전리수에서의 STS304의 부식

이종권,박소연,김범식 순천향대학교 산업기술연구소 2006 순천향 산업기술연구소논문집 Vol.12 No.1

.

炭素工具鋼(SK_3)의 熱傳導係數

權純範,李鍾鵬 경북대학교 공과대학 1981 工大硏究誌 Vol.10 No.-

The numerical value of the thermal conductivity indicates how fast heat will flow in a given material. And the thermal conductivity is temperature-dependent. When the temperature was changed, the thermal conductivity of heat-treated carbon tool steel(SK_3) was obtained by experimental measurements.

공정변수의 변동을 고려한 호감도 함수를 통한 다중반응표면 최적화

권준범,이종석,이상호,전치혁,김광재 한국경영과학회 2005 한국경영과학회지 Vol.30 No.1

A desirability function approach to a multiresponse problem is proposed considering process parameter fluctuation which may amplify the variance of response. It is called POE(propagation of error), which is defined as the standard deviation of the transmitted variability in the response as a function of process parameters. In order to obtain more robust process parameter setting, a new desirability function is proposed by considering POE as well as distance-to-target of response and variance. The proposed method is illustrated using a rubber product case in Ribeiro et al. (2000).

창원지역 중고등학생들의 환경보전에 관한 의식분석

권혁범,이동근,김종오 경상대학교 환경보전연구소 1998 環境保全硏究所報 Vol.6 No.1

This study has been carried out to investigate the consciousness of the middle and high school students in Changwon city on environmental protection. A certain logical questionnaire containing various environmental items was answered by the 432 students, and the results could be summarized as follows : 1. The students were very interested in environmental problems, and they also worried about environmental problems more deeply than the other problems such as a threat of war, a population explosion and a exhaustion of resources. 2. Most of the students took the underground water as a drinking water and they didn't believe that the water supplied by the local government is safe enough for drinking. Therefore, the administration has to try to purify water further in order to recover the belief on environmental policies of the local government. 3. Most of the students said that the more academic subjects associated with environmental problems are needed to obtain detailed knowledges about environmental problems and protection. They generally meet the environmental problems through the mass communications such as TV and radio. When the academic subjects concerning about environmental problem are open in the curriculum, they wanted to attend the class readily. 4. The students recognized that environmental problems are serious. Although they think that they should do their best to solve the environmental problems, they actually were not active enough to put their thought in practice.

유류오염 토양에 대한 복원기술의 적용과 선정 방법

이우범,이원준,권경오,박종천 國立 麗水大學校 환경문제硏究所 2001 環境硏究論文集 Vol.4 No.-

This paper has attempted to provide the latest design approaches, their application site characterization and selecting alternatives for the remediation action of oil contaminated soil. The classification of hazardous materials, the fate of hazardous contaminants in soil and the conventional prediction model and assesment tools were introduced. From the investigation of the trends of soil remediation technology in USA, the classification of organic compounds for the treatability evaluation. the assesment techniques of teratability of contaminants and the estimatcd cost of remediation technology, the fundamentals that support to select the alternatives for the oil contaminated soil in petrochemical complex were suggest.

Serratia marcescens Purine Nucleoside Phosphorylase의 생합성에 대한 글리옥실산의 대사적 역할

신종란,방선권,최병범 한국식품영양학회 1999 韓國食品營養學會誌 Vol.12 No.1

최소 배지에 여러 퓨린 분해 대사 산물을 첨가하여 배양시킨 Serratia marcescens ATTC 25419 세포 추출물에서 purine nucleoside phosphorylase(PNP)의 활성을 조사한 결과, 구아노신은 대조군에 비해 효소의 활성을 5∼15mM에서 60% 이상 감소시켰고, 이노신은 7∼15mM에서 30% 정도 감소시켰으나 0.1∼1mM에서 효소의 활성을 원래대로 회복시켰다. 아데노신, 히포크산틴 및 크산틴도 5∼15mM에서 효소의 활성을 40∼50%정도 감소시켰으나 0.1∼0.5mM에서는 원래대로 회복시켰다. 한편, 요산은 효소의 활성을 0.5mM에서 20% 증가시킨 반면 15mM에서 80% 감소시켰다. 요산의 최종 분해 산물인 글리옥실산도 효소의 활성을 0.5mM에서 20% 증가시킨 반면 3∼15mM에서 30∼50% 정도 감소시켰다. 5mM 농도의 이노신, 히포크산틴 및 요산을 동시에 첨가했을 경우 효소의 활성을 20% 정도 감소된 반면, 이노신과 요산, 세 퓨린 분해 대사 산물은 각각 0.5mM씩 동시 첨가했을 경우는 각각 22, 33%씩 증가시켰다. 이 결과는 낮은 농도 (0.5mM)의 글리옥실산이 S. marcescens purine nucleoside phosphorylase (PNP)의 활성을 증가시키고 고 농도의 글리옥실산은 감소시키는 것을 나타내기 때문에 퓨린 분해 대사 과정에서 글리옥실산이 PNP 생합성의 조절 역할을 하는 것으로 분석된다. The effects of purine catabolites in growth media on the Serratia marcescens purine nucleoside phosphorylase activity were examined. The enzyme activity was decreased above 60% by guanosine (5 to 15mM). The enzyme activity was decreased approximately by 30% in the presence of high concentrations of inosine (7∼15mM), but was not affected at low concentration of inosine (0.1∼1mM). The enzyme activity was decreased approximately by 40∼50% in the presence of high concentrations of adenosine, hypoxanthine, and xanthine (5∼15mM), but was not affected at low concentration of adenosine, hypoxanthine, and xanthine (0.1∼0.5mM). However, the enzyme activity was increased by 20% with low concentrations of uric acid (0.5mM), but was decreased by 80% with high concentrations of same purine catabolite (15mM). Also, the enzyme activity was increased by 20% with low concentration of glyoxylate (0.5mM), final degradative product of uric acid , but was decreased by 30∼50% with high concentrations of glyoxylate (3∼15mM). The enzyme activity was decreased approximately by 20% by the simultaneous addition of inosine, hypoxanthine and uric acid at 5mM each, whereas it was increased by 22 and 33% by the combination of inosine and uric acid, three purine catabolites at 0.5 mM, respectively. These data suggest that S. marcescens purine nucleoside phosphorylase is positively regulated by a glyoxylate concentration, and then may play a regulatory role in a purine catabolism.

