower vacuum chamber of the orifice flow type vacuum standards system. The systematic error of the vacuum measurement has been reduced by measuring temperature accurately by reducing leak rate of the flowmeter and by attaching the ballast tank to flowmeter. We measure N_2, He and Ar gases for the sensitivity of nude ionization gauge for the check of the vacuum accuracy. The results are compared with the result of other research institute.

톨루엔을 포함한 유기용제의 직업적 폭로로 인한 신경내분비계 영향

이채언,이종태,정의화,손혜숙,문덕환,전진호,강정학,이창희,김휘동,김종한,정귀옥 大韓産業醫學會 1995 대한직업환경의학회지 Vol.7 No.2

Long term occupational exposure to solvent mixtures may cause adverse effects to the central nervous system with neurobehavioral symptoms. And some organic slovents have been suggested to cause impairment of tuberoinfundibular dopaminergic activity and neurochemical mechanisms controlling pituitary secretion. For the purpose of assessing neuroendocrine effects in occupational solvents exposure, hormonal study settings (shoes-manufacturing industry & fishing products industry) and compared with nonexposed controls(33 men, 85 women). Male workers exposed to solvent mixtures had significantly lower plasma level of follicle-stimulating hormone(FSH) than nonexposed male controls. While female workers exposed to solvent mixtures had significantly lower plasma levels of growth hormone(GH), and thyroid-stimulating hormone(TSH) than nonexposed female controls. The results of significant decrease in plasma concentrations of pituitary hormones(FSH, GH, and TSH) in workers exposed solvent mixtures indicate that occupational exposure to solvent mixtures may induce neuroendocrine effects through an effect on hypothalamic pituitary axis.

Toluene, Xylene, Trichloroethylene 투여가 흰쥐의 시상하부와 뇌하수체의 GnRH, GnRH Receptor, Pit-1 유전자 발현에 미치는 영향

기노석,이종태,강대성,김대환,이채관,이헌,전진호,김정호,이채언 大韓産業醫學會 1998 대한직업환경의학회지 Vol.10 No.2

The workplace exposure of chemicals has steadily increased, therefore the concern for subsequent effect on reproductive outcome has been an important issue in occupational medicine. In previous studies, higher rates of spontaneous abortion, reduced fertility and menstrual disorder among women, and an impairement of sperm quantity and quality among men have been associated with a wide variety of chemical agents. This study was conducted to evaluate the effects of toluene, xylene and trichloroethylene(TCE) injection on the mRNA levels of GnRH, GnRH receptor and Pit-1 genes in male rats hypothalamus and pituitary and the effects on the plasma levels of FSH, LH, prolactin and testosterone. Sprague-Dawley male rats were divided into five groups of five each according to concentration of toluene, xylene and TCE. The rats were injected subcutaneously to 0, 50, 100, 200, 400 mg/kg body weight/day of toluene, xylene and TCE, respectively for 6 days. Rat brains were excised and hypothalamus and pituitary were separated. Reverse transcription-polymerase chain reaction (RT-PCR) and RNase protection assay(RPA) were used to evaluate the GnRH, GnRH receptor and Pit-1 mRNA levels. Plasma concentrations of FSH, LH, prolactin and testosterone were assayed by radioimmunoassay(RIA). The results were as follows; 1. GnRH, GnRH receptor and Pit-1 mRNA levels in toluene and xylene injected groups, and GnRH receptor mRNA levels in TCE injected group were lowered dose-dependently. Especially, GnRH receptor and Pit-1 mRNA levels in 200mg/kg of toluene injected group, and GnRH, GnRH receptor and Pit-1 mRNA levels in 400mg/kg of toluene injected group were significantly lower than control group (p<0.05). GnRH receptor and Pit-1 mRNA levels in 400mg/kg of xylene injected group, and GnRH receptor mRNA levels in 400mg/kg of TCE injected group were significantly lower than control group(p<0.05). 2. The plasma levels of prolactin and testosterone in 400mg/kg of toluene injected group, and LH in 100, 200 and 400mg/kg of xylene injected group, and testosterone in 400 mg/kg of TCE injected group were significantly lower than control group(p<0.05). In conclusion, we speculated that toluene and xylene affected reproductive system secondarily through hypothalamus-pituitary axis, and TCE affected directly through steroidogenesis. And we recommended that further study for assessment of the reproductive toxicity of mixed organic solvent exposures should be conducted.

