분자역학적 방법을 이용한 부산시내 대형건물 냉각탑수의 레지오넬라균의 형별 분류

김정만,정석훈,서대영,박은희,송은주,최재철,이은엽,장철훈 대한임상미샐물학회 2004 Annals of clinical microbiology Vol.7 No.1

흰쥐에서 심정지후 Pentoxifylline이 뇌의 허혈-재관류 손상에 미치는 효과

정시경,김영민,오동렬,최경호,박승현,이운정,박규남,유은영,이원재,김세경 大韓應急醫學會 1999 대한응급의학회지 Vol.10 No.2

Background: Two major events occurring in the cerebral hemodynamics after successful resuscitation from cardiac arrest are reactive hyperemia and postischemic hypoperfusion. In this study, we examined the effect of Pentoxifylline(PTX) on the rat brain following cardiac arrest. Methods: Fourteen rats were anesthetized and artificially ventilated. Cardiac arrest was produced by chest compression and clamping of tracheal tube for 3 minutes in ketamine anesthetized rats. Circulation was restored by standard cardiopulmonary resuscitation methods. In 7 rats, PTX 10mg/kg was infused at 10min after cardiac arrest(PTX group). In the other 7 rats, same amount of normal saline was infused(control group). Results: In both groups, hemodynamic variables, neurologic deficit(ND) score and histopathologic findings of hippocampal CA1 neurons were observed. Hemodynamic variables and ND score were not significantly different between two groups. Delayed ischemic neurons of hippocampal CA1 were decreased in PTX group(2.2±2.4%) compared with control group(9.1±1.2%). Conclusions: We conclude that PTX prevented development of delayed ischemic neurons in hippocampal CA1 after cardiac arrest. PTX may be useful in emergency situations following cardiac arrest.

홀로그램 연결방식에 의한 광병렬 연산처리기에 관한 연구

은재정 國立 昌原大學校 産業技術硏究所 1993 産技硏論文集 Vol.7 No.-

This paper describes various optical phenomena in self-pumped phase conjugate mirror(SPPCM) and applications in optical computing. especially the temporal behavior of the SPPCM is investigated for using real-time optical memory. Also an explanation is given for the unstable effects observed on the phase-conjugate beam and that give rise to pulsations and oscillations. And optical parallel logic processor is constructed using liquid-crystal spatial light modulator(LCSLM) and SPPCM as holographic memory. Contents-addressable memory type LUT(look-up table) scheme for parallel processing is proposed and to reduce the required storage the residue number system(RNS) minimization methods are studies.

Acriflavine-Guanosine 복합제 (AG60)의 조직내 분포에 대한 형광현미경적 연구

고정식,임수재,안의태,김진국,김상건,이경영,강종구,홍은경,정영신,유보림,한영복 대한해부학회 1999 Anatomy & Cell Biology Vol.32 No.1

