Acetic acid로 유도된 위궤양에 대한 고백반, 적석지, 해표초의 항궤양 효과 비교 연구

이내경 충남대학교 대학원 1996 論文集 Vol.16 No.-

미용실 예약시스템에 대한 소비자인식과 재방문의도의 관계에서 소비자행동의 조절효과

이내경,고경숙 한국미용학회 2023 한국미용학회지 Vol.29 No.2

The purpose of this study was to examine the influence on the moderating effect of consumer behavior in the relationship between consumer perception of the beauty salon reservation system and revisit intention. The questionnaire copies collected from 298 study subjects residing in the Daejeon area were used as the final analysis data, and such data was analyzed using the SPSS Statistics 27.0 program and PROCESS macro. The study results were as follows: First, it was confirmed that consumer perception had a significant positive influence on beauty salon revisit intention. Namely, it was confirmed that beauty salon revisit intention increases as consumer perception of the beauty salon reservation system increases. Second, it was confirmed that consumer perception had a significant positive influence on consumer behavior. Namely, it was confirmed that consumer behavior increases as consumer perception of the beauty salon reservation system increases. Third, it was confirmed that consumer behavior had a significant positive influence on revisit intention. Namely, it was confirmed that beauty salon revisit intention increases as consumer behavior increases.

내 안의 우물, 바다를 꿈꾸다 —나의 문학 수업기

이내경(李來京) 아동문학평론사 2020 兒童文學評論 Vol.45 No.3

[신작 동화] 내가 박쥐가 되었다고?

이내경(李來京) 아동문학평론사 2020 兒童文學評論 Vol.45 No.3

인공 피부, 인공 각막 모델을 활용한 동물실험 대체법 연구의 최근 동향

이내경 ( Nae Kyung Lee ),박현지 ( Hyeon Ji Park ),임경민 ( Kyung Min Lim ) 한국동물실험대체법학회 2014 동물실험대체법학회지 Vol.8 No.1

Cosmetics and drug products must be safe and effective to human and for ensuring their safety and efficacy, animal tests have been widely employed that ensued the sacrifice of numerous experimental animals. However, animal tests impose considerable pains and discomforts to laboratory animals and the results obtained cannot always predict the responses of human accurately. To resolve these ethical issues accompanying animal tests and to obtain more human-relevant test results, reconstructed human tissue models are being actively investigated and employed to animal alternative test methods. Especially, reconstructed human skin and cornea models have advanced into practical application steps in the development of cosmetics. Human reconstructed skin and cornea models provide high degrees of similarity to real human tissues and accordingly, they are expected to be able to produce more human relevant results. Their application to safety and efficacy tests of cosmetics have been continuously expanding. Here we review the current trends in the research of human reconstructed skin and cornea models.

흰쥐의 실험적 위궤양에 대한 고백반 , 적석지 , 해표초의 효과

이내경(Rae Kyong Lee),윤효인(Hyo In Yun),박승춘(Seung Chun Park),박종일(Jong Il Park),조명행(Myung Haing Cho) 한국응용약물학회 1997 Biomolecules & Therapeutics(구 응용약물학회지) Vol.5 No.3

This study was performed to evaluate antiulcer effects of traditional folk medicines such as heat-treated alumen, halloysitum rubrum and os sepiae against stomach ulcer induced by acetic acid in Sprague-Dawley rats. Various pharmacological parameters were utilized to compare the antiulcer effects of aforementioned drugs based on the size of ulcer lesion, pepsin activity, free and total acidity, gastric secretory volume, and 5-HT (hydxoytrytamine) content. All folk medicines and ranitidine as control drug were shown to decrease ulcer lesion size after 5-day treatments, with the order of halloysitum rubrum, os sepiae, heat-treated alumen and ranitidine. All treated drugs except os sepiae inhibited the gastric volume as compared with that in the control group. Ranitidine most significantly inhibited the gastric volume. All the experimented drugs in this study lowered the gastric acidity. Halloysitum rubrum decreased it most remarkably, followed by ranitidine, os sepiae and heat-treated alumen after 5-day treatments. All used drugs alleviated the pepsin activity as compared with the control group, os sepiae being the highest then halloysitum rubrum, heat-treated alumen and ranitidine in turn. Heat-treated alumen and halloysitum rubrum showed mucin production to the great extent, and ranitidine had slight increasing effect thereon. At the end of observation period, all drugs except ranitidine increased 5-HT contents as compared to the normal group. From the above results, we could confirm the folk medicines such as heat-treated alumen, halloysitum rubrum and os sepiae have not only remarkable antiulcer effects but also preventing effects for the stomach ulcer recurrence, which suggest the experimented folk medicines could be developed as new antiulcer agents.