골형성 종양의 골조직에서 비교원성 골단백질의 분포

김미숙,이승철,박희경,채종민 慶北大學校 醫科大學 1995 慶北醫大誌 Vol.36 No.3

목적 : 골조직내에는 여러 가지 비교원성 단백질이 포함되어 있다. 이들 단백질은 골 구성 세포들의 분화, 성장 및 골조직 형성을 조절하는 것으로 알려져 있다. 본 연구는 골 조직에서 발생하는 각종 종양에서 비교원성 단백질의 분포를 관찰하여 이를 골종양 감별 진단적 표지자로서의 가치를 규명하고자 한다. 대상 및 방법 : 1990년부터 1995년 4월까지 경북대학교병원에서 각 종 골종양을 수술하여 얻은 조직을 osteocalcin, osteonectin, 및 단구-대식구 항원에 대한 면역조직화학적 방법으로 염색을 하여 이들 단백의 분포를 관찰하였다. 결과 : osteocalcin 및 osteonectin은 골육종 및 골모 세포종에서 강한 양성 반응을 보였다. 그리고 osteonectin은 일부 연골 형성 종양 및 거대세포 종양에도 부분적인 양성 반응을 보였고 osteocalcin은 거대세포 종양에도 양성 반응을 보였다. Ewing 육종, 악성 림프종, 및 골수종 등은 osteonectin 및 osteocalcin 모두 음성 반응을 나타내었다. 그리고 단구-대식구 항원에 대한 반응은 거대세포 종양에서 강하게 발현하였다. 결과 및 결론 : 이상의 성적으로 보아 osteocalcin 및 osteonectin은 골형성 종양의 감별 진단에 유효하며 단구-대식구 항원 검사는 거대세포종 진단에 도움이 될 것이라고 생각된다. To ascertain the effective value of non-collagenous bone proteins as a diagnostic marker of osteogenic neoplasm, the expressions of osteonectin and osteocalcin, together with monocyte-macrophage antigen were evaluated in tissue sections obtained from primary bone tumors. Osteonectin and osteocalcin were detected in entire neoplastic component of osteogenic bone tumors and giant cell tumors. Osteonectin was also demonstrated in neoplastic component of some cartilage-forming tumors, whereas osteocalcin was specifically detected in bone forming tumor with osteoblastic differentiation. osteonectin and osteocalcin were not detected in Ewing's sarcoma, malignant lymphoma, and multiple myeloma. On the other hand, monocyte-macrophage antibody positive stains in the mononuclear and multinucleated giant cell components of giant cell tumor and the reactive multinucleated giant cells of entire primary bone tumors were observed. The results suggested that osteonectin and oiteocalcin as well as monocyte-macrophage antigen may be helpful in the histologic diagnosis of bone tumors, particularly osteocalcin is expected to be more useful for the diagnosis of osteosarcomas.

고온 플라즈마를 이용한 폐기물 용융 소각기술 개발

엄태인,채종성,성지선,전영남,황순모,김영석 한밭대학교 생산기반기술연구소 2004 생산기반기술연구소 논문집 Vol.5 No.1

A high proportion of hazardous (PVC, asbestos, chlorinated solvents) and infection wastes are treated in incinerators, the high temperature and high energy characteristics of plasma may be employed to convert waste materials into inert small volume products and combustible gases, plasma torch melting(PTM) is one of the most widely used tool for the vitrification of wastes. The ash product generated is of low bulk density and may also contain leachable quantities of toxic heavy metal and organic species. Plasma processing is able to treat these ashes, destroying any contained polyaromatic hydrocarbons components. Also we presented a steady three-dimensional model for a plasma melting furnace optimum designed in this study with RNG k-ε model, and its use in characterizing the structure of the flow field, temperature field and reaction field. Among various types of plasma torches, non-transferred hollow cathode type torch is best suited due to its long lifetime, easy power controllability and steady power output. Development of a plasma torch showed the lifetime longer than 300 hours and efficiency better than 65% And the various factors(electrode diameter, cooling flow rate and temperature and gas flow rate affecting the thermal efficiency of the torch) were experimentally evaluated.