TNF-α 유전자형과 방광암과의 관계

정필두,김은정,엄민식,서정원,윤석중,김종석,이상철,김원재 충북대학교 의학연구소 2001 忠北醫大學術誌 Vol.11 No.2

연구목적: TNF-α는 일부 종양의 종양화 과정과 관련이 있는 것으로 알려져 있다. 본 연구는 TNF-α 발현에 영향을 미치는 TNF-α 촉진자 -308 부위의 유전적 다형성이 방광암과 관련이 있는지 유무를 알고자 시행하였다. 대상 및 방법: 유전자 분석을 위하여 환자 113명 및 대조군 109명으로부터 혈액을 채취하여 genomic DNA를 분리한 후 PCR-RFLP 및 direct DNA sequencing을 통하여 TNF-α유전자의 다형성을 조사하여 방광암의 발생, 병기 및 분화도와 비교 검토하였다. 결과: TNF-α 촉진자 -308 부위의 유전형은 대조군에서는 GG형이 83.5%(90례 및 GA형이 16.5%(19례)로 관찰되었으며 AA형은 없었다. 환자군에서는 GG 형이 85.4%(97례), GA형 및 AA형은 각각 13.1%(15례)및 0.8%(1례)에서 관찰되었다. 두 군 모두에서 GG형이 가장 많이 나타났으며 다음으로 GA형을 보이고 AA형은 1례의 방광암 환자에서만 관찰되었다. -308부위의 경우도 두 군 사이에 유전자형의 차이는 없었다(p=0.259) 분화도별 분포를 보면 grade I이 20례, grade II가 49례, grade Ⅲ은 34례였고 병기별로 표재성인 경우가 90례였으며 침윤성은 14례였다. 분화도가 나빠질수록 GA형이 증가하였다(p=0.04). 그러나 병기와 TNF-α promoter -308부위의 유전자형 사이에는 유의한 상관 관계가 없었다(p=0.123). 결론: 방광암 환자의 혈액에서 GA genotype이 관찰되는 경우, 분화도가 나쁠 가능성이 매우 높기 때문에 좀 더 적극적인 치료와 세밀한 추적관찰을 함으로써 방광암으로 인한 사망과 암의 진행을 예방할 수 있을 것으로 기대한다. Purpose : Tumor necrosis factor-alpha (TNF-α) is involved in tumorigenesis of several cancers as an endogenous tumor promoter. The purpose of this study was to investigate whether genetic polymorphism of TNF-α promoter region (-308) was associated with human bladder tumor. Materials and Methods: The DNA from 113 and 109 respective blood samples of bladder tumor Patients and control group was analyzed by PCR-based restriction fragment length polymorphism (RFLP) and direct DNA sequencing methods to characterize the genetic polymorphism of -308 promoter region of the TNF-α gene in bladder tumor patients. We compared the association of bladder tumor with genetic Polymorphism of TNF-α promoter region(-308) in relation to the stage, grade, recurrence and progressio. Results : Eighty-six percents(97/113) of bladder tumor patients and 83.5% (90/109) of control group showed genotype GG at -308 region of TNF-α. Difference in genetic variations of TNF-α promoter (-308) did not exist between bladder tumor patients and control group(p=0.259). Tumor grade was significantly related to the GA genotype (p=0.04). The higher is the grade in bladder tumor, the more frequent was the GA genotype. Tumor stage, recurrence and progression were not significantly associated with genetic polymorphism of TNF-α promoter region (-308). Conclusion: The GA genotype of TNF-a promoter region (-308) had a significant impact on TNF-α production and was related to higher grade tumor compared to GG genotype. TNF-α serum levels in bladder tumor patients were significantly higher than controls. These data suggested that TNF-α might involve the tumorigenesis of the bladder rather than treatment or prevention of bladder tumor.

1980년대(1981-1990) 전·후반기 피부과 외래환자의 통계적 비교 관찰

은 철,강승구,권상진,정성재,조지형,권철욱,김영진,김재홍 한양대학교 의과대학 1997 한양의대 학술지 Vol.17 No.1

To study the prevalence of common dermatoses 37,638 and 30,286 new outpatients who visited dermatology clinic with Hanyang University Hospital from January 1981 to December 1985 and from January 1986 to December 1990, respectively. Among the 37,638 outpatients in the first 5 years, the total number of male patients were 18,107(48.1%) and female patients were 19,531 (51.9%). Among the 30286 outpatients in the last 5 years, the total number of male patients were 14,705 (48.6%) and female patients were 15,581 (51.4%). In the both periods, the most frequent age groups was 21-30 (27.3%,25.2% respectively). The 15 common dermatoses, bacterial infection, seborreic dermatitis, drug eruption, verruca, syphilis, psoriasis, herpes zoster, and hypopigmentary disorder, in order of frequency. In thelast 5years, dermatophytosis, contact dermatitis, urticaria, acne, other eczema, atopic dermatitis, seborrheic dermatitis, bacterial infection, drug eruption, verruca, gerpes zoster, psoriasis, hypopigmentary disorder, scabies and syphilis were the 15 common dermatoses, as frequency. In both periods, the dermatosis which showed annually increasing tendency was dermatophytosis and those of decreasing tendency was bacterial infection. In the both periods, dermatophytosis, urticaria, bacterial infection, seborrheic dermatitis, verruca, and hypopigmentary disorder occurred most frequently during the summer season, and the incidence of other ecxema, scabies, atopic dermatitis, and herpes zoster increased during the winter season.