공유물분할청구권의 대위행사 가부: 보전의 필요성과 대위의 객체 - 대법원 2020. 5. 21. 선고 2018다879 전원합의체 판결 -

이내경(Naekyeong Lee),이용현(Yonghyun Lee) 서울대학교 법학평론 편집위원회 2021 법학평론 Vol.11 No.-

본고는 타당성과 안정성의 견지에서 대법원 2020. 5. 21. 선고 2018다879 전원합의체 판결의 결론과 논리 구성을 평가하고, 그에 관한 대안을 제시하고자 하였다. 대상판결은 원고인 채권자가 자신의 금전채권의 이행을 확보할 목적으로 강제집행을 우회하여 채무자의 공유물분할청구권을 대위행사하고자 한 사안이다. 채무자 명의의 공유지분에 대한 경매신청은 공동근저당권에 관한 민법 제368조 제2항과 민사집행법 제102조 제1항이 중첩 적용됨으로 인해 ‘남을 가망이 없어’ 받아들여질 수 없었으며, 이에 원고는 대금분할을 위한 경매로 이익을 얻을 목적으로 대위행사를 청구하였다. 이에 대상판결의 다수의견은 채무자의 자력 유무, 채권자가 보전하려는 권리와 대위하여 행사하려는 권리의 관련성 등을 종합적으로 고려할 때, 사안에서 공유물분할청구권 행사로 인하여 책임재산이 보전되는 부분이 없다는 점을 주된 논거로 삼으며 ‘보전의 필요성’이 없다고 보았다. 이에 대하여, 본고는 우선 청구를 받아들이지 아니한 다수의견이 그 결론에 있어서 타당하다는 점을 입증하였다. 강제집행의 준비 내지 보전절차인 채권자대위권의 기능적 본질에 비추면, 책임재산 보전의 존부는 집행절차에 공여될 재산을 확보하는 단계를 기준으로 결정되어야 하며, 사후적 사정인 현금화 단계를 선취하여 책임재산의 증감이라고 평가할 수 없다. 또한 행사 단계에서부터 강제집행이 아닌 채권 만족절차만을 목적으로 하는 채권자대위권 행사는 허용될 수 없으므로, 사안에서 강제집행이 어려워진 이상 이를 우회하는 다른 수단을 강구하여야 한다는 취지의 반대의견은 타당하다고 볼 수 없다. 다만 다수의견의 논리 구성에 대해서는, ‘보전의 필요성’에 관하여 합리적으로 축적되어 온 판례이론을 재단·이탈하여 법적 안정성을 침해한다는 점에서 부적절한 것으로 평가하였다. 종래 대법원은 금전채권을 보전하기 위한 대위행사의 경우 대위 목적물의 속성인 채권의 내용이 아니라 채무자의 속성인 무자력 여부를 원칙적인 기준으로 ‘보전의 필요성’ 요건을 판단하여 왔으며, 이는 ‘보전의 필요성’의 의미를 피보전채권 만족에의 위험으로 파악한 결과이다. 대상판결의 다수의견은 논리적 설명 없이 이러한 법리를 이탈하여 ‘보전의 필요성’의 의미를 모호하게 하며, ‘보전의 필요성’의 판단요소 중 하나인 ‘관련성 법리’을 임의적으로 사용하여 향후 사안에서 채권자대위권 행사의 가능 여부에 관한 예측가능성을 저하시키고 있다. 이에 본고는 다수의견에 대한 대안으로 ‘대위의 객체 해당성’ 요건의 실질화를 제시하였다. 공유물분할청구권은 이를 청구하여 법원의 결정이 내려지기 전까지 당사자가 해당 권리의 구체적 내용을 알 수 없는 상당히 이례적인 권리에 해당한다. 채권자와 채무자 사이의 이해관계를 조정하여야 하는 채권자대위권 제도의 취지상 그 내용이 구체화되지 않은 권리는 채권자대위권의 목적이 되지 않는 권리로 봄이 합당하며, 공유물분할청구권은 그러한 권리의 대표적인 예에 해당할 것이다. This paper aims to review the conclusion and reasoning of the Supreme Court en banc decision 2018Da879 decided May 21, 2020 (hereinafter ‘the case’) in perspective of validity and legal certainty, and also introduce an alternative approach. In the case, the plaintiff, who is the obligee, claimed the subrogation of the right of the obligor to demand partition of jointly owned property, in order to preserve his monetary claim. Although the plaintiff had already applied for the auction of the co-owned share of the obligor, it was revoked by the court because the surplus of the proceeds of the auction sale would not remain(due to Article 102 of the Civil Execution Act). So the plaintiff exercised the obligee’s right of subrogation to detour the limitation of the Civil Execution Act. Majority opinion