전신장기의 호산구 침윤을 동반한 급성 심내막염과 심근염 : An Autopsy Case 부검증례

이상한,이숙희,임재원,곽정식,채종민 大韓法醫學會 1996 대한법의학회지 Vol.20 No.1

We experienced an autopsy case of acute endocarditis and myocarditis with systemic organic eosinophilic infiltration probably due to Clonorchis sinensis infection. Localized hypersensitivity reaction due to parasitic infection is common. Systemic eosinophilic infiltration is generally noted in idiopathic hypereosinophilic syndrome, drug induced reaction and parasitic infection.

접속증가에 따른 ADSL망 트래픽 증가에 대한 연구 : ADSL Network Traffic

노승현,이석환,채덕재,안종근 순천향대학교 부설 산업기술연구소 2001 순천향 산업기술연구소논문집 Vol.7 No.2

With the explosive increace of Internet users, wide installation of fiber optical networks is necessary. However, for various reasons, use of conventional network is still popular as an interim solution to the problems. Among many conventional network technologies to support Internet users, ADSL is one of the most popular one. In this paper we are to analyze the traffic on the network, as the number of simultaneously connected users increase.

축구선수의 Detraining과 Retraining이 혈청지질 및 호르몬농도에 미치는 영향

정정화,박재현,채종훈,성혜련,황지인,윤미숙,노금선,윤종관,윤영학,노순덕,정경숙,박일규,김은희,박현태,박상갑 대한스포츠의학회 1999 대한스포츠의학회지 Vol.17 No.1

The purpose of this study was to investigate the effects of detraining and retraining on serum lipid and hormones in soccer players. Subjects were seven male high-school soccer players. V˙O_2max was determined for each subjects by administering a treadmill test(initial speed: 90m/min, grade: 5%, increasing speed per 3 min: 30m/min). Serum lipid(T-C, TG, HDL-C LDL-C) and hormones(epinephrine, norepinephrine, growth hormones, cortisol) were assayed pre and post detraining in 10, 20, 30 days after retraining. The repeated ANOVA was used to determine significant differences. The 0.05 level of significance was as critical level for the study. The results of the study were as follows: 1. V˙O_2max(ml/min) were 3576.3±204.2ml/min pre detraining, 3234.1±198.9 ml/min post detraining. There are significant(p<.05) difference between pre and post detraining. In 10, 20, 30 days after retraining, V˙O_2max(ml/min) were 3601.4±170.9 ml/min. There were significantly(p<.05) increased in retraining periods. 2. V˙O_2max(ml/kg/min) were significantly(p<.05) decreased from 62.3±2.9 ml/kg/min to 55.9±4.7 ml/kg/min in detraining. In 10, 20, 30 days after retraining, V˙O_2max(ml/kg/min) were 62.4±3.4ml/kg/min, 62.7±2.3ml.kg/min, 67.3±7.2ml/kg/min respectively. There were significantly(p<.05) increased in retraining periods. 3. T-C were significantly (p<.05) increased from 166.6±8.5mg/dl to 175.3±10.3 mg/dl in detraining. In 10, 20, 30 days after retraining, T-C were 160.1± 3.2mg/dl, 156.7±3.7mg/dl, 140.3±9.0mg/dl. There were significantly(p<.05) decreased in retraining periods. 4. HDL-C were 61.4±6.6mg/di pre detraining, 5.3±6.6mg/dl post detraining. There are significant(p<.05) difference between pre and post detraining. In 10, 20, 30 days after retraining, HDL-C were 56.9±7.1mg/dl, 56.4±9.2mg/dl, 57.7±9.1mg/dl respectively. There were no significant difference in retraining periods. 5. The hormones(epinephrine. norepinephrine, growth hormone, cortisol) were changed as same patterns. Epinephrine were 26.0±7.0[g/ml pre detraining, 24.6±3.2pg/ml post detraining. In 10, 20, 30 days after retraining, epinephrine were 26.9±5.6pg/ml, 30.6±6.2pg/ml, 29.4±5.6pg/ml respectively. There were no significant difference in retraining periods. In conclusion, HDL-C, epinephrine, norepinephrine, growth hormone and cortisol were decreased, T-C, LDL-C and TG were increased in detraining. But HDL-C, epinephrine, norepinephrine, growth hormone and cortisol were increased, T-C, LDL-C and TG were decreased in retraining.