括數根 水溶性 蛋白質의 細胞毒性

殷載淳,鄭甲基,梁在憲,權鎭,吳贊鎬,全焄 又石大學校 1995 論文集 Vol.17 No.-

The purpose of this research was to investigate effect of water-soluble protein of Trichosanthes kirillowii(TKP) on the proliferation of human tumor cells. TKP inhibited the proliferation of HeLa cells and KHOS-NP cells. The inhibitory activity of doxorubicin on HeLa cells and its of mitomycin C on KHOS-NP cells were increased by the combination of TKP. TKP did not affect on the proliferation of Balb/c 3T3 cells, but inhibited the proliferation of mouse spleen cells and human lymphocyte at 1 ㎍/ml. These results suggest that TKP bas the cytotoxicity on HeLa and KHOS-NP cells, and increase the cytotoxicity of doxorubicin or mitomycin C.

김천과하주의 유래에 관한 연구

정은재 東國專門大學 1998 金龜論叢 Vol.6 No.1

김천과하주의 제조방법 확립을 위하여 관련 문헌을 중심으로 제조방법을 조사하였다. 김천과하주의 제법은 문헌상으로 구체화된 것이 없을 뿐만 아니라 상이한 점이 많았다. 원료미의 처리 방법, 과하주 명칭의 유래, 발효제로써의 누룩의 특성, 급수량별 및 단담금과 2단담금별로 구분하여 조사하였으며 원료미의 처리방법은 떡을 쳐서 후수하는 방법과 고두밥 상태로 누룩을 물에 침출시킨 침출액을 사용하는 것으로 조사되었다. 발효제로써의 누룩은 문헌상에서와 같이 쑥과 국화를 깔고 띄운 누룩으로 담근 술이 우수하였다고 유래되고 있다. 따라서 본 문헌적 고찰 결과 쑥과 국화를 깔고 띄운 누룩을 사용하고 김천의 과하천 샘물을 사용하여 급수율 120-170%로 2단담금하는 제조방법이 김천과하주의 제조방법에 가장 근접한 것으로 조사되었다.

신경회로망을 이용한 이면비드 폭 예측에 관한 연구

정재원,김일수,박창언,김학형,서주환,김인주,심지연 한국공작기계학회 2008 한국공작기계학회 춘계학술대회논문집 Vol.2008 No.-

The development of robotic welding process is a very complex assignment because the system is affected by a number of process parameters which are very difficult to determine or predict in practice. The full automation welding has not yet been achieved partly because the mathematical model for the process parameters of a given welding task is not fully understood and quantified. Several mathematical models to control welding quality, Productivity, micro structure and weld properties in arc welding processed have been studied. However, it is not an easy task to apply them to the various practical situations because the relationship between the process parameters and the bead geometry is non-linear and also they are usually dependent on specific experimental result. Practically, it is difficult, but important to know how to establish a mathematical model that can predict the result of the actual welding process and how to select the optimum welding condition under a certain constraint. In this paper, an attempt has been made to develop an neural network model to predict the back-bead width as a function of key process parameters in the GMA (Gas Metal Arc) welding and to compare the developed models with the experimental results

두개내 동맥 병변을 보인 혈관형 베체트씨병 2예

박은미,성정준,이정주,강동화,노재규 대한신경과학회 1999 대한신경과학회지 Vol.17 No.1