held that the court should decide whether there exists the need for preservation of the obligee’s right by exercising the obligor’s right, one of the key requirements for exercising the obligee’s right of subrogation, by comprehensively considering whether the obligor is insolvent and whether the obligee’s and the obligor’s right are closely related, etc. And they held that there was no need to preserve the obligee’s right in the case as there was no responsible property preserved by exercising the obligor’s right of demanding partition of jontly owned property. This paper agrees with the conclusion of Majority opinion which rejected the claim. In respect of the function of the obligee’s right of subrogation, which is preparation for the compulsory execution, the obligee’s right of subrogation should not be exercised without any relevance with the compulsory execution. Therefore, Dissenting opinion, claiming that exercising the obligee’s right of subrogation should be allowed in order to satisfy the obligee’s own right if he/she could not use the compulsory execution, is unreasonable. Nevertheless, the reasoning of Majority opinion is inappropriate on account of the breach of legal certainty. Previously, the Supreme court, in principle, admitted the need for preservation if the obligor was insolvent in cases where the obligee’s rights were monetary. The court only concerned the relevance between the obligee’s and the obligor’s right in exceptional cases where the obligor is solvent. In this case, however, Majority opinion denied the necessity of preservation even though the obligor was insolvent. The Court deviated from the precedents without any logical explanation, obscuring the meaning of need to preserve the obligee’s right and lowering the predictability of possibility of exercising the obligee’s right of subrogation. As an alternative, this paper focuses on another requirement, ‘eligibility for the right being subrogated’. The right to demand partition of jointly owned property is a right of which neither party can specify the contents before the court’s decision. As it is understood that the purpose of the obligee’s right of subrogation is to adjust the interests of the obligee and the obligor, it would be reasonable to deny the obligee to subrogate the obligor’s right whose contents are not specified, including the right to demand partition of jointly owned property.