엔로플록사신 액제의 닭 호흡기 및 소화기 감염증에 대한 예방 및 치료효과

윤효인,박병권,조준형,정상희,박경환,장범수,김종춘,황윤환,임종환,이내경,박승춘 충남대학교 수의과대학 동물의과학연구소 2000 動物醫科學硏究誌 Vol.8 No.-

We evaluated the efficacy of the liquid form of enrofloxacin against poultry respiratory and digestive infections, the major problems in the poultry industry, from diverse diagnosis viewpoints. Results obtained through this study were as follows: 1. The liquid form of enrofloxacin showed good acceptability to poultry owing to no abhorrence to the drug by chickens, which indicated its suitability for mixing in drinking water. 2. The application of the enrofloxacin formulation improved the productivity of the chicken farm to a great extent by lowering the death toll of chicken raised in the farm. 3. The use of the drug shortened the days to the market, and increased the body weight at the time of marketing. 4. Preventive and therapeutic effects of the liquid enrofloxacin were observed higher than ampicillin, a major antibiotic used in poultry farming. From above results, the liquid form of enrofloxacin would find its use for the prevention and treatment of digestive and respiratory infections, let alone the growth promotion and feed efficiency, especially in the chicken farming practice.

엔로플록사신 액제의 닭유래 병원세균에 대한 시험관내 항균효과 시험

윤효인,박병권,조준형,정상희,박경환,장범수,김종춘,황윤환,임종환,이내경,박승춘 충남대학교 수의과대학 동물의과학연구소 2000 動物醫科學硏究誌 Vol.8 No.-

In this study the antimicrobial spectrum and sensitivity of a liquid formulation of enrofloxacin against the major six pathogenic bacteria isolated from the diseased poultry in Korea were evaluated in comparison with ciprfloxacin (CFX), gentamicin (GM) and penicillin (PC). A liquid form of enrofloxacin, a test material and ciprofloxacin showed at least 83% antibacterial activity against all of six test pathogenic microorganisms at the fixed concentration of 10 ㎍/㎖. Gentamicin and penicillin revealed much lower antibacterial activity at the same condition. We evaluated the liquid form of enrofloxacin as having widespread antibacterial spectrum against poultry infections. The liquid form of enrofloxacin showed potent antibacterial activity, with the MIC range being 0.12∼2 ㎍/㎖ against Gram positives, 0.06∼2 ㎍/㎖ against Gram negatives and 0.5∼2 ㎍/㎖ against Mycoplasma spp. These values were equivalent to or somewhat higher than those of ciprofloxacin, but much lower than those of gentamicn and penicillin. This new liquid form of enrofloxacin would find its way in application of mixing with drinking water for the prevention and treatment of diverse infections in chickens.

外筒과 윗板이 回轉하는 二重圓筒內에서의 定常層流 流動解析

姜昌壽,權純範,李鍾鵬 경북대학교 공과대학 1981 工大硏究誌 Vol.10 No.-

In this paper, steady laminar flow in a tank of double cylinder with rotating outer cylinder and upper disc was analyzed numerically. For simplicity, the stream function and vorticity have been introduced into the Navier-Stokes and the continuity equations. The transformed governing equations were converted into the fimite difference equations which were solved numerically by ADI (Alternating direction implicit) and SUR (Successive under relaxation) method.

항정신병약물 사용 중인 정신분열병 환자에서 올란자판으로의 교체 방법에 관한 연구(II) : Comparison of Safety 안전성 비교

안용민,권용실,권준수,민성호,박두병,양문정,소형석,송종호,신윤식,우행원,유범희,이홍석,정한용,한창환,김용식 大韓神經精神醫學會 2002 신경정신의학 Vol.41 No.5

연구목적: 이 다기관 공동임상연구는 사용 중인 항정신병약물을 ’직접 교체 방법’또는 ’시작-감량 교체 방법’중 한 가지 방법으로 올란자핀으로 교체한 후, 안정성 측면에서 두 교체 방법 간의 비교와 교체후의 변화를 관찰하기 위한 것이다. 방법: 국내 13개 병원의 입원 및 외래에 내원한 환자들 중 ICD-10 지단기준으로 정신분열병에 해당되며, 임상적으로 항정신병약물 교체가 필요한 환자를 대상으로 하였다. 두 가지 교체 방법 중 한 가지를 무작위로 피험자에 적용하였으며, ’직접 교체 방법’에 배정된 경우에는 사용중인 항정신병약물을 일시에 중단하고 10㎎의 올란자핀을 바로 투여하였고, ’시작-감량 교체 방법’에 배정된 경우는 10㎎의 올란자핀 투여하고 2주에 걸쳐서 기존 약물을 감량하여 중단하였다. 올란자핀 사용기간은 총 6주이며, 용량은 5∼20㎎ 범위로 제한하였다. 한정성 평가를 위해서 체중, 생명징후, 자발적인 이상반응 복, 실험실 검사 그리고 Simpson-Angus Scale(SAS), Barnes akathisia rating scale(BARS), Abnormal involuntary movement scale(AIMS). Liverpool University neuroleptic side effect rating scale(LUNSERS)등을 이용하였다. 결과: 총 103명의 정신분열병 환자를 대상으로 하였다. 사용한 올란자핀의 용량, 벤조디아제핀의 병용률, 탈락률과 탈락 사유, 자발적인 이상반응 보고, 생명징후, 실험실 검사 그리고 대부분의 부작용 척도 상에서 임상적으로 의미 있는 차이를 두 교체 방법간에 발견하지 못하였다. 다만 AIMS의 감소는 ’직접 교체 방법’군에서 보다 적었고, 항콜린제의 병용률은 ’시작-감량 교체 방법’군에서 보다 많았다. 기저 상태에서 전체 피험자의 SAS와 BARS 점수는 각각 3.5점과 1.8점이었으며 70% 이상의 피험자가 고프로락틴 혈증을 보였다. 올란자핀으로 교체한 후, SAS, BARS, AIMS 점수의 유의한 감소가 있었으며 고프로락틴 혈증을 보인 피험자 분율도 약 30%이하로 감소하였다. 그러나 교체 방법과 상관없이 올란자핀 교체 후 유의한 체중 증가가 있었다. 결론: 이 연구를 통해 교체 방법에 관계없이 비교적 안전하고 용이하게 올란자핀으로 교체 할 수 있음을 알 수 있었다. 그리고 기존 항정신병약물을 올란자핀으로 교체함으로써 일부 부작용들을 줄일 수 있음을 간접적으로 관찰할 수 있었다. 하지만 이 연구는 여러 제한점과 문제점을 지니고 있기 때문에 보다 체계적인 연구를 통해 검정이 필요하리라 생각된다. Objectives: This multicenter clinical trial involving 13 hospital sites compared the safely of switching to olanzapine between ’direct switching method’ and ’start-tapering switching method’. Method: This study included both inpatients and outpatients who fulfilled the criteria for schizophrenia as defined in the ICD-10, and were in need to be appropriate for switching antipsychotics. Subjects were randomly assigned to one of the two switching methods. For ’direct switching method’group, previous antipsychotics were abruptly discontinued and 10㎎ of olanzapine was administered, and previous antipsychotics was gradually tapered for 2 weeks. Olanzapine was used for 6 weeks and the dose was adjusted within the range of 5-20㎎. The safety of switching to olanzapine was measured with vital sings including body weight, adverse events reported spontaneously, laboratory tests, and various scales such as Simpson-Angus Scale(SAS), Barnes Akathisia Rating Scale(BARS). Abnormal Involuntary Movement Scale(AIMS), and Liverpool University Neuroleptic Side Effect Rating Scale(LUNSERS). Results: 103 patients were switched to olanzapine in this study. The comparison between two switching methods did not show any significant difference in the dosage of olanzapine used, the concomitant use of benzodiazepine, the rate and reasons of drop-out, the adverse events, vital signs, laboratory tests, and most scales for measuring side-effects. However, the decrease in AIMS scores was significantly lower in ’direct switching method’ group, and the concomitant use of anticholinergics was comparatively greater in ’start-tapering switching method’ group. At baseline, SAS and BARS scores were 3.5 and 1.8 points respectively, and more than 70% of the subjects showed hyperprolactinemia. After switching to olanzapine, SAS, BARS, and AIMS scores were significantly decreased and the proportion of the patients with hyperprolactinemia was also decreased to less than 30%. However significant weight gain after the treatment of olanzapine was observed regardless of switching method. Conclusion: This study may suggest that switching to olanzapine can be done with relatively high safety regardless of switching methods and olanzapine can significantly decrease some side-effects induced by other antipsychotics.