연구논문 : 인공 피부, 인공 각막 모델을 활용한 동물실험 대체법 연구의 최근 동향

이내경 ( Nae Kyung Lee ),박현지 ( Hyeon Ji Park ),임경민 ( Kyung Min Lim ) 한국동물실험대체법학회 2014 동물실험대체법학회지 Vol.8 No.1

Cosmetics and drug products must be safe and effective to human and for ensuring their safety and efficacy, animal tests have been widely employed that ensued the sacrifice of numerous experimental animals. However, animal tests impose considerable pains and discomforts to laboratory animals and the results obtained cannot always predict the responses of human accurately. To resolve these ethical issues accompanying animal tests and to obtain more human-relevant test results, reconstructed human tissue models are being actively investigated and employed to animal alternative test methods. Especially, reconstructed human skin and cornea models have advanced into practical application steps in the development of cosmetics. Human reconstructed skin and cornea models provide high degrees of similarity to real human tissues and accordingly, they are expected to be able to produce more human relevant results. Their application to safety and efficacy tests of cosmetics have been continuously expanding. Here we review the current trends in the research of human reconstructed skin and cornea models.

흰쥐에서 Tiletamine-Zolazepam 및 Lidocaine의 경막외투여시의 마취 효과

윤영탁,김명철,이내경,김민규 한국임상수의학회 1999 한국임상수의학회지 Vol.16 No.1

This study was performed to evaluate the anesthetic effects of the epidural administration of tiletamin-zolazepam and lidocaine to rats. Blood pressure, heart rate, respiratoty rate and blood chemistry were examined according to the time lapse, after the administration of tiletamine-zolazepam, lidocaine or saline. The results obtained were as follows. 1, Tiletamine-zolazepam group revealed fast anesthesia onset time (p<0.01) and also revealed prolonged ambulation time compared with lidocaine group (p<0.01). 2. In the effects of blood pressure, tiletamine-zolazepam group revealed significantly higher value than lidocaine group or saline group, and revealed the highest value at 20 minutes after administration. According to the time lapse, blood pressure of tiletamine-zolazepam group was recovered and showed similar value with lidocaine group and control group at 90 minutes after administration. 3. In the effects of heart rate, tiletamine-zolazepam group revealed significantly lower value than lidocaine group or saline group and revealed the lowest value at 30 minutes after administration, and recovered similar value with pre-administration at 90 minutes after administration. 4. In the effects of respiratory rate, lidocaine group revealed significantly lower value at 30 minutes administration compared with 0 and 60 minutes after administration (p<0.01). Tiletamine-zolazepam group also revealed significantly lower value at 30 minutes compared with 0 and 60 minutes after administration (p<0.01). The changes at 60 minutes after administration, lidocaine group revealed lower value than saline or tiletamine-zolazepam group, and tiletamine-zolazepam group revealed similar value with 0 minutes. 5. In the effects of tidal volume, lidocaine group revealed significantly lower value than saline group (p<0.001) and tiletamine-zolazepam group also revealed lower value than saline group, at 30 minutes after administration. The values at 60 minutes after administration, revealed similar results with that of 30 minutes after administration. 6. In the blood chemistry, the values of alanine transminase (ALT), aspartate transminase(AST) and creatinine did not reveal significant results at 60 minutes after administration. The values of ALT at 60 minutes slightly decreased compared with pre-administration, and revealed normal level.

한우와 돼지에서 간의 약물 대사효소의 활성 비교

이관복,윤효인,박승춘,김민규,이내경,조준형,이동우,Lee, Gwan-bok,Yun, Hyo-in,Park, Seung-chun,Kim, Min-kyu,Lee, Rae-kyung,Cho, Joon-hyung,Lee, Dong-woo 대한수의학회 1998 大韓獸醫學會誌 Vol.38 No.1

Drug-metabolizing activities of Korean native cattle and swine were investigated from viewpoints of the cytochrome P-450's level, their dependent mixed function oxidase activities, the reactive oxygen species formation and cytosolic enzyme acitivities from each liver homogenates. Level of cytochrome P-450 in the liver microsome of Korean native cattle was $0.28{\pm}0.05nmole/mg$ and that in pigs $0.35{\pm}0.03nmole/mg$. Level of cytochrome $b_5$ of Korean native cattle was $0.24{\pm}0.06nmole/mg$, and that of pigs $0.2{\pm}0.05nmole/mg$, showing no difference between two species. NADPH P-450 reductase were higher in Korean native cattle ($58.3{\pm}5.3nmole/mg/min$) than in pigs ($29.9{\pm}3.8nmole/mg/min$)(p<0.01). The activities of cytochrome P-450 dependent monooxygenases such as ethoxyresorufin O-deethylase (cattle, $96.5{\pm}12.5nmole/mg/min$ ; pigs, $13.6{\pm}2.1nmole/mg/min$), N-benzphetamine N-demethylase (cattle, $5.23{\pm}0.82nmole/mg/min$ ; pigs, $0.76{\pm}0.3nmole/mg/min$) and aniline hydroxylase (cattle, $0.95{\pm}0.1nmole/mg/min$ ; pigs, $0.33{\pm}0.08nmole/mg/min$) were much higher in Korean native cattle than in swine(p<0.01). However, the activity of testosterone $7{\alpha}$-hydroxylase was higher in swine ($90.4{\pm}1.2nmole/mg/min$) than cattle (cattle, $32.8{\pm}1.2nmole/mg/min$). Interestingly, testosterone $16{\alpha}$-hydroxylase, a marker enzyme for P-450 IIA was not detected in both animal species. These results suggest that Korean native cattle and pigs have high contents of P-450 IA1 and P-450 IIIA. Total sulfhydryl compound (cattle, $10.3{\pm}1.1nmole/mg$ ; Pigs, $14.5{\pm}1.8nmole/mg$) and glutathione related enzymes except glutathione reductase (cattle, $38.1{\pm}7.9nmole/mg/min$; swine, $22{\pm}3.6nmole/mg/min$) showed higher levels in swine than in Korean native cattle. Superoxide dismutase (cattle, $7.64{\pm}0.84nmole/mg/min$ ; pigs, $4.47{\pm}0.94nmole/mg/min$) and catalase (cattle, $30.4{\pm}3.7nmole/mg/min$ ; pigs, $17.2{\pm}1.8nmole/mg/min$) were remarkably higher in Korean native cattle than in swine (p<0.05).